Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirus
2003 ◽
Vol 84
(3)
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pp. 567-572
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We have investigated the contribution of the interferon (IFN)-α/β system, IFN-γ and nitric oxide to recovery from infection with Murray Valley encephalitis virus, using a mouse model for flaviviral encephalitis where a small dose of virus was administered to 6-week-old wild-type and gene knockout animals by the intravenous route. We show that a defect in the IFN-α/β responses results in uncontrolled extraneural virus growth, rapid virus entry into the brain and 100 % mortality. In contrast, mice deficient in IFN-γ or nitric oxide production display an only marginally increased susceptibility to infection with the neurotropic virus.
2015 ◽
Vol 112
(8)
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pp. 2431-2436
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1999 ◽
Vol 66
(6)
◽
pp. 974-980
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2001 ◽
Vol 69
(12)
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pp. 7711-7717
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