scholarly journals Covid-19 presentation among symptomatic healthcare workers in Ireland

2021 ◽  
Author(s):  
G O’Sullivan ◽  
S Jacob ◽  
P M Barrett ◽  
J Gallagher
Keyword(s):  
Healthcare Workers ◽  
Conditional Logistic Regression ◽  
Retrospective Chart Review ◽  
Health Staff ◽  
Logistic Regression Models ◽  
Presenting Symptoms ◽  
Matched Case ◽  
Polymerase Chain ◽  
Specific Symptoms ◽  
Control Study

Abstract Background It is recognized that healthcare workers (HCWs) are at high risk of contracting Covid-19. It is incumbent on occupational health staff to recognize potential symptoms of Covid-19 among HCWs. Aims The aims of the study were to describe the presenting symptoms of HCWs who developed Covid-19 in Ireland, and to estimate the odds of specific symptoms being associated with a positive Covid-19 polymerase chain reaction (PCR) result. Methods A retrospective chart review of all symptomatic HCWs who self-presented for Covid-19 testing in Cork from March to May 2020 was conducted. A sex-matched case–control study was carried out to compare presenting features among those who tested positive compared to those who tested negative. Univariate and multivariable-adjusted conditional logistic regression models were run using Stata 15.0 to identify the symptoms associated with positive Covid-19 swab results. Results Three hundred and six HCWs were included in the study; 102 cases and 204 controls. Common presenting features among cases were fever/chills (55%), cough (44%) and headache (35%). The symptoms which were significantly associated with a positive Covid-19 swab result were loss of taste/smell (adjusted odds ratio [aOR] 12.15, 95% confidence interval [CI] 1.36–108.79), myalgia (aOR 2.36, 95% 1.27–4.38), fatigue (aOR 2.31, 95% CI 1.12–4.74), headache (aOR 2.11, 95% CI 1.19–3.74) and fever/chills (aOR 1.88, 95% CI 1.12–3.15). Conclusions Fever, fatigue, myalgia, loss of taste/smell and headache were associated with increased odds of a Covid-19 diagnosis among symptomatic self-referred HCWs compared with those had negative swab results. Testing criteria for HCWs should reflect the broad range of possible symptoms of Covid-19.

scholarly journals Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0247163
Author(s):  
Priyamadhaba Behera ◽  
Binod Kumar Patro ◽  
Arvind Kumar Singh ◽  
Pradnya Dilip Chandanshive ◽  
Ravikumar S. R. ◽  
...  
Keyword(s):  
Vitamin C ◽  
Healthcare Workers ◽  
Case Control Study ◽  
Infection Type ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Logistic Regression Models ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Background Ivermectin is one among several potential drugs explored for its therapeutic and preventive role in SARS-CoV-2 infection. The study was aimed to explore the association between ivermectin prophylaxis and the development of SARS-CoV-2 infection among healthcare workers. Methods A hospital-based matched case-control study was conducted among healthcare workers of AIIMS Bhubaneswar, India, from September to October 2020. Profession, gender, age and date of diagnosis were matched for 186 case-control pairs. Cases and controls were healthcare workers who tested positive and negative, respectively, for COVID-19 by RT-PCR. Exposure was defined as the intake of ivermectin and/or hydroxychloroquine and/or vitamin-C and/or other prophylaxis for COVID-19. Data collection and entry was done in Epicollect5, and analysis was performed using STATA version 13. Conditional logistic regression models were used to describe the associated factors for SARS-CoV-2 infection. Results Ivermectin prophylaxis was taken by 76 controls and 41 cases. Two-dose ivermectin prophylaxis (AOR 0.27, 95% CI, 0.15–0.51) was associated with a 73% reduction of SARS-CoV-2 infection among healthcare workers for the following month. Those involved in physical activity (AOR 3.06 95% CI, 1.18–7.93) for more than an hour/day were more likely to contract SARS-CoV-2 infection. Type of household, COVID duty, single-dose ivermectin prophylaxis, vitamin-C prophylaxis and hydroxychloroquine prophylaxis were not associated with SARS-CoV-2 infection. Conclusion Two-dose ivermectin prophylaxis at a dose of 300 μg/kg with a gap of 72 hours was associated with a 73% reduction of SARS-CoV-2 infection among healthcare workers for the following month. Chemoprophylaxis has relevance in the containment of pandemic.

scholarly journals A case–control study of factors associated with SARS-CoV-2 infection among healthcare workers in Colombia

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Merida Rodriguez-Lopez ◽  
Beatriz Parra ◽  
Enrique Vergara ◽  
Laura Rey ◽  
Mercedes Salcedo ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
High Performance ◽  
Case Control Study ◽  
Case Control ◽  
Protective Equipment ◽  
Logistic Regression Models ◽  
Factors Associated ◽  
Modifiable Factors ◽  
Polymerase Chain ◽  
Control Study

Abstract Background Healthcare Workers (HCW) are repeatedly exposed to SARS-CoV-2 infection. The aim of this study was to identify factors associated with SARS-CoV-2 infection among HCW in one of the largest cities in Colombia. Methods We conducted a case–control study, where cases had a positive reverse transcription-polymerase chain reaction and controls had a negative result. Participants were randomly selected and interviewed by phone. Analyses were performed using logistic regression models. Results A total of 110 cases and 113 controls were included. Men (AdjOR 4.13 95% CI 1.70–10.05), Nurses (AdjOR 11.24 95% CI 1.05–119.63), not using a high-performance filtering mask (AdjOR 2.27 95% CI 1.02–5.05) and inadequate use of personal protective equipment (AdjOR 4.82 95% CI 1.18–19.65) were identified as risk factors. Conversely, graduate (AdjOR 0.06 95% CI 0.01–0.53) and postgraduate (AdjOR 0.05 95% CI 0.005–0.7) education, feeling scared or nervous (AdjOR 0.45 95% CI 0.22–0.91), not always wearing any gloves, caps and goggles/face shields (AdjOR 0.10 95% CI 0.02–0.41), and the use of high-performance filtering or a combination of fabric plus surgical mask (AdjOR 0.27 95% CI 0.09–0.80) outside the workplace were protective factors. Conclusion This study highlights the protection provided by high-performance filtering masks or double masking among HCW. Modifiable and non-modifiable factors and the difficulty of wearing other protective equipment needs to be considered in designing, implementing and monitoring COVID-19 biosafety protocols for HCW.

scholarly journals A Case-Control Study of Factors Associated with SARS-CoV-2 Infection Among Healthcare Workers in Colombia.

2021 ◽  
Author(s):  
Merida Rodriguez-Lopez ◽  
Beatriz Parra ◽  
Enrique Vergara ◽  
Laura Rey ◽  
Mercedes Salcedo ◽  
...  
Keyword(s):  
Regression Models ◽  
Healthcare Workers ◽  
High Performance ◽  
Case Control Study ◽  
Case Control ◽  
Protective Equipment ◽  
Logistic Regression Models ◽  
Factors Associated ◽  
Polymerase Chain ◽  
Control Study

Abstract Background: Healthcare Workers (HCW) are repeatedly exposed to SARS-CoV-2 infection. The aim of this study was to identify factors associated with SARS-CoV-2 infection among HCW in one of the largest cities in Colombia. Methods: We conducted a case-control study, where cases had a positive reverse transcription-polymerase chain reaction and controls had a negative result. Participants were randomly selected and interviewed by phone. Analyses were performed using logistic regression models. Results: A total of 110 cases and 113 controls were included. Men (AdjOR 4.1 95%CI 1.7-10), Nurses (AdjOR 11.2 95%CI 1.1-119.6), not using a high-performance filtering mask (AdjOR 2.2 95%CI 1-5.1) and inadequate use of personal protective equipment (AdjOR 4.8 95%CI 1.1-19.6) were identified as risk factors. Conversely, graduate (AdjOR 0.1 95%CI 0.01-0.5) and postgraduate (AdjOR 0.05 95%CI 0.004-0.5) education, feeling scared or nervous (AdjOR 0.5 95%CI0.2-0.9), not wearing any of gloves, hat and googles/face shields (AdjOR 0.1 95%CI0.02-0.4), and the use of high-performance filtering or a combination of fabric plus surgical mask (AdjOR 0.2 95%CI 0.1-0.8) outside the workplace were protective factors. Conclusion: This study highlights the protection provided by high-performance filtering mask or double masking among HCW. Individual factors and the difficulties of wearing other protective equipment needs to be considered in designing, implementing and monitoring COVID-19 biosafety protocols for HCW.

scholarly journals Effect of Adherence to a Mediterranean Diet and Olive Oil Intake during Pregnancy on Risk of Small for Gestational Age Infants

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1234 ◽  
Author(s):  
Juan Martínez-Galiano ◽  
Rocío Olmedo-Requena ◽  
Rocío Barrios-Rodríguez ◽  
Carmen Amezcua-Prieto ◽  
Aurora Bueno-Cavanillas ◽  
...  
Keyword(s):  
Olive Oil ◽  
Mediterranean Diet ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Conditional Logistic Regression ◽  
Statistical Significance ◽  
Odds Ratios ◽  
Logistic Regression Models ◽  
Matched Case ◽  
Control Study

To quantify the effect of a Mediterranean dietary pattern, as well as the consumption of olive oil (OO), on the risk of having a small for gestational age infants (SGA), a matched case-control study was conducted in Spain. Dietary intake during pregnancy was assessed using a validated food frequency questionnaire. Three indices were used to evaluate the adherence to Mediterranean diet (MD) (Predimed, Trichopoulou and Panagiotakos). Crude odds ratios (cOR) and adjusted odds ratios (aOR) and their 95% confidence intervals (CI) were estimated using conditional logistic regression models. Results were stratified by severity of SGA: moderate (percentiles 6–10), and severe (percentiles ≤5). For moderate, four or more points in the Predimed´s index was associated with a 41% reduction of having SGA compared with women with a score ≤3, aOR = 0.59 (95% CI 0.38–0.98); for severe, the reduction in risk was not statistically significant. Similar results were found when the other MD indexes were used. An intake of OO above 5 g/day was associated with a lower risk of SGA (aOR = 0.53, 95% CI 0.34–0.85); statistical significance was observed for moderate SGA (aOR = 0.53, 95% CI 0.30–0.96), but not for severe SGA (aOR = 0.51, 95% CI 0.24–1.07), although the magnitude of ORs were quite similar. Adherence to a MD and OO intake is associated with a reduced risk of SGA.

scholarly journals Role of ivermectin in the prevention of COVID-19 infection among healthcare workers in India: A matched case-control study

2020 ◽  
Author(s):  
Priyamadhaba Behera ◽  
Binod Kumar Patro ◽  
Arvind Kumar Singh ◽  
Pradnya Dilip Chandanshive ◽  
Ravi Kumar S.R. ◽  
...  
Keyword(s):  
Vitamin C ◽  
Healthcare Workers ◽  
Large Scale ◽  
Case Control Study ◽  
Infection Type ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

BackgroundIvermectin is one among several potential drugs explored for its therapeutic and preventive role in COVID-19 infection. The study was aimed to explore the association between ivermectin prophylaxis and development of COVID-19 infection among healthcare workers.MethodsA hospital-based matched case-control study was conducted among healthcare workers of AIIMS Bhubaneswar, India, from September to October 2020. Profession, gender, age and date of diagnosis were matched for 186 case-control pairs. Cases and controls were healthcare workers who tested positive and negative, respectively, for COVID-19 by RT-PCR. Exposure was defined as the intake of ivermectin and/or hydroxychloroquine and/or vitamin-C and/or other prophylaxis for COVID-19. Data collection and entry was done in Epicollect5, and analysis was performed using STATA version 13. Conditional logistic regression models were used to describe the associated factors for COVID-19 infection.ResultsIvermectin prophylaxis was taken by 77 controls and 38 cases. Two-dose ivermectin prophylaxis (0.27, 95% CI, 0.15-0.51) was associated with 73% reduction of COVID-19 infection among healthcare workers for the following one month, those who were involved in physical activity (3.06 95% CI, 1.18-7.93) for more than an hour/day were more likely to contract COVID-19 infection. Type of household, COVID duty, single-dose ivermectin prophylaxis, vitamin-C prophylaxis and hydroxychloroquine prophylaxis were not associated with COVID-19 infection.ConclusionTwo-dose ivermectin prophylaxis at a dose of 300 μg/kg with a gap of 72 hours was associated 73% reduction of COVID-19 infection among healthcare workers for the following one-month. Further research is required before its large scale use.

scholarly journals 717. Antibiotic treatment of Shiga toxin-producing Escherichia coli related gastroenteritis and the risk of hemolytic uremic syndrome: a population based matched case-control study in Japan

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S409-S410
Author(s):  
Shota Myojin ◽  
Kyongsun Pak ◽  
Mayumi Sako ◽  
Tohru Kobayashi ◽  
Takuri Takahashi ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Shiga Toxin ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Population Based ◽  
Case Control ◽  
Age Group ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Abstract Background The role of therapeutic intervention, particularly antibiotics, for Shiga toxin-producing Escherichia coli (STEC) related infection is controversial. Methods We performed a population based matched case-control study to assess the association between treatment (antibiotics, antidiarrheal agents and probiotics) for STEC related infections and HUS development. We identified all STEC HUS patients as cases and matched five non-HUS patients as controls using the data from the National Epidemiological Surveillance of Infectious Diseases (NESID) between January 1, 2017, and December 31, 2018. Further medical information was obtained by standardized questionnaires answered by physicians who registered each patient. We used multivariate conditional logistic regression model to evaluate the association between exposures (use of antibiotics, use of antidiarrheal agents, days between disease onset and fosfomycin administration [within two or three days]) and the development of HUS, by matched odds ratios (OR) and 95% confidence intervals (CI). Covariates we used were sex, age group, area code, presence of diarrhea and other factors. We also performed subgroup analyses using age (adults and children) as a stratification factor. Results 7,760 STEC related patients were registered in the NESID. We selected patients who had a record of HUS diagnosis (n=182) and matched controls without HUS (n=910). After collecting standardized paper-based questionnaires, we enrolled 90 HUS patients and 371 non-HUS patients for analysis. In the main analysis, matched OR of fosfomycin was 0.75(0.47-1.20) in all ages, 1.41(0.51-3.88) in adults and 0.58(0.34-1.01) in children. Matched OR of antidiarrheal agents was 2.07(1.07-4.03) in all ages, 1.84(0.32-10.53) in adults, 2.65(1.21-5.82) in children. Matched OR of probiotics was 0.86(0.46-1.61) in all ages, 0.76(0.21-2.71) in adults, 1.00(0.48-2.09) in children. There was no significant association between the timing of fosfomycin use in the first two or five days of illness and HUS development in any age group. Conclusion Our results suggest that fosfomycin might decrease the risk of HUS in children younger than 15 years of age with STEC confirmed bacterial gastroenteritis. Disclosures All Authors: No reported disclosures

Occupational load as a risk factor for clinically relevant base of thumb osteoarthritis

2020 ◽  
Vol 77 (3) ◽  
pp. 168-171 ◽  
Author(s):  
Jennifer Moriatis Wolf ◽  
Aleksandra Turkiewicz ◽  
Isam Atroshi ◽  
Martin Englund
Keyword(s):  
Sex Education ◽  
Conditional Logistic Regression ◽  
Occupational Tasks ◽  
Standard Classification ◽  
Matched Case ◽  
The Mean ◽  
Thumb Carpometacarpal ◽  
The Relationship ◽  
Control Study

ObjectiveIt is postulated that increased load from pinch and grasp in occupational tasks increases the risk of thumb carpometacarpal (CMC1) osteoarthritis (OA). We sought to characterise the relationship between doctor-diagnosed CMC1 OA and occupation in a large working population.MethodsWe performed a matched case–control study using a Swedish healthcare register. We identified residents aged 30–65 years in 2013 with physician-diagnosed CMC1 OA from 1998 to 2013. We matched four controls per person with CMC1 OA by age, sex, education and postcode. Swedish Standard Classification of Occupations was used to assign occupation. Occupation was categorised as light, light–moderate, moderate and heavy labour. We used conditional logistic regression to estimate ORs with 95% CIs.ResultsWe identified 3462 patients with CMC1 OA and matched 13 211 controls. The mean age of the CMC1 OA group was 63 (SD 7) years, with 81% women. The ORs for CMC1 OA in men were 1.31 (95% CI 0.96 to 1.79) for light–moderate, 1.76 (95% CI 1.29 to 2.40) for moderate and 2.00 (95% CI 1.59 to 2.51) for heavy compared with light work. Women had ORs for CMC1 OA of 1.46 (95% CI 1.32 to 1.61) for light–moderate, 1.27 (95% CI 1.10 to 1.46) for moderate and 1.31 (95% CI 1.07 to 1.59) for heavy compared with light work.ConclusionsThe association between increased manual load in occupation and risk of CMC1 OA is more pronounced in men than in women, likely due to higher workload in the heavy labour category.

scholarly journals Types of Carbohydrates Intake during Pregnancy and Frequency of a Small for Gestational Age Newborn: A Case-Control Study

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 523 ◽  
Author(s):  
Carmen Amezcua-Prieto ◽  
Juan Martínez-Galiano ◽  
Naomi Cano-Ibáñez ◽  
Rocío Olmedo-Requena ◽  
Aurora Bueno-Cavanillas ◽  
...  
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Inverse Association ◽  
Odds Ratios ◽  
Case Control Studies ◽  
Logistic Regression Models ◽  
Matched Case ◽  
Brown Bread

The objective of this study was to assess the relationship between consumption of different types of carbohydrates (CHO) during pregnancy and the risk of having a small for gestational age (SGA) newborn. A retrospective matched case–control design was carried out with a total of 518 mother-offspring pairs. A total of 137 validated items were included in the food frequency questionnaire (FFQ). Conditional logistic regression models were used to calculate crude odds ratios (cORs) and adjusted odds ratios (aORs) with 95% confidence intervals (CIs). Having more than 75 g/day of brown bread showed an inverse association with SGA (aOR = 0.64, CI 0.43–0.96). In contrast, an intake of industrial sweets more than once a day (aOR = 2.70, CI 1.42–5.13), or even 2–6 times a week (aOR = 1.84, CI 1.20–2.82), increased the odds of having a SGA newborn. During pregnancy, the higher the increase of wholegrain cereal and bread, the lower the possibility of having a SGA newborn, but the opposite occurred with refined sugar products—just consuming industrial bakery products or pastries twice a week increased the odds of having an SGA infant. Case–control studies cannot verify causality and only show associations, which may reflect residual confusion due to the presence of unknown factors. It is possible that a high consumption of sugary foods is a marker of a generally poor lifestyle.

scholarly journals Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

2020 ◽  
Vol 113 (1) ◽  
pp. 162-171
Author(s):  
Raul Zamora-Ros ◽  
Leila Lujan-Barroso ◽  
David Achaintre ◽  
Silvia Franceschi ◽  
Cecilie Kyrø ◽  
...  
Keyword(s):  
Multiple Testing ◽  
Conditional Logistic Regression ◽  
Differentiated Thyroid Carcinoma ◽  
Blood Concentrations ◽  
Logistic Regression Models ◽  
Not Otherwise Specified ◽  
Ferulic Acids ◽  
Nested Case Control ◽  
Control Study ◽  
Prospective Investigation

ABSTRACT Background Polyphenols are natural compounds with anticarcinogenic properties in cellular and animal models, but epidemiological evidence determining the associations of these compounds with thyroid cancer (TC) is lacking. Objectives The aim of this study was to evaluate the relations between blood concentrations of 36 polyphenols and TC risk in EPIC (the European Prospective Investigation into Cancer and Nutrition). Methods A nested case–control study was conducted on 273 female cases (210 papillary, 45 follicular, and 18 not otherwise specified TC tumors) and 512 strictly matched controls. Blood polyphenol concentrations were analyzed by HPLC coupled to tandem MS after enzymatic hydrolysis. Results Using multivariable-adjusted conditional logistic regression models, caffeic acid (ORlog2: 0.55; 95% CI: 0.33, 0.93) and its dehydrogenated metabolite, 3,4-dihydroxyphenylpropionic acid (ORlog2: 0.84; 95% CI: 0.71, 0.99), were inversely associated with differentiated TC risk. Similar results were observed for papillary TC, but not for follicular TC. Ferulic acid was also inversely associated only with papillary TC (ORlog2: 0.68; 95% CI: 0.51, 0.91). However, none of these relations was significant after Bonferroni correction for multiple testing. No association was observed for any of the remaining polyphenols with total differentiated, papillary, or follicular TC. Conclusions Blood polyphenol concentrations were mostly not associated with differentiated TC risk in women, although our study raises the possibility that high blood concentrations of caffeic, 3,4-dihydroxyphenylpropionic, and ferulic acids may be related to a lower papillary TC risk.

scholarly journals In-Hospital Transfer Is a Risk Factor for Invasive Filamentous Fungal Infection among Hospitalized Patients with Hematological Malignancies: A Matched Case-Control Study

2015 ◽  
Vol 36 (3) ◽  
pp. 320-328 ◽  
Author(s):  
Angèle Gayet-Ageron ◽  
Anne Iten ◽  
Christian van Delden ◽  
Natacha Farquet ◽  
Stavroula Masouridi-Levrat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fungal Infection ◽  
Hematological Malignancies ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Care Process ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

OBJECTIVEImmunocompromised patients now benefit from a longer life expectancy due to advanced medical techniques, but they are also weakened by aggressive treatment approaches and are at high risk for invasive fungal disease. We determined risk factors associated with an outbreak of invasive filamentous fungal infection (IFFI) among hospitalized hemato-oncological patients.METHODSA retrospective, matched, case-control study was conducted between January 1, 2009, and April 31, 2011, including 29 cases (6 proven, 8 probable, and 15 possible) of IFFI and 102 matched control patients hospitalized during the same time period. Control patients were identified from the hospital electronic database. Conditional logistic regression was performed to identify independent risk factors for IFFI.RESULTSOverall mortality associated with IFFI was 20.7% (8.0%–39.7%). Myelodysplastic syndrome was associated with a higher risk for IFFI compared to chronic hematological malignancies. After adjustment for major risk factors and confounders, >5 patient transfers outside the protected environment of the hematology ward increased the IFFI risk by 6.1-fold. The risk increased by 6.7-fold when transfers were performed during neutropenia.CONCLUSIONThis IFFI outbreak was characterized by a strong association with exposure to the unprotected environment outside the hematology ward during patient transfer. The independent associations of a high number of transfers with the presence of neutropenia suggest that affected patients were probably not sufficiently protected during transport in the corridors. Our study highlights that a heightened awareness of the need for preventive measures during the entire care process of at-risk patients should be promoted among healthcare workers.Infect Control Hosp Epidemiol 2014;00(0): 1–9

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