scholarly journals A Simple Optimization Workflow to Enable Precise and Accurate Imputation of Missing Values in Proteomic Datasets

2020 ◽  
Author(s):  
Kruttika Dabke ◽  
Simion Kreimer ◽  
Michelle R. Jones ◽  
Sarah J. Parker
Keyword(s):  
Large Scale ◽  
Missing Values ◽  
Imputation Method ◽  
Protein Quantification ◽  
Series Data ◽  
Data Sets ◽  
Independent Data ◽  
Data Set ◽  
Imputation Methods ◽  
Different Levels

AbstractMissing values in proteomic data sets have real consequences on downstream data analysis and reproducibility. Although several imputation methods exist to handle missing values, there is no single imputation method that is best suited for a diverse range of data sets and no clear strategy exists for evaluating imputation methods for large-scale DIA-MS data sets, especially at different levels of protein quantification. To navigate through the different imputation strategies available in the literature, we have established a workflow to assess imputation methods on large-scale label-free DIA-MS data sets. We used two distinct DIA-MS data sets with real missing values to evaluate eight different imputation methods with multiple parameters at different levels of protein quantification; dilution series data set and an independent data set with actual experimental samples. We found that imputation methods based on local structures within the data, like local least squares (LLS) and random forest (RF), worked well in our dilution series data set whereas, imputation methods based on global structures within the data, like BPCA performed well in our independent data set. We also found that imputation at the most basic level of protein quantification – fragment level-improved accuracy and number of proteins quantified. Overall, this study indicates that the most suitable imputation method depends on the overall structure and correlations of proteins within the data set and can be identified with the workflow presented here.

scholarly journals Comparison of Selected Multiple Imputation Methods for Continuous Variables – Preliminary Simulation Study Results

2019 ◽  
Vol 6 (339) ◽  
pp. 73-98
Author(s):  
Małgorzata Aleksandra Misztal
Keyword(s):  
Missing Data ◽  
Multiple Imputation ◽  
Missing Values ◽  
Imputation Accuracy ◽  
Imputation Method ◽  
Data Sets ◽  
Continuous Variables ◽  
Imputation Methods ◽  
Study Results ◽  
Almost All

The problem of incomplete data and its implications for drawing valid conclusions from statistical analyses is not related to any particular scientific domain, it arises in economics, sociology, education, behavioural sciences or medicine. Almost all standard statistical methods presume that every object has information on every variable to be included in the analysis and the typical approach to missing data is simply to delete them. However, this leads to ineffective and biased analysis results and is not recommended in the literature. The state of the art technique for handling missing data is multiple imputation. In the paper, some selected multiple imputation methods were taken into account. Special attention was paid to using principal components analysis (PCA) as an imputation method. The goal of the study was to assess the quality of PCA‑based imputations as compared to two other multiple imputation techniques: multivariate imputation by chained equations (MICE) and missForest. The comparison was made by artificially simulating different proportions (10–50%) and mechanisms of missing data using 10 complete data sets from the UCI repository of machine learning databases. Then, missing values were imputed with the use of MICE, missForest and the PCA‑based method (MIPCA). The normalised root mean square error (NRMSE) was calculated as a measure of imputation accuracy. On the basis of the conducted analyses, missForest can be recommended as a multiple imputation method providing the lowest rates of imputation errors for all types of missingness. PCA‑based imputation does not perform well in terms of accuracy.

scholarly journals Evaluating the Performance of Multiple Imputation Methods for Handling Missing Values in Time Series Data: A Study Focused on East Africa, Soil-Carbonate-Stable Isotope Data

Stats ◽  
2019 ◽  
Vol 2 (4) ◽  
pp. 457-467 ◽  
Author(s):  
Hossein Hassani ◽  
Mahdi Kalantari ◽  
Zara Ghodsi
Keyword(s):  
Time Series ◽  
East Africa ◽  
Quantitative Research ◽  
Missing Values ◽  
Time Series Data ◽  
Extreme Values ◽  
Singular Spectrum Analysis ◽  
Series Data ◽  
Data Set ◽  
Imputation Methods

In all fields of quantitative research, analysing data with missing values is an excruciating challenge. It should be no surprise that given the fragmentary nature of fossil records, the presence of missing values in geographical databases is unavoidable. As in such studies ignoring missing values may result in biased estimations or invalid conclusions, adopting a reliable imputation method should be regarded as an essential consideration. In this study, the performance of singular spectrum analysis (SSA) based on L 1 norm was evaluated on the compiled δ 13 C data from East Africa soil carbonates, which is a world targeted historical geology data set. Results were compared with ten traditionally well-known imputation methods showing L 1 -SSA performs well in keeping the variability of the time series and providing estimations which are less affected by extreme values, suggesting the method introduced here deserves further consideration in practice.

scholarly journals Comparative Study of Three Imputation Methods to Treat Missing Values

2013 ◽  
Vol 11 (7) ◽  
pp. 2779-2786
Author(s):  
Rahul Singhai
Keyword(s):  
Data Mining ◽  
Missing Data ◽  
Missing Values ◽  
Learning Algorithm ◽  
Poor Quality ◽  
Imputation Method ◽  
Data Set ◽  
Imputation Methods ◽  
Missing Data Treatment

One relevant problem in data preprocessing is the presence of missing data that leads the poor quality of patterns, extracted after mining. Imputation is one of the widely used procedures that replace the missing values in a data set by some probable values. The advantage of this approach is that the missing data treatment is independent of the learning algorithm used. This allows the user to select the most suitable imputation method for each situation. This paper analyzes the various imputation methods proposed in the field of statistics with respect to data mining. A comparative analysis of three different imputation approaches which can be used to impute missing attribute values in data mining are given that shows the most promising method. An artificial input data (of numeric type) file of 1000 records is used to investigate the performance of these methods. For testing the significance of these methods Z-test approach were used.

scholarly journals LARGE‐SCALE DATA VISUALIZATION WITH MISSING VALUES

2006 ◽  
Vol 12 (1) ◽  
pp. 44-49
Author(s):  
Sergiy Popov
Keyword(s):  
Dimensionality Reduction ◽  
Large Scale ◽  
Missing Values ◽  
Original Data ◽  
Nonlinear Dimensionality Reduction ◽  
Data Sets ◽  
Data Set ◽  
Large Scale Data ◽  
Learning Procedure ◽  
Scale Data

Visualization of large‐scale data inherently requires dimensionality reduction to 1D, 2D, or 3D space. Autoassociative neural networks with a bottleneck layer are commonly used as a nonlinear dimensionality reduction technique. However, many real‐world problems suffer from incomplete data sets, i.e. some values can be missing. Common methods dealing with missing data include the deletion of all cases with missing values from the data set or replacement with mean or “normal” values for specific variables. Such methods are appropriate when just a few values are missing. But in the case when a substantial portion of data is missing, these methods can significantly bias the results of modeling. To overcome this difficulty, we propose a modified learning procedure for the autoassociative neural network that directly takes the missing values into account. The outputs of the trained network may be used for substitution of the missing values in the original data set.

Feature-aware forecasting of large-scale time series data sets

2020 ◽  
Vol 62 (3-4) ◽  
pp. 157-168
Author(s):  
Claudio Hartmann ◽  
Lars Kegel ◽  
Wolfgang Lehner
Keyword(s):  
Time Series ◽  
Large Scale ◽  
Missing Values ◽  
Time Series Data ◽  
Series Data ◽  
The Internet ◽  
Data Sets ◽  
Similar Time ◽  
Forecast Time ◽  
The Internet Of Things

AbstractThe Internet of Things (IoT) sparks a revolution in time series forecasting. Traditional techniques forecast time series individually, which becomes unfeasible when the focus changes to thousands of time series exhibiting anomalies like noise and missing values. This work presents CSAR, a technique forecasting a set of time series with only one model, and a feature-aware partitioning applying CSAR on subsets of similar time series. These techniques provide accurate forecasts a hundred times faster than traditional techniques, preparing forecasting for the arising challenges of the IoT era.

scholarly journals Galaxy spin direction distribution in HST and SDSS show similar large-scale asymmetry

2020 ◽  
Vol 37 ◽  
Author(s):  
Lior Shamir
Keyword(s):  
Large Scale ◽  
Spiral Galaxies ◽  
Hubble Space Telescope ◽  
Gravitational Interaction ◽  
Large Data ◽  
Sloan Digital Sky Survey ◽  
Data Sets ◽  
Dipole Axis ◽  
Data Set ◽  
The Asymmetry

Abstract Several recent observations using large data sets of galaxies showed non-random distribution of the spin directions of spiral galaxies, even when the galaxies are too far from each other to have gravitational interaction. Here, a data set of $\sim8.7\cdot10^3$ spiral galaxies imaged by Hubble Space Telescope (HST) is used to test and profile a possible asymmetry between galaxy spin directions. The asymmetry between galaxies with opposite spin directions is compared to the asymmetry of galaxies from the Sloan Digital Sky Survey. The two data sets contain different galaxies at different redshift ranges, and each data set was annotated using a different annotation method. The results show that both data sets show a similar asymmetry in the COSMOS field, which is covered by both telescopes. Fitting the asymmetry of the galaxies to cosine dependence shows a dipole axis with probabilities of $\sim2.8\sigma$ and $\sim7.38\sigma$ in HST and SDSS, respectively. The most likely dipole axis identified in the HST galaxies is at $(\alpha=78^{\rm o},\delta=47^{\rm o})$ and is well within the $1\sigma$ error range compared to the location of the most likely dipole axis in the SDSS galaxies with $z>0.15$ , identified at $(\alpha=71^{\rm o},\delta=61^{\rm o})$ .

scholarly journals Handling Complex Missing Data Using Random Forest Approach for an Air Quality Monitoring Dataset: A Case Study of Kuwait Environmental Data (2012 to 2018)

2021 ◽  
Vol 18 (3) ◽  
pp. 1333
Author(s):  
Ahmad R. Alsaber ◽  
Jiazhu Pan ◽  
Adeeba Al-Hurban 
Keyword(s):  
Air Quality ◽  
Missing Data ◽  
Random Forest ◽  
Missing Values ◽  
Imputation Method ◽  
Environmental Data ◽  
Environmental Research ◽  
Quality Data ◽  
Data Set ◽  
Air Quality Data

In environmental research, missing data are often a challenge for statistical modeling. This paper addressed some advanced techniques to deal with missing values in a data set measuring air quality using a multiple imputation (MI) approach. MCAR, MAR, and NMAR missing data techniques are applied to the data set. Five missing data levels are considered: 5%, 10%, 20%, 30%, and 40%. The imputation method used in this paper is an iterative imputation method, missForest, which is related to the random forest approach. Air quality data sets were gathered from five monitoring stations in Kuwait, aggregated to a daily basis. Logarithm transformation was carried out for all pollutant data, in order to normalize their distributions and to minimize skewness. We found high levels of missing values for NO2 (18.4%), CO (18.5%), PM10 (57.4%), SO2 (19.0%), and O3 (18.2%) data. Climatological data (i.e., air temperature, relative humidity, wind direction, and wind speed) were used as control variables for better estimation. The results show that the MAR technique had the lowest RMSE and MAE. We conclude that MI using the missForest approach has a high level of accuracy in estimating missing values. MissForest had the lowest imputation error (RMSE and MAE) among the other imputation methods and, thus, can be considered to be appropriate for analyzing air quality data.

scholarly journals The Midlatitude Continental Convective Clouds Experiment (MC3E) sounding network: operations, processing and analysis

2015 ◽  
Vol 8 (1) ◽  
pp. 421-434 ◽  
Author(s):  
M. P. Jensen ◽  
T. Toto ◽  
D. Troyan ◽  
P. E. Ciesielski ◽  
D. Holdridge ◽  
...  
Keyword(s):  
Large Scale ◽  
Scale Model ◽  
Data Sets ◽  
Central Plains ◽  
Data Set ◽  
Convective Systems ◽  
Convective Clouds ◽  
Quality Checks ◽  
Network Operations ◽  
The Impact

Abstract. The Midlatitude Continental Convective Clouds Experiment (MC3E) took place during the spring of 2011 centered in north-central Oklahoma, USA. The main goal of this field campaign was to capture the dynamical and microphysical characteristics of precipitating convective systems in the US Central Plains. A major component of the campaign was a six-site radiosonde array designed to capture the large-scale variability of the atmospheric state with the intent of deriving model forcing data sets. Over the course of the 46-day MC3E campaign, a total of 1362 radiosondes were launched from the enhanced sonde network. This manuscript provides details on the instrumentation used as part of the sounding array, the data processing activities including quality checks and humidity bias corrections and an analysis of the impacts of bias correction and algorithm assumptions on the determination of convective levels and indices. It is found that corrections for known radiosonde humidity biases and assumptions regarding the characteristics of the surface convective parcel result in significant differences in the derived values of convective levels and indices in many soundings. In addition, the impact of including the humidity corrections and quality controls on the thermodynamic profiles that are used in the derivation of a large-scale model forcing data set are investigated. The results show a significant impact on the derived large-scale vertical velocity field illustrating the importance of addressing these humidity biases.

scholarly journals A fast methodology for large-scale focusing inversion of gravity and magnetic data using the structured model matrix and the 2-D fast Fourier transform

2020 ◽  
Vol 223 (2) ◽  
pp. 1378-1397
Author(s):  
Rosemary A Renaut ◽  
Jarom D Hogue ◽  
Saeed Vatankhah ◽  
Shuang Liu
Keyword(s):  
Fourier Transform ◽  
Fast Fourier Transform ◽  
Linear Systems ◽  
Large Scale ◽  
Surface Measurement ◽  
Magnetic Data ◽  
Uniform Grid ◽  
Data Sets ◽  
Inversion Algorithm ◽  
Data Set

SUMMARY We discuss the focusing inversion of potential field data for the recovery of sparse subsurface structures from surface measurement data on a uniform grid. For the uniform grid, the model sensitivity matrices have a block Toeplitz Toeplitz block structure for each block of columns related to a fixed depth layer of the subsurface. Then, all forward operations with the sensitivity matrix, or its transpose, are performed using the 2-D fast Fourier transform. Simulations are provided to show that the implementation of the focusing inversion algorithm using the fast Fourier transform is efficient, and that the algorithm can be realized on standard desktop computers with sufficient memory for storage of volumes up to size n ≈ 106. The linear systems of equations arising in the focusing inversion algorithm are solved using either Golub–Kahan bidiagonalization or randomized singular value decomposition algorithms. These two algorithms are contrasted for their efficiency when used to solve large-scale problems with respect to the sizes of the projected subspaces adopted for the solutions of the linear systems. The results confirm earlier studies that the randomized algorithms are to be preferred for the inversion of gravity data, and for data sets of size m it is sufficient to use projected spaces of size approximately m/8. For the inversion of magnetic data sets, we show that it is more efficient to use the Golub–Kahan bidiagonalization, and that it is again sufficient to use projected spaces of size approximately m/8. Simulations support the presented conclusions and are verified for the inversion of a magnetic data set obtained over the Wuskwatim Lake region in Manitoba, Canada.

scholarly journals Six years of total ozone column measurements from SCIAMACHY nadir observations

2009 ◽  
Vol 2 (1) ◽  
pp. 87-98 ◽  
Author(s):  
C. Lerot ◽  
M. Van Roozendael ◽  
J. van Geffen ◽  
J. van Gent ◽  
C. Fayt ◽  
...  
Keyword(s):  
Cross Sections ◽  
Total Ozone ◽  
Large Scale ◽  
European Space Agency ◽  
Data Sets ◽  
Data Set ◽  
Ozone Data ◽  
Space Agency ◽  
German Aerospace ◽  
The Impact

Abstract. Total O3 columns have been retrieved from six years of SCIAMACHY nadir UV radiance measurements using SDOAS, an adaptation of the GDOAS algorithm previously developed at BIRA-IASB for the GOME instrument. GDOAS and SDOAS have been implemented by the German Aerospace Center (DLR) in the version 4 of the GOME Data Processor (GDP) and in version 3 of the SCIAMACHY Ground Processor (SGP), respectively. The processors are being run at the DLR processing centre on behalf of the European Space Agency (ESA). We first focus on the description of the SDOAS algorithm with particular attention to the impact of uncertainties on the reference O3 absorption cross-sections. Second, the resulting SCIAMACHY total ozone data set is globally evaluated through large-scale comparisons with results from GOME and OMI as well as with ground-based correlative measurements. The various total ozone data sets are found to agree within 2% on average. However, a negative trend of 0.2–0.4%/year has been identified in the SCIAMACHY O3 columns; this probably originates from instrumental degradation effects that have not yet been fully characterized.

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