Background: Serum uric acid has been closely linked and considered as an independent risk factor for development of hypertension. This study was carried out to assess the serum uric acid levels in essential hypertension and its correlation with the severity and known duration of hypertension.Methods: The present observational case control study was conducted between November 2019 to February 2020 on total 100 out patients (30-65 years) of which 50 known cases of essential hypertension irrespective of treatment status and were graded into different stages of hypertension as per Joint National Committee VII (JNC VII) guidelines. Rest 50 patients who were age- sex matched and without any co-morbidity were included as control. Relevant clinical and laboratory data were recorded using proforma. Statistical analysis was done using Statistical package for social software (SPSS) software.Results: Mean systolic/diastolic blood pressure (BP) was found significantly higher in cases 168/102 mmHg compare to control 114/74 mmHg. Among cases maximum patients were found in stage 2 hypertension which has significant difference in mean systolic/diastolic BP (186/112 mmHg, p<0.001) compare with stage 1 (146/94 mmHg) and isolated hypertensive patients (148/85 mmHg). Serum uric acid levels were significantly higher in stage 2 than other two hypertensive stages among cases and also compare to controls. Patients with >5 years of hypertension also has significant high serum uric acid level than <5 years of hypertension.Conclusions: Serum uric acid can be used probably as an early biochemical marker to determine the severity of hypertension as stage 2 hypertensive had more elevation in serum uric acid levels as compared to other hypertensive patients.
Serum uric acid is an independent risk factor for cardiovascular disease and mortality in hypertensive patients
