scholarly journals Incidence of atrial septal defects in children attended the Cardiac Center of Ethiopia during January 2016 to December 2018

2020 ◽  
Author(s):  
Abdu Hassen Musa ◽  
Mekbeb Afework ◽  
Mohammed Bedru ◽  
Shibikom Tamirat ◽  
Keyword(s):  
Young Children ◽  
Addis Ababa ◽  
Age Groups ◽  
Surgical Closure ◽  
Septal Defects ◽  
Large Size ◽  
Echocardiographic Findings ◽  
Cardiac Center ◽  
Infants And Young Children

AbstractBackgroundAlthough it appears that an atrial septal defect (ASD) occurs frequently in Ethiopia there are only a few published studies available so far on this matter. This study is therefore aimed to evaluate the prevalence and echocardiographic characteristics of ASDs in children (aged ≤ 15 years) attended a cardiac referral center in Ethiopia.MethodsThis retrospective study reviewed the sociodemographic data and the initial echocardiographic findings of the children with ASDs who were diagnosed at the Cardiac Center of Ethiopia (CCE), Addis Ababa, from January 2016 to December 2018.ResultsA total of 116 children (56.9% females and 43.1% males) with a mean age of 3.47± 3.72 years (range: 15 days to 15 years) were diagnosed with ASDs. The most prevalent age groups were infancy (50%) and early childhood (29.3%). All the studied cases were diagnosed with ostium secundum ASD while there were no cases with ostium primum, sinus venosus and coronary sinus defects. The most frequent ostium secundum ASD was large size (61.2%) and was more frequent in infants (23.3%) and young children (21.6% of all cases).ConclusionOstium secundum ASD is the most prevalent IAS defect and more common among female cases. Large size ostium secundum ASD is more frequent in the studied children and is more prevalent in infants and young children. This survey may provide data for the currently lacking statistics on ASDs at the CCE and might be helpful for the management and follow-up of children with ASDs. Scheduled follow-up and intervention studies are required to evaluate the incidence and patterns of spontaneous and surgical closure of ASD and their outcomes.

scholarly journals 1105. Vibriocidal Titer Variation and Likelihood of Protection in Children Compared With Adults in a Cholera Endemic Area

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S331-S331
Author(s):  
Alaina Ritter ◽  
Fahima Chowdhury ◽  
Rachel Becker ◽  
Taufiq Bhuiyan ◽  
Ashraful Khan ◽  
...  
Keyword(s):  
Young Children ◽  
Vaccine Development ◽  
Massachusetts General Hospital ◽  
Age Groups ◽  
Older Children ◽  
Baseline Serum ◽  
Household Contacts ◽  
Antibody Titers ◽  
Training Grant

Abstract Background Vibrio cholerae, the causative agent of cholera, is responsible for significant morbidity and mortality worldwide. Children less than 5 years old have the highest disease burden of cholera in endemic areas. While children develop serum vibriocidal antibody responses to cholera vaccines, they derive less protection from vaccination compared with adults. The aim of our study was to determine whether the vibriocidal immune responses to V. cholerae infection are equally accurate as markers of protection in all age groups. Methods Cholera patients and their household contacts, who are known to be at high risk of V. cholerae infection, were enrolled between 2001 and 2017 in Dhaka, Bangladesh. Baseline vibriocidal titers were measured at the time of enrollment of household contacts, and participants were followed prospectively for development of V. cholerae infection. Results We studied 50 contacts < 5 years old (“young children”), 228 contacts 5–16 years old (“older children”), and 548 contacts > 16 years old (“adults”). The baseline serum vibriocidal titer was higher in contacts who remained uninfected from all age groups than in contacts who developed cholera during the follow-up period (young children: P = 0.0092; older children: P = 0.0003, adults: P = 0.0012). Conclusion We found that higher vibriocidal antibody titers were associated with protection against V. cholerae infection across all three age categories. These findings may help increase our understanding of the protective immune response against V. cholerae infection and have importance for future vaccine development strategies. Acknowledgments: This research was supported by Massachusetts General Hospital training grant T32AI007061. Disclosures All authors: No reported disclosures.

Vitamin Intake of 3- to 36-Month-Old German Infants and Children – Results of the DONALD-Study

1999 ◽  
Vol 69 (4) ◽  
pp. 285-291 ◽  
Author(s):  
Alexy ◽  
Kersting ◽  
Sichert-Hellert ◽  
Manz ◽  
Schöch
Keyword(s):  
Young Children ◽  
Reference Values ◽  
Age Groups ◽  
Infants And Children ◽  
Infant Food ◽  
Diet Records ◽  
Lack Of Information ◽  
Vitamin Intake ◽  
First Year Of Life ◽  
Infants And Young Children

Infants and young children are a vulnerable group with regard to nutrition. However, there is a lack of information about the dietary composition of healthy German infants and children. Therefore, the intake of vitamins (A, C, E, B1, B2, B6, folate, niacin) was assessed in 354 healthy German infants and children aged 3 to 36 months from 3-day-weighed diet records and compared with German, European and US reference values. Intake of all B-vitamins (B1, B2, B6, folate, niacin) increased during the first 3 years of life, whereas intake of vitamin E decreased. Intake of vitamin A and C varied between age groups. The highest levels of the nutrient densities of most vitamins were found at the end of the first year of life. Depending on the reference values chosen, the vitamin supply of the study population ranged between sufficient and very good. The reported satisfactory intake of vitamins in infants and young children in this study gives rise to the question of whether the current extent of fortification of commercial infant food in Germany is necessary.

scholarly journals Transcatheter closure of perimembranous and muscular ventricular septal defects: short and medium-term outcome

2020 ◽  
Author(s):  
Anh Binh Ho
Keyword(s):  
Success Rate ◽  
Transcatheter Closure ◽  
Central Hospital ◽  
Ventricular Septal Defects ◽  
Medium Term ◽  
Term Outcome ◽  
Surgical Closure ◽  
Septal Defects ◽  
First Choice

Transcatheter closure of perimembranous and muscular ventricular septal defects: short and medium-term outcome ABSTRACT Objective: This study attempted to report the initial results: the safety and efficacy of transcatheter closure of ventricular septal defects (VSDs) at Hue Central Hospital with the short and medium-term follow-up. Methods: From September 2012 to May 2017, a total of 36 patients with perimembranous or muscular VSD underwent an attempt of transcatheter closure at the Department of Interventional Cardiology, Hue Central Hospital. Results: 14 males and 26 females participated in this study, with the age of 17,29  13.72 and 24.23  12.32 respectively. Among these patients, 19.44% of them were under 6-year-old; 72.22% had perimembranous VSDs, 27.78% had muscular VSDs, and 33.33% had aneurysm. The distance to AV was 5.62 ± 4.32 mm. The device size was 15.31± 8.12 mm. Procedures lasted for 57.17 ± 26.5 min with 15.31± 8.12 min of exposure. The complete closure rates by transthoracic echocardiography after 24 hours, 1 month, 3 months and 6 months (transthoracic) were 94.44%; 94.44% ; 97.22% and 100%, respectively. Mean time of follow-up was 11.92 ± 8.36 (3-38) months. Success rate was 97.22% and no death occurred. There was 1 case of hematuria, lasting 1 month; no Atrioventricular (AV) block. Conclusions: Transcatheter closure of VSDs is a novel, feasible and safe technique with high success rate (97.22%). The transcather approach provides a less invasive alternative than surgical closure and might become the first choice treatment in selected patients. Key words: transcatheter closure, ventricular septal defects

scholarly journals Persistence of hepatitis A vaccine induced seropositivity in infants and young children by maternal antibody status: 10-year follow-up

Hepatology ◽  
2012 ◽  
Vol 56 (2) ◽  
pp. 516-522 ◽  
Author(s):  
Umid M. Sharapov ◽  
Lisa R. Bulkow ◽  
Susan E. Negus ◽  
Philip R. Spradling ◽  
Chriss Homan ◽  
...  
Keyword(s):  
Young Children ◽  
Hepatitis A ◽  
Maternal Antibody ◽  
Infants And Young Children

scholarly journals Nevirapine- Versus Lopinavir/Ritonavir-Based Antiretroviral Therapy in HIV-Infected Infants and Young Children: Long-term Follow-up of the IMPAACT P1060 Randomized Trial

2016 ◽  
Vol 63 (8) ◽  
pp. 1113-1121 ◽  
Author(s):  
Linda Barlow-Mosha ◽  
Konstantia Angelidou ◽  
Jane Lindsey ◽  
Moherndran Archary ◽  
Mark Cotton ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Young Children ◽  
Randomized Trial ◽  
Long Term Follow Up ◽  
Infants And Young Children

Melamine-Related Urinary Stones in 195 Infants and Young Children: Clinical Features within 2 Years of Follow-Up

2011 ◽  
Vol 87 (4) ◽  
pp. 429-433 ◽  
Author(s):  
Jian Guo Wen ◽  
Qing Long Chang ◽  
An Feng Lou ◽  
Zhen Zhen Li ◽  
Shan Lu ◽  
...  
Keyword(s):  
Young Children ◽  
Clinical Features ◽  
Urinary Stones ◽  
Infants And Young Children

scholarly journals Context-specific complementary feeding recommendations developed using Optifood could improve the diets of breast-fed infants and young children from diverse livelihood groups in northern Kenya

2016 ◽  
Vol 20 (6) ◽  
pp. 971-983 ◽  
Author(s):  
Marieke Vossenaar ◽  
Frances A Knight ◽  
Alison Tumilowicz ◽  
Christine Hotz ◽  
Peter Chege ◽  
...  
Keyword(s):  
Young Children ◽  
Complementary Feeding ◽  
Age Groups ◽  
Population Level ◽  
Age Group ◽  
Northern Kenya ◽  
Pastoralist Communities ◽  
Context Specific ◽  
Breast Fed ◽  
Infants And Young Children

AbstractObjectiveTo formulate age- and context-specific complementary feeding recommendations (CFR) for infants and young children (IYC) and to compare the potential of filling population-level nutrient gaps using common sets of CFR across age groups.DesignLinear programming was used to develop CFR using locally available and acceptable foods based on livelihood- and age-group-specific dietary patterns observed through 24 h dietary recalls. Within each livelihood group, the nutrient potential of age-group-specific v. consolidated CFR across the three age groups was tested.SettingThree food-insecure counties in northern Kenya; namely, settled communities from Isiolo (n 300), pastoralist communities from Marsabit (n 283) and agro-pastoralist communities from Turkana (n 299).SubjectsBreast-fed IYC aged 6–23 months (n 882).ResultsAge-specific CFR could achieve adequacy for seven to nine of eleven modelled micronutrients, except among 12–23-month-old children in agro-pastoralist communities. Contribution of Fe, Zn and niacin remained low for most groups, and thiamin, vitamin B6 and folate for some groups. Age-group-consolidated CFR could not reach the same level of nutrient adequacy as age-specific sets among the settled and pastoralist communities.ConclusionsContext- and age-specific CFR could ensure adequate levels of more modelled nutrients among settled and pastoralist IYC than among agro-pastoralist communities where use of nutrient-dense foods was limited. Adequacy of all eleven modelled micronutrients was not achievable and additional approaches to ensure adequate diets are required. Consolidated messages should be easier to implement as part of a behaviour change strategy; however, they would likely not achieve the same improvements in population-level dietary adequacy as age-specific CFR.

Sudden Death Due to Ventricular Septal Defect

1999 ◽  
Vol 2 (4) ◽  
pp. 327-332 ◽  
Author(s):  
Stephen D. Cohle ◽  
Elizabeth Balraj ◽  
Michael Bell
Keyword(s):  
Sudden Death ◽  
Common Denominator ◽  
Unexpected Death ◽  
Septal Defects ◽  
Life Threatening ◽  
The Common ◽  
Medial Thickening ◽  
Attending Physician ◽  
Infants And Young Children

Ventricular septal defects (VSD) are usually considered non-life-threatening, usually closing spontaneously or causing symptoms of congestive heart failure, which can be surgically treated in time to save the patient's life. Despite the usually benign clinical course of VSD, serious arrhythmias occur in 16–31% of patients. Sudden death accounted for one-third of all deaths in a series of medically managed patients and occurred in 4.2% of patients in a study of VSD and arrhythmias. Cardiac hypertrophy is the common denominator in all cases reported in detail of VSD-associated sudden death. We have encountered four cases of sudden unexpected death from VSD in infants ranging in age from 1 week to 3 and ½ months. In each case there was cardiomegaly and in one case there was pulmonary arteriolar medial thickening, with extension of smooth muscle into small intralobular vessels. In half of our cases the attending physician was sued for malpractice. We believe that VSD in infants and young children are potentially life-threatening malformations which warrant careful clinical follow-up.

scholarly journals A retrospective study of electroencephalogram parameters during general anaesthesia in infants and young children

2021 ◽  
Author(s):  
Zhengzheng Gao ◽  
Jianmin Zhang ◽  
Xiaoxue Wang ◽  
Mengnan Yao ◽  
Lan Sun ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Retrospective Study ◽  
Young Children ◽  
General Anaesthesia ◽  
Age Groups ◽  
Final Analysis ◽  
Primary Objective ◽  
Burst Suppression ◽  
Spectral Edge Frequency ◽  
Infants And Young Children

Abstract Background This retrospective study describes electroencephalogram (EEG) parameters in infants and young children under general anaesthesia. The study’s primary objective was to detect determinants of patient state index (PSI) levels. Methods We analysed EEG parameters in patients aged 1–36 months who received sevoflurane or propofol as the primary anaesthetic in Beijing Children’s Hospital from September 1, 2019, to April 30, 2020. Patients were stratified into two age groups: 1–12 and 13–36 months. The relationship between EEG parameters and clinical parameters was analysed by multivariable linear regression. Results Sixty-two patients were involved in the final analysis, including 35 boys and 27 girls. Average patient age and weight were 14.5 (5.8–24.0) months and 9.9 (8.0–12) kg, respectively. Spectral edge frequency (SEF), PSI and blood pressure were lower (p < 0.001) and burst suppression rate (BSR) and heart rate higher (p < 0.001) at the age of 1–12 months under general anaesthesia. The most significant factor associated with higher levels of PSI was a higher SEF at the age of 1–36 months (1–12 months p = 0.001; 13–26 months p < 0.001); burst suppression occurrence decreased the PSI level (p = 0.031). Older age or higher blood pressure increased PSI levels in children under 1 year old (p = 0.028 and p = 0.002). Conclusions SEF was the most significant determinant associated with PSI levels in infants and young children during general anaesthesia, and burst suppression occurrence decreases the PSI level. Moreover, age and blood pressure might affect PSI levels in infants.

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