scholarly journals Retrospective study to identify risk factors for chronic kidney disease in children with congenital solitary functioning kidney detected by neonatal renal ultrasound screening

Medicine ◽  
2018 ◽  
Vol 97 (32) ◽  
pp. e11819 ◽  
Author(s):  
Adela Urisarri ◽  
Marta Gil ◽  
Natalia Mandiá ◽  
Luís Aldamiz-Echevarría ◽  
Roca Iria ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Retrospective Study ◽  
Kidney Disease ◽  
Renal Ultrasound ◽  
Ultrasound Screening ◽  
Solitary Functioning Kidney ◽  
Functioning Kidney

scholarly journals Renal Nitric Oxide Deficiency and Chronic Kidney Disease in Young Sheep Born with a Solitary Functioning Kidney

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Reetu R. Singh ◽  
Lawrence K. Easton ◽  
Lindsea C. Booth ◽  
Markus P. Schlaich ◽  
Geoffrey A. Head ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Solitary Functioning Kidney ◽  
Nitric Oxide Deficiency ◽  
Functioning Kidney

scholarly journals Efficacy And Renal Safety of Febuxostat In Management of Gout And Chronic Kidney Disease: A Retrospective Study

2021 ◽  
Author(s):  
Peiyu Zhang ◽  
Mo Chen ◽  
Jundi Wang ◽  
Shunjie Hu ◽  
Xiaoyong Lu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Retrospective Study ◽  
Kidney Disease ◽  
Logistic Regression Analysis ◽  
Serum Urate ◽  
Acute Arthritis ◽  
Renal Safety

Abstract Background: Elevated serum urate levels are associated with renal deterioration of chronic kidney disease (CKD). Whether urate-lowering treatment with febuxostat can improve renal function or attenuate the decline of the estimated glomerular filtration rate (eGFR) is controversial. The current study sought to explore efficacy and renal safety of febuxostat in gout patients with CKD and explore factors correlated with target serum urate (sUA).Methods: The current study was a single-center retrospective study comprising male gout patients with CKD. sUA, the rate of sUA < 360 µmol/L and renal safety were analyzed in subjects who had been treated with febuxostat for more than 44 weeks. Factors correlated with target sUA were explored by logistic regression analysis. Results: A total of 87 patients who had been diagnosed with gout and CKD met the inclusion criteria for the study. Twenty-five (28.73%) patients presented with stage 2 CKD, 58 (66.67%) were diagnosed with stage 3 CKD and 4 (4.60%) were diagnosed with stage 4 CKD. Analysis of sUA level showed a significant reduction at week 44~ (598.22 ± 95.11 µmol/L vs. 429.76 ± 123.45 μmol/L; P < 0.05), and the RAT increased to 34.50%. eGFR level of all patients was 52.37 ± 11.74 ml/min/1.73cm2 at baseline and 56.51 ± 15.01 ml/min/1.73cm2 at week 44~ (P < 0.05). The findings showed improvement of eGFR level in different stages of CKD, mainly in stage 3 CKD patients (P < 0.05). After stratification based on risk factors of hypertension, diabetic mellitus, hyperlipidemia and the usage of Non-Steroidal Anti-inflammatory Drugs (NSAIDs), the findings showed that eGFR levels of patients with ≤ 1 risk factors showed significant improvement (P < 0.05). Logistic regression analysis indicated that baseline sUA level and acute arthritis were correlated with the RAT in gout and CKD patients treated with febuxostat.Conclusions: In this retrospective study, febuxostat demonstrated effective and renal safety in gout patients with CKD. Baseline sUA level and acute arthritis may affect achieving of target sUA.

scholarly journals Comorbidities and Negative Prognostic Factors in Lebanese Patients Presenting with Acute Decompensated Heart Failure with Preserved Ejection Fraction: A Multicenter Retrospective Study

2021 ◽  
Vol 1 (1) ◽  
pp. 124-134
Author(s):  
Joseph El Khoury ◽  
Ronza Bachnak ◽  
Hiba El Assaad ◽  
Nahed Damaj ◽  
Jad Terro
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Chronic Kidney Disease ◽  
Retrospective Study ◽  
Kidney Disease ◽  
Ejection Fraction ◽  
Acute Decompensated Heart Failure ◽  
Decompensated Heart Failure ◽  
Preserved Ejection Fraction ◽  
Valvular Heart Diseases

Background: Congestive heart failure is responsible for repeated hospital admissions. It is classified into three types: (1) Heart Failure with reduced ejection fraction, (2) Heart failure with mid-range ejection fraction, and (3) Heart failure with preserved ejection fraction (HFpEF). It is essential to describe the risk factors of HFpEF patients' profiles as targeting them is crucial for management. Aim: Our retrospective study aims to identify the clinical and echocardiographic characteristics associated with HFpEF and its mortality among hospitalized patients with acute decompensated heart failure. Methods: 390 patients of all age groups presenting with acute heart failure decompensation at Mount Lebanon Hospital (MLH) and Middle East Institute of Health (MEIH, Bsalim) were recruited retrospectively between January 2014 and December 2016. We included 133 cases of HFpEF and collected data on each case including: baseline characteristics and comorbidities, electrocardiograms, laboratory studies, and echocardiographic parameters. Results: The 133 Lebanese patients having HFpEF were elderly (76 ± 10 years), with predominantly female gender (56%). Hypertension (87.96%) and diabetes (53.38%) were the most frequently reported comorbidities. The overall in-hospital mortality was 4.5%. Data was compared between living and deceased patients and the frequency of valvular heart disease (p=0.005) and chronic kidney disease (p=0.018) was significantly higher among deceased patients. Right ventricular (RV) dilation on echocardiography was significantly correlated with mortality. Elevated troponin, increased creatinine, hypochloremia, hyponatremia, and anemia were all lab markers associated with increased mortality (p<0.05). Conclusion: Patients with HFpEF represent 43.5% of all decompensated HF cases, with chronic kidney disease, valvular heart diseases, anemia and troponinemia, being the predominant risk factors for adverse clinical outcomes. HFpEF remains an enormous burden on cardiologists for appropriate evaluation, triage, and management.

Factors Increasing Risk of Septicemia in Acute Cholycystectomy Patients

2021 ◽  
Vol 15 (11) ◽  
pp. 3155-3156
Author(s):  
Shafqat Ullah ◽  
Samina Karim ◽  
Dileep Kumar ◽  
Muhammad Aqil Razzaq ◽  
Muhammad Hanif ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Retrospective Study ◽  
Kidney Disease ◽  
Clinical History ◽  
Medical College ◽  
Systematic Inflammatory Response Syndrome ◽  
Operative Complications ◽  
The Mean ◽  
Increasing Risk

Background: Septicemia is defined as systematic inflammatory response syndrome which is formed as a result of an infection. Objective: To identify the factors increasing risk of septicemia in acute cholecystectomy patients. Study Design: Retrospective study Place and Duration of Study: Department of Surgery, Sahara Medical College, Narowal from 1st August 2020 to 31st May 2021. Methodology: One hundred and seventy acute cholecystectomy patients were enrolled. The patient’s demographic, clinical history, comorbidities and post-operative complications were listed. All procedures were done through laparoscopic method. Results: There were 54.1% females and 45.9% males. The mean age of patients was 52.17±14.33 years. There were 11.7% cases who developed septicemia. The immune deficient patients were 0.9% and 1.8% had perforated gall bladder. There were 2.7% cases having obesity, cirrhosis or complicated diabetes with 3.6% having chronic kidney disease. Conclusion: The factors of complicated diabetes, cirrhosis, obesity and chronic kidney disease are associated with risk of septicemia in acute cholecystectomy. Key words: Cholecystectomy, Septicemia, Risk factors, Obesity, Chronic kidney disease

Stroke in chronic renal failure

2008 ◽  
Vol 149 (15) ◽  
pp. 691-696
Author(s):  
Dániel Bereczki
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Disease ◽  
Chronic Renal Disease ◽  
Kidney Diseases ◽  
Cerebrovascular Diseases ◽  
Lipid Lowering ◽  
Increased Risk ◽  
Intracerebral Hemorrhages

Chronic kidney diseases and cardiovascular diseases have several common risk factors like hypertension and diabetes. In chronic renal disease stroke risk is several times higher than in the average population. The combination of classical risk factors and those characteristic of chronic kidney disease might explain this increased risk. Among acute cerebrovascular diseases intracerebral hemorrhages are more frequent than in those with normal kidney function. The outcome of stroke is worse in chronic kidney disease. The treatment of stroke (thrombolysis, antiplatelet and anticoagulant treatment, statins, etc.) is an area of clinical research in this patient group. There are no reliable data on the application of thrombolysis in acute stroke in patients with chronic renal disease. Aspirin might be administered. Carefulness, individual considerations and lower doses might be appropriate when using other treatments. The condition of the kidney as well as other associated diseases should be considered during administration of antihypertensive and lipid lowering medications.

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