scholarly journals On-Demand Intraoperative 3-Dimensional Printing of Custom Cranioplastic Prostheses

2018 ◽  
Vol 15 (3) ◽  
pp. 341-349 ◽  
Author(s):  
Alexander I Evins ◽  
John Dutton ◽  
Sayem S Imam ◽  
Amal O Dadi ◽  
Tao Xu ◽  
...  
Keyword(s):  
3D Printing ◽  
Perioperative Complications ◽  
Ease Of Use ◽  
Patient Specific ◽  
Production Time ◽  
3 Dimensional ◽  
3D Print ◽  
Fused Deposition ◽  
On Demand ◽  
Dimensional Printing

Abstract BACKGROUND Currently, implantation of patient-specific cranial prostheses requires reoperation after a period for design and formulation by a third-party manufacturer. Recently, 3-dimensional (3D) printing via fused deposition modeling has demonstrated increased ease of use, rapid production time, and significantly reduced costs, enabling expanded potential for surgical application. Three-dimensional printing may allow neurosurgeons to remove bone, perform a rapid intraoperative scan of the opening, and 3D print custom cranioplastic prostheses during the remainder of the procedure. OBJECTIVE To evaluate the feasibility of using a commercially available 3D printer to develop and produce on-demand intraoperative patient-specific cranioplastic prostheses in real time and assess the associated costs, fabrication time, and technical difficulty. METHODS Five different craniectomies were each fashioned on 3 cadaveric specimens (6 sides) to sample regions with varying topography, size, thickness, curvature, and complexity. Computed tomography-based cranioplastic implants were designed, formulated, and implanted. Accuracy of development and fabrication, as well as implantation ability and fit, integration with exiting fixation devices, and incorporation of integrated seamless fixation plates were qualitatively evaluated. RESULTS All cranioprostheses were successfully designed and printed. Average time for design, from importation of scan data to initiation of printing, was 14.6 min and average print time for all cranioprostheses was 108.6 min. CONCLUSION On-demand 3D printing of cranial prostheses is a simple, feasible, inexpensive, and rapid solution that may help improve cosmetic outcomes; significantly reduce production time and cost—expanding availability; eliminate the need for reoperation in select cases, reducing morbidity; and has the potential to decrease perioperative complications including infection and resorption.

scholarly journals 3D Printing of Mini Tablets for Pediatric Use

2021 ◽  
Vol 14 (2) ◽  
pp. 143
Author(s):  
Julius Krause ◽  
Laura Müller ◽  
Dorota Sarwinska ◽  
Anne Seidlitz ◽  
Malgorzata Sznitowska ◽  
...  
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Dosage Forms ◽  
Small Scale ◽  
Fused Deposition ◽  
On Demand ◽  
Pediatric Diseases ◽  
Deposition Modeling ◽  
Manufacturing Techniques ◽  
Pediatric Use

In the treatment of pediatric diseases, suitable dosages and dosage forms are often not available for an adequate therapy. The use of innovative additive manufacturing techniques offers the possibility of producing pediatric dosage forms. In this study, the production of mini tablets using fused deposition modeling (FDM)-based 3D printing was investigated. Two pediatric drugs, caffeine and propranolol hydrochloride, were successfully processed into filaments using hyprolose and hypromellose as polymers. Subsequently, mini tablets with diameters between 1.5 and 4.0 mm were printed and characterized using optical and thermal analysis methods. By varying the number of mini tablets applied and by varying the diameter, we were able to achieve different release behaviors. This work highlights the potential value of FDM 3D printing for the on-demand production of patient individualized, small-scale batches of pediatric dosage forms.

Three-Dimensional Printing in Cleft Care: A Systematic Review

2021 ◽  
pp. 105566562110131
Author(s):  
Farrukh R. Virani ◽  
Evan C. Chua ◽  
Mary Roz Timbang ◽  
Tsung-yen Hsieh ◽  
Craig W. Senders
Keyword(s):  
Systematic Review ◽  
3D Printing ◽  
Clinical Outcomes ◽  
Outcome Measures ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Secondary Outcome ◽  
Exclusion Criteria ◽  
3 Dimensional ◽  
Dimensional Printing

Objective: To determine the current applications of 3-dimensional (3D) printing in the care of patients with cleft lip and palate. We also reviewed 3D printing limitations, financial analysis, and future implications. Design: Retrospective systematic review. Methods: Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were used by 3 independent reviewers. Articles were identified from Cochrane library, Ovid Medline, and Embase. Search terms included 3D printing, 3 dimensional printing, additive manufacturing, rapid prototyping, cleft lip, and cleft palate. Exclusion criteria included articles not in English, animal studies, reviews without original data, oral presentations, abstracts, opinion pieces, and articles without relevance to 3D printing or cleft lip and palate. Main Outcome Measures: Primary outcome measure was the purpose of 3D printing in the care of patients with cleft lip and palate. Secondary outcome measures were cost analysis and clinical outcomes. Results: Eight-four articles were identified, and 39 met inclusion/exclusion criteria. Eleven studies used 3D printing models for nasoalveolar molding. Patient-specific implants were developed via 3D printing in 6 articles. Surgical planning was conducted via 3D printing in 8 studies. Eight articles utilized 3D printing for anatomic models/educational purposes. 3-Dimensional printed models were used for surgical simulation/training in 6 articles. Bioprinting was utilized in 4 studies. Secondary outcome of cost was addressed in 8 articles. Conclusion: 3-Dimensional printing for the care of patients with cleft lip and palate has several applications. Potential advantages of utilizing this technology are demonstrated; however, literature is largely descriptive in nature with few clinical outcome measures. Future direction should be aimed at standardized reporting to include clinical outcomes, cost, material, printing method, and results.

Effect of copper or carbon fiber addition to the 3D printing of polylactid samples

2020 ◽  
Vol 62 (7) ◽  
pp. 727-732
Author(s):  
L. Zárybnická ◽  
D. Machová ◽  
K. Dvořák
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Depth Of Field ◽  
3D Print ◽  
Fused Deposition ◽  
Printing Quality ◽  
Digital Microscope ◽  
Effect Of Copper ◽  
The Right

Abstract This paper presents the effect of additives on the quality of a product created by 3D print. The product is created by the most widely used 3D printing method - Fused Deposition Modeling (FDM). Polylactic acid (PLA) filaments are tested without and with the addition of carbon fibers or copper. The specimens are characterized by different methods, such as mechanical testing, measuring roughness by digital microscope with a large depth of field and thermal analysis. In fact, FDM is a problematic process with numerous criterions that affect printing quality. Printing parameters such as print temperature, pad temperature, print speed for 3D printing, printing orientation etc. have an important impact on the performance and quality of FDM components. Due to the correct parameters, the product of the required quality with a longer service life is obtained. The results of testing show that the quantity and choice of the right ingredient has a major impact on the mechanical properties and overall quality of the investigated product.

scholarly journals Characterization of 3-Dimensional Printing and Casting Materials for use in Magnetic Resonance Imaging Phantoms at 3 T

2020 ◽  
Vol 125 ◽  
Author(s):  
B. E. Yunker ◽  
K. F. Stupic ◽  
J. L. Wagner ◽  
S. Huddle ◽  
R. Shandas ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Tensile Strength ◽  
Magnetic Resonance ◽  
3D Printing ◽  
Spin Echo ◽  
Relaxation Times ◽  
Patient Specific ◽  
Resonance Imaging ◽  
Fused Deposition ◽  
Imaging Phantoms

Imaging phantoms are used to calibrate and validate the performance of magnetic resonance imaging (MRI) systems. Many new materials have been developed for additive manufacturing (three-dimensional [3D] printing) processes that may be useful in the direct printing or casting of dimensionally accurate, anatomically accurate, patient-specific, and/or biomimetic MRI phantoms. The T1, T2, and T2* spin relaxation times of polymer samples were tested to discover materials for use as tissue mimics and structures in MRI phantoms. This study included a cohort of polymer compounds that was tested in cured form. The cohort consisted of 101 standardized polymer samples fabricated from: two-part silicones and polyurethanes used in commercial casting processes; one-part optically cured polyurethanes used in 3D printing; and fused deposition thermoplastics used in 3D printing. The testing was performed at 3 T using inversion recovery, spin echo, and gradient echo sequences for T1, T2, and T2*, respectively. T1, T2, and T2* values were plotted with error bars to allow the reader to assess how well a polymer matches a tissue for a specific application. A correlation was performed between T1, T2 , T2* values and material density, elongation, tensile strength, and hardness. Two silicones, SI_XP-643 and SI_P-45, may be usable mimics for reported liver values; one silicone, SI_XP-643, may be a useful mimic for muscle; one silicone, SI_XP-738, may be a useful mimic for white matter; and four silicones, SI_P-15, SI_GI-1000, SI_GI-1040, and SI_GI-1110, may be usable mimics for spinal cord. Elongation correlated to T2 (p = 0.0007), tensile strength correlated to T1 (p = 0.002), T2 (p = 0.0003), and T2* (p = 0.003). The 80 samples not providing measurable signal with T1, T2, T2* relaxation values too short to measure with the standard sequences, may be useful for MRI-invisible fixturing and medical devices at 3 T.

scholarly journals Laboratory 3D printing system

2018 ◽  
Vol 7 (2.23) ◽  
pp. 68 ◽  
Author(s):  
Anton V. Mironov ◽  
Aleksandra O. Mariyanac ◽  
Olga A. Mironova ◽  
Vladimir K. Popov
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Uv Laser ◽  
Universal System ◽  
Fused Deposition ◽  
On Demand ◽  
Drop On Demand ◽  
Different Types ◽  
Deposition Modeling ◽  
Printing System

Present work describes the results of the development of the universal system, which capable to utilize varies 3D printing methodologies. The main goal of the study is to provide cheap, versatile and easy expandable equipment for multiple purpose research in the field of material science. 3D printing system was experimentally validated for fused deposition modeling, hydrogel, liquid dispensing and drop-on-demand printing, as well as 3D photopolymerisation by UV laser and/or LED light using different types of materials.  

scholarly journals Designing a delta tripod based robot fused deposition modelling 3 dimensional printer using an open-source Arduino development platform

2018 ◽  
Vol 184 ◽  
pp. 02013
Author(s):  
Tamás Templom ◽  
Timotei István Erdei ◽  
Zsolt Molnár ◽  
Edwin Shaw ◽  
Géza Husi
Keyword(s):  
3D Printing ◽  
Rapid Prototyping ◽  
Open Source ◽  
Fused Deposition Modelling ◽  
3 Dimensional ◽  
Development Platform ◽  
Fused Deposition

The pinnacle of 3D printing is its effect on the field of rapid prototyping. The major advantage comes from the fact that designers can quickly materialize a part or object, which then could be tested in practice, and can be effortlessly modified if needed. This obviously cuts the development expenses and time by a significant percent. Moreover, it’s possible to create complex and precise shapes with the technology, which would take more time and would be resource intensive if done by older methods, for example manual or automatic machining.

scholarly journals Mesh processing for improved perceptual quality of 3D printed relief

2020 ◽  
Author(s):  
Yifan Yang ◽  
Yutaka Ohtake ◽  
Hiromasa Suzuki
Keyword(s):  
3D Printing ◽  
User Interfaces ◽  
Large Scale ◽  
Ease Of Use ◽  
Perceptual Quality ◽  
Triangle Mesh ◽  
3D Print ◽  
Mesh Processing ◽  
3D Printed

Abstract Making arts and crafts is an essential application of 3D printing. However, typically, 3D printers have limited resolution; thus, the perceptual quality of the result is always low, mainly when the input mesh is a relief. To address this problem using existing 3D printing technology, we only operate the shape of the input triangle mesh. To improve the perceptual quality of a 3D printed product, we propose an integrated mesh processing that comprises feature extraction, 3D print preview, feature preservation test, and shape enhancement. The proposed method can identify and enlarge features that need to be enhanced without large-scale deformation. Besides, to improve ease of use, intermediate processes are visualized via user interfaces. To evaluate the proposed method, the processed triangle meshes are 3D printed. The effectiveness of the proposed approach is confirmed by comparing photographs of the original 3D prints and the enhanced 3D prints.

scholarly journals Novel On-Demand 3-Dimensional (3-D) Printed Tablets Using Fill Density as an Effective Release-Controlling Tool

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1872 ◽  
Author(s):  
Rishi Thakkar ◽  
Amit Raviraj Pillai ◽  
Jiaxiang Zhang ◽  
Yu Zhang ◽  
Vineet Kulkarni ◽  
...  
Keyword(s):  
Drug Release ◽  
Hydroxypropyl Methylcellulose ◽  
Amorphous State ◽  
Dosage Forms ◽  
Water Soluble ◽  
Patient Specific ◽  
3 Dimensional ◽  
Fused Deposition ◽  
3D Printed ◽  
The Impact

This research demonstrates the use of fill density as an effective tool for controlling the drug release without changing the formulation composition. The merger of hot-melt extrusion (HME) with fused deposition modeling (FDM)-based 3-dimensional (3-D) printing processes over the last decade has directed pharmaceutical research towards the possibility of printing personalized medication. One key aspect of printing patient-specific dosage forms is controlling the release dynamics based on the patient’s needs. The purpose of this research was to understand the impact of fill density and interrelate it with the release of a poorly water-soluble, weakly acidic, active pharmaceutical ingredient (API) from a hydroxypropyl methylcellulose acetate succinate (HPMC-AS) matrix, both mathematically and experimentally. Amorphous solid dispersions (ASDs) of ibuprofen with three grades of AquaSolveTM HPMC-AS (HG, MG, and LG) were developed using an HME process and evaluated using solid-state characterization techniques. Differential scanning calorimetry (DSC), powder X-ray diffraction (pXRD), and polarized light microscopy (PLM) confirmed the amorphous state of the drug in both polymeric filaments and 3D printed tablets. The suitability of the manufactured filaments for FDM processes was investigated using texture analysis (TA) which showed robust mechanical properties of the developed filament compositions. Using FDM, tablets with different fill densities (20–80%) and identical dimensions were printed for each polymer. In vitro pH shift dissolution studies revealed that the fill density has a significant impact (F(11, 24) = 15,271.147, p < 0.0001) and a strong negative correlation (r > −0.99; p < 0.0001) with the release performance, where 20% infill demonstrated the fastest and most complete release, whereas 80% infill depicted a more controlled release. The results obtained from this research can be used to develop a robust formulation strategy to control the drug release from 3D printed dosage forms as a function of fill density.

Options for additive rapid prototyping methods (3D printing) in MEMS technology

2014 ◽  
Vol 20 (5) ◽  
pp. 403-412 ◽  
Author(s):  
Victor A. Lifton ◽  
Gregory Lifton ◽  
Steve Simon
Keyword(s):  
3D Printing ◽  
Rapid Prototyping ◽  
Method Development ◽  
Fused Deposition Modeling ◽  
Microelectromechanical Systems ◽  
Mems Devices ◽  
Content Type ◽  
3D Print ◽  
Fused Deposition ◽  
Mems Technology

Purpose – This study aims to investigate the options for additive rapid prototyping methods in microelectromechanical systems (MEMS) technology. Additive rapid prototyping technologies, such as stereolithography (SLA), fused deposition modeling (FDM) and selective laser sintering (SLS), all commonly known as three-dimensional (3D) printing methods, are reviewed and compared with the resolution requirements of the traditional MEMS fabrication methods. Design/methodology/approach – In the 3D print approach, the entire assembly, parts and prototypes are built using various plastic and metal materials directly from the software file input, completely bypassing any additional processing steps. The review highlights their potential place in the overall process flow to reduce the complexity of traditional microfabrication and long processing cycles needed to test multiple prototypes before the final design is set. Findings – Additive manufacturing (AM) is a promising manufacturing technique in micro-device technology. Practical implications – In the current state of 3D printing, microfluidic and lab-on-a-chip devices for fluid handling and manipulation appear to be the most compatible with the 3D print methods, given their fairly coarse minimum feature size of 50-500 μm. Future directions in the 3D materials and method development are identified, such as adhesion and material compatibility studies of the 3D print materials, wafer-level printing and conductive materials development. One of the most important goals should be the drive toward finer resolution and layer thickness (1-10 μm) to stimulate the use of the 3D printing in a wider array of MEMS devices. Originality/value – The review combines two discrete disciplines, microfabrication and AM, and shows how microfabrication and micro-device commercialization may benefit from employing methods developed by the AM community.

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