Proteins with SH2 and SH3 domains couple receptor tyrosine kinases to intracellular signalling pathways
1993 ◽
Vol 340
(1293)
◽
pp. 279-285
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Keyword(s):
The targets of receptor protein-tyrosine kinases are characterized by Src homology 2 (SH2) domains, that mediate specific interactions with receptor autophosphorylation sites. SH 2-mediated interactions are important for the activation of biochemical signalling pathways in cells stimulated with growth factors. A distinct protein module, the SH3 domain, is frequently found in polypeptides that contain SH2 domains, and is also implicated in controlling protein-protein interactions in signal transduction. Evidence suggesting that SH2 and SH3 domains act synergistically in stimulation of the Ras pathway is discussed.
2007 ◽
Vol 35
(5)
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pp. 966-969
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1992 ◽
Vol 12
(4)
◽
pp. 1835-1845
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Keyword(s):
1992 ◽
Vol 12
(4)
◽
pp. 1835-1845
Keyword(s):
2003 ◽
Vol 185
(14)
◽
pp. 4081-4086
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Keyword(s):
1994 ◽
Vol 14
(7)
◽
pp. 4509-4521
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