Acute urinary retention and subsequent catheterization cause lipid peroxidation and oxidative DNA damage in the bladder: preventive effect of edaravone, a free-radical scavenger

2009 ◽  
Vol 104 (5) ◽  
pp. 713-717 ◽  
Author(s):  
Shogo Shimizu ◽  
Motoaki Saito ◽  
Yukako Kinoshita ◽  
Emi Kazuyama ◽  
Mayuko Tamamura ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Dna Damage ◽  
Free Radical ◽  
Urinary Retention ◽  
Oxidative Dna Damage ◽  
Acute Urinary Retention ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Preventive Effect

Photoirradiation of representative polycyclic aromatic hydrocarbons and twelve isomeric methylbenz[a]anthracene with UVA light: formation of lipid peroxidation

2006 ◽  
Vol 22 (4) ◽  
pp. 147-156 ◽  
Author(s):  
Qingsu Xia ◽  
Ming W Chou ◽  
Jun J Yin ◽  
Paul C Howard ◽  
Hongtao Yu ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Free Radical ◽  
Methyl Linoleate ◽  
Aromatic Hydrocarbons ◽  
Lipid Peroxide ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Uva Light ◽  
Polycyclic Aromatic

Polycyclic aromatic hydrocarbons (PAHs) are widespread genotoxic environmental pollutants, which require metabolic activation in order to exert biological activities, including mutagenicity and carcinogenicity. Photoactivation is another activation pathway that can lead to PAH genotoxicity. In this paper, we demonstrate that photoirradiation of a series of representative PAHs, with and without bearing a methyl substituent, with UVA light in the presence of methyl linoleate resulted in the formation of methyl linoleate hydroperoxides (a lipid peroxide). The lipid peroxide formation was inhibited by dithiothreitol (DTT) (free radical scavenger), NaN3 (singlet oxygen and free radical scavenger), and superoxide dismutase (SOD) (superoxide scavenger), but was enhanced by the presence of deuterium oxide (D2O) (extends singlet oxygen lifetime). These results suggest that photoirradiation of PAHs by UVA light generates reactive oxygen species (ROS), which induce lipid peroxidation.

scholarly journals Effects of carbon tetrachloride on isolated rat hepatocytes. Inhibition of protein and lipoprotein secretion

1979 ◽  
Vol 178 (2) ◽  
pp. 509-512 ◽  
Author(s):  
E Gravela ◽  
E Albano ◽  
M U Dianzani ◽  
G Poli ◽  
T F Slater
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Carbon Tetrachloride ◽  
Inhibitory Action ◽  
Rat Hepatocytes ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Isolated Rat Hepatocytes ◽  
Lipoprotein Secretion ◽  
Isolated Rat

The effects of carbon tetrachloride on protein and lipoprotein secretion, and on lipid peroxidation, have been investigated in isolated rat hepatocytes. It was found that although the free-radical scavenger promethazine completely suppressed the increased peroxidation produced by carbon tetrachloride, it had no effect on the inhibitory action of carbon tetrachloride on lipoprotein secretion. In consequence, the latter effect of carbon tetrachloride does not appear to be mediated through a peroxidative stage.

Arjunic Acid, a Strong Free Radical Scavenger from Terminalia arjuna

2008 ◽  
Vol 36 (01) ◽  
pp. 197-207 ◽  
Author(s):  
Fang-Yun Sun ◽  
Xiu-Ping Chen ◽  
Jin-Hua Wang ◽  
Hai-Lin Qin ◽  
Su-Rong Yang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Lipid Peroxidation ◽  
Ascorbic Acid ◽  
Free Radical ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Dpph Method ◽  
Significant Difference

This study was designed to investigate the antioxidant and free radical scavenging capacities of arjunic acid, an aglycone obtained from the fruit of medicine Terminalia Fruit. Liver microsomes, mitochondria, and red blood cells (RBCs) were prepared from Wistar rats. The antioxidant capacity was determined by the inhibitory effect on lipid peroxidation, hydrogen peroxide induced RBCs hemolysis, and RBCs autoxidative hemolysis. The free radical scavenging activity was tested by DPPH method and 2′,7′-dichlorodihydrofluoresc in diacetate (DCFH2-DA) assay. Ascorbic acid was chosen as the positive controls. Results showed that arjunic acid was a strong antioxidant and a free radical scavenger, more potent than ascorbic acid, in microsomes lipid peroxidation, DPPH, hydrogen peroxide induced RBCs hemolysis, and (DCFH2-DA) assay (p < 0.05). However, no significant difference was observed in the RBCs autoxidative hemolysis assay (p > 0.05).

scholarly journals Neurodegenerative Evidence in Mice Brains with Cecal Ligation and Puncture-Induced Sepsis: Preventive Effect of the Free Radical Scavenger Edaravone

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e51539 ◽  
Author(s):  
Hiroki Yokoo ◽  
Seiichi Chiba ◽  
Kengo Tomita ◽  
Michinori Takashina ◽  
Hiroshi Sagara ◽  
...  
Keyword(s):  
Free Radical ◽  
Cecal Ligation ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Cecal Ligation And Puncture ◽  
Preventive Effect

scholarly journals The pyrrolopyrimidine U101033E is a potent free radical scavenger and prevents Fe(II)-induced lipid peroxidation in synaptosomal membranes

2000 ◽  
Vol 1501 (2-3) ◽  
pp. 149-161 ◽  
Author(s):  
Christopher M. Lauderback ◽  
Adam M. Breier ◽  
Janna Hackett ◽  
Sridhar Varadarajan ◽  
Jessica Goodlett-Mercer ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Synaptosomal Membranes

scholarly journals Bromodeoxyuridine amplifies free-radical-mediated DNA damage

1989 ◽  
Vol 261 (1) ◽  
pp. 269-271 ◽  
Author(s):  
M Poot ◽  
P S Rabinovitch ◽  
H Hoehn
Keyword(s):  
Dna Damage ◽  
Free Radical ◽  
Culture Medium ◽  
Oxygen Free Radicals ◽  
Cumene Hydroperoxide ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Sensitive Cell ◽  
G2 Arrest ◽  
G2 Phase

Elevated oxygen concentrations and paraquat, a superoxide-generating compound, induce an arrest of cells in the G2 phase of the cell cycle, which can be enhanced by adding bromodeoxyuridine (BrdU) to the culture medium. Experiments with the lipophilic peroxide cumene hydroperoxide and the free-radical scavenger vitamin E demonstrate that the BrdU-dependent G2 arrest is not mediated by lipid peroxidation. The BrdU-dependency of arrest in the G2 phase can be used as a sensitive cell biological assay to detect DNA damage elicited by oxygen free radicals.

CHARACTERISTICS AND THERAPEUTIC EFFECTS OF THE NOVEL FREE RADICAL SCAVENGER – EDARAVONE

2020 ◽  
Vol 04 (05) ◽  
pp. 17-20
Author(s):  
Mirza Mikayil Aliyev ◽  
◽  
Ulduz Yunis Safarova ◽  
Shafiqa Jahangir Jafarova ◽  
◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Arachidonic Acid ◽  
Free Radical ◽  
Hydroxyl Radicals ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Therapeutic Effects ◽  
The Novel ◽  
Prostacyclin Production

Edaravone is the first free radical scavenger which approved clinically and has an ability to decrease the level of free radicals in cells. Edaravone is a strong antioxidant, which can protect different cells (e.g. endothelial cells) against damage by ROS by inhibiting the lipoxygenase metabolism of arachidonic acid, by trapping hydroxyl radicals, by increasing prostacyclin production, by inhibiting alloxan-induced lipid peroxidation, etc. Because of that, Edaravone is used in treatment of diseases which are associated with oxidative stress. Key words: edaravone, free radical, antioxidant, neuroprotective agent, oxidative stress

scholarly journals Iron induced genotoxicity: attenuation by vitamin C and its optimization

2014 ◽  
Vol 7 (3) ◽  
pp. 154-158 ◽  
Author(s):  
Nuzhat Parveen ◽  
Shoeb Ahmad ◽  
G.G. Hammad A. Shadab
Keyword(s):  
Dna Damage ◽  
Free Radical ◽  
Vitamin C ◽  
Free Radical Scavenger ◽  
Iron Sulfate ◽  
Radical Scavenger ◽  
Optimum Level ◽  
Acute Administration ◽  
Oxygen Species ◽  
Indirect Action

ABSTRACT Vitamin C (VC) is a well-known antioxidant and strong free radical scavenger. Its antioxidant activity is useful for protection of cellular macromolecules, particularly DNA, from oxidative damage induced by different agents. This study was undertaken to evaluate the optimum level of VC in attenuating the chromosome aberrations (CAs) and DNA damage after iron sulfate (FeSO4) acute administration in Wistar rats. The results exhibited that the increase of CAs and DNA damage induced by FeSO4, 200 mg Fe/kg, could be reduced significantly by VC pretreatment at the dose of 500 mg/kg (p<0.001), but not in the 100 mg/kg group. The findings provide evidence that VC at the dose of 500 mg/kg exerted a possible protective effect against FeSO4 induced CAs and DNA damage. The possible mechanisms of VC may be attributed to its property as a free radical scavenger or to its indirect action in reducing the level of reactive oxygen species (ROS).

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