scholarly journals Pattern similarity and connectivity of hippocampal-neocortical regions support empathy for pain

2020 ◽  
Vol 15 (3) ◽  
pp. 273-284
Author(s):  
Isabella C Wagner ◽  
Markus Rütgen ◽  
Claus Lamm
Keyword(s):  
Perspective Taking ◽  
Mental Simulation ◽  
Retrosplenial Cortex ◽  
Anterior Insula ◽  
Data Set ◽  
Hand Pain ◽  
Pattern Similarity ◽  
Empathy For Pain ◽  
Human Participants ◽  
Similarity Pattern

Abstract Empathy is thought to engage mental simulation, which in turn is known to rely on hippocampal-neocortical processing. Here, we tested how hippocampal-neocortical pattern similarity and connectivity contributed to pain empathy. Using this approach, we analyzed a data set of 102 human participants who underwent functional MRI while painful and non-painful electrical stimulation was delivered to themselves or to a confederate. As hypothesized, results revealed increased pattern similarity between first-hand pain and pain empathy (compared to non-painful control conditions) within the hippocampus, retrosplenial cortex, the temporo-parietal junction and anterior insula. While representations in these regions were unaffected by confederate similarity, pattern similarity in the dorsal medial prefrontal cortex was increased the more dissimilar the other individual was perceived. Hippocampal-neocortical connectivity during first-hand pain and pain empathy engaged largely distinct but neighboring primary motor regions, and empathy-related hippocampal coupling with the fusiform gyrus positively scaled with trait measures of perspective taking. These findings suggest that shared representations and mental simulation might contribute to pain empathy via hippocampal-neocortical pattern similarity and connectivity, partially affected by personality traits and the similarity of the observed individual.

scholarly journals Pattern similarity and connectivity of hippocampal-neocortical regions support empathy for pain

2019 ◽  
Author(s):  
Isabella C. Wagner ◽  
Markus Rütgen ◽  
Claus Lamm
Keyword(s):  
Mental Simulation ◽  
Retrosplenial Cortex ◽  
The Other ◽  
Self Report ◽  
Data Set ◽  
Hand Pain ◽  
Pattern Similarity ◽  
Empathy For Pain ◽  
Human Participants ◽  
Neocortical Network

AbstractEmpathy is thought to engage mental simulation, which in turn is known to rely on hippocampal-neocortical processing. Here, we tested how hippocampal-neocortical pattern similarity and connectivity contributed to pain empathy. Using this approach, we analyzed a data set of 102 human participants who underwent functional MRI while painful and non-painful electrical stimulation was delivered to themselves or to a confederate. As hypothesized, results revealed increased pattern similarity between fist-hand pain and pain empathy (compared to non-painful control conditions) within the hippocampus, retrosplenial cortex, the temporo-parietal junction and anterior insula. While representations in these regions were unaffected by confederate similarity, pattern similarity in the dorsal MPFC was increased the more dissimilar the other individual was perceived. Moreover, hippocampal connectivity with regions engaged in first-hand pain was also increased during pain empathy, during which hippocampal coupling with the fusiform gyrus positively scaled with self-report measures of individual perspective taking skills. These findings highlight that shared representations and interactions within a hippocampal-neocortical network support pain empathy. This potentially reflects memory-based mental simulation processes, which seem partially modulated by personality traits and the perceived similarity of the other individual in pain.

scholarly journals Neural differentiation is moderated by age in scene- but not face-selective cortical regions

2020 ◽  
Author(s):  
Sabina Srokova ◽  
Paul F. Hill ◽  
Joshua D. Koen ◽  
Danielle R. King ◽  
Michael D. Rugg
Keyword(s):  
Cognitive Aging ◽  
Neural Differentiation ◽  
Memory Performance ◽  
Retrosplenial Cortex ◽  
Stimulus Category ◽  
Age Related ◽  
Pattern Similarity ◽  
Cortical Regions ◽  
Neural Selectivity ◽  
Parahippocampal Place Area

AbstractThe aging brain is characterized by neural dedifferentiation – an apparent decrease in the functional selectivity of category-selective cortical regions. Age-related reductions in neural differentiation have been proposed to play a causal role in cognitive aging. Recent findings suggest, however, that age-related dedifferentiation is not equally evident for all stimulus categories and, additionally, that the relationship between neural differentiation and cognitive performance is not moderated by age. In light of these findings, in the present experiment younger and older human adults (males and females) underwent fMRI as they studied words paired with images of scenes or faces prior to a subsequent memory task. Neural selectivity was measured in two scene-selective (parahippocampal place area and retrosplenial cortex) and two face-selective (fusiform and occipital face areas) regions of interest using both a univariate differentiation index and multivoxel pattern similarity analysis. Both methods provided highly convergent results which revealed evidence of age-related reductions in neural dedifferentiation in scene-selective but not face-selective cortical regions. Additionally, neural differentiation in the parahippocampal place area demonstrated a positive, age-invariant relationship with subsequent source memory performance (recall of the image category paired with each recognized test word). These findings extend prior findings suggesting that age-related neural dedifferentiation is not a ubiquitous phenomenon, and that the specificity of neural responses to scenes is predictive subsequent memory performance independently of age.Significance StatementIncreasing age is associated with reduced neural specificity in cortical regions that are selectively responsive to a given perceptual stimulus category (age-related neural dedifferentiation), a phenomenon which has been proposed to contribute to cognitive aging. Recent findings reveal that age-related neural dedifferentiation is not present for all types of visual stimulus categories, and the factors which determine when the phenomenon arises remain unclear. Here, we demonstrate that scene- but not face-selective cortical regions exhibit age-related neural dedifferentiation during an attentionally-demanding task. Additionally, we report that higher neural selectivity in the scene-selective ‘parahippocampal place area’ is associated with better memory performance after controlling for variance associated with age group, adding to evidence that neural differentiation impacts cognition across the adult lifespan.

Authentic Empathy: A Cultural Basis for the Development of Empathy in Children

2020 ◽  
pp. 002216782093422
Author(s):  
Tracey Woolrych ◽  
Michelle J. Eady ◽  
Corinne A. Green
Keyword(s):  
Thematic Analysis ◽  
Perspective Taking ◽  
Empirical Data ◽  
Primary Schools ◽  
Research Paradigm ◽  
Top Down ◽  
Data Set ◽  
Cultural Elements ◽  
Rich Data ◽  
Gain Access

Culture is important for the development of social skills in children, including empathy. Although empathy has long been linked with prosocial behaviors and attitudes, there is little research that links culture with development of empathy in children. This project sought to investigate and identify specific culturally related empathy elements in a sample of Dene and Inuit children from Northern Canada. Across seven different grade (primary) schools, 92 children aged 7 to 9 years participated in the study. Children’s drawings, and interviews about those pictures, were uniquely employed as empirical data which allowed researchers to gain access to the children’s perspective about what aspects of culture were important to them. Using empathy as the theoretical framework, a thematic analysis was conducted in a top-down deductive approach. The research paradigm elicited a rich data set revealing three major themes: sharing; knowledge of self and others; and acceptance of differences. The identified themes were found to have strong links with empathy constructs such as sharing, helping, perspective-taking, and self–other knowledges, revealing the important role that culture may play in the development of empathy. Findings from this study can help researchers explore and identify specific cultural elements that may contribute to the development of empathy in children.

Psychopharmacological modulation of event-related potentials suggests that first-hand pain and empathy for pain rely on similar opioidergic processes

2018 ◽  
Vol 116 ◽  
pp. 5-14 ◽  
Author(s):  
M. Rütgen ◽  
E.-M. Seidel ◽  
C. Pletti ◽  
I. Riečanský ◽  
A. Gartus ◽  
...  
Keyword(s):  
Event Related Potentials ◽  
Hand Pain ◽  
Empathy For Pain ◽  
Related Potentials

scholarly journals Reduced Multivoxel Pattern Similarity of Vicarious Neural Pain Responses in Psychopathy

2020 ◽  
Vol 34 (5) ◽  
pp. 628-649
Author(s):  
Kathryn Berluti ◽  
Katherine M. O'Connell ◽  
Shawn A. Rhoads ◽  
Kristin M. Brethel-Haurwitz ◽  
Elise M. Cardinale ◽  
...  
Keyword(s):  
Preliminary Evidence ◽  
Anterior Insula ◽  
Neural Responses ◽  
Live Video ◽  
Experienced Pain ◽  
Pattern Similarity ◽  
Personality Construct ◽  
Pain Responses

Psychopathy is a personality construct characterized by interpersonal callousness, boldness, and disinhibition, traits that vary continuously across the population and are linked to impaired empathic responding to others’ distress and suffering. Following suggestions that empathy reflects neural self–other mapping—for example, the similarity of neural responses to experienced and observed pain, measurable at the voxel level—we used a multivoxel approach to assess associations between psychopathy and empathic neural responses to pain. During fMRI scanning, 21 community-recruited participants varying in psychopathy experienced painful pressure stimulation and watched a live video of a stranger undergoing the same stimulation. As total psychopathy, coldheartedness, and self-centered impulsivity increased, multivoxel similarity of vicarious and experienced pain in the left anterior insula decreased, effects that were not observed following an empathy prompt. Our data provide preliminary evidence that psychopathy is characterized by disrupted spontaneous empathic representations of others’ pain that may be reduced by instructions to empathize.

scholarly journals Medial Prefrontal–Medial Temporal Theta Phase Coupling in Dynamic Spatial Imagery

2017 ◽  
Vol 29 (3) ◽  
pp. 507-519 ◽  
Author(s):  
Raphael Kaplan ◽  
Daniel Bush ◽  
James A. Bisby ◽  
Aidan J. Horner ◽  
Sofie S. Meyer ◽  
...  
Keyword(s):  
Working Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Theta Rhythm ◽  
Mental Simulation ◽  
Retrosplenial Cortex ◽  
Delay Period ◽  
Phase Coupling ◽  
Theta Phase ◽  
Dynamic Imagery

Hippocampal–medial prefrontal interactions are thought to play a crucial role in mental simulation. Notably, the frontal midline/medial pFC (mPFC) theta rhythm in humans has been linked to introspective thought and working memory. In parallel, theta rhythms have been proposed to coordinate processing in the medial temporal cortex, retrosplenial cortex (RSc), and parietal cortex during the movement of viewpoint in imagery, extending their association with physical movement in rodent models. Here, we used noninvasive whole-head MEG to investigate theta oscillatory power and phase-locking during the 18-sec postencoding delay period of a spatial working memory task, in which participants imagined previously learned object sequences either on a blank background (object maintenance), from a first-person viewpoint in a scene (static imagery), or moving along a path past the objects (dynamic imagery). We found increases in 4- to 7-Hz theta power in mPFC when comparing the delay period with a preencoding baseline. We then examined whether the mPFC theta rhythm was phase-coupled with ongoing theta oscillations elsewhere in the brain. The same mPFC region showed significantly higher theta phase coupling with the posterior medial temporal lobe/RSc for dynamic imagery versus either object maintenance or static imagery. mPFC theta phase coupling was not observed with any other brain region. These results implicate oscillatory coupling between mPFC and medial temporal lobe/RSc theta rhythms in the dynamic mental exploration of imagined scenes.

scholarly journals Objective (Real-world) Motion Responses in Scene Responsive Regions

2017 ◽  
Author(s):  
Didem Korkmaz Hacialihafiz ◽  
Andreas Bartels
Keyword(s):  
Real World ◽  
Reference Frames ◽  
Retrosplenial Cortex ◽  
Natural Scenes ◽  
Special Role ◽  
Perceptual Stability ◽  
Retinal Motion ◽  
Motion Responses ◽  
Human Participants

AbstractWe perceive scenes as stable even when eye movements induce retinal motion, for example during pursuit of a moving object. Mechanisms mediating perceptual stability have primarily been examined in motion regions of the dorsal visual pathway. Here we examined whether motion responses in human scene regions are encoded in eye- or world centered reference frames. We recorded brain responses in human participants using fMRI while they performed a well-controlled visual pursuit paradigm previously used to examine dorsal motion regions. In addition, we examined effects of content by using either natural scenes or their Fourier scrambles. We found that parahippocampal place area (PPA) responded to motion only in world- but not in eye-centered coordinates, regardless of scene content. The occipital place area (OPA) responded to both, objective and retinal motion equally, and retrosplenial cortex (RSC) had no motion responses but responded to pursuit. Only PPA’s objective motion responses were higher during scenes than scrambled images, although there was a similar trend in OPA. These results indicate a special role of PPA in representing its content in real-world coordinates. Our results question a strict subdivision of dorsal “what” and ventral “where” streams, and suggest a role of PPA in contributing to perceptual stability.

scholarly journals Reconfiguration of the cortical-hippocampal interaction may compensate for Sharp-Wave Ripple deficits in APP/PS1 mice and support spatial memory formation

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243767
Author(s):  
Bartosz Jura ◽  
Dariusz Młoźniak ◽  
Hanna Goszczyńska ◽  
Katarzyna Blinowska ◽  
Nathalie Biendon ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Cingulate Cortex ◽  
Memory Formation ◽  
Retrosplenial Cortex ◽  
Wild Type ◽  
Effective Coupling ◽  
Data Set ◽  
Type Group ◽  
Sharp Wave ◽  
In The Wild

Hippocampal-cortical dialogue, during which hippocampal ripple oscillations support information transfer, is necessary for long-term consolidation of spatial memories. Whereas a vast amount of work has been carried out to understand the cellular and molecular mechanisms involved in the impairments of memory formation in Alzheimer’s disease (AD), far less work has been accomplished to understand these memory deficiencies at the network-level interaction that may underlie memory processing. We recently demonstrated that freely moving 8 to 9-month-old APP/PS1 mice, a model of AD, are able to learn a spatial reference memory task despite a major deficit in Sharp-Wave Ripples (SWRs), the integrity of which is considered to be crucial for spatial memory formation. In order to test whether reconfiguration of hippocampal-cortical dialogue could be responsible for the maintenance of this ability for memory formation, we undertook a study to identify causal relations between hippocampal and cortical circuits in epochs when SWRs are generated in hippocampus. We analyzed the data set obtained from multielectrode intracranial recording of transgenic and wild-type mice undergoing consolidation of spatial memory reported in our previous study. We applied Directed Transfer Function, a connectivity measure based on Granger causality, in order to determine effective coupling between distributed circuits which express oscillatory activity in multiple frequency bands. Our results showed that hippocampal-cortical coupling in epochs containing SWRs was expressed in the two frequency ranges corresponding to ripple (130–180 Hz) and slow gamma (20–60 Hz) band. The general features of connectivity patterns were similar in the 8 to 9-month-old APP/PS1 and wild-type animals except that the coupling in the slow gamma range was stronger and spread to more cortical sites in APP/PS1 mice than in the wild-type group. During the occurrence of SWRs, the strength of effective coupling from the cortex to hippocampus (CA1) in the ripple band undergoes sharp increase, involving cortical areas that were different in the two groups of animals. In the wild-type group, retrosplenial cortex and posterior cingulate cortex interacted with the hippocampus most strongly, whereas in the APP/PS1 group more anterior structures interacted with the hippocampus, that is, anterior cingulate cortex and prefrontal cortex. This reconfiguration of cortical-hippocampal interaction pattern may be an adaptive mechanism responsible for supporting spatial memory consolidation in AD mice model.

scholarly journals Global and Local Head Direction Coding in the Human Brain

2021 ◽  
Author(s):  
J. P. Shine ◽  
T. Wolbers
Keyword(s):  
Reference Frames ◽  
Brain Regions ◽  
Retrosplenial Cortex ◽  
Specific Reference ◽  
Head Direction ◽  
Imaging Data ◽  
Neural Basis ◽  
Local Environments ◽  
Human Participants ◽  
Global And Local

AbstractOrientation-specific head direction (HD) cells increase their firing rate to indicate one’s facing direction in the environment. Rodent studies suggest HD cells in distinct areas of thalamus and retrosplenial cortex (RSC) code either for global (relative to the wider environment) or local (e.g., room-specific) reference frames. To investigate whether similar neuroanatomical dissociations exist in humans, we reanalysed functional magnetic resonance imaging data in which participants learned the orientation of unique images in separate local environments relative to distinct global landmarks (Shine, Valdés-Herrera, Hegarty, & Wolbers, 2016). The environment layout meant that we could establish two separate multivariate analysis models in which the HD on individual trials was coded relative either to global (North, South, East, West) or local (Front, Back, Right, Left) reference frames. Examining the data first in key regions of interest (ROI) for HD coding, we replicated our previous results and found that global HD was decodable in the thalamus and precuneus; the RSC, however, was sensitive only to local HD. Extending recent findings in both humans and rodents, V1 was sensitive to both HD reference frames. Additional small volume-corrected searchlight analyses supported the ROI results and indicated that the anatomical locus of the thalamic global HD coding was located in the medial thalamus, bordering the anterior thalamus, a region critical for global HD coding in rodents. Our findings elucidate further the putative neural basis of HD coding in humans, and suggest that distinct brain regions code for different frames of reference in HD.Significance statementHead direction (HD) cells provide a neural signal as to one’s orientation in the environment. HD can be coded relative to global or local (e.g., room-specific) reference frames, with studies suggesting that distinct areas of thalamus and retrosplenial cortex (RSC) code for this information. We reanalysed fMRI data where human participants associated images with global HDs before undergoing scanning. The design enabled us to examine both global and local HD coding. Supporting previous findings, global HD was decodable in thalamus, however the RSC coded only for local HD. We found evidence also for both reference frames in V1. These findings elucidate the putative neural basis of HD coding in humans, with distinct brain regions coding for different HD reference frames.

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