Persistence, Magnitude and Patterns of Post-acute Symptoms and Quality of Life Following Onset of SARS-CoV-2 Infection: Cohort Description and Approaches for Measurement

Abstract BACKGROUND There is mounting evidence for the presence of post-acute sequelae of SARS-CoV-2 infection (PASC), but there is limited information on the spectrum, magnitude, duration, and patterns of these sequelae as well as their influence on quality of life. METHODS We assembled a cohort of adults with documented history of SARS-CoV-2 RNA-positivity who were ≥ 2 weeks past onset of COVID-19 symptoms or, if asymptomatic, first positive test. At 4-month intervals, we queried physical and mental health symptoms and quality of life. RESULTS Of the first 179 participants enrolled, 10 were asymptomatic during the acute phase of SARS-CoV-2 infection, 125 symptomatic but not hospitalized, and 44 symptomatic and hospitalized. During the post-acute phase, fatigue, shortness of breath, concentration problems, headaches, trouble sleeping and anosmia/dysgeusia were most common through 8 months of observation. Symptoms were typically at least somewhat bothersome and sometimes exhibited a waxing-and-waning course. Some participants experienced symptoms of depression, anxiety, and post-traumatic stress, as well as difficulties with performance of usual activities. The median visual analogue scale rating of general health was lower at 4 and 8 months compared to pre-COVID-19. Two clusters of symptom domains were identified. CONCLUSION Many participants report bothersome symptoms following onset of COVID-19 with variable patterns of persistence and impact on quality of life. The substantial variability suggests the existence of multiple sub-phenotypes of PASC. A rigorous approach to the prospective measurement of symptoms and functional manifestations sets the stage for the next phase of research focusing on the pathophysiologic causes of the various sub-groups of PASC.

Download Full-text

Differences between Slovak and Dutch patients scheduled for coronary artery bypass graft surgery regarding clinical and psychosocial predictors of physical and mental health-related quality of life

European Journal of Cardiovascular Nursing ◽

10.1177/1474515117747571 ◽

2017 ◽

Vol 17 (4) ◽

pp. 324-335 ◽

Cited By ~ 6

Author(s):

Noha El-Baz ◽

Daniela Ondusova ◽

Martin Studencan ◽

Jaroslav Rosenberger ◽

Sijmen A Reijneveld ◽

...

Keyword(s):

Quality Of Life ◽

Coronary Artery ◽

Health Related Quality ◽

Symptoms Of Depression ◽

Type D ◽

Related Quality ◽

Health Related ◽

History Of ◽

Artery Disease

Background: Differences in health-related quality of life in coronary artery disease patients and associated factors between patients of central and western European descent are rarely investigated. We aim to test differences between Dutch and Slovak health-related quality of life, whether nationality predicted health-related quality of life and if standardised beta weights of health-related quality of life determinants differ across countries. Design: An observational multicentre study at university cardiac centres in the Netherlands and Slovakia. Methods: In 226 coronary artery disease patients, health-related quality of life was measured by the Short Form Health Survey 36, anxiety and depression were measured using the Hospital Anxiety and Depression Scale, and type D personality was assessed with the 14-item Type D Scale. Multivariate analysis was used to explore the effect of patient characteristics on the physical and mental component summaries. Estimates of each predictor’s beta value of the physical and mental component summaries in the Slovak and Dutch patient sample were separately calculated using the Cummings criterion for comparison of two independent betas. Results: Stronger predictors of physical health-related quality of life in Slovak patients were educational level, current smoking, poor functional status, history of diabetes and amount of social support. In Dutch patients, only more symptoms of depression was a stronger predictor ( P<0.05). Regarding Slovak mental health-related quality of life, stronger predictors were educational level, current smoking and amount of social support. Female gender, history of myocardial infarction and more symptoms of depression were stronger predictors in Dutch patients ( P<0.05). Conclusion: Descent and differences between both populations in determinants of health-related quality of life should be considered while planning care, follow-up, health education and rehabilitation.

Download Full-text

Gambaran Tingkat Depresi pada Lansia di Wilayah Kerja Puskesmas Guguak Kabupaten 50 Kota Payakumbuh

Health & Medical Journal ◽

10.33854/heme.v1i2.235 ◽

2019 ◽

Vol 1 (2) ◽

pp. 12-16

Author(s):

Mutiara Anissa ◽

Rinita Amelia ◽

Nadia Purnama Dewi

Keyword(s):

Quality Of Life ◽

High School ◽

Major Depression ◽

The Elderly ◽

Physical Symptoms ◽

Mild Depression ◽

Level Of Education ◽

Symptoms Of Depression ◽

History Of

Depression is a mental disorder that is often found in the elderly. Symptoms of depression in the elderly are often covered by physical symptoms. Depression in the elderly is influenced by various factors such as biology, psychology and social. Depression can further reduce the quality of life in the elderly. The study is a descriptive observational study and observed on 30 subjects were carried out on April 7, 2018. Aim of the study to determine the description of the Depression Rate in the Elderly in the Guguak Health Center Working Area District 50 Payakumbuh City. In the study, the subjects were 8 men (11.3%) and 22 women (73.3%). Theaverage subject age is 69.3. year. The highest level of education in the study subjects was high school (40%). Most patients did not have a history of other medical diseases (60%). In the study, 33.3% of the elderly were depressed. The levels of depression experienced were mild depression (23.3%) and major depression (10%).

Download Full-text

Clinical Holistic Medicine: Pilot Study on the Effect of Vaginal Acupressure (Hippocratic Pelvic Massage)

The Scientific World JOURNAL ◽

10.1100/tsw.2006.340 ◽

2006 ◽

Vol 6 ◽

pp. 2100-2116 ◽

Cited By ~ 9

Author(s):

Søren Ventegodt ◽

Birgitte Clausen ◽

Joav Merrick

Keyword(s):

Quality Of Life ◽

Pilot Study ◽

Simple Procedure ◽

Qualitative Evaluation ◽

Likert Scale ◽

Physical And Mental Health ◽

History Of ◽

Clinically Significant ◽

The Relationship

This is a pilot study of 20 female patients with a long history of sexual problems (mean is 8.92 years) who received vaginal acupressure (VA) with a quantitative and qualitative evaluation: 56% experienced help and none reported setbacks, 89% rated the treatment to be of high quality, and 89% rated it as valuable. After the treatment, most reported their problems to be less serious and their general quality of life improved. Only 17% reported minor or temporary side effects. VA was found statistically and clinically significant (p< 0.05, improvement more than 0.5 step on a 5-point Likert scale) to help patients with chronic genital pains, pain or discomfort during sexual intercourse, lack of desire or orgasm, and subjective sexual insufficiency, and all patients taken as one group (about 1 step up a 5-point Likert scale). Self-evaluated physical and mental health was significantly improved for the total group; the relationship with partner, the subjective sexual ability, and the quality of life that were measured with QOL1 and QOL5 questionnaires were all significantly improved. VA or Hippocratic pelvic massage is technically a simple procedure corresponding to the explorative phase of the standard pelvic examination, supplemented with the patient’s report on the feelings provoked followed by processing and integration of these feelings, but ethical aspects are complicated. Acupressure through the vagina/pelvic massage must be done according to the highest ethical standard with great care, after obtaining consent and the necessary trust of the patient within the framework of the local laws. It must be followed by conversational therapy and further holistic existential processing.

Download Full-text

Faculty Opinions recommendation of Late complications and long-term quality of life for survivors (>5 years) with history of head and neck cancer.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717952796.793457670 ◽

2012 ◽

Author(s):

Giulio Cantu ◽

Madia Pompilio ◽

Paolo Formillo

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Late Complications ◽

History Of

Download Full-text

Patients With a History of Oronasal Fistula Repair Exhibit Lower Oral Health Measured With Patient-Centric Outcomes Measures

The Cleft Palate-Craniofacial Journal ◽

10.1177/1055665620981331 ◽

2020 ◽

pp. 105566562098133

Author(s):

Alyssa Fritz ◽

Diana S. Jodeh ◽

Fatima Qamar ◽

James J. Cray ◽

S. Alex Rottgers

Keyword(s):

Quality Of Life ◽

Oral Health ◽

Cleft Palate ◽

Fistula Repair ◽

Old Patients ◽

Oronasal Fistula ◽

Patient Reported ◽

History Of ◽

The Impact

Introduction: Oronasal fistulae following palatoplasty may affect patients’ quality of life by impacting their ability to eat, speak, and maintain oral hygiene. We aimed to quantify the impact of previous oronasal fistula repair on patients’ quality of life using patient-reported outcome psychometric tools. Methods: A cross-sectional study of 8- to 9-year-old patients with cleft palate and/or lip was completed. Patients who had a cleft team clinic between September 2018 and August 2019 were recruited. Participants were divided into 2 groups (no fistula, prior fistula repair). Differences in the individual CLEFT-Q and Child Oral Health Impact Profile-Short Form 19 (COHIP-SF 19) Oral Health scores between the 2 groups were evaluated using a multivariate analysis controlling for Veau classification and syndromic diagnosis. Results: Sixty patients with a history of cleft palate were included. Forty-two (70%) patients had an associated cleft lip. Thirty-two (53.3%) patients had no history of fistula and 28 (46.7%) patients had undergone a fistula repair. CLEFT-Q Dental, Jaw, and Speech Function were all higher in patients without a history of a fistula repair; however, none of these differences were statistically significant. The COHIP-SF 19 Oral Health score demonstrated a significantly lower score in the fistula group, indicating poorer oral health ( P = .05). Conclusions: One would expect that successful repair of a fistula would result in improved function and patient satisfaction, but the consistent trend toward lower CLEFT-Q scores and significantly increased COHIP-SF 19 Oral Health scores in our study group suggests that residual effects linger and that the morbidity of a fistula may not be completely treated with a secondary correction.

Download Full-text

Sleep Disorders in Adults with Down Syndrome

Journal of Clinical Medicine ◽

10.3390/jcm10143012 ◽

2021 ◽

Vol 10 (14) ◽

pp. 3012

Author(s):

Sandra Giménez ◽

Miren Altuna ◽

Esther Blessing ◽

Ricardo M. Osorio ◽

Juan Fortea

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Down Syndrome ◽

Sleep Disorders ◽

Negative Impact ◽

Current Knowledge ◽

Sleep Disruption ◽

Physical And Mental Health ◽

Future Directions

Sleep disorders, despite being very frequent in adults with Down syndrome (DS), are often overlooked due to a lack of awareness by families and physicians and the absence of specific clinical sleep guidelines. Untreated sleep disorders have a negative impact on physical and mental health, behavior, and cognitive performance. Growing evidence suggests that sleep disruption may also accelerate the progression to symptomatic Alzheimer’s disease (AD) in this population. It is therefore imperative to have a better understanding of the sleep disorders associated with DS in order to treat them, and in doing so, improve cognition and quality of life, and prevent related comorbidities. This paper reviews the current knowledge of the main sleep disorders in adults with DS, including evaluation and management. It highlights the existing gaps in knowledge and discusses future directions to achieve earlier diagnosis and better treatment of sleep disorders most frequently found in this population.

Download Full-text

Guided Self-help Teletherapy for Behavioural Difficulties in Children with Epilepsy

Journal of Clinical Psychology in Medical Settings ◽

10.1007/s10880-021-09768-2 ◽

2021 ◽

Author(s):

Sophie Bennett ◽

Isobel Heyman ◽

Sophia Varadkar ◽

Anna Coughtrey ◽

Fahreen Walji ◽

...

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Unmet Need ◽

Hospital Setting ◽

Physical And Mental Health ◽

Paediatric Hospital ◽

Complex Needs ◽

Self Help ◽

Behavioural Difficulties

AbstractBehavioural difficulties impact greatly upon quality of life for children with chronic illness and their families but are often not identified or adequately treated, possibly due to the separation of physical and mental health services. This case study describes the content and outcomes of guided self-help teletherapy for behavioural difficulties in a child with epilepsy and complex needs using an evidence-based behavioural parenting protocol delivered within a paediatric hospital setting. Behavioural difficulties and progress towards the family’s self-identified goals were monitored at each session. Validated measures of mental health and quality of life in children were completed before and after intervention and satisfaction was measured at the end of treatment. Measures demonstrated clear progress towards the family’s goals and reduction in weekly ratings of behavioural difficulties. This case demonstrates that a guided self-help teletherapy approach delivered from within the paediatric setting may be one way of meeting unmet need.

Download Full-text

Quality of Life and Philosophy of Life Determines Physical and Mental Health: Status Over Research Findings From The Quality of Life Research Center, Copenhagen, 1991-2007

The Scientific World JOURNAL ◽

10.1100/tsw.2007.261 ◽

2007 ◽

Vol 7 ◽

pp. 1743-1751 ◽

Cited By ~ 4

Author(s):

Søren Ventegodt ◽

Isack Kandel ◽

Joav Merrick

Keyword(s):

Quality Of Life ◽

Good Life ◽

Public Awareness ◽

Social Indicators ◽

Health Science ◽

Physical And Mental Health ◽

Quality Of Life Research ◽

Global Quality Of Life ◽

The Individual

Quality of life (QOL) has over the past decade become an important part of health science and also increased public awareness. It has become increasingly apparent that illness is closely related to the individual perception of a good life, and therefore the exploration of indicators related to quality of life appears to be of broad importance for the prevention and treatment of diseases. Identifying, which factors constitute a good life may reveal an understanding about what areas in life should be encouraged, in order to enhance the global quality of life, health, and ability. In this paper we present results from studies initiated in 1989 to examine quality of life in relation to disease. The purpose of this presentation was to assemble the results from the study carried out in the years between 1993 and 1997, examining a total of 11.500 Danes, to show the association between quality of life and a wide series of social indicators.

Download Full-text