Definition of Endometrial Carcinoma Precursors

AbstractObjectivesTo explore the survival and definition of stage IA mixed endometrial carcinoma.MethodsFrom June 1, 2010, to June 1, 2017, cases with stage IA endometrial cancer were included in this study. The survival outcomes were compared among patients with endometrioid (group A), nonendometrioid (group B), and mixed subtypes (group C) and among patients with different proportions of nonendometrioid components (<5%, >50%, and others).ResultsIn total, 890 cases were included, comprising 808 (90.8%), 33 (3.7%), and 47 (5.3%) cases in groups A, B, and C, respectively. After a median follow-up of 55.9 months, groups B and C had significantly more inferior disease-free survival, overall survival, and cancer-specific overall survival. Patients with a nonendometrioid proportion of more than 50% and serous subtype also had a significantly more inferior prognosis. Adjuvant therapy could improve the prognosis in mixed endometrial carcinomas.ConclusionsPatients with endometrial cancer of mixed subtypes had inferior survival outcomes.

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Undifferentiated endometrial carcinoma arising in the background of high‐grade endometrial carcinoma – Expanding the definition of dedifferentiated endometrial carcinoma

Histopathology ◽

10.1111/his.14186 ◽

2020 ◽

Vol 77 (5) ◽

pp. 769-780 ◽

Cited By ~ 4

Author(s):

Aurelia Busca ◽

Carlos Parra‐Herran ◽

Sharon Nofech‐Mozes ◽

Bojana Djordjevic ◽

Nadia Ismiil ◽

...

Keyword(s):

Endometrial Carcinoma ◽

High Grade ◽

Definition Of

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Refining Adjuvant Therapy for Endometrial Cancer: New Standards and Perspectives

Biology ◽

10.3390/biology10090845 ◽

2021 ◽

Vol 10 (9) ◽

pp. 845

Author(s):

Alessandra Giustozzi ◽

Vanda Salutari ◽

Elena Giudice ◽

Lucia Musacchio ◽

Caterina Ricci ◽

...

Keyword(s):

Endometrial Carcinoma ◽

Current Knowledge ◽

Early Stage ◽

Treatment Options ◽

Molecular Features ◽

Improve Patient Management ◽

Patient Prognosis ◽

Definition Of ◽

Near Future ◽

Improve Patient

Endometrial carcinoma is the most frequent cancer of the reproductive female organs. Most endometrial cancers are diagnosed at early stage (75%). Treatment options depend on pathogenetic, histopathologic and clinical characteristic at the diagnosis. To improve patient management in the near future, recent research has focused on new molecular features; evidence has shown that these give a better definition of patient prognosis and can help in tailoring adjuvant treatments by identifying specific subgroups of patients whose tumors may benefit from specific therapeutic approaches. In this review, we will focus on current knowledge of adjuvant treatment of endometrial carcinoma, using a prognostic-risk group stratification based on pathogenetic, clinical and molecular features, and will take a look at the ongoing trials that will further change the therapeutic approach in coming years.

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Introductory paper

Symposium - International Astronomical Union ◽

10.1017/s0074180900053031 ◽

1966 ◽

Vol 24 ◽

pp. 3-5

Author(s):

W. W. Morgan

Keyword(s):

Line Intensity ◽

Classification Scheme ◽

Two Dimensional ◽

Spectral Classification ◽

Dimensional Array ◽

Rr Lyrae ◽

Metallic Line ◽

Introductory Paper ◽

Parameter Varying ◽

Definition Of

1. The definition of “normal” stars in spectral classification changes with time; at the time of the publication of theYerkes Spectral Atlasthe term “normal” was applied to stars whose spectra could be fitted smoothly into a two-dimensional array. Thus, at that time, weak-lined spectra (RR Lyrae and HD 140283) would have been considered peculiar. At the present time we would tend to classify such spectra as “normal”—in a more complicated classification scheme which would have a parameter varying with metallic-line intensity within a specific spectral subdivision.

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2.2. Working Group 2: Conceptual Definitions of Reference Coordinate Systems for Earth Dynamics

International Astronomical Union Colloquium ◽

10.1017/s0252921100050867 ◽

1975 ◽

Vol 26 ◽

pp. 21-26

Keyword(s):

Coordinate System ◽

Working Group ◽

General Character ◽

Coordinate Systems ◽

Reference Coordinate System ◽

Group 2 ◽

Definition Of ◽

Earth Dynamics

An ideal definition of a reference coordinate system should meet the following general requirements:1. It should be as conceptually simple as possible, so its philosophy is well understood by the users.2. It should imply as few physical assumptions as possible. Wherever they are necessary, such assumptions should be of a very general character and, in particular, they should not be dependent upon astronomical and geophysical detailed theories.3. It should suggest a materialization that is dynamically stable and is accessible to observations with the required accuracy.

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Symbiotic Stars at Optical, Infrared and Radio Wavelengths

International Astronomical Union Colloquium ◽

10.1017/s025292110007336x ◽

1979 ◽

Vol 46 ◽

pp. 125-149 ◽

Cited By ~ 3

Author(s):

David A. Allen

Keyword(s):

Temperature Regime ◽

Type Star ◽

Stellar Systems ◽

Symbiotic Stars ◽

Lower Excitation ◽

Definition Of ◽

Original Type

No paper of this nature should begin without a definition of symbiotic stars. It was Paul Merrill who, borrowing on his botanical background, coined the termsymbioticto describe apparently single stellar systems which combine the TiO absorption of M giants (temperature regime ≲ 3500 K) with He II emission (temperature regime ≳ 100,000 K). He and Milton Humason had in 1932 first drawn attention to three such stars: AX Per, CI Cyg and RW Hya. At the conclusion of the Mount Wilson Ha emission survey nearly a dozen had been identified, and Z And had become their type star. The numbers slowly grew, as much because the definition widened to include lower-excitation specimens as because new examples of the original type were found. In 1970 Wackerling listed 30; this was the last compendium of symbiotic stars published.

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Immunoferritin localization of intracellular antigens in positively stained frozen sections

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010008170x ◽

1978 ◽

Vol 36 (2) ◽

pp. 168-169

Author(s):

K. T. Tokuyasu

Keyword(s):

Surface Tension ◽

Water Surface ◽

Thin Layers ◽

The Other ◽

Positive Staining ◽

Frozen Sections ◽

The Past ◽

Ultrathin Frozen Sections ◽

Definition Of

During the past investigations of immunoferritin localization of intracellular antigens in ultrathin frozen sections, we found that the degree of negative staining required to delineate u1trastructural details was often too dense for the recognition of ferritin particles. The quality of positive staining of ultrathin frozen sections, on the other hand, has generally been far inferior to that attainable in conventional plastic embedded sections, particularly in the definition of membranes. As we discussed before, a main cause of this difficulty seemed to be the vulnerability of frozen sections to the damaging effects of air-water surface tension at the time of drying of the sections.Indeed, we found that the quality of positive staining is greatly improved when positively stained frozen sections are protected against the effects of surface tension by embedding them in thin layers of mechanically stable materials at the time of drying (unpublished).

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Initial Polymerization Sites Indicated During Mitochondrial Oxidation of Diaminobenzidine after Toluene Treatment

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100079498 ◽

1977 ◽

Vol 35 ◽

pp. 408-409

Author(s):

W. A. Shannon ◽

M. A. Matlib

Keyword(s):

Membrane Permeability ◽

Cytochrome Oxidase ◽

Rat Liver ◽

Precise Definition ◽

Cytochemical Localization ◽

Oxidative Reaction ◽

Mitochondrial Oxidation ◽

Definition Of ◽

Exogenous Substrates

Numerous studies have dealt with the cytochemical localization of cytochrome oxidase via cytochrome c. More recent studies have dealt with indicating initial foci of this reaction by altering incubation pH (1) or postosmication procedure (2,3). The following study is an attempt to locate such foci by altering membrane permeability. It is thought that such alterations within the limits of maintaining morphological integrity of the membranes will ease the entry of exogenous substrates resulting in a much quicker oxidation and subsequently a more precise definition of the oxidative reaction.The diaminobenzidine (DAB) method of Seligman et al. (4) was used. Minced pieces of rat liver were incubated for 1 hr following toluene treatment (5,6). Experimental variations consisted of incubating fixed or unfixed tissues treated with toluene and unfixed tissues treated with toluene and subsequently fixed.

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Application of Scanning Electron Microscopy to Medical Research

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100061963 ◽

1969 ◽

Vol 27 ◽

pp. 12-13

Author(s):

J. D. Hutchison

Keyword(s):

Electron Microscopy ◽

Electron Microscope ◽

Medical Research ◽

Prosthetic Heart Valve ◽

School Of Medicine ◽

Transmission Electron ◽

Definition Of ◽

Mechanism Of Failure ◽

The Brain ◽

Scanning Electron

When the transmission electron microscope was commercially introduced a few years ago, it was heralded as one of the most significant aids to medical research of the century. It continues to occupy that niche; however, the scanning electron microscope is gaining rapidly in relative importance as it fills the gap between conventional optical microscopy and transmission electron microscopy.IBM Boulder is conducting three major programs in cooperation with the Colorado School of Medicine. These are the study of the mechanism of failure of the prosthetic heart valve, the study of the ultrastructure of lung tissue, and the definition of the function of the cilia of the ventricular ependyma of the brain.

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