scholarly journals Reversal of Integrase Inhibitor- and Tenofovir Alafenamide-Related Weight Gain after Switching Back to Tenofovir DF/Emtricitabine/Efavirenz

2021 ◽  
Author(s):  
F Will Pohlman ◽  
Kara S McGee ◽  
Mehri McKellar
Keyword(s):  
Weight Loss ◽  
Weight Gain ◽  
Antiretroviral Therapy ◽  
Integrase Inhibitor ◽  
Rapid Weight Loss ◽  
Tenofovir Df ◽  
Specific Factors ◽  
Gain And Loss ◽  
Tenofovir Alafenamide

Abstract We report a case of substantial weight gain in a virologically suppressed patient with HIV after changing his antiretroviral therapy from efavirenz/emtricitabine/tenofovir DF to elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide with subsequent rapid weight loss upon switching back. The role of antiretrovirals in weight gain and loss and patient- and HIV-specific factors are discussed.

scholarly journals INFLUÊNCIA DA COMPOSIÇÃO DA SALMOURA SOBRE OS PARÂMETROS FÍSICO-SENSORIAIS E MICROBIOLÓGICOS DE FILÉS DE PEITO DE FRANGO MARINADOS POR IMERSÃO

2000 ◽  
Vol 18 (2) ◽  
Author(s):  
ANNA CLAUDIA SIMAS PORTO ◽  
REGINA COELI DE OLIVEIRA TÔRRES ◽  
EUNICE CASSANEGO ILHA ◽  
MARILDE TEREZINHA BORDIGNON LUIZ ◽  
ERNANI SEBASTIÃO SANT’ANNA
Keyword(s):  
Staphylococcus Aureus ◽  
Weight Loss ◽  
Weight Gain ◽  
Isoelectric Point ◽  
Rosmarinus Officinalis ◽  
Raw Material ◽  
Highest Weight ◽  
Microbiological Parameters ◽  
Gain And Loss ◽  
And Staphylococcus Aureus

Avaliou-se a influência da composição da salmoura sobre os parâmetros físicosensoriais e microbiológicos de filés de peito de frango marinados por imersão. O experimento foi constituído por cinco formulações de salmoura. A proporção salmoura:frango foi de 2:1 (v/p). O processo de marinação ocorreu a temperatura de 5 C/12 horas, seguido de drenagem por 30 minutos. As amostras destinadas ao acompanhamento da vida de prateleira, 6 e 11 dias, foram armazenadas a 5 C. Foram avaliados ganho de peso durante a marinação e perda de peso no cozimento, sendo efetuadas determinação de pH, contagem de microrganismos aeróbios psicrotróficos, contagem de Staphylococcus aureus e pesquisa de Salmonella sp. Os menores ganhos de peso foram verificados para os tratamentos com adição de vinagre na salmoura, fato atribuído à redução do pH próximo ao ponto isoelétrico da carne. Estes tratamentos evidenciaram as maiores perdas de peso durante o cozimento. A matériaprima apresentou ausência de Salmonella sp. e contagens de Staphylococcus aureus e microrganismos psicrotróficos dentro dos limites estabelecidos pelo ICMSF. Após 11 dias de armazenamento, apenas os tratamentos com vinagre na composição da salmoura apresentaram contagem de microrganismos aeróbios psicrotróficos dentro do limite estabelecido pelo ICMSF (107 UFC/g). As melhores texturas foram verificadas nos tratamentos com adição de alecrim na composição da salmoura. Abstract It was evaluated the influence of brine composition on physicosensory and microbiological parameters in breast fillet of marinated chicken by immersion. The experiment was constituted by five brine formulations. The proportion of brine:fillet was 2:1 (v/w) for all treatments. The marination process occurred at 5 C/12 hours, following of drainage for 30 minutes. The samples were stored at 5 C at 6 and 11 days to monitor shelflife. It was then evaluated weight gain and loss, pH determination, count of psicrotrophics microorganisms and Staphylococcus aureus and absence of Salmonella sp. The lowest values of weight gain were observed in treatments with addition of vinegar in brine, probably due to the decrease of pH close to the meat isoelectric point. This treatments also evidenced the highest weight loss during the cooking. The raw material presented absence of Salmonella sp. and a count of Staphylococcus aureus and psicrotrophics microorganisms within quality limits established by ICMSF. After 11 days of storage, the treatments with vinegar in the brine composition presented count of psicrotrophics microorganisms within limits established by ICMSF (107 CFU/g). The best textures were presented in treatments with addition of rosemary (Rosmarinus officinalis) in brine composition.

Rapid Weight Gain Following Weight Cutting in Male and Female Professional Mixed Martial Artists

2021 ◽  
pp. 1-9
Author(s):  
Kadhiresan R. Murugappan ◽  
Ariel Mueller ◽  
Daniel P. Walsh ◽  
Shahzad Shaefi ◽  
Akiva Leibowitz ◽  
...  
Keyword(s):  
Weight Loss ◽  
Weight Gain ◽  
Body Mass ◽  
Martial Arts ◽  
Female Athletes ◽  
Rapid Weight Loss ◽  
Mixed Martial Arts ◽  
Rapid Weight Gain ◽  
Male And Female ◽  
Small Series

Rapid weight loss or “weight cutting” is a common but potentially harmful practice used in mixed martial arts competition. Following the official weigh-in, competitors refeed and rehydrate themselves in a process known as rapid weight gain (RWG) to realize a potential competitive advantage. While data from surveys and small series have indicated the majority of mixed martial arts athletes engage in rapid weight loss, there is a lack of officially collected data from sanctioning organizations describing its prevalence. The present investigation represents a summary of the data collected between December 2015 and January 2018 by the California State Athletic Commission. In total, 512 professional mixed martial artists (455 males and 57 females) were included. Of these, 503 (98%) athletes gained body mass between weigh-in and their bouts. Total RWG between weigh-in and competition was 5.5 ± 2.5 kg, corresponding to an 8.1% ± 3.6% body mass increase. Total RWG was 5.6 ± 2.5 kg (8.1% ± 3.6%) for males and 4.5 ± 2.3 kg (8.0% ± 3.8%) for females. More than one quarter of men and one third of women gained >10% body mass between weigh-in and competition. Athletes from leading international promotions gained more absolute, but not relative, body mass than those from regional promotions. Our findings indicate RWG is nearly ubiquitous in professional , with a similar prevalence in male and female athletes. Trends based on promotion suggest a larger magnitude of RWG in presumably more experienced and/or successful mixed martial artists from leading international promotions.

scholarly journals Extreme Rapid Weight Loss and Rapid Weight Gain Observed in UK Mixed Martial Arts Athletes Preparing for Competition

2017 ◽  
Vol 27 (2) ◽  
pp. 122-129 ◽  
Author(s):  
Joseph John Matthews ◽  
Ceri Nicholas
Keyword(s):  
Weight Loss ◽  
Weight Gain ◽  
Body Mass ◽  
Martial Arts ◽  
Repeated Measures ◽  
Hydration Status ◽  
Rapid Weight Loss ◽  
Mixed Martial Arts ◽  
Rapid Weight Gain ◽  
Repeated Measures Design

There is a lack of research documenting the weight-making practices of mixed-martial-arts (MMA) competitors. The purpose of the investigation was to quantify the magnitude and identify the methods of rapid weight loss (RWL) and rapid weight gain (RWG) in MMA athletes preparing for competition. Seven athletes (mean ± SD, age 24.6 ± 3.5 yrs, body mass 69.9 ± 5.7 kg, competitive experience 3.1 ± 2.2 yrs) participated in a repeated-measures design. Measures of dietary intake, urinary hydration status, and body mass were recorded in the week preceding competition. Body mass decreased significantly (p < .0005) from baseline by 5.6 ± 1.4 kg (8 ± 1.8%). During the RWG period (32 ± 1 hr) body mass increased significantly (p < .001) by 7.4 ± 2.8 kg (11.7 ± 4.7%), exceeding RWL. Mean energy and carbohydrate intake were 3176 ± 482 kcal・day-1 and 471 ± 124 g・day-1, respectively. At the official weigh-in 57% of athletes were dehydrated (1033 ± 19 mOsmol・kg-1) and the remaining 43% were severely dehydrated (1267 ± 47 mOsmol・kg-1). Athletes reported using harmful dehydration-based RWL strategies, including sauna (43%) and training in plastic suits (43%). Results demonstrated RWG greater than RWL, this is a novel finding and may be attributable to the 32 hr duration from weigh-in till competition. The observed magnitude of RWL and strategies used are comparable to those which have previously resulted in fatalities. Rule changes which make RWL impractical should be implemented with immediate effect to ensure the health, safety and wellbeing of competitors.

scholarly journals Possible role of the gut microbiota in the pathogenesis of anorexia nervosa

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Nobuyuki Sudo
Keyword(s):  
Eating Disorders ◽  
Weight Loss ◽  
Anorexia Nervosa ◽  
Eating Disorder ◽  
Weight Gain ◽  
Gut Microbiota ◽  
Psychosocial Factors ◽  
Biological Factors ◽  
Fear Of Weight Gain

AbstractAnorexia nervosa (AN), an eating disorder, is characterized by extreme weight loss and fear of weight gain. Psychosocial factors are thought to play important roles in the development and progression of AN; however, biological factors also presumably contribute to eating disorders. Recent evidence has shown that the gut microbiota plays an important role in pathogenesis of neuropsychiatric disorders including AN. In this article, we describe the possible role of the gut microbiota in the development and persistence of AN, based on the latest research works, including those of our group.

Weight Gain and Loss In Cancer Patients Undergoing Chemotherapy: Importance of Dose Adjustment

2021 ◽  
Vol 08 ◽  
Author(s):  
Maria Ayanny de Lima Fernandes ◽  
Andreza Tallyne de Aguiar Silva ◽  
Iago Dillion Lima Cavalcanti ◽  
Adrya Lúcia Peres Bezerra de Medeiros ◽  
Lígia Maria de Oliveira Lima ◽  
...  
Keyword(s):  
Weight Loss ◽  
Weight Gain ◽  
Cancer Patients ◽  
Antineoplastic Agent ◽  
Skinfold Thickness ◽  
Significant Loss ◽  
Arm Circumference ◽  
Gain And Loss ◽  
Triceps Skinfold Thickness ◽  
Anthropometric Assessment

Introduction: The established dose of chemotherapy is based on the values of the patient's body weight, where variations during treatment can increase the toxicity of chemotherapy, with the development of nephrotoxicity, among other toxicity profiles, as well as in cases of weight gain, patients may receive low doses and compromise the therapeutic response to the tumor. Objective: to evaluate weight gain and loss in cancer patients undergoing chemotherapy. Methods: Longitudinal analytical study with patients at the end of chemotherapy treatment of both genders. The type, location of the tumor and the antineoplastic agent used were collected from the medical records, as well as height and weight at the beginning of treatment. At the time of collection, anthropometric assessment was performed using body mass index, arm circumference, arm muscle circumference, triceps skinfold thickness and percentage of weight loss. Results: Among the patients included in the study, 47.5% had a weight gain of around 2.5 kg, while the remaining patients (52.5%) had a weight loss of around 2.8 kg. Of the patients who had GFR, 55.5% had severe PP, 33.4% had no significant loss and 11.1 had significant loss. In the current study, only 22% had a GFR <60ml/min/1.73m², but they would already need to readjust the medication calculation. Conclusion: It is important to evaluate body surface variations and also the GFR to adjust the dose of the antineoplastic agent and to prevent or minimize nephrotoxicity, as well as to reduce the risk of underdosing and inefficiency of the therapy.

scholarly journals 881. Long-term Weight Gain After Initiating Combination Antiretroviral Therapy in Treatment-naïve Asian People Living with HIV

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S532-S533
Author(s):  
Naokatsu Ando ◽  
Takeshi Nishijima ◽  
Daisuke Mizushima ◽  
Yosuke Inaba ◽  
Yohei Kawasaki ◽  
...  
Keyword(s):  
Weight Gain ◽  
Antiretroviral Therapy ◽  
Transcriptase Inhibitor ◽  
People Living With Hiv ◽  
Strand Transfer ◽  
Clinical Issue ◽  
Asian Populations ◽  
Asian Patients ◽  
Treatment Naïve ◽  
Tenofovir Alafenamide

Abstract Background Weight gain after the initiation of antiretroviral therapy (ART) is becoming a major clinical issue in treatment-naïve people living with human immunodeficiency virus (PLWH). However, limited data exist for the Asian populations. We aimed to investigate changes in weight after the initiation of ART therapy in treatment-naïve Asian patients. Methods We evaluated adult, treatment-naïve Asian PLWH who started integrase strand transfer inhibitor (INSTI)-, protease inhibitor (PI)-, or nonnucleoside reverse transcriptase inhibitor (NNRTI)-based ART at AIDS Clinical Center, Tokyo, between January 2005 and February 2019. They were followed up until October 2019. Multivariate linear mixed-effects models were used to generate marginal predictions of weight over time. Predicted weight by ART class (INSTI, PI, and NNRTI), each key drug (dolutegravir [DTG], elvitegravir [EVG], raltegravir [RAL], and darunavir [DRV]), and each key drug with or without the use of tenofovir alafenamide (TAF)/emtricitabine (FTC) was reported at 3-month intervals until censoring or 5 years. Results Among the 1,579 study patients, 610 (38.6%), 929 (58.8%), and 40 (2.5%) started INSTI-, PI-, and NNRTI-based ART. After 5 years, PLWH who initiated DTG- (5.3 kg), DRV- (4.0 kg), and EVG-based treatment (4.6 kg) gained more weight than those who initiated RAL-based treatment (1.8 kg). PLWH who initiated DTG plus TAF/FTC (6.7 kg) gained the largest weight. Conclusion In the Asian PLWH population, ART-associated weight gain continues to increase for 5 years after treatment initiation. DTG plus TAF/FTC was associated with the largest weight gain. Disclosures All Authors: No reported disclosures

scholarly journals Psychiatric Disorders after Switching to Dolutegravir: A Case Report of a 59-Year-Old Virosuppressed HIV-1 Positive Woman

2020 ◽  
Vol 2020 ◽  
pp. 1-2
Author(s):  
Daniele Mengato ◽  
Raffaella Binazzi ◽  
Ivan Unterholzner ◽  
Elke M. Erne ◽  
Alicia Tavella
Keyword(s):  
Case Report ◽  
Antiretroviral Therapy ◽  
Psychiatric Disorders ◽  
Psychiatric Symptoms ◽  
Beta Blockers ◽  
Integrase Inhibitor ◽  
Cardiovascular Disorders ◽  
Positive Woman ◽  
Tenofovir Alafenamide ◽  
Hiv 1

We report a case of a woman who experienced psychiatric disorders after switching her antiretroviral therapy (c-ART) to dolutegravir (DTG). She is a 59-year-old HIV-1 positive woman with a recent story of cardiovascular disorders treated with beta-blockers, clopidogrel, and rosuvastatin. She underwent a c-ART switch from darunavir/cobicistat and maraviroc to emtricitabine/tenofovir alafenamide fumarate in association with dolutegravir due to drug-drug interactions. One week later, she started to show psychiatric symptoms that required admission to the psychiatric unit. These disorders resolved within a couple of days after DTG discontinuation to allow a regular discharge. With this case-report, we would like to analyse the possible correlation between integrase inhibitor and severe psychiatric disorders in order to confirm the evidences already published in literature.

scholarly journals Cabotegravir Is Not Associated With Weight Gain in Human Immunodeficiency Virus–uninfected Individuals in HPTN 077

2019 ◽  
Vol 70 (2) ◽  
pp. 319-322 ◽  
Author(s):  
Raphael J Landovitz ◽  
Sahar Z Zangeneh ◽  
Gordon Chau ◽  
Beatriz Grinsztejn ◽  
Joseph J Eron ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Weight Gain ◽  
Antiretroviral Therapy ◽  
Hiv Prevention ◽  
Integrase Inhibitor ◽  
Excess Weight ◽  
Metabolic Parameters ◽  
Excess Weight Gain ◽  
Immunodeficiency Virus ◽  
Prevention Trials

AbstractStudies in human immunodeficiency virus (HIV)–infected individuals suggest excess weight gain with integrase inhibitor–based antiretroviral therapy. The HIV Prevention Trials Network Study 077 evaluated changes in weight and fasting metabolic parameters in HIV-uninfected individuals randomized to cabotegravir or a placebo. No differences between arms were found for change in weight or fasting metabolic parameters overall or for subgroups.

Sign in / Sign up

Export Citation Format

Share Document