scholarly journals Digital phenotyping of negative symptoms: the relationship to clinician ratings

2020 ◽  
Author(s):  
Alex S Cohen ◽  
Elana Schwartz ◽  
Thanh P Le ◽  
Tovah Cowan ◽  
Brian Kirkpatrick ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
Psychometric Property ◽  
Reliability And Validity ◽  
Digital Phenotyping ◽  
Computational Sciences ◽  
Indispensable Tool ◽  
Audio Video ◽  
The Relationship ◽  
Vocal Speech ◽  
Sufficient Precision

Abstract Negative symptoms are a critical, but poorly understood, aspect of schizophrenia. Measurement of negative symptoms primarily relies on clinician ratings, an endeavor with established reliability and validity. There have been increasing attempts to digitally phenotype negative symptoms using objective biobehavioral technologies, eg, using computerized analysis of vocal, speech, facial, hand and other behaviors. Surprisingly, biobehavioral technologies and clinician ratings are only modestly inter-related, and findings from individual studies often do not replicate or are counterintuitive. In this article, we document and evaluate this lack of convergence in 4 case studies, in an archival dataset of 877 audio/video samples, and in the extant literature. We then explain this divergence in terms of “resolution”—a critical psychometric property in biomedical, engineering, and computational sciences defined as precision in distinguishing various aspects of a signal. We demonstrate how convergence between clinical ratings and biobehavioral data can be achieved by scaling data across various resolutions. Clinical ratings reflect an indispensable tool that integrates considerable information into actionable, yet “low resolution” ordinal ratings. This allows viewing of the “forest” of negative symptoms. Unfortunately, their resolution cannot be scaled or decomposed with sufficient precision to isolate the time, setting, and nature of negative symptoms for many purposes (ie, to see the “trees”). Biobehavioral measures afford precision for understanding when, where, and why negative symptoms emerge, though much work is needed to validate them. Digital phenotyping of negative symptoms can provide unprecedented opportunities for tracking, understanding, and treating them, but requires consideration of resolution.

scholarly journals Geolocation as a Digital Phenotyping Measure of Negative Symptoms and Functional Outcome

2020 ◽  
Vol 46 (6) ◽  
pp. 1596-1607
Author(s):  
Ian M Raugh ◽  
Sydney H James ◽  
Cristina M Gonzalez ◽  
Hannah C Chapman ◽  
Alex S Cohen ◽  
...  
Keyword(s):  
Functional Outcome ◽  
Convergent Validity ◽  
Negative Symptoms ◽  
Computational Models ◽  
Discriminant Validity ◽  
Rating Scales ◽  
Reliability And Validity ◽  
Objective Measure ◽  
Clinical Rating ◽  
Digital Phenotyping

Abstract Objective Negative symptoms and functional outcome have traditionally been assessed using clinical rating scales, which rely on retrospective self-reports and have several inherent limitations that impact validity. These issues may be addressed with more objective digital phenotyping measures. In the current study, we evaluated the psychometric properties of a novel “passive” digital phenotyping method: geolocation. Method Participants included outpatients with schizophrenia or schizoaffective disorder (SZ: n = 44), outpatients with bipolar disorder (BD: n =19), and demographically matched healthy controls (CN: n = 42) who completed 6 days of “active” digital phenotyping assessments (eg, surveys) while geolocation was recorded. Results Results indicated that SZ patients show less activity than CN and BD, particularly, in their travel from home. Geolocation variables demonstrated convergent validity by small to medium correlations with negative symptoms and functional outcome measured via clinical rating scales, as well as active digital phenotyping behavioral indices of avolition, asociality, and anhedonia. Discriminant validity was supported by low correlations with positive symptoms, depression, and anxiety. Reliability was supported by good internal consistency and moderate stability across days. Conclusions These findings provide preliminary support for the reliability and validity of geolocation as an objective measure of negative symptoms and functional outcome. Geolocation offers enhanced precision and the ability to take a “big data” approach that facilitates sophisticated computational models. Near-continuous recordings and large numbers of samples may make geolocation a novel outcome measure for clinical trials due to enhanced power to detect treatment effects.

Effect of implicit prototype theory on employees' proactive behavior

2020 ◽  
Vol 48 (5) ◽  
pp. 1-12
Author(s):  
Hongwu Xiao ◽  
Donghan Wang ◽  
Xiaohan Liu ◽  
Yi Liu
Keyword(s):  
Role Theory ◽  
Reliability And Validity ◽  
Leader Member Exchange ◽  
Prototype Theory ◽  
Proactive Behavior ◽  
Regression Analyses ◽  
Theoretical Support ◽  
Member Exchange ◽  
Managerial Implications ◽  
The Relationship

We applied role theory to test a theoretical model that explained how and why an implicit prototype match influences employees' proactive behavior in interpersonal contexts. After analyzing the reliability and validity of the variables, we used correlation and regression analyses to test our hypotheses with 342 participants from enterprises in China. The results show that (a) a stronger implicit prototype match increased employees' proactive behavior, (b) leader–member exchange mediated the relationship between implicit prototype match and proactive behavior, and (c) leader–member liking (employee's liking for leader and vice versa) moderated the relationship between implicit prototype match and leader–member exchange. Our findings provide theoretical support for implicit prototype theory from the implicit match perspective and have managerial implications for organizations seeking to improve employees' proactive behavior.

Evaluation of positive and negative symptoms in schizophrenia

1986 ◽  
Vol 1 (2) ◽  
pp. 108-122 ◽  
Author(s):  
Nancy C. Andreasen ◽  
William M. Grove
Keyword(s):  
Negative Symptoms ◽  
The United States ◽  
Psychotic Symptoms ◽  
Positive Symptoms ◽  
University Of Iowa ◽  
Normal Functions ◽  
Subsequent Investigation ◽  
The University ◽  
The Relationship ◽  
Positive And Negative Symptoms

SummaryMost investigators concur that schizophrenia is probably a heterogeneous group of disorders that share the common features of psychotic symptoms, partial response to neuroleptics, and a relatively poor outcome. The subdivision of schizophrenia into two subtypes, positive versus negative, has achieved wide acceptance throughout the world during recent years. This distinction has heuristic and theoretical appeal because it unites phenomenology, pathophysiology, and etiology into a single comprehensive hypothesis.In spite of its wide appeal, the distinction has a number of problems. These include the failure to distinguish between symptom syndromes and diseases; failure to deal with the mixed patient; failure to take longitudinal course into account; and failure to address conceptually and methodologically the distinction between positive and negative symptoms.This paper focuses primarily on the conceptual basis for two instruments designed to measure positive and negative symptoms, the Scale for the Assessment of Negative Symptoms (SANS) and the Scale for the Assessment of Positive Symptoms (SAPS), originally described in 1982. Since their description, these scales have been used in a variety of other centers. These scales are based on the hypothesis that negative symptoms represent a deficit or diminution in normal psychological functions wliile positive symptoms represent an excess or distortion of normal functions. Reliability data are now available from Italy, Spain, and Japan which suggest that these scales can be used reliably in cultural settings outside the United States. The results of these studies are summarized in this paper. In addition, a replication study involving a new sample of 117 schizophrenics collected at the University of Iowa is described. In this second study of the SANS and SAPS, internal consistency is found to be quite high in the SANS. Thus negative symptoms appear to be more internally correlated with one another than are positive symptoms. The implications of this result are discussed. A principal components analysis is used to explore the relationship between positive and negative symptoms. While the study reported in 1982 suggested that positive and negative symptoms are negatively correlated, in the present study they appear to be uncorrelated. Overall, the results suggest that the SANS and SAPS are useful comprehensive instruments for the evaluation of positive and negative symptoms. The relationship between these symptoms and external validators such as cognitive functioning or CT scan abnormalities will be reported in a subsequent investigation.

scholarly journals Reliability and Validity of Facial Check Sheet (FCS): Checklist for Self-Satisfaction with Cosmetic Acupuncture

Medicines ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 18
Author(s):  
Hiroshi Kuge ◽  
Hidetoshi Mori ◽  
Tim Hideaki Tanaka ◽  
Ryouta Tsuji
Keyword(s):  
Reliability And Validity ◽  
Internet Survey ◽  
Age Group ◽  
Facial Skin ◽  
Moderate Correlation ◽  
Skin Rejuvenation ◽  
Facial Region ◽  
Practical Tool ◽  
Multiple Comparison Procedure ◽  
The Relationship

Background: In recent years, cosmetic acupuncture has gained popularity among individuals interested in improving their facial appearance. We have created an original facial check sheet (FCS) to obtain cosmetic acupuncture patients’ perspectives on treatment outcomes. This study examined the reliability and validity of FCS. Methods: We conducted an Internet survey on the appearance of the facial region among Japanese women. A reliability analysis was performed between each item of FCS. A multiple comparison procedure was used to determine the relationship between the age group, the FCS score, and the number of terms used in the open-ended question. Results: The most frequently stated concern was blotchiness and hyperpigmented spots (47.2%, n = 67). The FCS items showed reliability (Cronbach α = 0.871). The number of extracted terms and the FCS score showed a moderate correlation (r = 0.407; p < 0.001). There was a significant relationship between age and FCS score (p = 0.005, r2 = 0.255), which indicated that the FCS score increases with aging. Conclusions: The FCS can be used as a practical tool to evaluate facial appearances and assess satisfaction levels of patients who underwent cosmetic acupuncture or other facial skin rejuvenation procedures.

Panic Attacks in Chronic Schizophrenia

1990 ◽  
Vol 157 (3) ◽  
pp. 430-433 ◽  
Author(s):  
Nicholas Argyle
Keyword(s):  
Maintenance Therapy ◽  
Social Phobia ◽  
Negative Symptoms ◽  
Chronic Schizophrenia ◽  
Panic Attacks ◽  
Psychotic Symptoms ◽  
Relationship Of ◽  
The Relationship

Of 20 patients attending a clinic for maintenance therapy of schizophrenia, seven had regular panic attacks, and these were often associated with agoraphobia and social phobia. Similar fears and avoidance in other cases were associated with paranoid ideas and negative symptoms. The relationship of panic to psychotic symptoms varied greatly. In two patients neuroleptics were associated with an increase in panic attacks.

Negative symptoms mediate the relationship between neurocognition and function in individuals at ultrahigh risk for psychosis

2016 ◽  
Vol 135 (3) ◽  
pp. 250-258 ◽  
Author(s):  
L. B. Glenthøj ◽  
J. R. M. Jepsen ◽  
C. Hjorthøj ◽  
N. Bak ◽  
T. D. Kristensen ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
And Function ◽  
The Relationship

scholarly journals Classroom Instructional Practices of Islamic Education Teachers in the Basic Stage at Al-Mafraq Governorate and Its Relation to Gender and Experience Variables

2015 ◽  
Vol 7 (3) ◽  
pp. 77
Author(s):  
Nosiba Ali Al-Mousa
Keyword(s):  
Standard Deviation ◽  
Instructional Practices ◽  
Reliability And Validity ◽  
T Test ◽  
Islamic Education ◽  
Test Results ◽  
Social Standard ◽  
Basic Stage ◽  
The Relationship

<p>This study aimed to identify Classroom Instructional Practices of Islamic education teachers<br />at basic stage in AL- Mafraq and to identify the relationship between these practices and<br />gender and experience variables as well as interaction between them. The researcher prepared<br />a scale which its reliability and validity were checked to measure the level of classroom<br />instructional practices. The sample of study which consisted of (64) teachers (male and<br />female) was chosen randomly.<br />Data were collected and analyzed statistically using means, standard deviation, t-test and<br />Tuky test. Results revealed that the classroom studying practices of Islamic education<br />teachers in basic stage in AL- Mafraq agreed with acceptable educational and social standard<br />(80%), whereas the percentage of the classroom instructional practices was (81-89%). The<br />results also revealed lack of statistical significant differences in the classroom instructional<br />practices of Islamic education teachers in the basic stage in AL- Mafraq due to the gender<br />variable but there were statistical significant differences at (0,05=OC) in classroom<br />instructional practices due to experience variable in favor of respondents with experiences ( 4<br />years and less) and 10 years and more).Additionally, there were no statistical significant<br />differences in the classroom instructional practices of Islamic education teachers due to<br />interaction between gender and experience variable. The researcher recommended conducting<br />further studies with different variables.</p>

Predictors of outcome in first-episode schizophrenia over the first 4 years of illness

2008 ◽  
Vol 38 (8) ◽  
pp. 1141-1146 ◽  
Author(s):  
P. Whitty ◽  
M. Clarke ◽  
O. McTigue ◽  
S. Browne ◽  
M. Kamali ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
First Episode ◽  
Global Assessment Of Functioning ◽  
Methodological Issues ◽  
Course Of Illness ◽  
Dsm Iv ◽  
First Episode Schizophrenia ◽  
The Relationship ◽  
Positive And Negative Symptoms

BackgroundThe outcome of schizophrenia appears to be more favourable than once thought. However, methodological issues, including the reliance on diagnosis at first presentation have limited the validity of outcome studies to date.MethodWe conducted a first-episode follow-up study of 97 patients with DSM-IV schizophrenia over the first 4 years of illness. First presentation and follow-up assessments were compared using paired t tests and a forced-entry regression analysis was used to determine prognostic variables.ResultsThere were significant improvements in positive and negative symptoms and global assessment of functioning between first presentation and follow-up. At first presentation, fewer negative symptoms (t=−3.40, p<0.01), more years spent in education (t=3.25, p<0.01), and a shorter duration of untreated psychosis (DUP) (t=−2.77, p<0.01) significantly predicted a better outcome at follow-up.ConclusionsThe outcome of schizophrenia may not be as pessimistic as once thought and most patients did not display a downward deteriorating course of illness. This study supports the relationship between DUP and outcome beyond the early stages of illness.

The Empirical Heterogeneity of First Rank Symptoms in Schizophrenia

1982 ◽  
Vol 140 (5) ◽  
pp. 498-502 ◽  
Author(s):  
Richard Lewine ◽  
Robin Renders ◽  
Mark Kirchhofer ◽  
Ann Monsour ◽  
Norman Watt
Keyword(s):  
Psychiatric Symptoms ◽  
Empirical Studies ◽  
Reliability And Validity ◽  
Homogeneous Group ◽  
Schizophrenic Patients ◽  
First Rank Symptoms ◽  
The Relationship

SummaryFirst rank symptoms have assumed an important role in the assessment of schizophrenia. Only recently, however, have there been empirical studies of their reliability and validity. In this study, we examined the relationship between first rank and other psychiatric symptoms in 100 schizophrenic patients. The results are consistent with other research reports suggesting that first rank symptoms do not represent a homogeneous group of symptoms within an individual patient.

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