A free radical scavenger, edaravone (MCI-186), diminishes intestinal neutrophil lipid peroxidation and bacterial translocation in a rat hemorrhagic shock model*

2005 ◽  
Vol 33 (5) ◽  
pp. 1064-1069 ◽  
Author(s):  
Tsuyoshi Mori ◽  
Hiroshi Yamamoto ◽  
Takahisa Tabata ◽  
Tomoharu Shimizu ◽  
Yoshihiro Endo ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Hemorrhagic Shock ◽  
Bacterial Translocation ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Shock Model ◽  
Hemorrhagic Shock Model

Reduced synthesis of inflammatory cytokines by a free radical scavenger after hemorrhagic shock in rats

2000 ◽  
Vol 28 (7) ◽  
pp. 2522-2527 ◽  
Author(s):  
Fabienne Tamion ◽  
Vincent Richard ◽  
Guy Bonmarchand ◽  
Jacky Leroy ◽  
Martine Hiron ◽  
...  
Keyword(s):  
Free Radical ◽  
Hemorrhagic Shock ◽  
Inflammatory Cytokines ◽  
Free Radical Scavenger ◽  
Radical Scavenger

Photoirradiation of representative polycyclic aromatic hydrocarbons and twelve isomeric methylbenz[a]anthracene with UVA light: formation of lipid peroxidation

2006 ◽  
Vol 22 (4) ◽  
pp. 147-156 ◽  
Author(s):  
Qingsu Xia ◽  
Ming W Chou ◽  
Jun J Yin ◽  
Paul C Howard ◽  
Hongtao Yu ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Free Radical ◽  
Methyl Linoleate ◽  
Aromatic Hydrocarbons ◽  
Lipid Peroxide ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Uva Light ◽  
Polycyclic Aromatic

Polycyclic aromatic hydrocarbons (PAHs) are widespread genotoxic environmental pollutants, which require metabolic activation in order to exert biological activities, including mutagenicity and carcinogenicity. Photoactivation is another activation pathway that can lead to PAH genotoxicity. In this paper, we demonstrate that photoirradiation of a series of representative PAHs, with and without bearing a methyl substituent, with UVA light in the presence of methyl linoleate resulted in the formation of methyl linoleate hydroperoxides (a lipid peroxide). The lipid peroxide formation was inhibited by dithiothreitol (DTT) (free radical scavenger), NaN3 (singlet oxygen and free radical scavenger), and superoxide dismutase (SOD) (superoxide scavenger), but was enhanced by the presence of deuterium oxide (D2O) (extends singlet oxygen lifetime). These results suggest that photoirradiation of PAHs by UVA light generates reactive oxygen species (ROS), which induce lipid peroxidation.

scholarly journals Effects of carbon tetrachloride on isolated rat hepatocytes. Inhibition of protein and lipoprotein secretion

1979 ◽  
Vol 178 (2) ◽  
pp. 509-512 ◽  
Author(s):  
E Gravela ◽  
E Albano ◽  
M U Dianzani ◽  
G Poli ◽  
T F Slater
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Carbon Tetrachloride ◽  
Inhibitory Action ◽  
Rat Hepatocytes ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Isolated Rat Hepatocytes ◽  
Lipoprotein Secretion ◽  
Isolated Rat

The effects of carbon tetrachloride on protein and lipoprotein secretion, and on lipid peroxidation, have been investigated in isolated rat hepatocytes. It was found that although the free-radical scavenger promethazine completely suppressed the increased peroxidation produced by carbon tetrachloride, it had no effect on the inhibitory action of carbon tetrachloride on lipoprotein secretion. In consequence, the latter effect of carbon tetrachloride does not appear to be mediated through a peroxidative stage.

Arjunic Acid, a Strong Free Radical Scavenger from Terminalia arjuna

2008 ◽  
Vol 36 (01) ◽  
pp. 197-207 ◽  
Author(s):  
Fang-Yun Sun ◽  
Xiu-Ping Chen ◽  
Jin-Hua Wang ◽  
Hai-Lin Qin ◽  
Su-Rong Yang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Lipid Peroxidation ◽  
Ascorbic Acid ◽  
Free Radical ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Dpph Method ◽  
Significant Difference

This study was designed to investigate the antioxidant and free radical scavenging capacities of arjunic acid, an aglycone obtained from the fruit of medicine Terminalia Fruit. Liver microsomes, mitochondria, and red blood cells (RBCs) were prepared from Wistar rats. The antioxidant capacity was determined by the inhibitory effect on lipid peroxidation, hydrogen peroxide induced RBCs hemolysis, and RBCs autoxidative hemolysis. The free radical scavenging activity was tested by DPPH method and 2′,7′-dichlorodihydrofluoresc in diacetate (DCFH2-DA) assay. Ascorbic acid was chosen as the positive controls. Results showed that arjunic acid was a strong antioxidant and a free radical scavenger, more potent than ascorbic acid, in microsomes lipid peroxidation, DPPH, hydrogen peroxide induced RBCs hemolysis, and (DCFH2-DA) assay (p < 0.05). However, no significant difference was observed in the RBCs autoxidative hemolysis assay (p > 0.05).

scholarly journals The pyrrolopyrimidine U101033E is a potent free radical scavenger and prevents Fe(II)-induced lipid peroxidation in synaptosomal membranes

2000 ◽  
Vol 1501 (2-3) ◽  
pp. 149-161 ◽  
Author(s):  
Christopher M. Lauderback ◽  
Adam M. Breier ◽  
Janna Hackett ◽  
Sridhar Varadarajan ◽  
Jessica Goodlett-Mercer ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Synaptosomal Membranes

CHARACTERISTICS AND THERAPEUTIC EFFECTS OF THE NOVEL FREE RADICAL SCAVENGER – EDARAVONE

2020 ◽  
Vol 04 (05) ◽  
pp. 17-20
Author(s):  
Mirza Mikayil Aliyev ◽  
◽  
Ulduz Yunis Safarova ◽  
Shafiqa Jahangir Jafarova ◽  
◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Arachidonic Acid ◽  
Free Radical ◽  
Hydroxyl Radicals ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Therapeutic Effects ◽  
The Novel ◽  
Prostacyclin Production

Edaravone is the first free radical scavenger which approved clinically and has an ability to decrease the level of free radicals in cells. Edaravone is a strong antioxidant, which can protect different cells (e.g. endothelial cells) against damage by ROS by inhibiting the lipoxygenase metabolism of arachidonic acid, by trapping hydroxyl radicals, by increasing prostacyclin production, by inhibiting alloxan-induced lipid peroxidation, etc. Because of that, Edaravone is used in treatment of diseases which are associated with oxidative stress. Key words: edaravone, free radical, antioxidant, neuroprotective agent, oxidative stress

scholarly journals Investigation on antioxidants, free radical scavenger and lipid peroxidation activities of whole grains finger millet (Eleusine coracana L.)

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Abiodun Akeem Ajiboye ◽  
Oyinade Aderoju Dedeke ◽  
Folasade Comfort Adeyemo
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Finger Millet ◽  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Whole Grain ◽  
Oxidation Stress ◽  
Radical Scavenging Ability

This study evaluates the antioxidant potential and free radical scavenging ability of whole grain finger millet. The crude extracts were obtained by cold maceration using 80% ethanol and methanol. Concentrated extracts were subjected to radicals of 2,2’-diphenyl-1-picrylhydrazyl hydrate (DPPH), hydrogen peroxide, nitric oxide (NO) and malondialdehyde, while the antioxidant constituents evaluated includes total phenol and flavonoid. The results revealed that whole grain finger millet contained 14.65±0.41 and 38.19±0.60 mg QUE/g sample of flavoniods, 36.46±1.09 and 67.10±1.17 mg GAE/g sample of total phenolics and 17.61±0.70 and 35.89±1.32 mg AAE/g sample of total antioxidant capacity for methanol and ethanol respectively. Ethanolic extract of whole finger millet scavenged above 50% hyrogen peroxide, NO and DPPH radicals. Hence, it terminated up to 8.97-65.16% lipid peroxidation reaction chain that may result from auto-oxidation, photo-oxidation and any other oxidation stress that may occur in plant and animal tissues. Therefore, pharmocology attention has to be given to finger millet which showed an effective antioxdants and antiradical capacities. Also, cultivation of finger millet should be encouraged by farmers.

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