Factors associated with longitudinal change of meniscal extrusion in overweight women without clinical signs of osteoarthritis

Abstract Objectives To identify variables associated with longitudinal change in meniscal extrusion, which might be used as possible targets for knee osteoarthritis (KOA) prevention. Methods In a high-risk population of middle-aged overweight women, meniscal extrusion was assessed with magnetic resonance imaging (1.5 T, coronal proton density, in-plane resolution 0.5 mm2, Sante DICOM Editor) at baseline and after 30 months. Outcomes were the absolute change in medial and lateral extrusion (mm) and relative change in extrusion (%). Based upon literature, 11 factors were hypothesized to be associated with longitudinal change. Generalized estimating equations were used to model the effect on meniscal change (P <0.05). Results In total, 677 knees of 343 women were available for analysis, with a mean age of 55.7 years (+/−3.2) and a mean BMI of 32.3 kg/m2 (+/−4.2). The greatest change in meniscal extrusion appeared medially with incident meniscal tear (4.4%; absolute 0.9 mm (95% CI: 0.3, 1.5; P =0.004); relative 14.5% (4.4, 24.7; 0.005)). Varus malalignment was associated with an increase of medial extrusion of 0.6 mm (37.6%; 0.1, 1.0; 0.009). A 5 kg/m2 higher baseline BMI was associated with absolute and relative increase of medial extrusion of 0.2 mm and 2.96% (0.1, 0.3; <0.001 and 1.3, 4.8; 0.002). Less explicit but significant changes in extrusion appeared with longitudinal change in BMI. Conclusion Meniscal tears, varus malalignment and BMI were significantly associated with change in meniscal extrusion in middle-aged overweight women, providing viable therapeutic targets to prevent or reduce extrusion and thereby decelerate KOA development.

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Factors associated with longitudinal change of meniscal extrusion in overweight women without clinical signs of knee osteoarthritis

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2019.02.744 ◽

2019 ◽

Vol 27 ◽

pp. S337-S338

Author(s):

J.A. van der Voet ◽

D. Wesselius ◽

D. Vroegindeweij ◽

E.H. Oei ◽

S.M. Bierma - Zeinstra ◽

...

Keyword(s):

Knee Osteoarthritis ◽

Clinical Signs ◽

Longitudinal Change ◽

Meniscal Extrusion ◽

Overweight Women ◽

Factors Associated

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Retrospective Diagnosis of Pontocerebellar Hypoplasia Type 1B in a Family with Two Deceased Newborn Children

Journal of Pediatric Genetics ◽

10.1055/s-0040-1718536 ◽

2020 ◽

Author(s):

Irena Bradinova ◽

Silvia Andonova ◽

Alexey Savov

Keyword(s):

Clinical Signs ◽

Final Diagnosis ◽

Population Based ◽

Neuromuscular Disorder ◽

Population Characteristics ◽

High Risk Population ◽

Pontocerebellar Hypoplasia ◽

Clinical Genetic ◽

Retrospective Diagnosis ◽

Newborn Children

AbstractPontocerebellar hypoplasia type 1B is a severe autosomal recessive neurologic disorder characterized by a combination of cerebellar and spinal motor neuron degeneration beginning at birth. Pontocerebellar hypoplasia type 1B is caused by mutations in EXOSC3 gene. High prevalence of the p.Gly31Ala mutation was found recently, especially in the Roma ethnic minority. We present a young Bulgarian Roma family with two deceased newborn children manifesting severe neuromuscular disorder including severe muscle weakness, respiratory distress, and multiple joint contractures. Based on the clinical signs and family's population characteristics, DNA testing for the previously described EXOSC3 in Bulgarian Roma mutation c.92G > C; p.Gly31Ala was performed on blood samples of both parents and they were found to be heterozygous carriers. This finding indirectly confirmed the diagnosis of pontocerebellar hypoplasia type B in the deceased offspring. Knowledge of population-specific molecular bases of genetic conditions was the key to final diagnosis in the presented family. Designing of population-based clinical-genetic panels may be a powerful diagnostic tool for patients with such origin. Preconception carrier screening in high-risk population groups is a feasible option to discuss.

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Epidemiological Characteristics of Severe Fever with Thrombocytopenia Syndrome from 2010 to 2019 in Mainland China

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18063092 ◽

2021 ◽

Vol 18 (6) ◽

pp. 3092

Author(s):

Xiaoxia Huang ◽

Jiandong Li ◽

Aqian Li ◽

Shiwen Wang ◽

Dexin Li

Keyword(s):

Statistical Significance ◽

Regional Distribution ◽

Mainland China ◽

Deep Understanding ◽

Scientific Data ◽

High Risk Population ◽

Middle Aged ◽

Increasing Trend ◽

Epidemiological Characteristics ◽

Severe Fever

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that is a severe threat to public health considering its high fatality and person-to-person transmission. In order to obtain an updated and deep understanding of the epidemiological characteristics of SFTS in mainland China, we used Pearson’s chi-squared test to compare the fatality rate and demographic characteristics in different groups. Data were analyzed in R3.6.1 (R Development Core Team 2018), while the visualization was performed in ArcGIS 10 (ESRI, Redlands, CA, USA), and the statistical significance was set at p < 0.05. A total of 13,824 SFTS cases involving 8899 lab-confirmed cases and 4925 probable cases were reported and included in the epidemiological analysis. Our study found that the number of SFTS cases showed an increasing trend with a small decrease in the past three years. The laboratory-confirmed rate was about 64.4%, which varied between different years and areas. Although most cases (99.3%) were distributed in 7 provinces (Henan, Shandong, Anhui, Hubei, Liaoning, Zhejiang, and Jiangsu), the regional distribution of SFTS gradually expanded from 5 provinces in 2010 to 25 provinces by 2019, especially at the town level. The SFTS cases were mainly sporadic. A total of 96.5% occurred from April to October, and 93.3% of cases were concentrated in middle-aged and elderly people (40–84 years old). Farmers were the main high-risk population. Female cases were slightly more than male cases; however, there were differences between different provinces. The mortality rate showed an increasing trend with age. Overall, the SFTS cases were mainly middle-aged and elderly farmers that sporadically distributed throughout seven provinces with a spatially expanding trend. The laboratory-confirmed rate varied in different years and provinces, which implied that the diagnosis and report criteria for SFTS should be further updated and unified in order to get a better understanding of its epidemiological characteristics and provide scientific data for SFTS control.

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Effect of β3-adrenergic receptor gene polymorphism on body weight change in middle-aged, overweight women

Environmental Health and Preventive Medicine ◽

10.1007/bf02898145 ◽

2006 ◽

Vol 11 (2) ◽

pp. 69-74 ◽

Cited By ~ 5

Author(s):

Jung Su Lee ◽

Kiyoshi Kawakubo ◽

Shuji Inoue ◽

Akira Akabayashi

Keyword(s):

Body Weight ◽

Gene Polymorphism ◽

Weight Change ◽

Adrenergic Receptor ◽

Receptor Gene ◽

Body Weight Change ◽

Middle Aged ◽

Overweight Women ◽

Receptor Gene Polymorphism ◽

Adrenergic Receptor Gene

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Evaluation of Airway Complications in High-Risk Preterm Infants: Application of Flexible Fiberoptic Airway Endoscopy

PEDIATRICS ◽

10.1542/peds.95.4.567 ◽

1995 ◽

Vol 95 (4) ◽

pp. 567-572

Author(s):

Gregory J. Downing ◽

Howard W. Kilbride

Keyword(s):

High Risk ◽

Preterm Infants ◽

Clinical Signs ◽

Signs And Symptoms ◽

Subglottic Stenosis ◽

High Risk Population ◽

Risk Population ◽

Airway Complications ◽

Airway Injury ◽

Airway Abnormalities

Objectives. We sought to determine factors that would predict the development of subglottic stenosis (SGS) and tracheomalacia (TM) in preterm infants. The utility of a semiquantitative measurement of airway dimensions was assessed in relation to signs of airway complications. We also sought to determine from a high-risk population of infants those likely to have abnormal findings identified by bronchoscopic examination. Methods. Prospective airway endoscopy was performed for preterm infants who were intubated for 7 days or more or who demonstrated chronic oxygen needs beyond 28 days after birth and 36 weeks postconceptional age. Subjects were 117 preterm (less than 36 weeks' gestation) infants from two level III intensive care nurseries. Endoscopy was used to classify the type and degree of airway injury. Subglottic stenosis was defined subjectively and compared with an objective measurement using subglottic spatial relations described as a trans- subglottic/vocal cord ratio (TSG/VC). Clinical signs and symptoms and other risk factors were evaluated as significant predictors of SGS and TM, identified by bronchoscopy. Results. Moderate or severe airway abnormalities were identified in 32 patients (27.3%); 13 with SGS, 17 with TM, and 2 with both. All but one infant with TSG/VC less than 0.83 had signs and symptoms of airway dysfunction. Variables more commonly found in patients with SGS included greater number of intubations, use of inappropriately large endotracheal tubes, and longer duration of intubation. Higher averaged mean airway pressure during the first week after birth and lower gestational age were clinical features associated with TM. Conclusions. Flexible bronchoscopic evaluation of a high-risk population demonstrated a higher incidence of moderate or severe SGS or TM than previously suspected. Subglottic stenosis and TM appear to have different etiologies based on different factors associated with their development. The TSG/VC ratio correlated well with obstructive symptoms and may represent a means to quantitate clinically subglottic narrowing. Infants with chronic lung disease who have persistently elevated partial pressure of carbon dioxide, apnea, or phonation abnormalities are most likely to have airway abnormalities identifiable by bronchoscopy.

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Meniscal tear morphology independently affects pain relief following arthroscopic partial meniscectomy in middle-aged patients

Knee Surgery Sports Traumatology Arthroscopy ◽

10.1007/s00167-018-5238-2 ◽

2018 ◽

Vol 27 (8) ◽

pp. 2460-2467 ◽

Cited By ~ 3

Author(s):

Masayuki Kamimura ◽

Jutaro Umehara ◽

Atsushi Takahashi ◽

Yu Mori ◽

Daisuke Chiba ◽

...

Keyword(s):

Pain Relief ◽

Meniscal Tear ◽

Partial Meniscectomy ◽

Middle Aged ◽

Arthroscopic Partial Meniscectomy ◽

Aged Patients

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Longitudinal Change in Myocardial Function and Clinical Parameters in Middle-Aged Subjects: A 3-Year Follow-up Study

Diabetes & Metabolism Journal ◽

10.4093/dmj.2020.0132 ◽

2021 ◽

Author(s):

Dong-Hyuk Cho ◽

Hyung Joon Joo ◽

Mi-Na Kim ◽

Hee-Dong Kim ◽

Do-Sun Lim ◽

...

Keyword(s):

Myocardial Function ◽

Longitudinal Change ◽

Clinical Parameters ◽

Middle Aged ◽

Follow Up Study ◽

Aged Subjects

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Obesity Is Associated With Increased Susceptibility to Influenza A (H1N1pdm) but Not H3N2 Infection

Clinical Infectious Diseases ◽

10.1093/cid/ciaa928 ◽

2020 ◽

Author(s):

Hannah E Maier ◽

Guillermina Kuan ◽

Lionel Gresh ◽

Roger Lopez ◽

Nery Sanchez ◽

...

Keyword(s):

Influenza A ◽

Influenza Infection ◽

High Risk Population ◽

Virus Infections ◽

Middle Aged ◽

Symptomatic Infection ◽

Logistic Regression Models ◽

Susceptibility To Infection ◽

Associated Symptoms ◽

Increased Susceptibility

Abstract Background Obesity has been shown to increase the risk of severe outcomes and death for influenza virus infections. However, we do not understand the influence of obesity on susceptibility to infection or on nonsevere influenza outcomes. Methods We performed a case-ascertained, community-based study of influenza transmission within households in Nicaragua. To investigate whether obesity increases the likelihood of influenza infection and symptomatic infection we used logistic regression models. Results Between 2015 and 2018, a total of 335 index cases with influenza A and 1506 of their household contacts were enrolled. Obesity was associated with increased susceptibility to symptomatic H1N1pdm infection among adults (odds ratio [OR], 2.10; 95% confidence interval [CI], 1.08–4.06) but not children, and this association increased with age. Among adults with H1N1pdm infection, obesity was associated with increased likelihood of symptoms (OR, 3.91; 95% CI, 1.55–9.87). For middle-aged and older adults with obesity there was also a slight increase in susceptibility to any H1N1pdm infection (OR, 1.20; 95% CI, .62–2.34). Body mass index (BMI) was also linearly associated with increased susceptibility to symptomatic H1N1pdm infection, primarily among middle-aged and older women (5-unit BMI increase OR, 1.40; 95% CI, 1.00–1.97). Obesity was not associated with increased H3N2 susceptibility or associated symptoms. Conclusions We found that, among adults, obesity is associated with susceptibility to H1N1pdm infection and with symptoms associated with H1N1pdm infection, but not with susceptibility to H3N2 infection or associated symptoms. These findings will help target prevention efforts and therapeutics to this high-risk population.

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