scholarly journals Incidental identification of maternal malignancies in two Asian women underwent noninvasive prenatal test

2016 ◽  
Author(s):  
Xing Ji ◽  
Fang Chen ◽  
Yafeng Zhou ◽  
Jia Li ◽  
Yuying Yuan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
False Positive ◽  
Malignant Tumors ◽  
Asian Population ◽  
Trisomy 13 ◽  
Asian Women ◽  
Aberrant Chromosome ◽  
Prenatal Test ◽  
First Time ◽  
Positive Results

AbstractNoninvasive prenatal test (NIPT) has been widely used as a screening test for trisomy 13, 18 and 21 worldwide. Recently, coexistence of maternal malignancy and pregnancy has drawn increasing attention in NIPT studies. Malignancy in pregnant women potentially affected NIPT results, which may cause false positive results or failed tests. However, no such case has ever been reported in Asian population. In this study, for the first time, we reported a stage III dysgerminoma and advanced gastric cancer during pregnancy accidentally identified during NIPT tests. These two women showed aberrant chromosome aneuploidies in NIPT results and concordant pattern of genome disruption found in tumor samples. The findings in this study further validate the effect of maternal malignancy on NIPT results and strengthen the possibility of detecting malignant tumors through NIPT in the future.

Trisomy 13 or 18 (mosaicism) in first trimester cytotrophoblast cells: false-positive results in 11 out of 51 cases

2002 ◽  
Vol 101 (2) ◽  
pp. 161-168 ◽  
Author(s):  
G.Heleen Schuring-Blom ◽  
Kees Boer ◽  
Alida C Knegt ◽  
Marjan Verjaal ◽  
Nico J Leschot
Keyword(s):  
False Positive ◽  
First Trimester ◽  
Trisomy 13 ◽  
Cytotrophoblast Cells ◽  
Positive Results

False-positive galactomannan antigen testing in pulmonary nocardiosis

2020 ◽  
Author(s):  
Arnon Haran ◽  
Violeta Temper ◽  
Marc Assous ◽  
Michael Bergel ◽  
Noga Chahanian ◽  
...  
Keyword(s):  
At Risk ◽  
Early Diagnosis ◽  
False Positive ◽  
Clinical Sample ◽  
Lavage Fluid ◽  
Enzyme Linked Immunosorbent Assay ◽  
Pulmonary Nocardiosis ◽  
First Time ◽  
Positive Results

Abstract Early diagnosis of invasive aspergillosis (IA) is facilitated by detection of galactomannan (GM) in serum and bronchoalveolar lavage fluid (BALF) using an enzyme-linked immunosorbent assay (ELISA). Although accurate, false positive results have been reported with these tests in numerous contexts. We report for the first time the occurrence of false positive GM ELISA due to nocardiosis, initially in a clinical sample of BALF from a patient with pulmonary nocardiosis, and subsequently corroborated by in vitro reactivity of 26% of tested isolates. Since patients at risk for IA are also at risk for nocardiosis, this finding has important clinical implications. Lay Summary Early diagnosis of aspergillosis has been facilitated by the routine use of antibody-based detection of galactomannan in various bodily fluids. We report for the first time the occurrence of false positive results of this assay in the context of nocardiosis.

Critical Evaluation of Impedance Phlebography for the Diagnosis of Deep Vein Thrombosis

1974 ◽  
Vol 31 (02) ◽  
pp. 273-278
Author(s):  
Kenneth K Wu ◽  
John C Hoak ◽  
Robert W Barnes ◽  
Stuart L Frankel
Keyword(s):  
Deep Vein Thrombosis ◽  
False Positive ◽  
False Negative ◽  
Critical Evaluation ◽  
Original Method ◽  
Vein Thrombosis ◽  
Negative Results ◽  
False Negative Results ◽  
Deep Vein ◽  
Positive Results

SummaryIn order to evaluate its daily variability and reliability, impedance phlebography was performed daily or on alternate days on 61 patients with deep vein thrombosis, of whom 47 also had 125I-fibrinogen uptake tests and 22 had radiographic venography. The results showed that impedance phlebography was highly variable and poorly reliable. False positive results were noted in 8 limbs (18%) and false negative results in 3 limbs (7%). Despite its being simple, rapid and noninvasive, its clinical usefulness is doubtful when performed according to the original method.

The new in monitoring of provision of cancer care in the Russian Federation

2019 ◽  
Vol 2019 (4) ◽  
pp. 35-37
Author(s):  
Наталья Стадченко ◽  
Natal'ya Stadchenko
Keyword(s):  
Russian Federation ◽  
Treatment Guidelines ◽  
Malignant Tumors ◽  
Patient Specific ◽  
Insurance Fund ◽  
Medical Aid ◽  
Proven Case ◽  
The Russian Federation ◽  
Positive Results ◽  
Made In

The Federal Compulsory Medical Insurance Fund created the system of a monitoring of medical aid provided for the oncology patients, which allows realizing control over execution of the treatment guidelines on every stage. Changes been made in the governing documents, aimed at development of patient-specific records of provided medical aid at suspicion on the malignant tumors or in proven case of the malignant tumors. The article presents the data on control and expert activities demonstrating positive results of that work.

A RARE CASE OF METASTASIS OF GASTRIC CANCER IN THE SPLEEN

2017 ◽  
Vol 63 (1) ◽  
pp. 153-154
Author(s):  
Oleg Kit ◽  
Yevgeniy Kolesnikov ◽  
Mikhail Kozhushko ◽  
Aleksandr Snezhko
Keyword(s):  
Gastric Cancer ◽  
Rare Case ◽  
Clinical Observation ◽  
Malignant Tumors

The spleen’s damage by metastases of malignant tumors is occasional. There is presented a clinical observation of rare isolated metastasis of gastric cancer in the spleen without concomitant dissemination that is interesting.

Comparison of two rapid tests for the detection of legionellaceae in water: a microbiological-immunological method and a commercial gene-probe testkit

1995 ◽  
Vol 31 (5-6) ◽  
pp. 403-406 ◽  
Author(s):  
E. Frahm ◽  
U. Obst
Keyword(s):  
Monoclonal Antibodies ◽  
Conventional Method ◽  
Standard Method ◽  
False Positive ◽  
Gene Probe ◽  
Immunological Method ◽  
Probe Test ◽  
Rapid Tests ◽  
Positive Results

Two recently developed Legionella detection tests, a microbiological-immunological method based on monoclonal antibodies (carried out as a colony-blot assay) and a commercial gene-probe testkit (the EnvironAmp Legionella Kit), are compared with the standard method. The colony-blot assay is faster than the conventional method; the gene-probe test is much faster still and is the most sensitive, but in consequence is at greater risk of false-positive results.

scholarly journals MiRNA Expression in Neuroendocrine Neoplasms of Frequent Localizations

2021 ◽  
Vol 7 (3) ◽  
pp. 38
Author(s):  
Alexandra Korotaeva ◽  
Danzan Mansorunov ◽  
Natalya Apanovich ◽  
Anna Kuzevanova ◽  
Alexander Karpukhin
Keyword(s):  
Mirna Expression ◽  
Malignant Tumors ◽  
Neuroendocrine Neoplasms ◽  
Specific Expression ◽  
Clinical Biomarkers ◽  
Different Types ◽  
Functional Features ◽  
First Time ◽  
Potential Biomarkers

Neuroendocrine neoplasms (NEN) are infrequent malignant tumors of a neuroendocrine nature that arise in various organs. They occur most frequently in the lungs, intestines, stomach and pancreas. Molecular diagnostics and prognosis of NEN development are highly relevant. The role of clinical biomarkers can be played by microRNAs (miRNAs). This work is devoted to the analysis of data on miRNA expression in NENs. For the first time, a search for specificity or a community of their functional characteristics in different types of NEN was carried out. Their properties as biomarkers were also analyzed. To date, more than 100 miRNAs have been characterized as differentially expressed and significant for the development of NEN tumors. Only about 10% of the studied miRNAs are expressed in several types of NEN; differential expression of the remaining 90% was found only in tumors of specific localizations. A significant number of miRNAs have been identified as potential biomarkers. However, only a few miRNAs have values that characterized their quality as markers. The analysis demonstrates the predominant specific expression of miRNA in each studied type of NEN. This indicates that miRNA’s functional features are predominantly influenced by the tissue in which they are formed.

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