The Threefold Selves in García Márquez’s Writing

2021 ◽  
pp. 573-595
Author(s):  
Robert Sims
Keyword(s):  
Essential Role ◽  
Early Age ◽  
Investigative Journalism ◽  
The 1950S

This study examines the evolution and interaction of writerly, autobiographical, and testimonial selves in García Márquez’s work by concentrating on a select number of texts from 1955 to 2004. Three factors contribute to the role of these selves in his writing: (1) the author states in his memoir that he realized at an early age that he only wanted to be a writer; (2) From the publication of One Hundred Years of Solitude in 1967 to the end of his life, he remained universally loved by readers and critics; and (3) the use of the refrito, or follow-up story, in his investigative journalism for El Espectador in the 1950s in Bogotá became an integral part of his writing. Although the interplay of his writerly, autobiographical, and testimonial selves appears at different moments in his fiction as well as his nonfiction, he achieves the most intricate balance between the three in Chronicle of a Death Foretold. While his writerly self overshadows his autobiographical and testimonial selves, they nevertheless play a prominent and essential role in his writing, albeit in hybridized forms.

Challenges Facing E-Publishing Over Cloud Computing on Scientists' Social Network Service

2019 ◽  
pp. 233-260
Author(s):  
Evon Abu-Taieh ◽  
Auhood Alfaries ◽  
Shaha Al-Otaibi
Keyword(s):  
Cloud Computing ◽  
Social Network ◽  
Financial Support ◽  
Essential Role ◽  
Network Services ◽  
Writing Research ◽  
Research Document ◽  
Grant Management

This chapter illustrates the difficulties facing e-publishing over cloud computing pertaining to scientifically-oriented social network services from three axioms: the life cycle of the research document, an explanation of what a researcher juggles to conduct proper research, and the researcher knowledge pertaining to both scholarly search engines and citation indices. The chapter discusses the essential role of the researcher in teaching, being a beacon of hope, and explains the steps towards research conducting, when an original idea is deduced, as well as the step of writing research addressing the financial support for researchers: from submitting proposals, follow up proposals, grant management if funding is secured, whilst conducting the research, and publishing the results in accredited journals approved by the researcher's institute and financing partner, while publishing the research in accordance with the laws and regulations of the institute.

scholarly journals A thrombomodulin mutation that impairs activated protein C generation results in uncontrolled lung inflammation during murine tuberculosis

Blood ◽  
2005 ◽  
Vol 106 (8) ◽  
pp. 2761-2768 ◽  
Author(s):  
Sebastiaan Weijer ◽  
Catharina W. Wieland ◽  
Sandrine Florquin ◽  
Tom van der Poll
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Inflammatory Response ◽  
Lung Inflammation ◽  
Protein C ◽  
Essential Role ◽  
Activated Protein C ◽  
Wild Type ◽  
Anti Inflammatory

AbstractThrombomodulin (TM) plays an essential role in the generation of activated protein C (APC), a mediator with both anticoagulant and anti-inflammatory properties, and is preferentially expressed in lungs. To investigate the role of TM in the coagulant and inflammatory response in the lung during tuberculosis, mice with a mutation in the TM gene (Thbd), which results in a minimal capacity for APC generation (TMpro/pro mice), were intranasally infected with live virulent Mycobacterium tuberculosis. Whereas pulmonary tuberculosis was not associated with activation of coagulation in either wild-type or TMpro/pro mice, 5 weeks after infection TMpro/pro mice displayed an uncontrolled inflammatory response in their lungs, as reflected by higher lung weights, a diminished ability to form well-shaped granulomas, elevated levels of proinflammatory cytokines, and concurrently reduced concentrations of anti-inflammatory cytokines. During a 36-week follow-up after infection with a lower dose of M tuberculosis, 35% of TMpro/pro mice died from week 28 onward versus none of the wild-type mice, and the surviving TMpro/pro mice displayed increased lung inflammation accompanied by higher mycobacterial loads in liver and spleen. These data suggest that a TM mutation that impairs APC generation results in uncontrolled lung inflammation during tuberculosis.

scholarly journals Ultrasound in pediatric orbital cellulitis

2020 ◽  
Vol 22 (2) ◽  
pp. 253
Author(s):  
Ana Falticeanu ◽  
Pierre Tritschler ◽  
Dana Dumitriu
Keyword(s):  
Emergency Room ◽  
Antibiotic Treatment ◽  
Essential Role ◽  
Paediatric Population ◽  
Orbital Cellulitis ◽  
Preseptal Cellulitis

Orbital cellulitis is an infrequent but serious complication of sinus infections in children, as was the case of a 7-year-old who presented to the emergency room with ultrasound signs of preseptal cellulitis. Despite a well conducted antibiotic treatment a control ultrasound demonstrated associated signs of retro-septal extension. This case brings to light the essential role of ultrasound in suspected cellulitis, as a mean to differentiate between preseptal cellulitis and retroseptal (orbital) cellulitis. In the paediatric population ultrasound should be the first intention exam to diagnose the extension of the illness, and help guide the management and follow-up of the patients.

Psychological Resilience Provides No Independent Protection From Suicidal Risk

Crisis ◽  
2016 ◽  
Vol 37 (2) ◽  
pp. 130-139 ◽  
Author(s):  
Danica W. Y. Liu ◽  
A. Kate Fairweather-Schmidt ◽  
Richard Burns ◽  
Rachel M. Roberts ◽  
Kaarin J. Anstey
Keyword(s):  
Risk Factors ◽  
Well Being ◽  
Current Status ◽  
Psychological Resilience ◽  
Cross Sectional ◽  
Life Project ◽  
Resilience Factors ◽  
First Time

Abstract. Background: Little is known about the role of resilience in the likelihood of suicidal ideation (SI) over time. Aims: We examined the association between resilience and SI in a young-adult cohort over 4 years. Our objectives were to determine whether resilience was associated with SI at follow-up or, conversely, whether SI was associated with lowered resilience at follow-up. Method: Participants were selected from the Personality and Total Health (PATH) Through Life Project from Canberra and Queanbeyan, Australia, aged 28–32 years at the first time point and 32–36 at the second. Multinomial, linear, and binary regression analyses explored the association between resilience and SI over two time points. Models were adjusted for suicidality risk factors. Results: While unadjusted analyses identified associations between resilience and SI, these effects were fully explained by the inclusion of other suicidality risk factors. Conclusion: Despite strong cross-sectional associations, resilience and SI appear to be unrelated in a longitudinal context, once risk/resilience factors are controlled for. As independent indicators of psychological well-being, suicidality and resilience are essential if current status is to be captured. However, the addition of other factors (e.g., support, mastery) makes this association tenuous. Consequently, resilience per se may not be protective of SI.

Abusive head trauma (AHT) outcome at long-term follow-up and the role of elective neurosurgical approach: A report of 22 cases

2013 ◽  
Author(s):  
Francesca Menegazzo ◽  
Melissa Rosa Rizzotto ◽  
Martina Bua ◽  
Luisa Pinello ◽  
Elisabetta Tono ◽  
...  
Keyword(s):  
Head Trauma ◽  
Abusive Head Trauma ◽  
Long Term Follow Up

Essential role of Sharpin in TNFα dependent NFκB activation in primary hepatocytes

2012 ◽  
Vol 50 (01) ◽  
Author(s):  
N Lange ◽  
S Sieber ◽  
A Erhardt ◽  
G Sass ◽  
HJ Kreienkamp ◽  
...  
Keyword(s):  
Essential Role ◽  
Primary Hepatocytes

Different Abilities of Thrombin Receptor Activating Peptide and Thrombin to Induce Platelet Calcium Rise and Full Release Reaction

1995 ◽  
Vol 74 (05) ◽  
pp. 1323-1328 ◽  
Author(s):  
Dominique Lasne ◽  
José Donato ◽  
Hervé Falet ◽  
Francine Rendu
Keyword(s):  
Essential Role ◽  
Calcium Influx ◽  
Dense Granule ◽  
Receptor Interaction ◽  
Thrombin Receptor ◽  
Release Reaction ◽  
External Calcium ◽  
Maximum Rise ◽  
Granule Release

SummarySynthetic peptides (TRAP or Thrombin Receptor Activating Peptide) corresponding to at least the first five aminoacids of the new N-terminal tail generated after thrombin proteolysis of its receptor are effective to mimic thrombin. We have studied two different TRAPs (SFLLR, and SFLLRN) in their effectiveness to induce the different platelet responses in comparison with thrombin. Using Indo-1/AM- labelled platelets, the maximum rise in cytoplasmic ionized calcium was lower with TRAPs than with thrombin. At threshold concentrations allowing maximal aggregation (50 μM SFLLR, 5 μM SFLLRN and 1 nM thrombin) the TRAPs-induced release reaction was about the same level as with thrombin, except when external calcium was removed by addition of 1 mM EDTA. In these conditions, the dense granule release induced by TRAPs was reduced by over 60%, that of lysosome release by 75%, compared to only 15% of reduction in the presence of thrombin. Thus calcium influx was more important for TRAPs-induced release than for thrombin-induced release. At strong concentrations giving maximal aggregation and release in the absence of secondary mediators (by pretreatment with ADP scavengers plus aspirin), SFLLRN mobilized less calcium, with a fast return towards the basal level and induced smaller lysosome release than did thrombin. The results further demonstrate the essential role of external calcium in triggering sustained and full platelet responses, and emphasize the major difference between TRAP and thrombin in mobilizing [Ca2+]j. Thus, apart from the proteolysis of the seven transmembrane receptor, another thrombin binding site or thrombin receptor interaction is required to obtain full and complete responses.

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