AEROBIC EXERCISE TRAINING IMPROVES INSULIN SENSITIVITY AND BLOOD PRESSURE INDEPENDENT OF PLASMA TNF-ALPHA LEVELS IN OLDER HYPERTENSIVES

2001 ◽  
Vol 33 (5) ◽  
pp. S3
Author(s):  
T H. Reynolds ◽  
M A. Supiano ◽  
M D. Brown ◽  
D R. Dengel
Keyword(s):  
Blood Pressure ◽  
Insulin Sensitivity ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Aerobic Exercise Training ◽  
Tnf Alpha ◽  
Pressure Independent

Sympathetic activity and the heterogenous blood pressure response to exercise training in hypertensives

2002 ◽  
Vol 92 (4) ◽  
pp. 1434-1442 ◽  
Author(s):  
Michael D. Brown ◽  
Donald R. Dengel ◽  
Robert V. Hogikyan ◽  
Mark A. Supiano
Keyword(s):  
Blood Pressure ◽  
Insulin Sensitivity ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Blood Pressure Response ◽  
Pressure Response ◽  
Aerobic Exercise Training ◽  
Sensitivity Index ◽  
Arterial Blood ◽  
Wide Range

To test whether changes in sympathetic nervous system (SNS) activity or insulin sensitivity contribute to the heterogeneous blood pressure response to aerobic exercise training, we used compartmental analysis of [3H]norepinephrine kinetics to determine the extravascular norepinephrine release rate (NE2) as an index of systemic SNS activity and determined the insulin sensitivity index (SI) by an intravenous glucose tolerance test, before and after 6 mo of aerobic exercise training, in 30 (63 ± 7 yr) hypertensive subjects. Maximal O2consumption increased from 18.4 ± 0.7 to 20.8 ± 0.7 ml · kg−1· min−1( P = 0.02). The average mean arterial blood pressure (MABP) did not change (114 ± 2 vs. 114 ± 2 mmHg); however, there was a wide range of responses (−19 to +17 mmHg). The average NE2did not change significantly (2.11 ± 0.15 vs. 1.99 ± 0.13 μg · min−1· m−2), but there was a significant positive linear relationship between the change in NE2and the change in MABP ( r = 0.38, P = 0.04). SIincreased from 2.81 ± 0.37 to 3.71 ± 0.42 μU × 10−4· min−1· ml−1( P = 0.004). The relationship between the change in SIand the change in MABP was not statistically significant ( r = −0.03, P = 0.89). When the changes in maximal O2consumption, percent body fat, NE2, and SIwere considered as predictors of the change in MABP, only NE2was a significant independent predictor. Thus suppression of SNS activity may play a role in the reduction in MABP and account for a portion of the heterogeneity of the MABP response to aerobic exercise training in older hypertensive subjects.

scholarly journals Increased blood cholesterol after a high saturated fat diet is prevented by aerobic exercise training

2013 ◽  
Vol 38 (1) ◽  
pp. 42-48 ◽  
Author(s):  
Juan Fernando Ortega ◽  
Valentín Emilio Fernández-Elías ◽  
Nassim Hamouti ◽  
Ricardo Mora-Rodriguez
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Insulin Sensitivity ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Saturated Fatty Acids ◽  
Density Lipoprotein ◽  
Aerobic Exercise Training ◽  
Blood Cholesterol ◽  
Post Intervention

A high saturated fatty acids diet (HSFAD) deteriorates metabolic and cardiovascular health while aerobic training improves them. The aim of this study was to investigate in physically inactive and overweight people if 2 weeks of HSFAD leads to hyperlipemia or insulin resistance and if concurrent aerobic exercise training counteracts those effects. Fourteen overweight (body mass index, 27.5 ± 0.6 kg·m−2), healthy, young individuals (aged 24.8 ± 1.8 years) were randomly assigned to a diet (D) or a diet plus exercise (D + E) group. During 14 consecutive days both groups increased dietary saturated fatty acids from 31 ± 10 to 52 ± 14 g·day−1(p < 0.001) while maintaining total fat intake. Concurrent to the diet, the D + E group underwent 11 cycle-ergometer sessions of 55 min at 60% peak oxygen uptake (V˙O2peak). Before and after intervention, insulin sensitivity and body composition were estimated, and blood lipids, resting blood pressure, and V̇O2peakwere measured. Body weight and composition, plasma free fatty acids composition and concentration, and insulin sensitivity remained unchanged in both groups. However, post-intervention total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) increased above pre-intervention values in the D group (147 ± 8 to 161 ± 9 mg·dL−1, p = 0.018 and 71 ± 10 to 82 ± 10 mg·dL−1, p = 0.034, respectively). In contrast, in the D + E group, TCand LDL-C remained unchanged (153 ± 20 to 157 ± 24 mg·dL−1and 71 ± 21 to 70 ± 25 mg·dL−1). Additionally, the D + E group lowered systolic blood pressure (6 ± 2 mm Hg, p = 0.029) and increased V̇O2peak(6 ± 2 mL·kg−1·min−1, p = 0.020). Increases in TCand LDL-C concentration induced by 14 days of HSFAD can be prevented by concurrent aerobic exercise training, which, in addition, improves cardiorespiratory fitness.

DIET BUT NOT AEROBIC EXERCISE TRAINING REDUCES SKELETAL MUSCLE TNF-ALPHA.

2004 ◽  
Vol 22 (Suppl. 1) ◽  
pp. S48
Author(s):  
Bronwyn Kingwell ◽  
K. E. Ferrier ◽  
P. Nestel ◽  
A. Taylor ◽  
B. G. Drew ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Aerobic Exercise Training ◽  
Tnf Alpha

scholarly journals Aerobic Exercise Training Enhances The Blood Pressure-lowering Effect Of Antihypertensive Medication.

2020 ◽  
Vol 52 (7S) ◽  
pp. 856-856
Author(s):  
MIGUEL RAMIREZ-JIMENEZ ◽  
FELIX MORALES-PALOMO ◽  
ALFONSO MORENO-CABAÑAS ◽  
JUAN FERNANDO ORTEGA ◽  
LAURA ALVAREZ-JIMENEZ ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Antihypertensive Medication ◽  
Aerobic Exercise Training ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Lowering Effect ◽  
Pressure Lowering

scholarly journals The sex Differences in Blood Pressure and Cardiac Autonomic Modulation during the Menopause Transition at Rest and after Aerobic Exercise Training

2019 ◽  
Author(s):  
Maycon Jr Ferreira ◽  
Rodrigo D. Esposti ◽  
Aline O. Jarrete ◽  
Carlos H. G. Sponton ◽  
Angelina Zanesco
Keyword(s):  
Blood Pressure ◽  
Sex Differences ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Aerobic Exercise Training ◽  
Menopausal Transition ◽  
Autonomic Modulation ◽  
Sod Activity ◽  
Cardiac Autonomic Modulation ◽  
Menopause Transition

Background: Sex differences in blood pressure (BP) exist during all reproductive life between women and men whereas a sharper increase in BP occurs after menopause which is associated with increased prevalence of cardiovascular diseases. This study examined cardiovascular and biochemical parameters in perimenopausal women (PW) aiming to investigate the influence of sex on a) office BP and for 24 hours; b) cardiac autonomic modulation; c) redox state by measuring MDA, SOD, and catalase; d) NOx- concentration. In addition, aerobic exercise training (AET) was applied for detecting changes in cardiovascular responsiveness during the menopausal transition. Methods: Thirty-one participants were enrolled, healthy PW and age-matched men. Cardiovascular and biochemical biomarkers were evaluated at baseline and after AET (8 weeks of exercise on a treadmill, three sessions/week, duration of 30-40 minutes). Results: At rest, PW presented: a) a lower diastolic BP during daytime; b) a lower absolute and normalized LF component as well as a higher HF normalized component; d) no sex differences for redox biomarkers and NOx- concentration. After AET, only PW was responsive in lowering systolic BP that was accompanied by an increase in NOx- concentration and SOD activity. Regarding HRV, both groups were responsive to the AET. Conclusions: During the menopausal transition, systolic BP was similar to men whereas cardiac autonomic modulation remained unaltered showing the influence of sex steroids on BP. In Addition, AET was fundamental during the menopause transition by preventing an elevation in BP, minimizing the effects of aging associated with estrogen deficiency on women's cardiovascular health.

Gender-dependent effects of exercise training on serum leptin levels in humans

1997 ◽  
Vol 272 (4) ◽  
pp. E562-E566 ◽  
Author(s):  
M. S. Hickey ◽  
J. A. Houmard ◽  
R. V. Considine ◽  
G. L. Tyndall ◽  
J. B. Midgette ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Fat Mass ◽  
Aerobic Capacity ◽  
Aerobic Exercise Training ◽  
Sensitivity Index ◽  
Insulin Sensitivity Index ◽  
Serum Leptin ◽  
Body Fat Content

Leptin, the product of the ob gene, is elevated in obese humans and appears to be closely related to body fat content. The purpose of the present investigation was to determine the effect of aerobic exercise training on systemic leptin levels in humans. Eighteen sedentary middle-aged men (n = 9) and women (n = 9) who did not differ in aerobic capacity (29.4 +/- 1.2 vs. 27.5 +/- 1.2 ml x kg(-1) x min(-1)) or insulin sensitivity index (3.41 +/- 1.12 vs. 4.88 +/- 0.55) were studied. Fat mass was significantly lower in females vs. males (21.83 +/- 2.25 vs. 26.99 +/- 2.37 kg, P < 0.05). Despite this, fasting serum leptin was significantly higher in the females vs. males (18.27 +/- 2.55 vs. 9.88 +/- 1.26 ng/ml, P < 0.05). Serum leptin concentration decreased 17.5% in females (P < 0.05) after 12 wk of aerobic exercise training (4 day/wk, 30-45 min/day) but was not significantly reduced in males. Fat mass was not altered after training in either group. In contrast, both aerobic capacity (+13% males, +9.1% females) and insulin sensitivity (+35% males, +82% females) were significantly improved subsequent to training. These data suggest that 1) women have higher circulating leptin concentrations despite lower fat mass and 2) exercise training appears to have a greater effect on systemic leptin levels in females than in males.

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