Reduced ICU demand with early CPAP and proning in COVID-19 at Bradford: a single centre cohort

Background Guidance in the management of COVID-19 respiratory failure has favoured early intubation, with concerns over the use of CPAP. We adopted early CPAP and self-proning, and evaluated the safety and efficacy of this approach. Methods This retrospective observational study included all patients with a positive COVID-19 PCR, and negative patients with high clinical suspicion. Our protocol advised early CPAP and self-proning for severe cases, aiming to prevent rather than respond to deterioration. CPAP was provided outside ICU by ward staff supported by physiotherapists and an intensive critical care outreach program. Data were analysed descriptively and compared against a large UK cohort (ISARIC). Results 559 patients admitted before 1/May/20 were included. 365 were discharged alive, 182 died, and 12 remain inpatient. 165 patients (29.5%) received CPAP, 40 (7.2%) were admitted to ICU and 27 (4.8%) were ventilated. Hospital mortality was 33.3%, ICU mortality 54.5%. Following CPAP 64% of patients with moderate or severe ARDS, who were candidates for escalation, avoided intubation. Figures for ICU admission, intubation and hospital mortality are lower than those from ISARIC, whilst ICU mortality is similar. Following ISARIC proportions we would have admitted 92 patients to ICU and intubated 55. Using the described protocol, we intubated 27 patients from 40 admissions, and remained within our expanded ICU capacity. Conclusion Bradford's protocol produced good results despite our population having high levels of co-morbidity and ethnicities associated with poor outcomes. In particular we avoided overloading ICU capacity. We advocate this approach as both effective and safe.

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Reduced critical care demand with early CPAP and proning in COVID-19 at Bradford: A single-centre cohort

Journal of the Intensive Care Society ◽

10.1177/17511437211018615 ◽

2021 ◽

pp. 175114372110186

Author(s):

Tom Lawton ◽

Kate Wilkinson ◽

Aaron Corp ◽

Rabeia Javid ◽

Laura MacNally ◽

...

Keyword(s):

Critical Care ◽

Hospital Mortality ◽

Outreach Program ◽

High Clinical Suspicion ◽

Early Intubation ◽

Co Morbidity ◽

Critical Care Admission ◽

Poor Outcomes ◽

Care Capacity ◽

Program Data

Background Guidance in COVID-19 respiratory failure has favoured early intubation, with concerns over the use of CPAP. We adopted early CPAP and self-proning, and evaluated the safety and efficacy of this approach. Methods This retrospective observational study included all patients with a positive COVID-19 PCR, and others with high clinical suspicion. Our protocol advised early CPAP and self-proning for severe cases, aiming to prevent rather than respond to deterioration. CPAP was provided outside critical care by ward staff supported by physiotherapists and an intensive critical care outreach program. Data were analysed descriptively and compared against a large UK cohort (ISARIC). Results 559 patients admitted before 1 May 2020 were included. 376 were discharged alive, and 183 died. 165 patients (29.5%) received CPAP, 40 (7.2%) were admitted to critical care and 28 (5.0%) were ventilated. Hospital mortality was 32.7%, and 50% for critical care. Following CPAP, 62% of patients with S:F or P:F ratios indicating moderate or severe ARDS, who were candidates for escalation, avoided intubation. Figures for critical care admission, intubation and hospital mortality are lower than ISARIC, whilst critical care mortality is similar. Following ISARIC proportions we would have admitted 92 patients to critical care and intubated 55. Using the described protocol, we intubated 28 patients from 40 admissions, and remained within our expanded critical care capacity. Conclusion Bradford’s protocol produced good results despite our population having high levels of co-morbidity and ethnicities associated with poor outcomes. In particular we avoided overloading critical care capacity. We advocate this approach as both effective and safe.

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Sepsis in Traumatic Brain Injury: Epidemiology and Outcomes

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/cjn.2019.320 ◽

2019 ◽

Vol 47 (2) ◽

pp. 197-201

Author(s):

Dustin Anderson ◽

Demetrios J. Kutsogiannis ◽

Wendy I. Sligl

Keyword(s):

Traumatic Brain Injury ◽

Intensive Care ◽

Brain Injury ◽

Hospital Mortality ◽

Administrative Databases ◽

Care Utilization ◽

Apache Ii Score ◽

Common Source ◽

Icu Mortality ◽

Co Morbidity

ABSTRACT:Background:Traumatic brain injury (TBI) is a leading cause of death and disability. Risk factors for in-hospital mortality include older age, co-morbidity, and TBI severity. Few studies have investigated the role of sepsis in individuals with TBI.Methods:We studied adult patients with TBI admitted to intensive care over a 5-year period. Patient characteristics were identified by linking clinical and administrative databases. Charts of individuals with TBI and sepsis were manually reviewed. Predictors of ICU and hospital mortality were identified using logistic regression modeling.Results:Four hundred eighty-six individuals with TBI were admitted to intensive care. Sixteen (3.3%) developed sepsis. Pneumonia was the most common source (94%). Staphylococcus aureus was the most common pathogen (75%). ICU lengths of stay (LOS) (12.2 days [interquartile range (IQR) 4.4–23.5] versus 3.7 days [IQR 1.7–8.2]; p < 0.001) and hospital LOS (28.0 days [IQR 11.8–41.4] versus 15.3 days [IQR 5.0–30.9]; p = 0.017) were longer in patients with TBI and sepsis. Sepsis was not associated with ICU (adjusted odds ratio [aOR] 0.51; 95%CI 0.12–2.27; p = 0.38) or hospital (aOR 0.78; 95% CI 0.21–2.96; p = 0.78) mortality, though age (aOR 1.02; 95% CI 1.00–1.04; p = 0.014 for hospital mortality), severe TBI (aOR 3.71; 95% CI 1.52–9.08; p = 0.004 for ICU mortality and 4.10; 95% CI 1.95–8.65; p < 0.001 for hospital mortality), and APACHE II score (aOR 1.19; 95% CI 1.11–1.28; p < 0.001 for ICU mortality and 1.22; 95% CI 1.14–1.31; p < 0.001 for hospital mortality) were.Conclusion:Sepsis in patients with TBI was not associated with mortality; however, sepsis was associated with increased health care utilization (ICU and hospital LOS).

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Incidence, characteristics, and outcomes of delirium in patients with noninvasive ventilation: A prospective observational study

10.21203/rs.3.rs-60456/v3 ◽

2021 ◽

Author(s):

Rui Zhang ◽

Linfu Bai ◽

Xiaoli Han ◽

Shicong Huang ◽

Lintong Zhou ◽

...

Keyword(s):

Observational Study ◽

Hospital Mortality ◽

Noninvasive Ventilation ◽

Prospective Observational Study ◽

Confusion Assessment Method ◽

Assessment Method ◽

Icu Mortality ◽

Medical Resources ◽

Lengths Of Stay ◽

Poor Outcomes

Abstract Background: Factors that may increase the risk for delirium and the firm knowledge around mechanism for delirium in noninvasive ventilation (NIV) patients is lacking. We investigated the incidence, characteristics, and outcomes of delirium in NIV patients. Methods: A prospective observational study was performed in an intensive care unit (ICU) of a teaching hospital. Patients in whom NIV was used as a first-line intervention were enrolled. During NIV intervention, delirium was screened using the Confusion Assessment Method for the ICU each day. The association between delirium and poor outcomes (e.g., NIV failure, ICU and hospital mortality) was investigated using forward stepwise multivariate logistic regression analyses.Results: We enrolled 1083 patients. Of these, 196 patients (18.1%) experienced delirium during NIV intervention. Patients with delirium had higher NIV failure rates (37.8% vs. 21.0%, p < 0.01), higher ICU mortality (33.2% vs. 14.3%, p < 0.01), and higher hospital mortality (37.2% vs. 17.0%, p < 0.01) than subjects without delirium. They also had a longer duration of NIV (median 6.3 vs. 3.7 days, p < 0.01), and stayed longer in the ICU (median 9.0 vs. 6.0 days, p < 0.01) and the hospital (median 14.5 vs. 11.0 days, p < 0.01). These results were confirmed in COPD and non-COPD cohorts. According to subtype, compared to hyperactive delirium patients, hypoactive and mixed delirium patients spent more days and many more days on NIV (median 3.4 vs. 6.5 vs. 10.1 days, p < 0.01). Similar outcomes were found for length of stay in the ICU and hospital. However, NIV failure, ICU mortality, and hospital mortality did not differ among the three subtypes.Conclusions: Delirium is associated with increases in poor outcomes (NIV failure, ICU mortality, and hospital mortality) and the use of medical resources (duration of NIV, and lengths of stay in the ICU and hospital). Regarding subtype, hypoactive and mixed delirium are associated with higher, and much higher, consumption of medical resources, respectively, compared to hyperactive delirium.

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Incidence, characteristics, and outcomes of delirium in patients with noninvasive ventilation: A prospective observational study

10.21203/rs.3.rs-60456/v2 ◽

2020 ◽

Author(s):

Rui Zhang ◽

Linfu Bai ◽

Xiaoli Han ◽

Shicong Huang ◽

Lintong Zhou ◽

...

Keyword(s):

Observational Study ◽

Hospital Mortality ◽

Noninvasive Ventilation ◽

Prospective Observational Study ◽

Confusion Assessment Method ◽

Assessment Method ◽

Icu Mortality ◽

Medical Resources ◽

Lengths Of Stay ◽

Poor Outcomes

Abstract Background: Knowledge of delirium in noninvasive ventilation (NIV) patients is lacking. We investigated the incidence, characteristics, and outcomes of delirium in NIV patients. Methods: A prospective observational study was performed in an intensive care unit (ICU) of a teaching hospital. Patients in whom NIV was used as a first-line intervention were enrolled. During NIV intervention, delirium was screened using the Confusion Assessment Method for the ICU each day. The association between delirium and poor outcomes (e.g., NIV failure, ICU and hospital mortality) was investigated using forward stepwise multivariate logistic regression analyses.Results: We enrolled 1083 patients. Of these, 196 patients (18.1%) experienced delirium during NIV intervention. Patients with delirium had higher NIV failure rates (37.8% vs. 21.0%, p < 0.01), higher ICU mortality (33.2% vs. 14.3%, p < 0.01), and higher hospital mortality (37.2% vs. 17.0%, p < 0.01) than subjects without delirium. They also had a longer duration of NIV (median 6.3 vs. 3.7 days, p < 0.01), and stayed longer in the ICU (median 9.0 vs. 6.0 days, p < 0.01) and the hospital (median 14.5 vs. 11.0 days, p < 0.01). Furthermore, delirium was independently associated with NIV failure, ICU mortality, and hospital mortality (OR = 1.97, 2.58, and 2.55, respectively; all p values < 0.01). These results were confirmed in COPD and non-COPD cohorts. According to subtype, compared to hyperactive delirium patients, hypoactive and mixed delirium patients spent more days and many more days on NIV (median 3.4 vs. 6.5 vs. 10.1 days, p < 0.01). Similar outcomes were found for length of stay in the ICU and hospital. However, NIV failure, ICU mortality, and hospital mortality did not differ among the three subtypes.Conclusions: Delirium is associated with increases in poor outcomes (NIV failure, ICU mortality, and hospital mortality) and the use of medical resources (duration of NIV, and lengths of stay in the ICU and hospital). Regarding subtype, hypoactive and mixed delirium are associated with higher, and much higher, consumption of medical resources, respectively, compared to hyperactive delirium.

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Incidence, characteristics, and outcomes of delirium in patients with noninvasive ventilation: a prospective observational study

BMC Pulmonary Medicine ◽

10.1186/s12890-021-01517-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Rui Zhang ◽

Linfu Bai ◽

Xiaoli Han ◽

Shicong Huang ◽

Lintong Zhou ◽

...

Keyword(s):

Observational Study ◽

Hospital Mortality ◽

Noninvasive Ventilation ◽

Prospective Observational Study ◽

Confusion Assessment Method ◽

Assessment Method ◽

Icu Mortality ◽

Medical Resources ◽

Lengths Of Stay ◽

Poor Outcomes

Abstract Background Factors that may increase the risk for delirium and the firm knowledge around mechanism for delirium in noninvasive ventilation (NIV) patients is lacking. We investigated the incidence, characteristics, and outcomes of delirium in NIV patients. Methods A prospective observational study was performed in an intensive care unit (ICU) of a teaching hospital. Patients in whom NIV was used as a first-line intervention were enrolled. During NIV intervention, delirium was screened using the Confusion Assessment Method for the ICU each day. The association between delirium and poor outcomes (e.g., NIV failure, ICU and hospital mortality) was investigated using forward stepwise multivariate logistic regression analyses. Results We enrolled 1083 patients. Of these, 196 patients (18.1%) experienced delirium during NIV intervention. Patients with delirium had higher NIV failure rates (37.8% vs. 21.0%, p < 0.01), higher ICU mortality (33.2% vs. 14.3%, p < 0.01), and higher hospital mortality (37.2% vs. 17.0%, p < 0.01) than subjects without delirium. They also had a longer duration of NIV (median 6.3 vs. 3.7 days, p < 0.01), and stayed longer in the ICU (median 9.0 vs. 6.0 days, p < 0.01) and the hospital (median 14.5 vs. 11.0 days, p < 0.01). These results were confirmed in COPD and non-COPD cohorts. According to subtype, compared to hyperactive delirium patients, hypoactive and mixed delirium patients spent more days and many more days on NIV (median 3.4 vs. 6.5 vs. 10.1 days, p < 0.01). Similar outcomes were found for length of stay in the ICU and hospital. However, NIV failure, ICU mortality, and hospital mortality did not differ among the three subtypes. Conclusions Delirium is associated with increases in poor outcomes (NIV failure, ICU mortality, and hospital mortality) and the use of medical resources (duration of NIV, and lengths of stay in the ICU and hospital). Regarding subtype, hypoactive and mixed delirium are associated with higher, and much higher, consumption of medical resources, respectively, compared to hyperactive delirium.

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Is oxygen therapy beneficial for normoxemic patients with acute heart failure? A propensity score matched study

Military Medical Research ◽

10.1186/s40779-021-00330-7 ◽

2021 ◽

Vol 8 (1) ◽

Author(s):

Yue Yu ◽

Ren-Qi Yao ◽

Yu-Feng Zhang ◽

Su-Yu Wang ◽

Wang Xi ◽

...

Keyword(s):

Heart Failure ◽

Linear Regression ◽

Propensity Score ◽

Hospital Mortality ◽

Acute Heart Failure ◽

Oxygen Therapy ◽

Ambient Air ◽

Supplemental Oxygen ◽

Research Database ◽

Icu Mortality

Abstract Background The clinical efficiency of routine oxygen therapy is uncertain in patients with acute heart failure (AHF) who do not have hypoxemia. The aim of this study was to investigate the association between oxygen therapy and clinical outcomes in normoxemic patients hospitalized with AHF using real-world data. Methods Normoxemic patients diagnosed with AHF on ICU admission from the electronic ICU (eICU) Collaborative Research Database were included in the current study, in which the study population was divided into the oxygen therapy group and the ambient-air group. Propensity score matching (PSM) was applied to create a balanced covariate distribution between patients receiving supplemental oxygen and those exposed to ambient air. Linear regression and logistic regression models were performed to assess the associations between oxygen therapy and length of stay (LOS), and all-cause in-hospital as well as ICU mortality rates, respectively. A series of sensitivity and subgroup analyses were conducted to further validate the robustness of our findings. Results A total of 2922 normoxemic patients with AHF were finally included in the analysis. Overall, 42.1% (1230/2922) patients were exposed to oxygen therapy, and 57.9% (1692/2922) patients did not receive oxygen therapy (defined as the ambient-air group). After PSM analysis, 1122 pairs of patients were matched: each patient receiving oxygen therapy was matched with a patient without receiving supplemental oxygen. The multivariable logistic model showed that there was no significant interaction between the ambient air and oxygen group for all-cause in-hospital mortality [odds ratio (OR) 1.30; 95% confidence interval (CI) 0.92–1.82; P = 0.138] or ICU mortality (OR 1.39; 95% CI 0.83–2.32; P = 0.206) in the post-PSM cohorts. In addition, linear regression analysis revealed that oxygen therapy was associated with prolonged ICU LOS (OR 1.11; 95% CI 1.06–1.15; P < 0.001) and hospital LOS (OR 1.06; 95% CI 1.01–1.10; P = 0.009) after PSM. Furthermore, the absence of an effect of supplemental oxygen on mortality was consistent in all subgroups. Conclusion Routine use of supplemental oxygen in AHF patients without hypoxemia was not found to reduce all-cause in-hospital mortality or ICU mortality.

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Relationship between 24-h venous blood glucose variation and mortality among patients with acute respiratory failure

Scientific Reports ◽

10.1038/s41598-021-87409-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Xiaoling Zhang ◽

Jingjing Zhang ◽

Jiamei Li ◽

Ya Gao ◽

Ruohan Li ◽

...

Keyword(s):

Blood Glucose ◽

Respiratory Failure ◽

Hospital Mortality ◽

Acute Respiratory Failure ◽

Venous Blood ◽

Sensitivity Analyses ◽

Icu Mortality ◽

Logistic Regression Models ◽

The Mean ◽

The Relationship

AbstractEvidence indicates that glucose variation (GV) plays an important role in mortality of critically ill patients. We aimed to investigate the relationship between the coefficient of variation of 24-h venous blood glucose (24-hVBGCV) and mortality among patients with acute respiratory failure. The records of 1625 patients in the Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC II) database were extracted. The 24-hVBGCV was calculated as the ratio of the standard deviation (SD) to the mean venous blood glucose level, expressed as a percentage. The outcomes included ICU mortality and in-hospital mortality. Participants were divided into three subgroups based on tertiles of 24-hVBGCV. Multivariable logistic regression models were used to evaluate the relationship between 24-hVBGCV and mortality. Sensitivity analyses were also performed in groups of patients with and without diabetes mellitus. Taking the lowest tertile as a reference, after adjustment for all the covariates, the highest tertile was significantly associated with ICU mortality [odds ratio (OR), 1.353; 95% confidence interval (CI), 1.018–1.797] and in-hospital mortality (OR, 1.319; 95% CI, 1.003–1.735), especially in the population without diabetes. The 24-hVBGCV may be associated with ICU and in-hospital mortality in patients with acute respiratory failure in the ICU, especially in those without diabetes.

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Frailty is associated with in-hospital mortality in older hospitalised COVID-19 patients in the Netherlands: the COVID-OLD study

Age and Ageing ◽

10.1093/ageing/afab018 ◽

2021 ◽

Author(s):

Laura C Blomaard ◽

Carolien M J van der Linden ◽

Jessica M van der Bol ◽

Steffy W M Jansen ◽

Harmke A Polinder-Bos ◽

...

Keyword(s):

The Netherlands ◽

Hospital Mortality ◽

Oxygen Demand ◽

Symptom Duration ◽

Clinical Frailty Scale ◽

Reactive Protein ◽

Increased Risk ◽

Co Morbidity ◽

Lower Oxygen ◽

Independent Association

Abstract Background During the first wave of the coronavirus disease 2019 (COVID-19) pandemic, older patients had an increased risk of hospitalisation and death. Reports on the association of frailty with poor outcome have been conflicting. Objective The aim of the present study was to investigate the independent association between frailty and in-hospital mortality in older hospitalised COVID-19 patients in the Netherlands. Methods This was a multicentre retrospective cohort study in 15 hospitals in the Netherlands, including all patients aged ≥70 years, who were hospitalised with clinically confirmed COVID-19 between February and May 2020. Data were collected on demographics, co-morbidity, disease severity and Clinical Frailty Scale (CFS). Primary outcome was in-hospital mortality. Results A total of 1,376 patients were included (median age 78 years (interquartile range 74–84), 60% male). In total, 499 (38%) patients died during hospital admission. Parameters indicating presence of frailty (CFS 6–9) were associated with more co-morbidities, shorter symptom duration upon presentation (median 4 versus 7 days), lower oxygen demand and lower levels of C-reactive protein. In multivariable analyses, the CFS was independently associated with in-hospital mortality: compared with patients with CFS 1–3, patients with CFS 4–5 had a two times higher risk (odds ratio (OR) 2.0 (95% confidence interval (CI) 1.3–3.0)) and patients with CFS 6–9 had a three times higher risk of in-hospital mortality (OR 2.8 (95% CI 1.8–4.3)). Conclusions The in-hospital mortality of older hospitalised COVID-19 patients in the Netherlands was 38%. Frailty was independently associated with higher in-hospital mortality, even though COVID-19 patients with frailty presented earlier to the hospital with less severe symptoms.

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Hospital Volume is Not a Predictor of Outcomes after Gastrectomy for Neoplasm

The American Surgeon ◽

10.1177/000313480907501015 ◽

2009 ◽

Vol 75 (10) ◽

pp. 932-936 ◽

Cited By ~ 5

Author(s):

Kevin M. Reavis ◽

Marcelo W. Hinojosa ◽

Brian R. Smith ◽

James B. Wooldridge ◽

Sindhu Krishnan ◽

...

Keyword(s):

Length Of Stay ◽

Hospital Mortality ◽

Gastric Surgery ◽

National Database ◽

Medical Centers ◽

Outcome Relationship ◽

Academic Medical ◽

Low Volume ◽

Poor Outcomes ◽

The University

Studies have shown conflicting data with regard to the volume and outcome relationship for gastrectomy. Using the University HealthSystem Consortium national database, we examined the influence of the hospital's volume of gastrectomy on outcomes at academic centers between 2004 and 2008. Outcome measures, including length of stay, 30-day readmission, morbidity, and in-hospital mortality, were compared among high- (13 or greater), medium- (6 to 12), and low-volume (five or less) hospitals. There were 10 high- (n = 593 cases), 36 medium- (n = 1076 cases), and 75 low-volume (n = 500 cases) hospitals. There were no significant differences between high- and low-volume hospitals with regard to length of stay, overall complications, 30-day readmission rate, and in-hospital mortality (2.4 vs 4.4%, respectively, P = 0.06). Despite the small number of gastrectomies performed at the low-volume hospitals, these same hospitals performed a large number of other types of gastric surgery such as gastric bypass for the treatment of morbid obesity (102 cases/year). Within the context of academic medical centers, lower annual volume of gastrectomy for neoplasm is not a predictor of poor outcomes which may be explained by the gastric operative experience derived from other types of gastric surgery.

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