Quality of Life of Patients With Advanced HIV/AIDS: Measuring the Impact of Both AIDS-Defining Events and Non-AIDS Serious Adverse Events

Background and aimHypoglossal nerve stimulation (HNS) decreases obstructive sleep apnoea (OSA) severity via genioglossus muscle activation and decreased upper airway collapsibility. This study assessed the safety and effectiveness at 6 months post-implantation of a novel device delivering bilateral HNS via a small implanted electrode activated by a unit worn externally, to treat OSA: the Genio™ system.MethodsThis prospective, open-label, non-randomised, single-arm treatment study was conducted at eight centres in three countries (Australia, France and the UK). Primary outcomes were incidence of device-related serious adverse events and change in the apnoea–hypopnoea index (AHI). The secondary outcome was the change in the 4% oxygen desaturation index (ODI). Additional outcomes included measures of sleepiness, quality of life, snoring and device use. This trial was registered with ClinicalTrials.gov, number NCT03048604.Results22 out of 27 implanted participants (63% male, aged 55.9±12.0 years, body mass index (BMI) 27.4±3.0 kg·m−2) completed the protocol. At 6 months BMI was unchanged (p=0.85); AHI decreased from 23.7±12.2 to 12.9±10.1 events·h−1, a mean change of 10.8 events·h−1 (p<0.001); and ODI decreased from 19.1±11.2 to 9.8±6.9 events·h−1, a mean change of 9.3 events·h−1 (p<0.001). Daytime sleepiness (Epworth Sleepiness Scale; p=0.01) and sleep-related quality of life (Functional Outcomes of Sleep Questionnaire-10; p=0.02) both improved significantly. The number of bed partners reporting loud, very intense snoring, or leaving the bedroom due to participant snoring decreased from 96% to 35%. 91% of participants reported device use >5 days per week, and 77% reported use for >5 h per night. No device-related serious adverse events occurred during the 6-month post-implantation period.ConclusionsBilateral HNS using the Genio™ system reduces OSA severity and improves quality of life without device-related complications. The results are comparable with previously published HNS systems despite minimal implanted components and a simple stimulation algorithm.

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Instrumen Pengukuran Kualitas Hidup Anak Terinfeksi HIV

Kesmas National Public Health Journal ◽

10.21109/kesmas.v6i3.103 ◽

2011 ◽

Vol 6 (3) ◽

pp. 126

Author(s):

Toha Muhaimin ◽

Budi Utomo ◽

Dharmayati B. Utoyo ◽

Nia Kurniati ◽

Triyanti Anugrahini ◽

...

Keyword(s):

Quality Of Life ◽

Measurement Instrument ◽

Immune Deficiency Syndrome ◽

Deficiency Syndrome ◽

Cronbach’S Alpha ◽

Cronbach's Alpha ◽

Special Instrument ◽

The Impact ◽

Hiv Aids

Anak penderita Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) di Indonesia memperlihatkan tren yang semakin meningkat karena meningkatnya proporsi perempuan terinfeksi HIV/AIDS. Pertimbangan pada dampak besar yang dihadapi anak penderita HIV mendorong kebutuhan pengembangan instrumen khusus untuk mengukur kualitas hidup mereka. Penelitian ini bertujuan mengembangkan instrumen kualitas hidup anak penderita AIDS dengan memodifikasi instrumenyang ada sesuai dengan konteks Indonesia. Pada penelitian ini ditemukan hasil bahwa instrumen yang dikembangkan mempunyai reliabilitas yang cukup baik pada balita dan anak usia 5 – 11 tahun. Nilai reliabilitas (Cronbach’s Alpha) balita, domain fungsi fisik, fungsi sosial, dan gejala HIV masing masing adalah 0,71; 0,72; dan 0,88, sedangkan pada anak 5 – 11 tahun, domain fungsi-fungsi fisik, psikologis, sosial, sekolah, dan gejala terkait HIV masing-masing 0,76; 0,89; 0,67; 0,67; dan 0,88. Penelitian ini menunjukkan untuk konteks Indonesia, nilai ambang batas CD4 yang menunjukkan perbedaan kualitas hidup adalah 15%. Pada balita, dari berbagai ketiga domain, hanya domain gejala terkait HIV yang cukup sensitif untuk mendeteksi perbedaan kualitas hidup anak, sementara pada anak 5 – 11 hanya domain fungsi fisik dan fungsi psikologis yang cukup sensitif untuk mendeteksi perbedaan kualitas hidup anak. Penelitian ini menunjukkan bahwa dampak HIV pada anak masih terkonsentrasi pada gangguan fungsi fisik, fungsi psikologis, dan gejala terkait HIV.Kata kunci: Instrumen pengukuran, anak terinfeksi HIV, kualitas hidupAbstractChildren with HIV/AIDS in Indonesia are increasing due to the increase of woman with HIV. A special instrument for measuring quality of life (QoL) of children with HIV is needed to be developed as the great impact of the infection to children. This study was conducted by modifying the existing QoL instrument of children for Indonesian context. The study indicated that thereliability of the instrument is quite good both for children under 5 and 5 – 11 years old. Reliability values (Cronbach’s Alpha) for under 5, domains of physical function, social function, and HIV-related symptoms are 71, 72, and 88 respectively while for children 5 – 11 years old, domains of physical, psychological, social, and school functions, and HIV-related symptoms are 76, 89, 67, 67, and 88 respectively. The study showed, for Indonesian context, 15% of CD4 is indicated as the threshold to detect the difference of QoL forchildren with HIV. However, for under 5 years old, only questions of HIV-related symptoms domain which is sensitive to detect difference QoL, whereas for children of 5 – 11 years old, the questions concerning physical and psychological domains which are sensitive to detect difference QoL. The study indicated that the impact of HIV on children is mostly on physical andpsychological functions and HIV-related symptoms.Key words: Measurement instrument, children with HIV, quality of life

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Retrospective Chart Review of Cryopreserved Amniotic Membrane for Knee Pain

Journal of Regenerative Biology and Medicine ◽

10.37191/mapsci-2582-385x-2(6)-047 ◽

2020 ◽

Author(s):

Ruben Berrocal Timmons

Keyword(s):

Quality Of Life ◽

Adverse Events ◽

Amniotic Membrane ◽

Chart Review ◽

Retrospective Chart Review ◽

Final Analysis ◽

Mean Values ◽

Number Of Patients ◽

The Impact

Objective: Treatment of joint pain with an injection of the amniotic membrane has not been adequately studied. This study retrospectively reviewed Visual Analog Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and analgesic usage data from patients treated with the injection of cryopreserved amniotic membrane (CAM) in their knees to determine the impact of treatment on patients’ pain, quality of life, and analgesic usage. Methods: Chart review was conducted on 40 patients. Institutional Review Board (IRB) approval was obtained prior to initiation of the project. The membrane was utilized as per the FDA guidance of 21CFR1271. Retrospective data, including demographics, medical history, pain score, quality of life score, analgesic usage and adverse events, were collected from their medical records for each consenting patient through 6 months after CAM injection. Results: A total of 40 patients were considered in the final analysis. Mean VAS for pain level improved from 7.0 to 2.6 (p<0.001). WOMAC daily activity function score improved from a mean score of 52 to 28 (p<0.001). Opioid and non-steroidal anti-inflammatory drug (NSAID) usage decreased from 97% to 25% (p<0.001). No adverse events were reported. Conclusion: Mean values for VAS and WOMAC scores significantly improved at all time points and the number of patients who used analgesics decreased as compared to baseline. CAM injection into painful knee joints decreases pain, improves physical function, and decreases the use of analgesics in the absence of adverse events.

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008 Associations between comorbidities and adverse events of antiepileptic drugs and quality of life: a survey of epilepsy patients in australia

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp-2019-anzan.8 ◽

2019 ◽

Vol 90 (e7) ◽

pp. A3.2-A3

Author(s):

Jeremy M Welton ◽

Christine Walker ◽

Kate Riney ◽

Alvin Ng ◽

Lisa M Todd ◽

...

Keyword(s):

Quality Of Life ◽

Adverse Events ◽

Antiepileptic Drugs ◽

List Type ◽

Linear Regression Models ◽

Cross Sectional ◽

Stepwise Selection ◽

Memory Problems ◽

The Impact

IntroductionThis study explored the impact of specific types of comorbidities and adverse events (AEs) from antiepileptic drugs (AEDs) on quality of life (QoL) among adult patients with epilepsy (PwE) in Australia.MethodsCross-sectional surveys were completed by PwE, or caregiver proxies, recruited via the online pharmacy application MedAdvisor and Australian PwE Facebook groups from May–August 2018 Data were collected on demographics, epilepsy severity and management, AEs, comorbidities, and QoL (using QOLIE-10-P total score).1 Multiple linear regression models were constructed to explore associations between AEs or comorbidities and QOLIE-10-P, with possible confounders determined using stepwise selection.Results978 responses were included (mean age 44.5 years, 64% female, 52% employed). 97% reported recent AED use, 47% on AED monotherapy, 35% exposed to ≤2 lifetime AEDs, and 55% seizure-free for >1 year. After stepwise selection, control variables included in both models were: time since diagnosis, employment status, seizure frequency, number of currently prescribed AEDs, and number of general practitioner visits per year. In the model for comorbidities, ‘psychiatric disorders’ was associated with the largest QOLIE-10-P decrease (-23.30, p<0.001). In the model for AEs, which additionally controlled for depression and anxiety disorder, ‘memory problems’ was associated with the largest decrease in QOLIE-10-P (-14.27, p<0.001).ConclusionsIn this survey of Australian PwE, of which many had relatively well-controlled epilepsy, psychiatric and memory problems were common and associated with the greatest detrimental impact on QoL. Further research is needed to understand causality, relationships between possibly interrelated or overlapping symptoms, and management strategies. UCB Pharma-sponsored.ReferenceCramer JA, Perrine K, Devinsky O, Meador K. A brief questionnaire to screen for quality of life in epilepsy: The QOLIE-10. Epilepsia 1996;37:577–582.

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Depressive and Bipolar Disorders

10.1093/med/9780199392742.003.0015 ◽

2017 ◽

Author(s):

Antoine Douaihy ◽

Matthew Conlon ◽

Maria Ferrara

Keyword(s):

Quality Of Life ◽

Antiretroviral Therapy ◽

Sexual Behaviors ◽

Depressive Disorders ◽

Bipolar Disorders ◽

Poor Quality ◽

Persons Living With Hiv ◽

The Impact ◽

Hiv Aids

Depressive disorders are highly prevalent among persons living with HIV/AIDS. Depressive disorders significantly negatively affects adherence to antiretroviral therapy and HIV viral suppression and is associated with poor quality of life and major impairment in overall functioning. This chapter reviews the prevalence, risk factors, assessment and diagnosis of depressive and bipolar disorders. It also examines the impact of depression on sexual behaviors, adherence to antiretroviral therapy, quality of life, and mortality. This chapter also includes a comprehensive discussion of treatment approaches and considerations for HIV-infected individuals with depressive disorders. Furthermore, it reviews the bipolar disorder spectrum in HIV/AIDS as well as other psychiatric disorders co-occurring with depressive disorders.

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Clinical determinants associated with quality of life for people who live with HIV/AIDS: a Meta-analysis

BMC Health Services Research ◽

10.1186/s12913-019-4659-z ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 11

Author(s):

Hesam Ghiasvand ◽

Katherine M. Waye ◽

Mehdi Noroozi ◽

Gholamreza Ghaedamini Harouni ◽

Bahram Armoon ◽

...

Keyword(s):

Quality Of Life ◽

Confidence Interval ◽

Effect Size ◽

Meta Analysis ◽

Random Effect Model ◽

Cd4 Count ◽

Co Morbidity ◽

The Impact ◽

Hiv Aids

Abstract Background During recent years, Quality of Life (QoL) is a significant assessment factor in clinical trials and epidemiological researches due to the advent of Antiretroviral Therapy (ART), Human Immunodeficiency Virus (HIV) has become a manageable,chronic disease. With regards, more attention must be paid to the QoL of infected patients. Limited evidence exists on the impact of ART on QoL among HIV infected patients. Due to lacking of a systematic approach to summarizing the available evidence on the clinical determinants of People Who Live with HIV/AIDS (PWLHs’) QoL, this study aimed to analyze the impact of clinical determinants (ART experience, CD4 count < 200, co-morbidities, time diagnosis and accessibility to cares) on QoL among PWLHs’. Methods This study was designed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). PubMed, Science Direct, Web of Science, and Cochrane electronic databases were searched in February 2017 to identify all past studies that discussed social and behavioral characteristics of QoL in PLWHA. To recognize effective factors on social and behavioral QoL, a meta-analysis was conducted. Polled Odds Ratios (ORs) were utilized at a 95% confidence level. Since sampling methods differed between articles in the systematic review, we evaluated pooled estimates using a random effect model. Metan, metareg, metacum, and metabias commands in STATA version 13.0 were applied to analyze the data. Results Our findings indicated that ART has a positive impact on QoL, with a pooled effect size at approximately 1.04 with a confidence interval between 0.42 to 1.66 which indicates this impact is not very considerable and may be relatively neutral. The pooled effect size for CD4 count on QoL was .29 (95%CI = .22–.35), indicating that there is a negative associate between CD4 count and QoL. The co-morbidity as a negative determinant for QoL among HIV/AIDS infected people. The pooled effect size implies on a relative neutral association, although the confidence interval is wide and ranges between 0.32 to 1.58. The pooled effect size is about 1.82 with confidence interval 1.27 to 2.37 which indicates a considerable positive association with lowest level of heterogeneity. Conclusions The results illustrated that time diagnosing and availability to hospital services had significant relationship with a higher QoL and CD4 < 200 was associated with a lower QoL. In conclusion, policy makers should set an agenda setting to provide a suitable diagnostic and therapeutic facilities to early detecting and continues monitoring the health status of People Who Live with HIV/AIDS (PWLHs’).

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Quality-of-Life (QOL) during Screening for Phase 1 Trial Studies in Patients with Advanced Solid Tumors and Its Impact on Risk for Serious Adverse Events

Cancers ◽

10.3390/cancers9070073 ◽

2017 ◽

Vol 9 (12) ◽

pp. 73 ◽

Cited By ~ 5

Author(s):

Sidra Anwar ◽

Wei Tan ◽

Chi-Chen Hong ◽

Sonal Admane ◽

Askia Dozier ◽

...

Keyword(s):

Quality Of Life ◽

Adverse Events ◽

Solid Tumors ◽

Phase 1 ◽

Advanced Solid Tumors ◽

Serious Adverse Events ◽

Phase 1 Trial

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Epidemiology, etiology, and pathogenesis of tendinopathy among athletes

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20215022 ◽

2021 ◽

Vol 9 (1) ◽

pp. 437

Author(s):

Syed Asif Hasan ◽

Ahmed Abdulrahman Othman ◽

Yousuf Kamal Shagdar ◽

Abdulrahman Anis Khan ◽

Amal Baalqasim Sulaimani ◽

...

Keyword(s):

Quality Of Life ◽

Literature Review ◽

Nerve Fibers ◽

Systemic Diseases ◽

Extrinsic Factors ◽

Serious Adverse Events ◽

Professional Careers ◽

The Impact ◽

Intrinsic And Extrinsic Factors

The treatment of tendinopathy can be challenging for clinicians and might be associated with serious adverse events. However, evidence shows that tendinopathy can significantly impact the professional careers of the affected athletes. The main clinical features of the condition include decreased performance and strength of the affected tendons, swelling, and localized pain. Although tendinopathy might seem a non-critical condition, estimates show that it might be career-ending for many professional athletes, and therefore, reducing their quality of life. In the present literature review, we have discussed the epidemiology, etiology, and pathogenesis of tendinopathy among athletes. Different intrinsic and extrinsic factors were found to contribute to the development of the condition and the impact of various systemic diseases. Evidence also shows that the prevalence of the condition is high among athletes. However, these rates were variable across the different studies in the literature. This is probably owing to various factors, like demographics and the process of detection. The pathogenesis of the condition is also very complicated, and the development of pain has been attributed to the process of angiogenesis and associated ingrowth of nerve fibers.

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Impact of Mental wellbeing and Quality of Life on Depression, Anxiety and Stress among people living with HIV/AIDS (PLWHA)

International Journal of Indian Psychology ◽

10.25215/0301.147 ◽

2015 ◽

Vol 3 (1) ◽

Author(s):

Bhavna Mukund ◽

Rejani Thudalikunil Gopalan

Keyword(s):

Quality Of Life ◽

Well Being ◽

Mental Wellbeing ◽

People Living With Hiv ◽

Depression And Anxiety ◽

Living With Hiv ◽

The Impact ◽

Mental Well Being ◽

Hiv Aids

Background: People living with HIV/AIDS (PLWHA) manifest a wide range of stress responses ranging from disbelief, denial, fear to extreme conditions of anxiety disorders, depression and even suicidal thoughts. These complications can have a significant impact on daily functioning and greatly diminish quality of life. Mental wellbeing and Quality of Life can help in better management of stress and facilitate adaptive coping among PLWHA. Aim: The research examined the impact of mental wellbeing and Quality of Life on Depression, Anxiety and Stress among people living with HIV/AIDS infection. Research Design: Cross sectional survey design was used. Sample: A sample of 60 people (males and females of equal number) over the age of 18 years and with the diagnosis for HIV/AIDS for more than six months participated in the study. Tools used: To assess the depression, anxiety and stress among PLWHA, DASS scale was used and to assess their psychological wellbeing, Warwick Edinburgh Mental Well-Being scale was used. In order to assess their present status of QOL regarding the illness, WHO’s QOL HIV-BREF Scale was used. Results: Majority of the PLWHA had moderate level of anxiety and mild level of depression after being diagnosed. Most of the participants have positive mental well-being and had enhanced quality of life. Conclusion: A direct effect of mental wellbeing has been found on the depression, anxiety and stress among PLWHA indicating that higher the mental wellbeing of the PLWHA, the greater is the likelihood that they do not suffer from depression, exhibit less anxiety and are living a stress free life and vice versa. The study also found direct impact of QOL on psychological distress, depression and anxiety among PLWHA i.e. poor QOL of PLWHA makes them more prone to and vulnerable to stress, depression and anxiety and vice versa.

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