scholarly journals Emergent processes in cognitive-emotional interactions

2010 ◽  
Vol 12 (4) ◽  
pp. 433-448 ◽  
Keyword(s):  
Basal Forebrain ◽  
Significant Progress ◽  
Brain Organization ◽  
The Past ◽  
Mind And Brain ◽  
The Mind ◽  
The Brain ◽  
Anatomical Evidence ◽  
Made In

Emotion and cognition have been viewed as largely separate entities in the brain. Within this framework, significant progress has been made in understanding specific aspects of behavior. Research in the past two decades, however, has started to paint a different picture of brain organization, one in which network interactions are key to understanding complex behaviors. From both basic and clinical perspectives, the characterization of cognitive-emotional interactions constitutes a fundamental issue in the investigation of the mind and brain. This review will highlight the interactive and integrative potential that exists in the brain to bring together the cognitive and emotional domains. First, anatomical evidence will be provided, focusing on structures such as hypothalamus, basal forebrain, amygdala, cingulate cortex, orbitofrontal cortex, and insula. Data on functional interactions will then be discussed, followed by a discussion of a dual competition framework, which describes cognitive-emotional interactions in terms of perceptual and cognitive competition mechanisms.

scholarly journals Synthesis and X-ray characterization of 15- and 16-vertex closo-carboranes

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Fangrui Zheng ◽  
Tsz Hin Yui ◽  
Jiji Zhang ◽  
Zuowei Xie
Keyword(s):  
Three Dimensional ◽  
Functional Materials ◽  
Building Blocks ◽  
Molecular Clusters ◽  
Significant Progress ◽  
X Ray ◽  
The Past ◽  
Silyl Groups ◽  
Made In

AbstractCarboranes are a class of carbon-boron molecular clusters with three-dimensional aromaticity, and inherent robustness. These endowments enable carboranes as valuable building blocks for applications ranging from functional materials to pharmaceuticals. Thus, the chemistry of carboranes has received tremendous research interest, and significant progress has been made in the past decades. However, many attempts to the synthesis of carboranes with more than 14 vertices had been unsuccessful since the report of a 14-vertex carborane in 2005. The question arises as to whether these long sought-after molecules exist. We describe in this article the synthesis and structural characterization of 15- and 16-vertex closo-carboranes as well as 16-vertex ruthenacarborane. Such a success relies on the introduction of silyl groups to both cage carbons, stabilizing the corresponding nido-carborane dianions and promoting the capitation reaction with HBBr2·SMe2. This work would shed some light on the preparation of carboranes with 17 vertices or more, and open the door for studying supercarborane chemistry.

scholarly journals Paving the way for transgenic schistosomes

Parasitology ◽  
2011 ◽  
Vol 139 (5) ◽  
pp. 651-668 ◽  
Author(s):  
S. BECKMANN ◽  
C. G. GREVELDING
Keyword(s):  
Rna Interference ◽  
Initial Phase ◽  
Functional Characterization ◽  
Reporter Genes ◽  
Significant Progress ◽  
Gene Insertion ◽  
Remarkable Progress ◽  
Made In ◽  
Silence Gene

SUMMARYIn parasitological research, significant progress has been made with respect to genomics and transcriptomics but transgenic systems for functional gene analyses are mainly restricted to the protozoan field. Gene insertion and knockout strategies can be applied to parasitic protozoa as well as gene silencing by RNA interference (RNAi). By contrast, research on parasitic helminthes still lags behind. Along with the major advances in genome and transcriptome analyses e.g. for schistosomes, methods for the functional characterization of genes of interest are still in their initial phase and have to be elaborated now, at the beginning of the post-genomic era. In this review we will summarize attempts made in the last decade regarding the establishment of protocols to transiently and stably transform or transfect schistosomes. Besides approaches using particle bombardment, electroporation or virus-based infection strateies to introduce DNA constructs into adult and larval schistosome stages to express reporter genes, first approaches have also been made in establishing protocols based on soaking, lipofection, and/or electroporation for RNA interference to silence gene activity. Although in these cases remarkable progress can be seen, the schistosome community eagerly awaits major breakthroughs especially with respect to stable transformation, but also for silencing or knock-down strategies for every schistosome gene of interest.

Philosophy of Neuroscience

2016 ◽  
Author(s):  
Adina L. Roskies ◽  
Carl F. Craver
Keyword(s):  
Experimental Study ◽  
Experimental Techniques ◽  
Central Research ◽  
Philosophy Of Neuroscience ◽  
The Past ◽  
Research Areas ◽  
Potential Impact ◽  
Rich Material ◽  
The Mind ◽  
The Brain

The experimental study of the brain has exploded in the past several decades, providing rich material for both philosophers of science and philosophers of mind. In this chapter, the authors summarize some central research areas in philosophy of neuroscience. Some of these areas focus on the internal practice of neuroscience, that is, on the assumptions underlying experimental techniques, the accepted structures of explanations, the goals of integrating disciplines, and the possibility of a unified science of the mind-brain. Other areas focus outwards on the potential impact that neuroscience is having on our conception of the mind and its place in nature.

Why We Should Reject Transhumanists’ Entire Lens on the Mind and Brain

2021 ◽  
pp. 42-84
Author(s):  
Susan B. Levin
Keyword(s):  
Dual Process ◽  
Appraisal Theory ◽  
Basic Emotion ◽  
Theoretical Approaches ◽  
Mind And Brain ◽  
Mental Operations ◽  
The Mind ◽  
The Brain

“Basic-emotion” and “dual-process” theorists, joined by transhumanists, view the mind as a set of compartments whose functionality is explained by dedicated areas or systems in the brain. The two theoretical approaches reflect core misconceptions and have been supplanted by “appraisal theory.” Beyond capturing well the entwining of reason and emotion in our mental operations, Klaus Scherer’s version of appraisal theory is compatible with mounting evidence of the brain’s complexity. Having developed a scientific line of argument against transhumanists’ lens on the mind and brain, the author turns to Aristotle’s rational essentialism. Wrongly invoked to support transhumanists’ extreme version, Aristotle’s rational essentialism incorporates a necessary role for nonrational faculties and intrapsychic harmony. While transhumanists’ lens on the mind and brain is at odds with contemporary findings, Aristotle’s view of the mind shares important commitments with Scherer’s appraisal theory and is broadly compatible with an emerging picture of the brain’s complexity.

Conclusion

2017 ◽  
pp. 279-292
Author(s):  
Thomas Fuchs
Keyword(s):  
Body Problem ◽  
Short Circuit ◽  
Living Organism ◽  
Human Being ◽  
Mind And Brain ◽  
Mind Body Problem ◽  
The Mind ◽  
The Brain

The ‘Conclusion’ summarizes fundamental concepts and insights of the book. The brain is presented as an organ of mediation, transformation, and resonance. Its functions are integrated by the living organism as a whole, or by the embodied person, respectively: persons have brains, they are not brains. The deadlocks of the mind–body problem result from a short circuit between mind and brain which follows as a consequence from the systematic exclusion of life. A combination of phenomenological, embodied, and enactive approaches seems best suited to overcome this deficit. In contrast to naturalistic reductionism, this leads to a personalistic concept of the human being which has its basis in intercorporeality: it is in the concrete bodily encounter that we primarily recognize each other as embodied subjects or persons.

Physical characterization of HfO2deposited on Ge substrates by MOCVD.

2004 ◽  
Vol 811 ◽  
Author(s):  
S. Van Elshocht ◽  
B. Brijs ◽  
M. Caymax ◽  
T. Conard ◽  
S. De Gendt ◽  
...  
Keyword(s):  
Physical Properties ◽  
Gate Dielectric ◽  
Substrate Material ◽  
Silicon Substrates ◽  
Enabling Technology ◽  
The Past ◽  
High K ◽  
Alternative Approach ◽  
Made In

ABSTRACTGermanium is because of its intrinsically higher mobility than Si, currently under consideration as an alternative approach to improve transistor performance. Germanium oxide, however, is thermodynamically unstable, preventing formation of the gate dielectric by simple oxidation. At present, high-k dielectrics might be considered as an enabling technology as much progress has been made in the deposition of thin high-quality layers.In this paper, we study the growth and physical properties of HfO2 deposited on Ge by MOCVD, using TDEAH and O2 as precursors, and compare the results to similar layers deposited on silicon substrates. Our results show that the physical properties of MOCVD-deposited HfO2 layers on Ge are very similar to what we have observed in the past for Si. Unfortunately, some of the negative aspects observed for Si, such as diffusion of substrate material in the high-k layer, a low density for thinner layers, or a rough top surface, are also observed for the case of Ge. However, careful surface pretreatments such as NH3 annealing the Ge substrate prior to deposition, can greatly improve the physical properties. An important observation is the very thin interfacial layer between HfO2 and Ge substrate, allowing a more aggressive scaling for Ge.

Human nature without a soul?

2004 ◽  
Vol 12 (1) ◽  
pp. 45-64 ◽  
Author(s):  
MALCOLM JEEVES
Keyword(s):  
Human Nature ◽  
Cognitive Neuroscience ◽  
Scientific Evidence ◽  
Neural Substrates ◽  
Top Down ◽  
The Past ◽  
Neural Processes ◽  
Mind And Brain ◽  
The Mind ◽  
To Receive

Rapid developments in neuroscience over the past four decades continue to receive wide media attention. Each new reported advance points to ever tightening links between mind and brain. For many centuries, what is today called ‘mind-talk’ was familiar as ‘soul-talk’. Since, for some, the possession of a soul is what makes us human, the challenges of cognitive neuroscience directly address this. This paper affords the non-specialist a brief overview of some of the scientific evidence pointing to the ever tightening of the mind-brain links and explores its wider implications for our understanding of human nature. In particular it brings together the findings from so-called bottom-up research, in which we observe changes in behaviour and cognition resulting from experimental interventions in neural processes, with top-down research where we track changes in neural substrates accompanying habitual modes of cognition or behaviour. Further reflection alerts one to how the dualist views widely held by New Agers, some humanists and many religious people, contrast with the views of academic philosophers, theologians and biblical scholars, who agree in emphasizing the unity of the person.

Musical Illusions and Phantom Words

2019 ◽  
Author(s):  
Diana Deutsch
Keyword(s):  
Music Perception ◽  
Musical Ability ◽  
Art And Science ◽  
Brain Organization ◽  
Early Form ◽  
The Real ◽  
Musical Patterns ◽  
Psychology Of Music ◽  
The Mind ◽  
The Brain

In this groundbreaking synthesis of art and science, Diana Deutsch, one of the world’s leading experts on the psychology of music, shows how illusions of music and speech – many of which she discovered - have fundamentally altered thinking about the brain. These astonishing illusions show that people can differ strikingly in how they hear musical patterns - differences that reflect both variations in brain organization and influences of language on music perception. They lead Deutsch to examine questions such as: When an orchestra performs a symphony, what is the ‘real’ music? Is it in the mind of the composer, or the conductor, or different members of the audience? Deutsch also explores extremes of musical ability, and other rare responses to music and speech. Why is perfect pitch so rare? Why are some people unable to recognize simple tunes? Why do some people hallucinate music or speech? Why do we hear phantom words and phrases? Why are most people subject to stuck tunes, or ‘earworms’? Why do we hear a spoken phrase as sung just because it is presented repeatedly? In evaluating these questions, she also shows how music and speech are intertwined, and argues that they stem from an early form of communication that had elements of both. Many of the illusions described here are so striking and paradoxical that you need to hear them to believe them. So the book enables you to listen to the sounds that are described while reading about them.

scholarly journals Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012–2018)

MedChemComm ◽  
2019 ◽  
Vol 10 (6) ◽  
pp. 840-866 ◽  
Author(s):  
Jillian Romsdahl ◽  
Clay C. C. Wang
Keyword(s):  
Aspergillus Terreus ◽  
Genome Mining ◽  
Gene Clusters ◽  
Genetic Identification ◽  
Biosynthetic Pathways ◽  
Biosynthetic Gene ◽  
Biosynthetic Gene Clusters ◽  
The Past ◽  
Made In

This review covers advances made in genome mining SMs produced by Aspergillus nidulans, Aspergillus fumigatus, Aspergillus niger, and Aspergillus terreus in the past six years (2012–2018). Genetic identification and molecular characterization of SM biosynthetic gene clusters, along with proposed biosynthetic pathways, is discussed in depth.

Supercarboranes: Achievements and perspectives

2012 ◽  
Vol 85 (4) ◽  
pp. 661-670 ◽  
Author(s):  
Jian Zhang ◽  
Zuowei Xie
Keyword(s):  
Reducing Agents ◽  
Future Perspectives ◽  
Significant Progress ◽  
Boron Clusters ◽  
The Past ◽  
The Future ◽  
Made In ◽  
Carborane Anions

This article highlights the achievements in the chemistry of supercarboranes (carboranes with more than 12 vertices) in the past decade and the future perspectives. The chemistry of boron clusters has been dominated by 12-vertex carboranes for several decades. Only in recent years has significant progress been made in the chemistry of supercarboranes. Such a breakthrough relies on the use of CAd (carbon-atoms-adjacent) 12-vertex nido-carborane anions as starting materials. A series of 13- and 14-vertex carboranes as well as their corresponding 14- and 15-vertex metallacarboranes have been prepared and structurally characterized. Reactions of supercarboranes with reducing agents, electrophiles, and nucleophiles are studied, which reveal a more diverse and richer reaction chemistry than their icosahedral cousins.

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