scholarly journals Ferrier Lecture - Some observations on the cerebral cortex of man

No greater honour could come to a Canadian surgeon than to be asked to give the Ferrier Lecture. But I reaIze that this invitation is rather a tribute to your associates across the Atlantic and a recognition of the fact that observations made in the operating room may have a value which is equal scientifically to those made in the laboratory. From a personal point of view, having received a major portion of my medical education in this country, I welcome the opportunity of paying tribute to English men of medicine and science. One of the most distinguished among them, at the close of the last century, was Sir David Ferrier, in whose memory his colleagues have founded this lectureship. He was an outstanding neurologist, psychologist and physiologist. But he was also the principal prophet of the surgery of the brain.

1936 ◽  
Vol 82 (337) ◽  
pp. 99-118 ◽  
Author(s):  
W. E. Le Gros Clark

The sensory material which provides the essential data for conscious activity is conveyed to the higher functional levels of the brain by impulses which stream up the olfactory tracts, the optic tracts, and the tracts of the brain-stem and spinal cord. With the exception only of the olfactory impulses, all these sensory impulses are filtered through the thalamic region of the brain, or diencephalon, before they can be relayed to the cerebral cortex which forms the anatomical substratum of the more elaborate mental processes. It is an interesting fact that, while the functional localization in the cerebral cortex and the functional localization in regard to the numerous fibre tracts in the brain-stem and spinal cord have been established in quite considerable detail by anatomical, physiological and clinical studies extending over many years, the localization and the connections of the various relay mechanisms in the diencephalon still remain obscure. Since the nature of the sensory material which is delivered to the cerebral cortex depends ultimately on the influences and modifications which may be imposed on the afferent impulses during their passage through the diencephalon, it becomes a matter of extreme importance, from the point of view of the study of the physiology of sensation and of psychological interpretation of sensory experience, that attention should be concentrated on this diencephalic mechanism. The minute anatomy of the diencephalon has recently been worked out in great detail, and it is now the task of the anatomist, physiologist and clinician to discover the functional significance of the numerous cell groups and fibre tracts which have been defined.


1945 ◽  
Vol 91 (383) ◽  
pp. 200-205 ◽  
Author(s):  
Gerald Caplan

Whatever the ultimate decision on the permanence of the results of electric convulsive therapy, there can be no doubt as to the present widespread popularity of this treatment in psychiatry. To meet the big demand there have become available in the last few years a number of different convulsant machines, most of which are fairly efficient, but not one being free from defects when exposed to the test of practical application. Some are too heavy and cumbersome, most are liable to minor technical breakdowns, which are the source of much annoyance because they disrupt the hospital routine, one has a faulty time switch which has caused the writer a considerable amount of anxiety when it jammed and allowed the current to flow for about 5 seconds—the patient developed a prolonged period of post-convulsive apnoea, but fortunately came round eventually and suffered no lasting ill-effects. Most machines incorporate one or more instruments to measure the current or the patient's resistance. Neymann et al. have shown the inaccuracy of such simple instruments, and it is doubtful whether they serve any useful purpose. The ammeters are relics of the early days of this treatment, when we were not sure about the safety range of the current, and they were included in the circuit as an extra safeguard. Our experience over the last five years has taught us what currents can be safely used, and an efficient convulsant machine can now be designed whose maximum voltage and maximum time give an output which is well within the limits of safety. A knowledge of the current used is of interest while the machine is undergoing the initial tests, but once this period is over its evaluation, even by an accurate method, is of little academic interest, and a waste of time from the point of view of the practical psychiatrist. The resistance measurements, too, are unnecessary in practice. They were originally made in the hope that they would enable the dosage to be correctly adjusted so as always to ensure a convulsion. But we now know, as Grey Walter has recently pointed out, that the convulsive threshold varies from individual to individual by as much as 1,000 per cent., and since it is a value which can only be found by a method of trial and error, the resistance instruments are of little use. Moreover, no great harm is done if an underdose actually is given—all that happens is that the patient has a temporary period of unconsciousness, and after a short interval a higher dose can be given, which will produce the desired convulsion. It is true, of course, as Kalinowsky (1939) said, that resistance measurements enable one to ensure that the electrodes are making good contact with the patient's skin, but one feels that this is an elaborate and costly method of doing something which could be more easily and quickly accomplished by training the nursing staff always to clean the patient's skin thoroughly before applying the dampened electrodes.


2021 ◽  
Vol 2 (1) ◽  
pp. 1-10
Author(s):  
Andrey Askarovich Badalov ◽  
Aleksandr Anatolievich Sorokin ◽  
Svetlana Nikolaevna Brovkina ◽  
Stepan Sergeevich Kalinin ◽  
Gulzhaina Kuralbaevna Kassymova ◽  
...  

In the article, from the point of view of evolutionary diatropics, a special cognitive structure of the personality is considered: the versative-ingenational-rapid intellectually gifted individual (VIR-type), which is the author's rethinking of the concept of urethral fixation by Z. Freud. The historical context of the formation of this concept is traced, its modern meaning is revealed, both from the point of view of the psychiatric clinic and from the position of pedagogical psychology. The material of the study of cross-correlation analysis of the electroencephalogram of 36 subjects with a VIR-type of personality demonstrates the features of the neurofunctioning of the cerebral cortex of these individuals: increased interaction of remote areas of the cortex and weakened integration of closely located zones. Illustrates the formation of a specific neurophysiological pattern, dubbed the “ikaric wings” and represents an intensive synchronization of the frontal and occipital lobes of the brain with the enhancement of their interaction both ipsilateral and contralateral. A comparison is made of the resulting pattern of functional activity of the cerebral cortex of the subjects with a VIR-type personality and patients with mental pathology. It is concluded that the presence of signs of mental disorders in the human population is necessary in order to form a special group of highly intelligent, creatively gifted individuals.


Author(s):  
S.S. Spicer ◽  
B.A. Schulte

Generation of monoclonal antibodies (MAbs) against tissue antigens has yielded several (VC1.1, HNK- 1, L2, 4F4 and anti-leu 7) which recognize the unique sugar epitope, glucuronyl 3-sulfate (Glc A3- SO4). In the central nervous system, these MAbs have demonstrated Glc A3-SO4 at the surface of neurons in the cerebral cortex, the cerebellum, the retina and other widespread regions of the brain.Here we describe the distribution of Glc A3-SO4 in the peripheral nervous system as determined by immunostaining with a MAb (VC 1.1) developed against antigen in the cat visual cortex. Outside the central nervous system, immunoreactivity was observed only in peripheral terminals of selected sensory nerves conducting transduction signals for touch, hearing, balance and taste. On the glassy membrane of the sinus hair in murine nasal skin, just deep to the ringwurt, VC 1.1 delineated an intensely stained, plaque-like area (Fig. 1). This previously unrecognized structure of the nasal vibrissae presumably serves as a tactile end organ and to our knowledge is not demonstrable by means other than its selective immunopositivity with VC1.1 and its appearance as a densely fibrillar area in H&E stained sections.


Author(s):  
Petar Kazakov ◽  
Atanas Iliev ◽  
Emil Ivanov ◽  
Dobri Rusev

Significant technical progress has been made in recent years in the development of algae-based bioenergy, and much of industrial and academic R&D projects have diverged from the biofuels strategy. This report summarizes the conclusions of a recently concluded symposium analyzing the prospects for using micro- and macroalgae as a feedstock for biofuels and bioenergy. It discusses international activities for the development of bio-energy and non-energy algae bioproducts, advances in the use of macroalgae (both non-cultivated and cultivated algae). Applications for various biochemical and thermochemical uses, bio-refining capabilities for various products, as well as an in-depth review of the process from the point of view of economy and energy sustainability are also given.


Author(s):  
Olena Karpenko ◽  
Tetiana Stoianova

The article is devoted to the study of personal names from a cognitive point of view. The study is based on the cognitive concept that speech actually exists not in the speech, not in linguistic writings and dictionaries, but in consciousness, in the mental lexicon, in the language of the brain. The conditions for identifying personal names can encompass not only the context, encyclopedias, and reference books, but also the sound form of the word. In the communicative process, during a free associative experiment, which included a name and a recipient’s mental lexicon. The recipient was assigned a task to quickly give some association to the name. The aggregate of a certain number of reactions of different recipients forms the associative field of a proper name. The associative experiment creates the best conditions for identifying the lexeme. The definition of a monosemantic personal name primarily includes the search of what it denotes, while during the process of identifying a polysemantic personal name recipients tend have different reactions. Scientific value is posed by the effect of the choice of letters for the name, sound symbolism, etc. The following belong to the generalized forms of identification: usage of a hyperonym; synonyms and periphrases or simple descriptions; associations denoting the whole (name stimulus) by reference to its part (associatives); cognitive structures such as “stimulus — association” and “whole (stimulus) — part (associative)”; lack of adjacency; mysterious associations. The topicality of the study is determined by its perspective to identify the directions of associative identification of proper names, which is one of the branches of cognitive onomastics. The purpose of the study is to identify, review, and highlight the directions of associative identification of proper names; the object of the research is the names in their entirety and variety; its subject is the existence of names in the mental lexicon, which determines the need for singling out the directions for the associative identification of the personal names.


Author(s):  
О.И. Кит ◽  
И.М. Котиева ◽  
Е.М. Франциянц ◽  
И.В. Каплиева ◽  
Л.К. Трепитаки ◽  
...  

Известно, что биогенные амины (БА) участвуют в злокачественном росте, их уровень изменяется в ЦНС при болевом воздействии, однако исследований о сочетанном влиянии хронической боли (ХБ) и онкопатологии на динамику БА в головном мозге не проводилось. Цель: изучить особенности баланса БА в коре головного мозга в динамике роста меланомы, воспроизведенной на фоне ХБ. Материалы и методы. Работа выполнена на 64 мышах-самках, весом 21-22 г. Животным основной группы меланому В16/F10 перевивали под кожу спины через 2 недели после перевязки седалищных нервов. Группой сравнения служили мыши с меланомой без боли. Уровни БА: адреналина, норадреналина, дофамина (ДА), серотонина (5-НТ), гистамина, а также 5-ОИУК определяли методом иммуноферментного анализа. Результаты. У мышей с ХБ уменьшается содержание большинства БА, однако уровень ДА не изменяется. Метаболизм 5-НТ происходит с участием МАО. Развитие меланомы сопровождается увеличением содержания ДА и 5-НТ, тогда как МАО - ингибируется. Направленность сдвигов БА при развитии меланомы на фоне ХБ оказалась практически такой же, как и без неё. В то же время ХБ ограничивает накопление 5-НТ в коре мозга при меланоме, что сопровождается более агрессивным её течением. Выводы. ХБ ограничивает включение стресс-лимитирующих механизмов в головном мозге при развитии меланомы у мышей, что приводит к более агрессивному течению злокачественного процесса. Biogenic amines (BA) are known to be involved in malignant growth, and their CNS levels change in pain; however, there are no studies of combined effects of chronic pain (CP) and cancer on BA dynamics in the brain. Aim: To study features of BA balance in the cerebral cortex during melanoma growth associated with CP. Material and methods. The study included 64 female mice weighing 21-22 g. In the main groups, B16/F10 melanoma was transplanted under the skin of the back two weeks following sciatic nerve ligation. Mice with melanoma without pain were used as the control. Concentrations of BA: adrenaline, noradrenaline, dopamine (DA), serotonin (5-HT), histamine and 5-HIAA were measured with ELISA. Results. Concentrations of BAs decreased in mice with CP although DA levels did not change. 5-HT metabolism involved MAO. The development of melanoma was accompanied by increases in DA and 5-HT whereas MAO was inhibited. The direction of BA changes during the development of melanoma was the same with and without CP. At the same time, CP with melanoma limited accumulation of 5-HT in the cerebral cortex, which resulted in even more aggressive course of cancer. Conclusion. CP restricted the activation of cerebral stress-limiting mechanisms during the development of melanoma in mice, which resulted in a more aggressive course of disease.


Author(s):  
Helena De Preester

This chapter argues that the most basic form of subjectivity is different from and more fundamental than having a self, and forwards a hypothesis about the origin of subjectivity in terms of interoception. None of those topics are new, and a consensus concerning the homeostatic-interoceptive origin of subjectivity is rapidly growing in the domains of the neurosciences and psychology. This chapter critically explores that growing consensus, and it argues that the idea that the brain topographically represents bodily states is unfit for thinking about the coming about of subjectivity. In the first part, four inherent characteristics of subjectivity are discussed from a philosophical phenomenological point of view. The second part explores whether a model of subjectivity in which interoception maintains its crucial role is possible without relying on topographical representations of the in-depth body, and giving due to the inherent characteristics of subjectivity.


2021 ◽  
Vol 21 (1-2) ◽  
pp. 56-71
Author(s):  
Janet van Niekerk ◽  
Haakon Bakka ◽  
Håvard Rue

The methodological advancements made in the field of joint models are numerous. None the less, the case of competing risks joint models has largely been neglected, especially from a practitioner's point of view. In the relevant works on competing risks joint models, the assumptions of a Gaussian linear longitudinal series and proportional cause-specific hazard functions, amongst others, have remained unchallenged. In this article, we provide a framework based on R-INLA to apply competing risks joint models in a unifying way such that non-Gaussian longitudinal data, spatial structures, times-dependent splines and various latent association structures, to mention a few, are all embraced in our approach. Our motivation stems from the SANAD trial which exhibits non-linear longitudinal trajectories and competing risks for failure of treatment. We also present a discrete competing risks joint model for longitudinal count data as well as a spatial competing risks joint model as specific examples.


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