Conclusion

Law for Sale ◽  
2019 ◽  
pp. 175-182
Author(s):  
Johanna Stark
Keyword(s):  
Race To The Top ◽  
Competitive Dynamics ◽  
Regulatory Competition ◽  
Nation State ◽  
Global Integration ◽  
Legal Standards ◽  
The Many ◽  
And Function ◽  
Globalized World

The final chapter summarizes the arguments of the book that have exposed the ‘philosophical externalities’ of regulatory competition. If taken seriously as an interpretive framework of law production and reform, regulatory competition commits us to an understanding of law that is inconsistent with other views about law and its role in society that we appear to hold. What does not follow from these arguments is that regulatory competition and the resulting law markets are, in any possible scenario, inherently bad. It would be utopian to assume that the clock on the structural preconditions that have led to competitive dynamics in several areas of law could simply be turned back. To a significant extent, regulatory competition is one of the many symptoms of globalization. The global integration of political, legal, and economic spheres in numerous ways calls into question the role and impact of the nation state. What you think about regulatory competition therefore may not depend so much on the plausibility of its resulting in a race to the top or the bottom in legal standards, but on what you think about the purpose and function of the state in a globalized world.

Governance

2017 ◽  
Author(s):  
Joia S. Mukherjee
Keyword(s):  
Global Health ◽  
Health System ◽  
Global Governance ◽  
Health Sector ◽  
Nation State ◽  
System A ◽  
Health Strategy ◽  
External Forces ◽  
Globalized World ◽  
Global Governance For Health

This chapter focuses on governance, a key building block of a health system. A government is responsible for the health of its people. It sets the health strategy and oversees the implementation of health programs. External forces and actors influence the governance of the health sector. This chapter explores governance of health from the perspective of the nation-state coordinating its own health system (sometimes called governance for global health). The chapter examines the internal and external forces that influence national governance for global health. The chapter also looks beyond the level of the nation-state to explore the concept of global governance for health. In the interconnected and globalized world, global governance for health is needed to coordinate the geopolitical forces that impact health and its social determinants.

scholarly journals Spanning the gap: unraveling RSC dynamics in vivo

2021 ◽  
Author(s):  
Heinz Neumann ◽  
Bryan J. Wilkins
Keyword(s):  
Cell Cycle ◽  
Posttranslational Modifications ◽  
Transcriptional Activation ◽  
Binding Mode ◽  
Binding Modes ◽  
Binding Domains ◽  
Binding Interface ◽  
The Many ◽  
And Function

AbstractMultiple reports over the past 2 years have provided the first complete structural analyses for the essential yeast chromatin remodeler, RSC, providing elaborate molecular details for its engagement with the nucleosome. However, there still remain gaps in resolution, particularly within the many RSC subunits that harbor histone binding domains.Solving contacts at these interfaces is crucial because they are regulated by posttranslational modifications that control remodeler binding modes and function. Modifications are dynamic in nature often corresponding to transcriptional activation states and cell cycle stage, highlighting not only a need for enriched spatial resolution but also temporal understanding of remodeler engagement with the nucleosome. Our recent work sheds light on some of those gaps by exploring the binding interface between the RSC catalytic motor protein, Sth1, and the nucleosome, in the living nucleus. Using genetically encoded photo-activatable amino acids incorporated into histones of living yeast we are able to monitor the nucleosomal binding of RSC, emphasizing the regulatory roles of histone modifications in a spatiotemporal manner. We observe that RSC prefers to bind H2B SUMOylated nucleosomes in vivo and interacts with neighboring nucleosomes via H3K14ac. Additionally, we establish that RSC is constitutively bound to the nucleosome and is not ejected during mitotic chromatin compaction but alters its binding mode as it progresses through the cell cycle. Our data offer a renewed perspective on RSC mechanics under true physiological conditions.

THE CRITICALLY ILL CHILD: SICKLE CELL DISEASE CRISES AND THEIR MANAGEMENT

PEDIATRICS ◽  
1971 ◽  
Vol 48 (4) ◽  
pp. 629-635
Author(s):  
Howard A. Pearson ◽  
Louis K. Diamond
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Mutant Gene ◽  
Point Of View ◽  
Clinical Aspects ◽  
Cell Disease ◽  
Form And Function ◽  
Heterozygous Form ◽  
The Many ◽  
And Function

This brief review, being limited in scope to the recognition and management of the life-threatening and painful crises in infants and children with sickle-cell disease, has not even touched on the intriguing mystery of the molecular basis for the sickling phenomenon–how one amino-acid substitution (gene controlled) in the beta chain sequence of 146 amino acids can cause such serious disruption in form and function; or how this mutation occurred in the first place and why it has persisted in contrast to the rapid disappearance of many other deleterious mutants. Nor has there been even mention of the many milder symptoms, signs, and complications due to the presence of Hb. S., either in the homozygous (disease-producing) state or heterozygous form when found in combination with other hereditary hemoglobin defects. The accumulated knowledge about this mutant gene, its biochemical effects, and geographic distribution is enormous. From a fundamental scientific standpoint, sickle cell disease is one of the best understood of human afflictions. However, from a practical point of view treatment of the patient himself is often only symptomatic and palliative. Nevertheless, prompt and effective therapy of the myriad manifestations of sickle cell disease can effectively reduce morbidity and mortality. The pediatrician who cares for black children in his practice should be familiar with the cardinal diagnostic and clinical aspects of sickle cell disease and its crises.

The expanding world of metabolic enzymes moonlighting as RNA binding proteins

2021 ◽  
Author(s):  
Nicole J. Curtis ◽  
Constance J. Jeffery
Keyword(s):  
Gene Expression ◽  
Regulatory Networks ◽  
Binding Proteins ◽  
Molecular Mechanisms ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Molecular Structures ◽  
Intermediary Metabolism ◽  
The Many ◽  
And Function

RNA binding proteins play key roles in many aspects of RNA metabolism and function, including splicing, transport, translation, localization, stability and degradation. Within the past few years, proteomics studies have identified dozens of enzymes in intermediary metabolism that bind to RNA. The wide occurrence and conservation of RNA binding ability across distant branches of the evolutionary tree suggest that these moonlighting enzymes are involved in connections between intermediary metabolism and gene expression that comprise far more extensive regulatory networks than previously thought. There are many outstanding questions about the molecular structures and mechanisms involved, the effects of these interactions on enzyme and RNA functions, and the factors that regulate the interactions. The effects on RNA function are likely to be wider than regulation of translation, and some enzyme–RNA interactions have been found to regulate the enzyme's catalytic activity. Several enzyme–RNA interactions have been shown to be affected by cellular factors that change under different intracellular and environmental conditions, including concentrations of substrates and cofactors. Understanding the molecular mechanisms involved in the interactions between the enzymes and RNA, the factors involved in regulation, and the effects of the enzyme–RNA interactions on both the enzyme and RNA functions will lead to a better understanding of the role of the many newly identified enzyme–RNA interactions in connecting intermediary metabolism and gene expression.

KAJIAN ORNAMEN GORGA DI RUMAH ADAT BATAK TOBA (Studi Kasus : Di Kawasan Desa Wisata Tomok, Huta Siallagan dan Huta Bolon Di Kabupaten Samosir)

2019 ◽  
Vol 2 (1) ◽  
pp. 1-14
Author(s):  
Dearma A Saragih ◽  
Yulianto Yulianto ◽  
Raimundus Pakpahan
Keyword(s):  
Comparative Research ◽  
Research Method ◽  
Toba Batak ◽  
Historical Heritage ◽  
The Many ◽  
Almost All ◽  
And Function ◽  
Meaning And Function ◽  
House Building

One of the interesting cultural potentials to be studied is traditional houses. This traditional house has its own uniqueness in every area. One of the uniqueness can be seen from the many ornaments in it. Diversity has its own meaning and function. Ornaments is one of the historical heritage of Indonesia where almost all the tribes in Indonesia can be found various kinds of ornaments that reflect the techniques of each region in Indonesia. Ornament Batak Toba is one of the many ornaments that exist in this country Indonesia. Toba Batak ornament can be found in North Sumatera Province precisely in Samosir regency which always apply Toba Batak ornament as decoration or as identity in important building for Batak Toba, for example in traditional house building in Huta Siallagan, Tomok Village and Huta Bolon.This research is classified in research using descriptive-comparative research method, doing the study by comparing the existing ornaments in these three villages with theories about Ornaments Gorga Rumah Adat Batak Toba, then do the analysis of the condition in accordance with the theory used as a reference

Policy Implications

2021 ◽  
pp. 155-186
Author(s):  
R. Barry Ruback
Keyword(s):  
Economic Sanctions ◽  
Penal Code ◽  
Policy Implications ◽  
Model Penal Code ◽  
State Governments ◽  
Legal Standards ◽  
Law And Courts ◽  
The Poor ◽  
Different Types

This last chapter, Chapter 8, looks at larger issues of economic sanctions. Reitz and Klingele, the reporters of the Model Penal Code argued that economic sanctions are unprincipled (they violate legal standards and discriminate against the poor), unsuccessful (they are generally unpaid and, as presently constituted, do not meet the purposes of sentencing), and are unending (local and state governments are continuing to impose economic sanctions and other legal financial obligations in order to meet budgetary needs). Also, in the final chapter the author discusses how the existing research can be used to inform policy, particularly regarding questions of whether there should be different types of economic sanctions, what those types should be, and what amounts of economic sanctions should be imposed. These policy arguments are based on the assumption that the law and courts should be concerned about victims, offenders, and the community.

Effects of Ocean Acidification on Sediment Fauna

2011 ◽  
Author(s):  
Stephen Widdicombe ◽  
John I. Spicer
Keyword(s):  
Ocean Acidification ◽  
Well Being ◽  
Unconsolidated Sediments ◽  
Ecosystem Functions ◽  
Biological Interactions ◽  
Goods And Services ◽  
Marine Realm ◽  
Critical Components ◽  
The Many ◽  
And Function

The vast majority of the seafloor is covered not in rocky or biogenic reefs but in unconsolidated sediments and, consequently, the majority of marine biodiversity consists of invertebrates either residing in (infauna) or on (epifauna) sediments (Snelgrove 1999). The biodiversity within these sediments is a result of complex interactions between the underlying environmental conditions (e.g. depth, temperature, organic supply, and granulometry) and the biological interactions operating between organisms (e.g. predation and competition). Not only are sediments important depositories of biodiversity but they are also critical components in many key ecosystem functions. Nowhere is this more apparent than in shallow coastal seas and oceans which, despite covering less than 10% of the earth’s surface, deliver up to 30% of marine production and 90% of marine fisheries (Gattuso et al. 1998). These areas are also the site for 80% of organic matter burial and 90% of sedimentary mineralization and nutrient–sediment biogeochemical processes. They also act as the sink for up to 90% of the suspended load in the world’s rivers and the many associated contaminants this material contains (Gattuso et al. 1998). Human beings depend heavily on the goods and services provided, for free, by the marine realm (Hassan et al. 2005 ) and it is no coincidence that nearly 70% of all humans live within 60 km of the sea or that 75% of all cities with more than 10 million inhabitants are in the coastal zone (Small and Nicholls 2003; McGranahan et al. 2007) Given these facts, it is clear that any broad-scale environmental impact that affects the diversity, structure, and function of sediment ecosystems could have a considerable impact on human health and well-being. It is therefore essential that the impacts of ocean acidification on sediment fauna, and the ecosystem functions they support, are adequately considered. This chapter will first describe the geochemical environment within which sediment organisms live. It will then explore the role that sediment organisms play as ecosystem engineers and how they alter the environment in which they live and the overall biodiversity of sediment communities.

Salvage Procedures

2018 ◽  
pp. 307-322
Author(s):  
Joaquin Sanchez-Sotelo
Keyword(s):  
Surgical Technique ◽  
Surgical Procedures ◽  
Glenohumeral Joint ◽  
Resection Arthroplasty ◽  
Successful Management ◽  
The Many ◽  
And Function ◽  
Surgical Option

The many surgical procedures summarized in previous chapters allow successful management of most shoulder conditions and result in improved pain, motion, and function. However, salvage procedures that sacrifice the glenohumeral joint or the scapulothoracic joint represent the best surgical option for a few patients. These salvage procedures are uncommon, but shoulder surgeons need to be familiar with their indications, surgical technique, and reported outcomes. This chapter addresses glenohumeral arthrodesis, scapulothoracic arthrodesis, and glenohumeral resection arthroplasty.

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