Introduction

This Introduction provides an overview of the current state of the debate on the epistemic condition of moral responsibility. Its main goal is to offer a framework that contextualizes the chapters that follow. Section 1 discusses the main concepts of ‘ignorance’ and ‘responsibility’. Section 2 asks why agents should inform themselves. Section 3 describes what is taken to be the core agreement among the main participants in the debate. Section 4 explains how this agreement invites a regress argument with a revisionist implication. Section 5 provides an overview of the main responses to the regress argument. Section 6 addresses the question of why blameless ignorance excuses. Section 7 describes further issues that are addressed in the book. Section 8 concludes with some discussion of future directions the debate might take.

Author(s):  
Jacob T. Fisher ◽  
Chelsea Lonergan ◽  
Frederic R. Hopp ◽  
René Weber

Media entertainment frequently elicits rapt attention, loss of self-consciousness, high levels of enjoyment along with a sense that time is passing more quickly or more slowly than usual. This state is often referred to as flow. For over two decades, scholars have sought to understand when and why media produce flow experiences in audiences. The synchronization theory of flow (STF) advanced flow research by specifying the neural underpinnings of flow experiences and how these neural substrates are influenced by entertaining media. In the intervening years, research from a variety of fields has provided support for the core predictions of STF and has highlighted promising areas for future investigation. This chapter reviews the current state and future directions of STF, focusing on its potential for creating a bridge between media entertainment research and other vibrant research domains including motivated decision-making and neuroaesthetics.


2018 ◽  
Vol 58 (1) ◽  
pp. 41-52 ◽  
Author(s):  
Péter Bucsky

Abstract The freight transport sector is a low profit and high competition business and therefore has less ability to invest in research and development in the field of autonomous vehicles (AV) than the private car industry. There are already different levels of automation technologies in the transport industry, but most of these are serving niche demands and answers have yet to be found about whether it would be worthwhile to industrialise these technologies. New innovations from different fields are constantly changing the freight traffic industry but these are less disruptive than on other markets. The aim of this article is to show the current state of development of freight traffic with regards to AVs and analyse which future directions of development might be viable. The level of automation is very different in the case of different transport modes and most probably the technology will favour road transport over other, less environmentally harmful traffic modes.


2019 ◽  
Vol 13 (2) ◽  
pp. 83-90 ◽  
Author(s):  
Hetal Patel ◽  
Mukesh Gohel

Enteric coated dosage form bypasses the stomach and releases the drug into the small intestine. Advantages of enteric coated pellets in comparison with enteric coated tablets are a) Pellets provide rapid onset of action and faster drug release due to the smaller size than tablets and b) Pellets exhibit less residence time of acid-labile drugs in the stomach compared to tablets. Dosage form coat can be damaged by longer resistance time in the stomach. The present review summarizes the current state of enteric coated pellets where core pellets are prepared by extrusion-spheronization technique and the enteric coating is applied in a fluidized bed processor. Two approaches are involved in the preparation of core pellets. In the first approach, a mixture of drug and excipient(s)/co-processed excipient is passed through extruders to prepare core pellets. In the second approach, excipient core pellets are prepared by extrusion technique and the drug is layered onto it before the enteric coating. The excipients present in the core pellets decide immediate or extended release of drug in the intestine. The coprocessed excipient pellets provide less batch variability and provide a platform for layering of many drugs before enteric coating. Some patents included enteric coating pellets [CN105456223 (A), CN105596310 (A), CN105616371 (A), CN105663095 (A), CN101611766B, CN106511862 (A), CN106668018 (A), CN106727381 (A), CN106924222 (A), TW200624127 (A), US 2017/0165248A1, US 2017/0224720A1] are discussed.


2021 ◽  
Vol 7 (1) ◽  
pp. 1880533
Author(s):  
Tiliksew Addis ◽  
Abera Kachi ◽  
Jun Wang

i-Perception ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 204166952110203
Author(s):  
Jonas K. Olofsson ◽  
Ingrid Ekström ◽  
Maria Larsson ◽  
Steven Nordin

Olfaction, the sense of smell, is characterized by a notable age-dependency such that aging individuals are more likely to have poor olfactory abilities. These impairments are considered to be mostly irreversible and as having potentially profound effects on quality of life and food behavior, as well as constituting warning signs of mortality, cognitive dysfunction, and dementia. Here, we review the current state of research on aging and olfaction, focusing on five topics which we regard to be of particular relevance for the field: nutrition and health, cognition and dementia, mortality, environment and genetics, and training-based enhancement. Under each of these headlines, we provide a state-of-the-art overview and discuss gaps in our knowledge which might be filled by further research. Understanding how olfactory abilities are diminished in aging, and how they may be alleviated or recovered, involves a set of challenging tasks for researchers in the years to come.


2021 ◽  
Vol 13 (15) ◽  
pp. 8430
Author(s):  
Lambros Mitropoulos ◽  
Annie Kortsari ◽  
Alexandros Koliatos ◽  
Georgia Ayfantopoulou

The hyperloop is an innovative land transport mode for passengers and freight that travels at ultra-high speeds. Lately, different stakeholders have been engaged in the research and development of hyperloop components. The novelty of the hyperloop necessitates certain directions to be followed toward the development and testing of its technological components as well the formation of regulations and planning processes. In this paper, we conduct a comprehensive literature review of hyperloop publications to record the current state of progress of hyperloop components, including the pod, the infrastructure, and the communication system, and identify involved EU stakeholders. Blending this information results in future directions. An online search of English-based publications was performed to finally consider 107 studies on the hyperloop and identify 81 stakeholders in the EU. The analysis shows that the hyperloop-related activities are almost equally distributed between Europe (39%) and Asia (38%), and the majority of EU stakeholders are located in Spain (26%) and Germany (20%), work on the traction of the pod (37%) and the tube (28%), and study impacts including safety (35%), energy (33%), and cost (30%). Existing tube systems and testing facilities for the hyperloop lack full-scale tracks, which creates a hurdle for the testing and development of the hyperloop system. The presented analysis and findings provide a holistic assessment of the hyperloop system and its stakeholders and suggest future directions to develop a successful transport system.


2021 ◽  
pp. 204589402110407
Author(s):  
Andrew J Sweatt ◽  
Raju Reddy ◽  
Farbod Rahaghi ◽  
Nadine Al-Naamani

In this conference paper, we review the 2020 American Thoracic Society (ATS) International Conference session titled, “What’s New in Pulmonary Hypertension Clinical Research: Lessons from the Best Abstracts”. This virtual mini-symposium took place on October 21, 2020, in lieu of the annual in-person ATS International Conference which was cancelled due to the COVID-19 pandemic. Seven clinical research abstracts were selected for presentation in the session, which encompassed five major themes: (1) standardizing diagnosis and management of pulmonary hypertension, (2) improving risk assessment in pulmonary arterial hypertension, (3) evaluating biomarkers of disease activity, (4) understanding metabolic dysregulation across the spectrum of pulmonary hypertension, and (5) advancing knowledge in chronic thromboembolic pulmonary hypertension. Focusing on these five thematic contexts we review the current state of knowledge, summarize presented research abstracts, appraise their significance and limitations, and then discuss relevant future directions in pulmonary hypertension clinical research.


2021 ◽  
Vol 54 (2) ◽  
pp. 1-36
Author(s):  
Sameen Maruf ◽  
Fahimeh Saleh ◽  
Gholamreza Haffari

Machine translation (MT) is an important task in natural language processing (NLP), as it automates the translation process and reduces the reliance on human translators. With the resurgence of neural networks, the translation quality surpasses that of the translations obtained using statistical techniques for most language-pairs. Up until a few years ago, almost all of the neural translation models translated sentences independently , without incorporating the wider document-context and inter-dependencies among the sentences. The aim of this survey article is to highlight the major works that have been undertaken in the space of document-level machine translation after the neural revolution, so researchers can recognize the current state and future directions of this field. We provide an organization of the literature based on novelties in modelling and architectures as well as training and decoding strategies. In addition, we cover evaluation strategies that have been introduced to account for the improvements in document MT, including automatic metrics and discourse-targeted test sets. We conclude by presenting possible avenues for future exploration in this research field.


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