Different Response to Immunotherapy According to Melanoma Histologic Subtype

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Laura Pala ◽  
Fabio Conforti ◽  
Eleonora Pagan ◽  
Vincenzo Bagnardi ◽  
Tommaso M. De Pas ◽  
...  
Keyword(s):  
Histologic Subtype ◽  
Different Response

Smoothing Facilitates the Detection of Coupled Responses in Psychophysiological Time Series

2000 ◽  
Vol 14 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Joni Kettunen ◽  
Niklas Ravaja ◽  
Liisa Keltikangas-Järvinen
Keyword(s):  
Time Series ◽  
Type I Error ◽  
Electrodermal Activity ◽  
Moving Average ◽  
Type I ◽  
Facial Electromyography ◽  
Response Characteristics ◽  
Smoothing Methods ◽  
Response Systems ◽  
Different Response

Abstract We examined the use of smoothing to enhance the detection of response coupling from the activity of different response systems. Three different types of moving average smoothers were applied to both simulated interbeat interval (IBI) and electrodermal activity (EDA) time series and to empirical IBI, EDA, and facial electromyography time series. The results indicated that progressive smoothing increased the efficiency of the detection of response coupling but did not increase the probability of Type I error. The power of the smoothing methods depended on the response characteristics. The benefits and use of the smoothing methods to extract information from psychophysiological time series are discussed.

Prophylactic Effects of Metoprolol on the Prevention of Atrial Fibrillation after Cardiac Surgery Are Dose Dependent

2014 ◽  
Vol 17 (1) ◽  
pp. 54 ◽  
Author(s):  
Nan Cheng ◽  
Changqing Gao
Keyword(s):  
Atrial Fibrillation ◽  
Cardiac Surgery ◽  
Heart Surgery ◽  
Beta Blockers ◽  
Open Heart Surgery ◽  
Asian Patients ◽  
Different Response ◽  
Prolonged Hospital ◽  
Dose Dependent ◽  
Study Dose

Atrial fibrillation (AF) is one of the most common complications after cardiac surgery. Many studies have reported an incidence of 20%-40% in patients undergoing open heart surgery, and the peak incidence usually occurs between the postoperative days [Fuller 1989; Aranki 1996; Svedjeholm 2000; Maisel 2001]. AF is commonly self-limited and rarely results in postoperative death. However, postoperative AF (POAF) is often associated with complications, including stroke, heart failure, prolonged hospital stay, and increased costs [Maisel 2001; Bramer 2010]. Many pharmacological methods have been used to prevent this complication, and beta-blockers, which have been investigated in several studies, have demonstrated effectiveness [Ali 1997; Connolly 2003; Crystal 2004; Halonen 2006; Imren 2007]. There is currently a consensus in the use of beta-blockers for the prevention of POAF. However, whether the effect of beta-blockers on POAF is dose dependent has not been widely studied [Coleman 2004; Lucio 2004]. In addition, patients with different racial backgrounds have a different response to metoprolol based on body shape. In addition, the CYP2D6 genotypes are different among white and Asian patients. In this study dose-dependent prophylactic effects of beta-blockers, which were obtained in a single center.

Boundary extension in the internal parts of images

2019 ◽  
Author(s):  
Jiri Lukavsky ◽  
Vojtěch Klinger
Keyword(s):  
Free Recall ◽  
Distractor Task ◽  
Boundary Extension ◽  
Computer Based ◽  
Response Phase ◽  
Ink Blot ◽  
Different Response ◽  
Size Adjustment

In boundary extension (BE), people confidently remember seeing a surrounding region of a scene that was not visible in the studied view. However, the content near image boundaries might be uninteresting, serving only as a background for a central figure.In our experiments, we presented participants with 24 photographs with a defect (cut-out hole or black ink blot). Participants were instructed to memorize the photograph and then either reproduce the size of the hole/blot (BE task) or identify a change (distractor task). In Exp. 1, we showed participants printed photographs (18×13 cm) with cut-out holes. Participants systematically drew smaller holes (87.5% diameter, N=32). When we replaced the holes with black ink blots (Exp. 2), the bias was still present (91.4%, N=30). The computer-based version with size-adjustment of black blots (Exp. 3) yielded similar effects (92.8%, N=30), which disappeared (Exp. 4, 100.7%, N=30) if the probe blot sizes were randomized.We argue that BE occurs in the internal parts of photographs. We explored the effect in different media (paper/screen) and using different response tasks (free recall/adjustment). People show uncertainty in the adjustment tasks and reproduce remembered holes/blots as smaller (consistent with BE) if they are presented with the occluded content in the response phase.

The Disappearance of Political Jokes in Post-Socialist Slovenia

2020 ◽  
Vol 53 (3) ◽  
pp. 172-188
Author(s):  
Primož Mlačnik ◽  
Peter Stanković
Keyword(s):  
Public Sphere ◽  
Market Economy ◽  
Social Pressures ◽  
The Social ◽  
Different Response

In the decades since the fall of socialism, political jokes seemed to have lost their significance in Slovenia. In order to confirm and understand this change, we collected a sample of 200 jokes from five of the most popular Slovenian Facebook groups and analyzed the jokes and their targets. The results show that political jokes have indeed largely disappeared from the Slovenian public sphere: only three of the jokes in the sample target politicians. In this article, we argue that this development indicates a different response to the social pressures of the market economy. Whereas during socialism the source of anxiety was more or less apparent (the communist elite) and consequently easier to ridicule, in post-socialist societies, sources of anxiety are more diverse and impersonal, making them more difficult to target in jokes.

scholarly journals Mutated p53 in HGSC—From a Common Mutation to a Target for Therapy

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3465
Author(s):  
Aya Saleh ◽  
Ruth Perets
Keyword(s):  
Cancer Progression ◽  
Target Genes ◽  
P53 Protein ◽  
Genetic Alterations ◽  
Common Mutation ◽  
Missense Mutations ◽  
P53 Expression ◽  
Histologic Subtype ◽  
Tp53 Mutations

Mutations in tumor suppressor gene TP53, encoding for the p53 protein, are the most ubiquitous genetic variation in human ovarian HGSC, the most prevalent and lethal histologic subtype of epithelial ovarian cancer (EOC). The majority of TP53 mutations are missense mutations, leading to loss of tumor suppressive function of p53 and gain of new oncogenic functions. This review presents the clinical relevance of TP53 mutations in HGSC, elaborating on several recently identified upstream regulators of mutant p53 that control its expression and downstream target genes that mediate its roles in the disease. TP53 mutations are the earliest genetic alterations during HGSC pathogenesis, and we summarize current information related to p53 function in the pathogenesis of HGSC. The role of p53 is cell autonomous, and in the interaction between cancer cells and its microenvironment. We discuss the reduction in p53 expression levels in tumor associated fibroblasts that promotes cancer progression, and the role of mutated p53 in the interaction between the tumor and its microenvironment. Lastly, we discuss the potential of TP53 mutations to serve as diagnostic biomarkers and detail some more advanced efforts to use mutated p53 as a therapeutic target in HGSC.

scholarly journals Parosteal Osteosarcoma with Pancreatic Metastasis and Multiple Relapses: A Case Report and Review of the Literature

2021 ◽  
pp. 983-988
Author(s):  
Daniel Cirotski ◽  
Jyoti Panicker
Keyword(s):  
Age Groups ◽  
Bone Cancer ◽  
Pancreatic Metastasis ◽  
Low Grade ◽  
Parosteal Osteosarcoma ◽  
Disease Course ◽  
Review Of The Literature ◽  
Histologic Subtype ◽  
Primary Bone ◽  
Multiple Relapses

Osteosarcoma is the most common primary bone cancer in all age groups. Metastasis mostly occurs with high-grade tumors disseminating to the lungs and other bones. Spread to the pancreas is rare and undocumented in the low-grade subtypes. Additionally, it is uncommon for the disease course of low-grade subtypes to involve multiple relapses. We present a 35-year-old woman with parosteal osteosarcoma who has experienced an atypical metastasis to the pancreas as well as multiple local and pulmonary relapses. The lesion was identified incidentally on routine imaging, and the patient underwent resection. We compare our case to the other reports of pancreatic metastasis in the literature. Despite being especially rare, clinicians ought to be aware of pancreatic metastasis of osteosarcoma. Furthermore, despite parosteal osteosarcoma’s less aggressive disease course, it can uncommonly lead to multiple relapses. We present a rare case exemplifying these phenomena in the prognostically favorable histologic subtype of parosteal osteosarcoma.

scholarly journals The Role of Aquaporin Overexpression in the Modulation of Transcription of Heavy Metal Transporters under Cadmium Treatment in Poplar

Plants ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 54
Author(s):  
Andrea Neri ◽  
Silvia Traversari ◽  
Andrea Andreucci ◽  
Alessandra Francini ◽  
Luca Sebastiani
Keyword(s):  
Heavy Metal ◽  
Transcriptional Response ◽  
Metal Transporters ◽  
Metal Transporter ◽  
Cadmium Treatment ◽  
Tolerance To Cadmium ◽  
Different Response ◽  
Cd Translocation ◽  
Hydroponic Conditions

Populus alba ‘Villafranca’ clone is well-known for its tolerance to cadmium (Cd). To determine the mechanisms of Cd tolerance of this species, wild-type (wt) plants were compared with transgenic plants over-expressing an aquaporin (aqua1, GenBank GQ918138). Plants were maintained in hydroponic conditions with Hoagland’s solution and treated with 10 µM of Cd, renewed every 5 d. The transcription levels of heavy metal transporter genes (PaHMA2, PaNRAMP1.3, PaNRAMP2, PaNRAMP3.1, PaNRAMP3.2, PaABCC9, and PaABCC13) were analyzed at 1, 7, and 60 d of treatment. Cd application did not induce visible toxicity symptoms in wt and aqua1 plants even after 2 months of treatment confirming the high tolerance of this poplar species to Cd. Most of the analyzed genes showed in wt plants a quick response in transcription at 1 d of treatment and an adaptation at 60 d. On the contrary, a lower transcriptional response was observed in aqua1 plants in concomitance with a higher Cd concentration in medial leaves. Moreover, PaHMA2 showed at 1 d an opposite trend within organs since it was up-regulated in root and stem of wt plants and in leaves of aqua1 plants. In summary, aqua1 overexpression in poplar improved Cd translocation suggesting a lower Cd sensitivity of aqua1 plants. This different response might be due to a different transcription of PaNRAMP3 genes that were more transcribed in wt line because of the importance of this gene in Cd compartmentalization.

Sign in / Sign up

Export Citation Format

Share Document