scholarly journals Intracarotid Delivery of Drugs

2008 ◽  
Vol 109 (3) ◽  
pp. 543-564 ◽  
Author(s):  
Shailendra Joshi ◽  
Phillip M. Meyers ◽  
Eugene Ornstein
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Endovascular Procedures ◽  
Molecular Techniques ◽  
Rapid Progress ◽  
The Past ◽  
Risk Patients ◽  
Kinetics Of ◽  
The Brain ◽  
Made In

The major efforts to selectively deliver drugs to the brain in the past decade have relied on smart molecular techniques to penetrate the blood-brain barrier, whereas intraarterial drug delivery has drawn relatively little attention. Meanwhile, rapid progress has been made in the field of endovascular surgery. Modern endovascular procedures can permit highly targeted drug delivery by the intracarotid route. Intracarotid drug delivery can be the primary route of drug delivery or it could be used to facilitate the delivery of smart neuropharmaceuticals. There have been few attempts to systematically understand the kinetics of intracarotid drugs. Anecdotal data suggest that intracarotid drug delivery is effective in the treatment of cerebral vasospasm, thromboembolic strokes, and neoplasms. Neuroanesthesiologists are frequently involved in the care of such high-risk patients. Therefore, it is necessary to understand the applications of intracarotid drug delivery and the unusual kinetics of intracarotid drugs.

scholarly journals An update of nanoparticle-based approaches for glioblastoma multiforme immunotherapy

Nanomedicine ◽  
2020 ◽  
Vol 15 (19) ◽  
pp. 1861-1871
Author(s):  
Lorenzo Taiarol ◽  
Beatrice Formicola ◽  
Roberta Dal Magro ◽  
Silvia Sesana ◽  
Francesca Re
Keyword(s):  
Drug Delivery ◽  
Glioblastoma Multiforme ◽  
Adverse Effects ◽  
Brain Tumors ◽  
Nucleic Acids ◽  
Targeted Drug Delivery ◽  
The Past ◽  
Targeted Drug ◽  
The Brain ◽  
Made In

Glioblastoma multiforme is a serious medical issue in the brain oncology field due to its aggressiveness and recurrence. Immunotherapy has emerged as a valid approach to counteract the growth and metastasization of glioblastoma multiforme. Among the different innovative approaches investigated, nanoparticles gain attention because of their versatility which is key in allowing precise targeting of brain tumors and increasing targeted drug delivery to the brain, thus minimizing adverse effects. This article reviews the progress made in this field over the past 2 years, focusing on nonspherical and biomimetic particles and on vectors for the delivery of nucleic acids. However, challenges still need to be addressed, considering the improvement of the particles passage across the blood–meningeal barrier and/or the blood–brain barrier, promoting the clinical translatability of these approaches.

Recent Advances in Targeted Drug Delivery Approaches using Lipidic and Polymeric Nanocarriers for the management of Alzheimer’s Disease

2021 ◽  
Vol 27 ◽  
Author(s):  
Dhara Lakdawala ◽  
Md Abdur Rashid ◽  
Farhan Jalees Ahmad
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
Blood Brain Barrier ◽  
Targeted Drug Delivery ◽  
Brain Barrier ◽  
Polymeric Nanocarriers ◽  
Blood Brain ◽  
Targeted Drug ◽  
The Brain

: Drug delivery to the brain has remained a significant challenge in treating neurodegenerative disorders such as Alzheimer's disease due to the presence of the blood-brain barrier, which primarily obstructs the access of drugs and biomolecules into the brain. Several methods to overcome the blood-brain barrier have been employed, such as chemical disruption, surgical intervention, focused ultrasound, intranasal delivery and using nanocarriers. Nanocarrier systems remain the method of choice and have shown promising results over the past decade to achieve better drug targeting. Polymeric nanocarriers and lipidic nanoparticles act as a carrier system providing better encapsulation of drugs, site-specific delivery, increased bioavailability and sustained release of drugs. The surface modifications and functionalization of these nanocarrier systems have greatly facilitated targeted drug delivery. The safety and efficacy of these nanocarrier systems have been ascertained by several in vitro and in vivo models. In the present review, we have elaborated on recent developments of nanoparticles as a drug delivery system for Alzheimer's disease, explicitly focusing on polymeric and lipidic nanoparticles.

Managing Aviation Technologies

1959 ◽  
Vol 63 (583) ◽  
pp. 381-393
Author(s):  
Charles J. McCarthy
Keyword(s):  
New York ◽  
Memorial Lecture ◽  
Rapid Progress ◽  
The Past ◽  
Anglo American ◽  
Wilbur Wright ◽  
Made In

It is a great distinction and a highly esteemed honour to be privileged to read the forty-seventh Wilbur Wright Memorial Lecture. It is also a distinct personal pleasure to be here. Over the past 15 years I have made periodic trips to England to visit the aircraft companies, to witness the spectacular Farnborough displays of the S.B.A.C. and to attend the Anglo-American Conferences of the Royal Aeronautical Society and the Institute of the Aeronautical Sciences. This has afforded opportunities to observe and admire the rapid progress you have made in aeronautics, the brilliant achievements of British engineers and scientists and, more importantly, the chance to make and deepen warm and valued friendships. The joint meetings of the Society and the Institute are proving to be fruitful ground for the exchange of ideas and for becoming better acquainted. May I express the sincere wish that I shall have the pleasure of welcoming many of you to the Seventh Anglo-American Conference which will be held in October 1959 in New York.

Diffusion Kinetics of Vitamin B12 from Alginate and Poly(vinyl acetate) Based Gel Scaffolds for Targeted Drug Delivery

2020 ◽  
Vol 59 (11) ◽  
pp. 713-730
Author(s):  
Ambuj Gupta ◽  
Jaykumar Bhasarkar ◽  
Mohammed Rehaan Chandan ◽  
Aabid Hussain Shaik ◽  
Bandaru Kiran ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Vitamin B12 ◽  
Vinyl Acetate ◽  
Targeted Drug Delivery ◽  
Diffusion Kinetics ◽  
Targeted Drug ◽  
Kinetics Of

scholarly journals Macrophages with cellular backpacks for targeted drug delivery to the brain

Biomaterials ◽  
2017 ◽  
Vol 140 ◽  
pp. 79-87 ◽  
Author(s):  
Natalia L. Klyachko ◽  
Roberta Polak ◽  
Matthew J. Haney ◽  
Yuling Zhao ◽  
Reginaldo J. Gomes Neto ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Drug ◽  
The Brain

scholarly journals Targeted drug delivery to the brain using magnetic nanoparticles

2015 ◽  
Vol 6 (10) ◽  
pp. 1145-1155 ◽  
Author(s):  
Louiza Bohn Thomsen ◽  
Maj Schneider Thomsen ◽  
Torben Moos
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Targeted Drug Delivery ◽  
Targeted Drug ◽  
The Brain

Money, Morphology and Molecules. Some comments on Wortley, Bennett and Scotland (2002), Taxonomy and phylogeny reconstruction: two distinct research agendas in systematics. (see p. 335 of this issue)

2002 ◽  
Vol 59 (3) ◽  
pp. 451-457 ◽  
Author(s):  
P. F. STEVENS
Keyword(s):  
Molecular Systematics ◽  
Large Scale ◽  
Species Level ◽  
Molecular Techniques ◽  
Morphological Data ◽  
Phylogeny Reconstruction ◽  
Reasonable Time ◽  
The Past ◽  
Short Time ◽  
Made In

The state of systematics, for convenience here divided into taxonomy (the delimitation, description and inventory of species) and phylogeny reconstruction, is evaluated. Molecular systematics may seem overemphasized, but the resulting gains made in our understanding of relationships in a relatively short time are very considerable. Although morphological data currently play only a limited role in detecting large-scale phylogenetic pattern, the analysis by Wortley et al. of the role morphology has played in the past is not easily interpreted. At species level, it is unclear what effect molecular techniques will have on our understanding of species limits, but it is likely to be considerable. Although taxonomy is both essential and underfunded, there seems little point in asking for more money until we can justify the limits of the species we describe more clearly and until we have cleared up the impediments that so much slow the practice of taxonomy. Business cannot remain as usual if any of the grand inventory projects we have started are to be finished within a reasonable time, or even to be of much use when they are.

scholarly journals Emergent processes in cognitive-emotional interactions

2010 ◽  
Vol 12 (4) ◽  
pp. 433-448 ◽  
Keyword(s):  
Basal Forebrain ◽  
Significant Progress ◽  
Brain Organization ◽  
The Past ◽  
Mind And Brain ◽  
The Mind ◽  
The Brain ◽  
Anatomical Evidence ◽  
Made In

Emotion and cognition have been viewed as largely separate entities in the brain. Within this framework, significant progress has been made in understanding specific aspects of behavior. Research in the past two decades, however, has started to paint a different picture of brain organization, one in which network interactions are key to understanding complex behaviors. From both basic and clinical perspectives, the characterization of cognitive-emotional interactions constitutes a fundamental issue in the investigation of the mind and brain. This review will highlight the interactive and integrative potential that exists in the brain to bring together the cognitive and emotional domains. First, anatomical evidence will be provided, focusing on structures such as hypothalamus, basal forebrain, amygdala, cingulate cortex, orbitofrontal cortex, and insula. Data on functional interactions will then be discussed, followed by a discussion of a dual competition framework, which describes cognitive-emotional interactions in terms of perceptual and cognitive competition mechanisms.

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