We Fear Villains

2020 ◽  
pp. 123-147
Author(s):  
James M. Jasper ◽  
Michael P. Young ◽  
Elke Zuern
Keyword(s):  
Activity Levels ◽  
Collective Identities ◽  
Political Strategies ◽  
Urgent Action ◽  
Sense Of Urgency

This chapter presents villains as part of a typology of primary characters including heroes, villains, victims, and minions. Within this framework, villains are bad and powerful. They can be cruel, arrogant, greedy, hypocritical, sacrilegious. They are also secretive. This heightens people’s sense of urgency in stopping them, generates collective identities forged against the evil outsiders, and places god-fearing citizens in the role of protective heroes prepared for sacrifice. People construct villains for the powerful emotions they inspire in audiences who fear and hate them. They focus blame, transforming anxiety and frustration into indignation and purpose. Demonizing opponents is one of the oldest political strategies, and still plays a role in politics today. Character workers exaggerate their opponents’ strength, malevolence, and activity levels. They may be either superhuman or subhuman, but urgent action is required to thwart them. They are always busy, looking for weaknesses.

Populism as a Political Strategy: An Approach’s Enduring — and Increasing — Advantages

2021 ◽  
pp. 003232172110026
Author(s):  
Kurt Weyland
Keyword(s):  
The Political ◽  
Political Strategy ◽  
Political Strategies ◽  
Chief Executives ◽  
Strategic Approach ◽  
Urgent Task ◽  
The World

Responding to Rueda’s questions, this essay explains the political-strategic approach (PSA) to populism and highlights its analytical strengths, which have become even more important with the emergence of populist governments across the world. PSA identifies populism’s core by emphasizing the central role of personalistic leaders who tend to operate in opportunistic ways, rather than consistently pursuing programmatic or ideological orientations. PSA is especially useful nowadays, when scholars’ most urgent task is to elucidate the political strategies of populist chief executives and their problematic repercussions, especially populism’s threat to democracy.

scholarly journals The role of corporate political strategies in M&As

2017 ◽  
Vol 43 ◽  
pp. 260-287 ◽  
Author(s):  
Ettore Croci ◽  
Christos Pantzalis ◽  
Jung Chul Park ◽  
Dimitris Petmezas
Keyword(s):  
Political Strategies ◽  
Corporate Political Strategies

scholarly journals Us Mob Online: The Perils of Identifying as Indigenous on Social Media

Genealogy ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 52
Author(s):  
Bronwyn Carlson ◽  
Tristan Kennedy
Keyword(s):  
Social Media ◽  
Indigenous People ◽  
Indigenous Peoples ◽  
Mixed Methods Research ◽  
Indigenous Communities ◽  
Digital Environment ◽  
Collective Identities ◽  
Social Media Platforms ◽  
Insight Into

Social media is a highly valuable site for Indigenous people to express their identities and to engage with other Indigenous people, events, conversations, and debates. While the role of social media for Indigenous peoples is highly valued for public articulations of identity, it is not without peril. Drawing on the authors’ recent mixed-methods research in Australian Indigenous communities, this paper presents an insight into Indigenous peoples’ experiences of cultivating individual and collective identities on social media platforms. The findings suggest that Indigenous peoples are well aware of the intricacies of navigating a digital environment that exhibits persistent colonial attempts at the subjugation of Indigenous identities. We conclude that, while social media remains perilous, Indigenous people are harnessing online platforms for their own ends, for the reinforcement of selfhood, for identifying and being identified and, as a vehicle for humour and subversion.

scholarly journals First Characterization of an Archaeal GTP-Dependent Phosphoenolpyruvate Carboxykinase from the Hyperthermophilic Archaeon Thermococcus kodakaraensis KOD1

2004 ◽  
Vol 186 (14) ◽  
pp. 4620-4627 ◽  
Author(s):  
Wakao Fukuda ◽  
Toshiaki Fukui ◽  
Haruyuki Atomi ◽  
Tadayuki Imanaka
Keyword(s):  
Binding Sites ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Cation Binding ◽  
Activity Levels ◽  
Binding Region ◽  
Hyperthermophilic Archaeon ◽  
Dependent Activity ◽  
Additional Role

ABSTRACT Phosphoenolpyruvate carboxykinase (PCK), which catalyzes the nucleotide-dependent, reversible decarboxylation of oxaloacetate to yield phosphoenolpyruvate and CO2, is one of the important enzymes in the interconversion between C3 and C4 metabolites. This study focused on the first characterization of the enzymatic properties and expression profile of an archaeal PCK from the hyperthermophilic archaeon Thermococcus kodakaraensis (Pck Tk ). Pck Tk showed 30 to 35% identities to GTP-dependent PCKs from mammals and bacteria but was located in a branch distinct from that of the classical enzymes in the phylogenetic tree, together with other archaeal homologs from Pyrococcus and Sulfolobus spp. Several catalytically important regions and residues, found in all known PCKs irrespective of their nucleotide specificities, were conserved in Pck Tk . However, the predicted GTP-binding region was unique compared to those in other GTP-dependent PCKs. The recombinant Pck Tk actually exhibited GTP-dependent activity and was suggested to possess dual cation-binding sites specific for Mn2+ and Mg2+. The enzyme preferred phosphoenolpyruvate formation from oxaloacetate, since the Km value for oxaloacetate was much lower than that for phosphoenolpyruvate. The transcription and activity levels in T. kodakaraensis were higher under gluconeogenic conditions than under glycolytic conditions. These results agreed with the role of Pck Tk in providing phosphoenolpyruvate from oxaloacetate as the first step of gluconeogenesis in this hyperthermophilic archaeon. Additionally, under gluconeogenic conditions, we observed higher expression levels of Pck Tk on pyruvate than on amino acids, implying that it plays an additional role in the recycling of excess phosphoenolpyruvate produced from pyruvate, replacing the function of the anaplerotic phosphoenolpyruvate carboxylase that is missing from this archaeon.

Patronage and Power: The Vicereines at the Court of Naples in the Reign of Philip III of Spain

2021 ◽  
Vol 43 (4) ◽  
pp. 149-170
Author(s):  
Alejandra Franganillo Álvarez
Keyword(s):  
Family Members ◽  
Political Strategies ◽  
Political Network ◽  
Political Contribution ◽  
Kingdom Of Naples

Recently, several studies have focused on the figure of the viceroy in the Spanish Monarchy, especially in the Kingdom of Naples. However, far less attention has been paid to the role of the vicereines of Naples. The goal of my study is to investigate and clarify the significant roles held by these noblewomen at one of the most important viceregal courts of the Spanish Monarchy. I will focus on one vicereine in particular, Catalina de Zúñiga y Sandoval, 6th Countess of Lemos and sister to the Duke of Lerma (1599–1601), who developed an extensive political network through copious correspondences, requesting and distributing mercedes (dignities and favours) among family members and her clientage. A revisionary analysis of the vicereines’ roles at the Neapolitan court demonstrates how knowledge of their political contribution is essential for a deeper understanding of the economic and political strategies deployed by their families.

The Susceptibility of Healthy People to COVID-19 Infection and the Role of ACE2

2021 ◽  
Author(s):  
Mehdi Kushkestani ◽  
Mohsen Parvani ◽  
Bakhtyar Tartibian ◽  
Rasoul Eslami
Keyword(s):  
Risk Factors ◽  
Cost Effective ◽  
Normal Subjects ◽  
Definitive Treatment ◽  
Activity Levels ◽  
Cost Effective Approach ◽  
Increased Risk ◽  
Physical Activity Levels ◽  
Ace2 Gene

The COVID-19 virus has caused many deaths of people worldwide since the pandemic began. However, no definitive treatment for this infection has been discovered so far. It has been shown that comorbidities such as diabetes, hypertension and cardiovascular diseases are associated with an increased risk of SARS-COV-2 infection. Interestingly, SARS-COV-2, like SARS-COV, uses the ACE2 gene to enter the host cell. Also, changes or imbalance in ACE2.ACE can affect SARS-COV-2 susceptibility, related outcomes and mortality. Regarding the crucial role of ACE2 protein in COVID-19 infection, the effect of different factors such as age, BMI, physical activity levels, nutritional status, altitude, as well as blood group was assessed on the level of this protein. Further, to our knowledge, no study has been conducted to examine factors that increase or decrease the risk of COVID-19 and its related severity and outcome in normal subjects emphasizing the pivotal role of ACE2. Therefore, the primary purpose of this study was to investigate the involved mechanisms of ACE2 protein and other risk factors causing infection in different situations and finally, to introduce a safe, accurate, and cost-effective approach to prevent SARS-COV-2 infection and hard clinical outcomes in normal subjects.

scholarly journals «Strong as Death is Love»: Eros and Education at the End of Time

2017 ◽  
Vol 4 (1) ◽  
Author(s):  
Sam D Rocha ◽  
Adi Burton
Keyword(s):  
Social Science ◽  
Song Of Songs ◽  
Leo Tolstoy ◽  
Rich Description ◽  
The Rich ◽  
Extended Reflection ◽  
The Relationship ◽  
Sense Of Urgency

This essay is an extended reflection on the relationship between death and love expressed in a fragment from Song of Songs 8:6: «Strong as death is love». The passage will be analyzed through a Jewish, Orthodox, and Catholic exegesis and literary reflection. In particular, the essay describes the role of a particular form of love (eros) within a particular form of education (education at the end of time). While eros has frequently been ignored or resigned to a purely sexualized role, we will look closely at Augustine’s eulogy of his mother, Monica, in the Confessions, suggesting that perhaps the most visceral expression of eros is to be found in the phenomenology of death. We will also draw on the phenomenological manifestation of death by looking to the rich description of dying provided by Leo Tolstoy in his novella, The Death of Ivan Ilych.Together these investigations of eros and education yield a «curriculum of death», which draws on the re-conceptualist notion of curriculum. Our claim is that this curriculum of death offers a sense of urgency and seriousness found lacking in schools today, where death abounds, but is rarely if ever addressed in a humanistic way. This final methodological emphasis on the humanities elucidates more directly and critically the role of research for a curriculum of death within the dominance of social science in the field of education.

Abstract P189: RhoA Functions as an Antihypertrophic Switch in the Mouse Heart

2011 ◽  
Vol 109 (suppl_1) ◽  
Author(s):  
Davy Vanhoutte ◽  
Jop Van Berlo ◽  
Allen J York ◽  
Yi Zheng ◽  
Jeffery D Molkentin
Keyword(s):  
Cardiac Hypertrophy ◽  
Pressure Overload ◽  
Small Gtpase ◽  
Mouse Heart ◽  
Activity Levels ◽  
Lung Weight ◽  
Pathological Cardiac Hypertrophy ◽  
Rhoa Protein

Background. Small GTPase RhoA has been previously implicated as an important signaling effector within the cardiomyocyte. However, recent studies have challenged the hypothesized role of RhoA as an effector of cardiac hypertrophy. Therefore, this study examined the in vivo role of RhoA in the development of pathological cardiac hypertrophy. Methods and results . Endogenous RhoA protein expression and activity levels (GTP-bound) in wild-type hearts were significantly increased after pressure overload induced by transverse aortic constriction (TAC). To investigate the necessity of RhoA within the adult heart, RhoA-LoxP-targeted (RhoA flx/flx ) mice were crossed with transgenic mice expressing Cre recombinase under the control of the endogenous cardiomyocyte-specific β-myosin heavy chain (β-MHC) promoter to generate RhoA βMHC-cre mice. Deletion of RhoA with β-MHC-Cre produced viable adults with > 85% loss of RhoA protein in the heart, without altering the basic architecture and function of the heart compared to control hearts, at both 2 and 8 months of age. However, subjecting RhoA βMHC-cre hearts to 2 weeks of TAC resulted in marked increase in cardiac hypertrophy (HW/BW (mg/g): 9.5 ± 0.3 for RhoA βMHC-cre versus 7.7 ± 0.4 for RhoA flx/flx ; and cardiomyocyte size (mm 2 ): 407 ± 21 for RhoA βMHC-cre versus 262 ± 8 for RhoA flx/flx ; n ≥ 8 per group; p<0.01) and a significantly increased fibrotic response. Moreover, RhoA βMHC-cre hearts transitioned more quickly into heart failure whereas control mice maintained proper cardiac function (fractional shortening (%): 23.3 ± 1.2 for RhoA βMHC-cre versus 29.3 ± 1.2 for RhoA flx/flx ; n ≥ 8 per group; p<0.01; 12 weeks after TAC). The latter was further associated with a significant increase in lung weight normalized to body weight and re-expression of the cardiac fetal gene program. In addition, these mice also displayed greater cardiac hypertrophy in response to 2 weeks of angiotensinII/phenylephrine infusion. Conclusion. These data identify RhoA as an antihypertrophic molecular switch in the mouse heart.

Policy Uncertainty and the Dual Role of Corporate Political Strategies

2017 ◽  
Author(s):  
Chansog (Francis) Kim ◽  
Incheol Kim ◽  
Christos Pantzalis ◽  
Jung Chul Park
Keyword(s):  
Dual Role ◽  
Policy Uncertainty ◽  
Political Strategies ◽  
Corporate Political Strategies
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