Correlation of psychopathology and white matter abnormalities in fathers of children with ADHD: Cross sectional study
Abstract Background Attention-deficit/hyperactivity disorder (ADM)) is one of the most common neurobehavioral disorders of childhood. Children with ADHD may experience significant adaptation problems because their functional level and behavior may not correspond to their chronological age or expected development level. ADHD is a chronic disease, the symptoms of which can persist into adulthood and become lifelong. Aim of the work evaluating the biological substrate in fathers of children with ADHD, assessing rate of occurrence of ADHD among fathers of children with ADHD. Subjects and Methods This descriptive observational cross-sectional study was conducted on 40 children with a diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) according to the DSNI-IV criteria who attended to the Child and Adolescent Outpatient clinics of the Institute of Psychiatry, Ain Shams University Hospital. Results Prevalence rate of diagnosis of adult ADHD among fathers of children with ADHD (6 to 12) years old was 60%, 20% with mixed hyperactive—inattentive type, 15%.predominantly hyperactive—impulsive type and 25% predominantly inattentive type. There were statistically significant differences between ADHD group of children’s fathers in comparison to Non-ADHD group, as the mean ADC of right and left middle cerebellar peduncle, was lower in ADHD group which indicates absence of abnormalities in white matter integrity in those areas. Conclusion prevalence rate of adult ADHD among fathers was 60%. There were no abnormalities in white matter integrity in group of fathers with diagnosis of adult ADHD.