Loss of diurnal behavioral rhythms and impaired lipid metabolism in growing pigs with mistimed feeding

2021 ◽  
Vol 35 (11) ◽  
Author(s):  
Qiang‐Jun Wang ◽  
Yao Guo ◽  
Chun‐Yan Yao ◽  
Ke‐Hao Zhang ◽  
Qin Li ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Growing Pigs ◽  
Behavioral Rhythms

scholarly journals Lipid metabolism and secretory function of porcine intramuscular adipocytes compared with subcutaneous and perirenal adipocytes

2006 ◽  
Vol 291 (2) ◽  
pp. E372-E380 ◽  
Author(s):  
Delphine Gardan ◽  
Florence Gondret ◽  
Isabelle Louveau
Keyword(s):  
Lipid Metabolism ◽  
Fatty Acid Synthase ◽  
Trapezius Muscle ◽  
Growing Pigs ◽  
Hormone Sensitive Lipase ◽  
Muscle Physiology ◽  
Mrna Levels ◽  
Secretory Function ◽  
Gene Expressions ◽  
Age Related

The function of adipocytes interspersed between myofiber fasciculi in skeletal muscle physiology and physiopathology is poorly documented. Because regional differences in adipocyte features have been reported in various species, we hypothesized that lipid metabolism and secretory function of intramuscular (IM) adipocytes differ from that of nonmuscular adipocytes. In the present study, adipocytes isolated from trapezius muscle were compared with subcutaneous and perirenal adipocytes in growing pigs. Between 80 and 210 days of age, gene expressions and/or activities of enzymes involved in lipogenesis or lipolysis were much lower ( P < 0.05) in adipocytes isolated from muscle than in those from other locations. Insulin-induced lipogenesis and lipolytic efficiency after catecholamine addition were also the lowest ( P < 0.05) in IM adipocytes. In these cells, the age-related increase (+300%) in the ratio of mRNA levels of fatty acid synthase to hormone-sensitive lipase paralleled the enlargement of adipocyte diameters (+70%, P < 0.05) and the increase in lipid content in muscle (+135%, P < 0.05) during growth. Expressions of genes coding for leptin, adiponectin, and IGF-I, as well as for various hormonal receptors, were lower ( P < 0.05) in IM adipocytes than in other adipocytes, whereas levels of TNF-α mRNA did not differ between sites. Interestingly, IGF-II mRNA levels were higher ( P < 0.05) in IM adipocytes than in other adipocytes. These data support the view that IM fat is not just an ectopic extension of other fat locations but displays specific biological features during growth.

scholarly journals A Methionine Deficient Diet Enhances Adipose Tissue Lipid Metabolism and Alters Anti-Oxidant Pathways in Young Growing Pigs

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0130514 ◽  
Author(s):  
Rosa Castellano ◽  
Marie-Hélène Perruchot ◽  
José Alberto Conde-Aguilera ◽  
Jaap van Milgen ◽  
Anne Collin ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Growing Pigs ◽  
Tissue Lipid ◽  
Deficient Diet ◽  
Anti Oxidant

β-Hydroxy-β-methylbutyrate modulates lipid metabolism in adipose tissues of growing pigs

2018 ◽  
Vol 9 (9) ◽  
pp. 4836-4846 ◽  
Author(s):  
Yehui Duan ◽  
Lingyu Zhang ◽  
Fengna Li ◽  
Qiuping Guo ◽  
Cimin Long ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Growing Pigs ◽  
Adipose Tissues

Background: The effects and roles of the leucine (Leu) metabolite β-hydroxy-β-methylbutyrate (HMB) in lipid metabolism in adipose tissues of pigs are still unknown.

scholarly journals Effect of Dietary Sorbose on Lipid Metabolism in Growing Pigs

1990 ◽  
Vol 61 (4) ◽  
pp. 371-374
Author(s):  
Mitsuhiro FURUSE ◽  
Toshizo TAGISHI ◽  
Haruo NARITA ◽  
Toshio SHIMIZU ◽  
Jun-ichi OKUMURA
Keyword(s):  
Lipid Metabolism ◽  
Growing Pigs

scholarly journals Transcriptomic Responses Induced in Muscle and Adipose Tissues of Growing Pigs by Intravenous Infusion of Sodium Butyrate

Biology ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 559
Author(s):  
He Zhang ◽  
Erdu Ren ◽  
Rongying Xu ◽  
Yong Su
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Lipid Metabolism ◽  
Amino Acid ◽  
Carbohydrate Metabolism ◽  
Muscle Tissue ◽  
Sodium Butyrate ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Growing Pigs

Butyrate has a central function in the regulation of energy metabolism as a metabolite of bacterial fermentation. This study evaluated the effects of intravenous sodium butyrate (SB) administration on the transcriptome of muscle and adipose tissue of pigs. Twelve crossbred barrows (Duroc × Landrace × Large White) were fitted with a medical polyethylene cannula via the internal jugular vein and were daily infused with 10 mL SB (200 mmol/L) or the same volume of physiological saline. Muscle transcriptome showed 11 DEGs related to carbohydrate metabolism, 28 DEGs related to lipid metabolism, and 10 DEGs related to amino acid metabolism. Among these, carbohydrate catabolic process-related genes (PPP1R3B, PRPS2, ALDOC), fatty acid synthase (FASN), and lipolysis-related genes (PLIN1) were upregulated, while the carbohydrate biosynthetic process-related genes (PCK1) and most amino acid metabolism-related genes were downregulated. Adipose transcriptome showed 12 DEGs related to carbohydrate metabolism, 27 DEGs related to lipid metabolism, and 10 DEGs related to amino acid metabolism. Among these, carbohydrate metabolism-related genes (IGF1, LEP, SLC2A4) and lipolysis-related genes (LPL) were upregulated, while lipolysis-related genes (ANGPTL4) and most amino acid metabolism-related genes were downregulated. The results suggest that short-term intravenous SB infusion could modulate the muscle and adipose tissue metabolism at the transcriptional level by decreasing amino acid metabolism pathways. Additionally, intravenous SB increased the glucose catabolism in muscle tissue and decreased the glucose utilization in adipose tissue. Intravenous SB increased the fatty acid synthesis, decreased the lipolysis in muscle tissue, and increased the lipolysis in adipose tissue. This suggests that systemic butyrate may display discriminative metabolic regulation in different tissues of barrows.

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