NIMG-57QUANTITATION OF 18F-DOPA UPTAKE ON PET PREDICTS TUMOR GRADE WITH HIGH SENSITIVITY AND SPECIFICITY IN NEWLY-DIAGNOSED GLIOMA: UCLA EXPERIENCE

Aim: Endometrial cancer is a gynecological malignancy that accounts for approximately 7% of new cancer cases and 4% of cancer-related deaths in women. The most important factor determining the prognosis of this ailment isthe depth of myometrial invasion, which has been reported to be associated with the tumor grade, lymph node metastasis, and patient survival. The aim of this study was to investigate the effectiveness of magnetic resonance imaging (MRI) and frozen results in determining the depth of myometrial invasion needed to guide the intraoperative decision-making process in endometrial cancer patients by comparing them with paraffin results, to evaluate the accuracy rate and to establish a reliable estimation model by using other data in the study.Methods: In this study, the files of patients who underwent surgery for endometrial cancer between January 01, 2012 and January 31, 2019 in Kocaeli Derince Training and Research Hospital, Department of Obstetrics and Gynecology, were evaluated retrospectively.Results: The results of the paraffin examination were found to be in good agreement with the frozen results, while the MRI showed a moderate agreement (Kappa coefficient 0.741 and 0.414, respectively). A logistic regression model based on the MRI and frozen results included MRI (less or more 50% invasion), frozen (less or more 50% invasion), age, gravida, parity, and CA 125 (U/ml). The Nagelkerke R square value for this model was 84,0%, and the sensitivity and specificity of the model for predicting paraffin examination results were 90,5% and 97.3%, respectively.Conclusion: Compared to MRI, frozen results are more reliable in determining myometrial invasion when the paraffin result is accepted as the gold standard. Myometrial invasion can be estimated with high sensitivity and specificity using a model including MRI, frozen, CA 125, age, parity.

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Evaluation of preoperative, intraoperative and postoperative myometrial invasion in endometrial cancers: comparıson of MRI, frozen and final pathology results

Journal of Theoretical Clinical and Experimental Morphology ◽

10.28942/jtcem.v3i1.164 ◽

2021 ◽

Vol 3 (1) ◽

pp. 1-8

Author(s):

Kemine Uzel

Keyword(s):

Endometrial Cancer ◽

Sensitivity And Specificity ◽

Myometrial Invasion ◽

High Sensitivity ◽

Tumor Grade ◽

Ca 125 ◽

Estimation Model ◽

Gynecological Malignancy ◽

Training And Research ◽

Magnetic Resonance Imaging Mri

Aim: Endometrial cancer is a gynecological malignancy that accounts for approximately 7% of new cancer cases and 4% of cancer-related deaths in women. The most important factor determining the prognosis of this ailment isthe depth of myometrial invasion, which has been reported to be associated with the tumor grade, lymph node metastasis, and patient survival. The aim of this study was to investigate the effectiveness of magnetic resonance imaging (MRI) and frozen results in determining the depth of myometrial invasion needed to guide the intraoperative decision-making process in endometrial cancer patients by comparing them with paraffin results, to evaluate the accuracy rate and to establish a reliable estimation model by using other data in the study.Methods: In this study, the files of patients who underwent surgery for endometrial cancer between January 01, 2012 and January 31, 2019 in Kocaeli Derince Training and Research Hospital, Department of Obstetrics and Gynecology, were evaluated retrospectively.Results: The results of the paraffin examination were found to be in good agreement with the frozen results, while the MRI showed a moderate agreement (Kappa coefficient 0.741 and 0.414, respectively). A logistic regression model based on the MRI and frozen results included MRI (less or more 50% invasion), frozen (less or more 50% invasion), age, gravida, parity, and CA 125 (U/ml). The Nagelkerke R square value for this model was 84,0%, and the sensitivity and specificity of the model for predicting paraffin examination results were 90,5% and 97.3%, respectively.Conclusion: Compared to MRI, frozen results are more reliable in determining myometrial invasion when the paraffin result is accepted as the gold standard. Myometrial invasion can be estimated with high sensitivity and specificity using a model including MRI, frozen, CA 125, age, parity.

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Detector-C: A Blood-based IVD with High Sensitivity and Specificity for Early Detection and Screening of Colorectal Cancer

Zeitschrift für Gastroenterologie ◽

10.1055/s-0030-1263628 ◽

2010 ◽

Vol 48 (08) ◽

Author(s):

A Rosenthal ◽

H Köppen ◽

R Musikowski ◽

R Schwanitz ◽

J Behrendt ◽

...

Keyword(s):

Colorectal Cancer ◽

Early Detection ◽

Sensitivity And Specificity ◽

High Sensitivity

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Trends in Diagnosis for Active Tuberculosis Using Nanomaterials

Current Medicinal Chemistry ◽

10.2174/0929867325666180912105617 ◽

2019 ◽

Vol 26 (11) ◽

pp. 1946-1959 ◽

Cited By ~ 3

Author(s):

Le Minh Tu Phan ◽

Lemma Teshome Tufa ◽

Hwa-Jung Kim ◽

Jaebeom Lee ◽

Tae Jung Park

Keyword(s):

Sensitivity And Specificity ◽

High Efficiency ◽

Point Of Care ◽

High Sensitivity ◽

Signs And Symptoms ◽

Diagnostic Methods ◽

Advantages And Disadvantages ◽

Treatment And Prevention ◽

Clinical Tools ◽

Diagnostic Applications

Background:Tuberculosis (TB), one of the leading causes of death worldwide, is difficult to diagnose based only on signs and symptoms. Methods for TB detection are continuously being researched to design novel effective clinical tools for the diagnosis of TB.Objective:This article reviews the methods to diagnose TB at the latent and active stages and to recognize prospective TB diagnostic methods based on nanomaterials.Methods:The current methods for TB diagnosis were reviewed by evaluating their advantages and disadvantages. Furthermore, the trends in TB detection using nanomaterials were discussed regarding their performance capacity for clinical diagnostic applications.Results:Current methods such as microscopy, culture, and tuberculin skin test are still being employed to diagnose TB, however, a highly sensitive point of care tool without false results is still needed. The utilization of nanomaterials to detect the specific TB biomarkers with high sensitivity and specificity can provide a possible strategy to rapidly diagnose TB. Although it is challenging for nanodiagnostic platforms to be assessed in clinical trials, active TB diagnosis using nanomaterials is highly expected to achieve clinical significance for regular application. In addition, aspects and future directions in developing the high-efficiency tools to diagnose active TB using advanced nanomaterials are expounded.Conclusion:This review suggests that nanomaterials have high potential as rapid, costeffective tools to enhance the diagnostic sensitivity and specificity for the accurate diagnosis, treatment, and prevention of TB. Hence, portable nanobiosensors can be alternative effective tests to be exploited globally after clinical trial execution.

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Value of Coronary Calcium Scoring in Symptomatic and Asymptomatic Coronary Artery Disease Patients

Current Medical Imaging Formerly Current Medical Imaging Reviews ◽

10.2174/1573405616666201023142030 ◽

2020 ◽

Vol 16 ◽

Author(s):

Hala T. Salem ◽

Eman A.S. Sabek

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Sensitivity And Specificity ◽

High Sensitivity ◽

Coronary Calcium ◽

Risk Estimate ◽

Calcium Scoring ◽

Coronary Calcium Scoring ◽

Framingham Risk ◽

Artery Disease

Aim and Objective: To estimate the relationship between Coronary Calcium Scoring (CCS)and presence of different degrees of obstructive coronary artery disease (CAD) to avoid unnecessary examinations and hence unnecessary radiation exposure and contrast injection. Background: Coronary Calcium Scoring (CCS) is a test uses x-ray equipment to produce pictures of the coronary arteries to determine the degree of its narrowing by the build-up of calcified plaques. Despite the lack of definitive data linking ionizing radiation with cancer, the American Heart Association supports widely that practitioners of Computed tomography Coronary Angiography (CTCA) should keep “patient radiation doses as low as reasonably achievable but consistent with obtaining the desired medical information”. Methods: Data obtained from 275 CTCA examinations were reviewed. Radiation effective doses were estimated for both CCS and CTCA, measures to keep it as low as possible were presented, CCS and Framingham risk estimate were compared to the final results of CTCA to detect sensitivity and specificity of each one in detecting obstructive lesions. Results: CCS is a strong discriminator for obstructive CAD and can with high sensitivity and specificity and correlates well with the degree of obstruction even more than Framingham risk estimate which has high sensitivity and low specificity. Conclusion: CCS helps reducing the effective radiation dose if properly evaluated to skip unnecessary CTCA if obstructive lesions was unlikely, and as a test does not use contrast material, harmful effect on the kidney will be avoided as most of coronary atherosclerotic patients have renal problems.

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Blood-Based Detection of Colorectal Cancer Using Cancer-Specific DNA Methylation Markers

Diagnostics ◽

10.3390/diagnostics11010051 ◽

2020 ◽

Vol 11 (1) ◽

pp. 51

Author(s):

Nam-Yun Cho ◽

Ji-Won Park ◽

Xianyu Wen ◽

Yun-Joo Shin ◽

Jun-Kyu Kang ◽

...

Keyword(s):

Colorectal Cancer ◽

Dna Methylation ◽

Sensitivity And Specificity ◽

Stage Iv ◽

High Sensitivity ◽

Liquid Biopsies ◽

Blood Leukocytes ◽

Marker Panel ◽

A Genome ◽

Methylight Assay

Cancer tissues have characteristic DNA methylation profiles compared with their corresponding normal tissues that can be utilized for cancer diagnosis with liquid biopsy. Using a genome-scale DNA methylation approach, we sought to identify a panel of DNA methylation markers specific for cell-free DNA (cfDNA) from patients with colorectal cancer (CRC). By comparing DNA methylomes between CRC and normal mucosal tissues or blood leukocytes, we identified eight cancer-specific methylated loci (ADGRB1, ANKRD13, FAM123A, GLI3, PCDHG, PPP1R16B, SLIT3, and TMEM90B) and developed a five-marker panel (FAM123A, GLI3, PPP1R16B, SLIT3, and TMEM90B) that detected CRC in liquid biopsies with a high sensitivity and specificity with a droplet digital MethyLight assay. In a set of cfDNA samples from CRC patients (n = 117) and healthy volunteers (n = 60), a panel of five markers on the platform of the droplet digital MethyLight assay detected stages I–III and stage IV CRCs with sensitivities of 45.9% and 95.7%, respectively, and a specificity of 95.0%. The number of detected markers was correlated with the cancer stage, perineural invasion, lymphatic emboli, and venous invasion. Our five-marker panel with the droplet digital MethyLight assay showed a high sensitivity and specificity for the detection of CRC with cfDNA samples from patients with metastatic CRC.

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