scholarly journals New-Onset Psychosis Associated With a Lesion Localized in the Rostral Tectum: Insights Into Pathway-Specific Connectivity Disrupted in Psychosis

2020 ◽  
Vol 46 (5) ◽  
pp. 1296-1305 ◽  
Author(s):  
Eleftheria Koropouli ◽  
Nikos Melanitis ◽  
Vasileios I Dimitriou ◽  
Asimina Grigoriou ◽  
Efstratios Karavasilis ◽  
...  
Keyword(s):  
Superior Colliculus ◽  
Diffusion Tensor ◽  
Periaqueductal Gray ◽  
Max Planck ◽  
Amygdala Activity ◽  
Discrete Area ◽  
The Right ◽  
Occipital Lobes ◽  
New Onset

Abstract Objective To investigate pathway-specific connectivity disrupted in psychosis. Methods We carried out a case study of a middle-aged patient who presented with new-onset psychosis associated with a space-occupying lesion localized in the right superior colliculus/periaqueductal gray. The study sought to investigate potential connectivity deficits related to the lesion by the use of diffusion tensor imaging and resting-state functional magnetic resonance imaging. To this aim, we generated a functional connectivity map of the patient’s brain, centered on the lesion area, and compared this map with the corresponding map of 10 sex- and age-matched control individuals identified from the Max Planck Institute–Leipzig Mind–Brain–Body database. Results Our analysis revealed a discrete area in the right rostral tectum, in the immediate vicinity of the lesion, whose activity is inversely correlated with the activity of left amygdala, whereas left amygdala is functionally associated with select areas of the temporal, parietal, and occipital lobes. Based on a comparative analysis of the patient with 10 control individuals, the lesion has impacted on the connectivity of rostral tectum (superior colliculus/periaqueductal gray) with left amygdala as well as on the connectivity of left amygdala with subcortical and cortical areas. Conclusions The superior colliculus/periaqueductal gray might play important roles in the initiation and perpetuation of psychosis, at least partially through dysregulation of left amygdala activity.

Isolated motor neglect following infarction of the posterior limb of the right internal capsule: a case study with diffusion tensor imaging-based tractography

2011 ◽  
Vol 259 (1) ◽  
pp. 100-105 ◽  
Author(s):  
Yuttachai Likitjaroen ◽  
Nijasri C. Suwanwela ◽  
Alex J. Mitchell ◽  
Sukalaya Lerdlum ◽  
Kammant Phanthumchinda ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Internal Capsule ◽  
Posterior Limb ◽  
Motor Neglect ◽  
The Right

scholarly journals Abnormalities of Cerebral White Matter Microstructure in Children With New-Onset, Untreated Idiopathic-Generalized Epilepsy

2021 ◽  
Vol 12 ◽  
Author(s):  
Ran Long ◽  
Yuting Wang ◽  
Lizhou Chen ◽  
Dingmei Deng ◽  
Lan Mei ◽  
...  
Keyword(s):  
White Matter ◽  
Diffusion Tensor ◽  
Pearson Correlation ◽  
Mean Diffusivity ◽  
Cerebral White Matter ◽  
Compensatory Mechanism ◽  
Idiopathic Generalized Epilepsy ◽  
Generalized Epilepsy ◽  
The Right ◽  
New Onset

Despite evidence for microstructural brain alterations in epilepsy patients, little is known about how these develop with age and the progress of the disease. The aim of this study was to investigate microstructural abnormalities of the white matter (WM) in children with new-onset, untreated idiopathic-generalized epilepsy (IGE) using the MRI technique of diffusion tensor imaging (DTI). The study was approved by the institutional review board, and all individuals or their parents gave signed informed consent. In total, 45 patients with IGE (age 5–18 years, male: female 26:19) and 32 healthy controls (HCs; age 5–18 years, male: female 21:11) were included. Voxel-based analysis (VBA) was used to compare patients and controls, and Pearson correlation analysis was used to investigate relationships between altered DTI metrics and clinical parameters. Compared with controls, patients with IGE showed increased mean diffusivity (MD) in the left splenium of the corpus callosum, increased fractional anisotropy (FA) in the right WM of the superior and middle frontal gyri, increased axial diffusivity (AD) in the WM of right corona radiata and left occipital lobe, and decreased AD in the WM of the left thalamus and the right middle cerebellar peduncle. There was no correlation between the altered diffusion parameters and clinical measures. Our study demonstrated several distinct microstructural impairments in children with new-onset, untreated IGE, of which altered AD might be the most sensitive marker of dysmyelination. The increased FA in the IGE group might suggest an initiating or compensatory mechanism that is activated prior to cognitive decline in these children.

The Calculation of Turbulent Diffusion Coefficients in Aquatic Ecosystems

2019 ◽  
Vol 70 (11) ◽  
pp. 3903-3907
Author(s):  
Galina Marusic ◽  
Valeriu Panaitescu
Keyword(s):  
Transport Equation ◽  
Turbulent Diffusion ◽  
Diffusion Coefficients ◽  
Aquatic Ecosystems ◽  
Specific Area ◽  
Left Bank ◽  
The Right ◽  
Prut River

The paper deals with the issues related to the pollution of aquatic ecosystems. The influence of turbulence on the transport and dispersion of pollutants in the mentioned systems, as well as the calculation of the turbulent diffusion coefficients are studied. A case study on the determination of turbulent diffusion coefficients for some sectors of the Prut River is presented. A new method is proposed for the determination of the turbulent diffusion coefficients in the pollutant transport equation for specific sectors of a river, according to the associated number of P�clet, calculated for each specific area: the left bank, the right bank and the middle of the river.

Traditionalism and politics: A case study of Northern Nigeria

1967 ◽  
Vol 2 (4) ◽  
pp. 509-524 ◽  
Author(s):  
B. J. O. Dudley
Keyword(s):  
Social Change ◽  
Local Government ◽  
Status Quo ◽  
Political Elite ◽  
High Time ◽  
The Political ◽  
Northern Nigeria ◽  
The North ◽  
The Right

In the debate on the Native Authority (Amendment) Law of 1955, the late Premier of the North, Sir Ahmadu Bello, Sardauna of Sokoto, replying to the demand that ‘it is high time in the development of local government systems in this Region that obsolete and undemocratic ways of appointing Emirs’ Councils should close’, commented that ‘the right traditions that we have gone away from are the cutting off of the hands of thieves, and that has caused a lot of thieving in this country. Why should we not be cutting (off) the hands of thieves in order to reduce thieving? That is logical and it is lawful in our tradition and custom here.’ This could be read as a defence against social change, a recrudescence of ‘barbarism’ after the inroads of pax Britannica, and a plea for the retention of the status quo and the entrenched privilege of the political elite.

scholarly journals Fieldwork on epistemic authority markers: What we can learn from different types of data

2020 ◽  
Vol 54 (2) ◽  
pp. 405-445 ◽  
Author(s):  
Karolina Grzech
Keyword(s):  
Data Collection ◽  
Discourse Markers ◽  
Epistemic Modality ◽  
Linguistic Meaning ◽  
Epistemic Authority ◽  
Data Collection And Analysis ◽  
The Right To Know ◽  
Cognitive Study ◽  
The Right

AbstractEpistemicity in language encompasses various kinds of constructions and expressions that have to do with knowledge-related aspects of linguistic meaning (cf. Grzech, Karolina, Eva Schultze-Berndt and Henrik Bergqvist. 2020c. Knowing in interaction: an introduction. Folia Linguistica [this issue]). It includes some well-established categories, such as evidentiality and epistemic modality (Boye, Kasper. 2012. Epistemic meaning: A crosslinguistic and functional-cognitive study. Berlin: De Gruyter Mouton), but also categories that have been less well described to-date. In this paper, I focus on one such category: the marking of epistemic authority, i.e. the encoding of “the right to know or claim” (Stivers, Tanya, Lorenza Mondada & Jakob Steensig. 2011b. Knowledge, morality and affiliation in social interaction. In Stivers et al. 2011a). I explore how the marking of epistemic authority can be documented and analysed in the context of linguistic fieldwork. The discussion is based on a case study of Upper Napo Kichwa, a Quechuan language spoken in the Ecuadorian Amazon that exhibits a rich paradigm of epistemic discourse markers, encoding meanings related to epistemic authority and distribution of knowledge between discourse participants. I describe and appraise the methodology for epistemic fieldwork used in the Upper Napo Kichwa documentation and description project. I give a detailed account of the different tools and methods of data collection, showing their strengths and weaknesses. I also discuss the decisions made at the different stages of the project and their implications for data collection and analysis. In discussing these issues, I extrapolate from the case study, proposing practical solutions for fieldwork-based research on epistemic markers.

Unemployment in the Affective Economy: Exploring the Affective Governing of Young Unemployed People in the Danish Welfare State

2020 ◽  
Vol 66 (3) ◽  
pp. 335-361
Author(s):  
Sabina Pultz
Keyword(s):  
Welfare State ◽  
Complex Relationship ◽  
Field Observations ◽  
Unemployed People ◽  
Political Implications ◽  
Governmentality Studies ◽  
The Right ◽  
The Unemployed ◽  
The Ideal

Abstract This case study investigates the affective governing of young unemployed people, and it concludes that getting money in the Danish welfare state comes with an “affective price”. In the quest for a job, unemployed people have been increasingly responsibilized in order to live up to the ideal of the active jobseeker. Consequently, when faced with unemployment, they are encouraged to work harder on themselves and their motivation. Based on an interview study with young unemployed people (N=39) and field observations made at employment fund agencies in Denmark (2014–15), I explore how young unemployed people are governed by and through their emotions. By supplementing governmentality studies (Foucault et al. 1988, 2010) with the concept of “affective economy” from Ahmed (2014), I discuss how young unemployed people who receive money from the Danish state are placed in a situation of debt. The paper unfolds how this debt becomes visible as the unemployed people often describe feeling under suspicion for not doing enough, for not being motivated enough. Through an abundance of (pro) activity, they have to prove the suspicion of being lazy wrong, and through managing themselves as active jobseekers, they earn the right to get money from the state. Here motivation, passion and empowerment are key currencies. I discuss the intricate interplay between monetary and affective currencies as well as political implications in the context of the Danish welfare. The article contributes by making visible the importance of taking affective matters into account when investigating the complex relationship between politics and psychology.

White Matter Alteration Following SWAT Explosive Breaching Training and the Moderating Effect of a Neck Collar Device: A DTI and NODDI Study

2021 ◽  
Author(s):  
Weihong Yuan ◽  
Jonathan Dudley ◽  
Alexis B Slutsky-Ganesh ◽  
James Leach ◽  
Pete Scheifele ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Moderating Effect ◽  
Significant Group ◽  
Blast Exposure ◽  
Diffusion Weighted ◽  
Weighted Data ◽  
The Right ◽  
The Impact

ABSTRACT Introduction Special Weapons and Tactics (SWAT) personnel who practice breaching with blast exposure are at risk for blast-related head trauma. We aimed to investigate the impact of low-level blast exposure on underlying white matter (WM) microstructure based on diffusion tensor imaging (DTI) and neurite orientation and density imaging (NODDI) in SWAT personnel before and after breacher training. Diffusion tensor imaging is an advanced MRI technique sensitive to underlying WM alterations. NODDI is a novel MRI technique emerged recently that acquires diffusion weighted data from multiple shells modeling for different compartments in the microstructural environment in the brain. We also aimed to evaluate the effect of a jugular vein compression collar device in mitigating the alteration of the diffusion properties in the WM as well as its role as a moderator on the association between the diffusion property changes and the blast exposure. Materials and Methods Twenty-one SWAT personnel (10 non-collar and 11 collar) completed the breacher training and underwent MRI at both baseline and after blast exposure. Diffusion weighted data were acquired with two shells (b = 1,000, 2,000 s/mm2) on 3T Phillips scanners. Diffusion tensor imaging metrices, including fractional anisotropy, mean, axial, and radial diffusivity, and NODDI metrics, including neurite density index (NDI), isotropic volume fraction (fiso), and orientation dispersion index, were calculated. Tract-based spatial statistics was used in the voxel-wise statistical analysis. Post hoc analyses were performed for the quantification of the pre- to post-blast exposure diffusion percentage change in the WM regions with significant group difference and for the assessment of the interaction of the relationship between blast exposure and diffusion alteration. Results The non-collar group exhibited significant pre- to post-blast increase in NDI (corrected P < .05) in the WM involving the right internal capsule, the right posterior corona radiation, the right posterior thalamic radiation, and the right sagittal stratum. A subset of these regions showed significantly greater alteration in NDI and fiso in the non-collar group when compared with those in the collar group (corrected P < .05). In addition, collar wearing exhibited a significant moderating effect for the alteration of fiso for its association with average peak pulse pressure. Conclusions Our data provided initial evidence of the impact of blast exposure on WM diffusion alteration based on both DTI and NODDI. The mitigating effect of WM diffusivity changes and the moderating effect of collar wearing suggest that the device may serve as a promising solution to protect WM against blast exposure.

HOUSEHOLD FORMATION IN 19TH-CENTURY CENTRAL ANATOLIA: THE CASE STUDY OF A TURKISH-SPEAKING ORTHODOX CHRISTIAN COMMUNITY

2002 ◽  
Vol 34 (3) ◽  
pp. 495-517
Author(s):  
Irini Renieri
Keyword(s):  
Central Anatolia ◽  
Household Formation ◽  
Greek Orthodox ◽  
Christian Community ◽  
Orthodox Christian ◽  
Complex Forms ◽  
The Right ◽  
Extended Households ◽  
The Village

This article explores household formation among the Greek Orthodox population of a mixed village of Cappadocia inhabited by Muslims, as well. The village, Çukur, was located on the right bank of the river Kızılırmak, 49 kilometers north–northwest of Kayseri.1 I aim to show that complex forms of household formation were the main type of social organization and were especially durable over time, with a high average household membership. I attempt to clarify whether the predominance of extended households—which, as other studies have shown, is not that common in the Asian portion of the Ottoman Empire—was related to the Christian character of this section of the Çukur population, or whether the agricultural basis of the village economy played a more important role.

scholarly journals Severe Hypertriglyceridemia-Induced Acute Pancreatitis

2021 ◽  
pp. 218-224
Author(s):  
Gyula Molnár ◽  
V. Anna Gyarmathy ◽  
Noémi Zádori ◽  
Péter Hegyi ◽  
Péter Kanizsai
Keyword(s):  
Acute Pancreatitis ◽  
Acute Abdominal Pain ◽  
Blood Cholesterol ◽  
Individual Factors ◽  
Lipid Levels ◽  
Human Monoclonal Antibodies ◽  
Pcsk9 Inhibitors ◽  
Severe Hypertriglyceridemia ◽  
The Right

The prevalence of familial hypercholesterolemia (FH) is about 1 in 200–500 in the general population, but approximately less than 1% of those affected are actually diagnosed. One of the most promising approaches to treat FH is utilizing human monoclonal antibodies. This is a case study describing a 47-year-old male patient who presented to the Emergency Department with acute abdominal pain caused by severe hypertriglyceridemia (HTG)-induced acute pancreatitis (AP). We report the steps necessary for establishing the right diagnosis and the management of HTG-induced AP, which are inevitable for the reduction of severity and mortality. This case study shows that hypercholesterolemia is an underdiagnosed and potentially lethal disease. Once diagnosed, all measures should be considered to control blood cholesterol and lipid levels. The decision to administer PCSK9 inhibitors should not be solely based on economical calculation, but rather individual factors should also be considered to weigh the risk/benefit ratio.

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