A Theory of Synaptic Transmission
Keyword(s):
Rapid and precise neuronal communication is enabled through a highly synchronous release of signaling molecules neurotransmitters into the synapse within just milliseconds of the action potential. We present an analytic theory that captures general principles of synaptic transmission while generating concrete predictions for particular synapses. A universal scaling is established, and demonstrated through a collapse of experimental data from different synapses onto a universal curve. The theory shows how key characteristics of synaptic function -- plasticity, fidelity, and efficacy -- emerge from molecular mechanisms of neurotransmitter release machinery.
2020 ◽
1999 ◽
Vol 81
(1)
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pp. 288-298
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2010 ◽
Vol 34
(2)
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pp. 115-116
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Keyword(s):
1990 ◽
Vol 68
(2)
◽
pp. 164-169
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