III. Some remarks on the physiological action of the
Tanghinia venenifera
The famous poison-tree of Madagascar was described for the first, time by Aubert du Petit Thouars in his ‘Genera Madagascarensia,’ under the name of Tanghinia venenifera . At a later period, Sir W. Hooker published a good description, with a figure of this tree, named by him Cerbera Tanghin (see Botanical Magazine, pi. 2968), so that nothing is wanted with regard to the botanical knowledge of this plant. On the other hand, the physiological effects of its poisonous parts have not been hitherto investigated. All we know is, that the fruit of the Tanghinia is a strong poison, and is used in Madagascar as an ordeal poison in the most strange and revolting way. The only experiment on animals made by Ollivier, showed that 12 grains kill a dog in some hours, but this experiment gave no further in sight into the real action of the Tanghinia. We hope, therefore, that the Royal Society will take some interest in the experiments which we undertook with this poison, of which the following is a short abstract. The poison used by us was the alcoholic extract of the leaves and small stems of the Tanghinia, prepared from dried specimens, which Prof. Pelikan had received from Count Seyderitz of Mecklenburg. About one centigram of this extract was sufficient to show the full effect of the poison on frogs, when introduced into a wound of the back. It acted also when given by the mouth, but in this case a somewhat larger dose was required to produce a full effect.