scholarly journals Interspecies activation correlations reveal functional correspondences between marmoset and human brain areas

2021 ◽  
Author(s):  
Yuki Hori ◽  
Justine C. Cléry ◽  
David J. Schaeffer ◽  
Ravi S. Menon ◽  
Stefan Everling
Keyword(s):  
Human Brain ◽  
Common Marmoset ◽  
Brain Regions ◽  
Higher Order ◽  
Primate Species ◽  
Human Face ◽  
Primate Model ◽  
Brain Functions ◽  
Similar Organization

AbstractThe common marmoset has enormous promise as a nonhuman primate model of human brain functions. While resting-state functional magnetic resonance imaging (fMRI) has provided evidence for a similar organization of marmoset and human cortices, the technique cannot be used to map the functional correspondences of brain regions between species. This limitation can be overcome by movie-driven fMRI (md-fMRI), which has become a popular tool for non-invasively mapping the neural patterns generated by rich and naturalistic stimulation. Here, we used md-fMRI in marmosets and humans to identify whole-brain functional correspondences between the two primate species. In particular, we describe functional correlates for the well-known human face, body, and scene patches in marmosets. We find that these networks have a similar organization in both species, suggesting a largely conserved organization of higher-order visual areas between New World marmoset monkeys and humans. However, while face patches in humans and marmosets were activated by marmoset faces, only human face patches responded to the faces of other animals. Together, the results demonstrate that md-fMRI is a powerful tool for interspecies functional mapping and characterization of higher-order visual functions.

scholarly journals Interspecies activation correlations reveal functional correspondences between marmoset and human brain areas

2021 ◽  
Vol 118 (37) ◽  
pp. e2110980118
Author(s):  
Yuki Hori ◽  
Justine C. Cléry ◽  
Janahan Selvanayagam ◽  
David J. Schaeffer ◽  
Kevin D. Johnston ◽  
...  
Keyword(s):  
Human Brain ◽  
Visual Processing ◽  
New World ◽  
Higher Order ◽  
Primate Species ◽  
Human Face ◽  
Primate Model ◽  
Brain Functions ◽  
Similar Organization ◽  
Marmoset Monkeys

The common marmoset has enormous promise as a nonhuman primate model of human brain functions. While resting-state functional MRI (fMRI) has provided evidence for a similar organization of marmoset and human cortices, the technique cannot be used to map the functional correspondences of brain regions between species. This limitation can be overcome by movie-driven fMRI (md-fMRI), which has become a popular tool for noninvasively mapping the neural patterns generated by rich and naturalistic stimulation. Here, we used md-fMRI in marmosets and humans to identify whole-brain functional correspondences between the two primate species. In particular, we describe functional correlates for the well-known human face, body, and scene patches in marmosets. We find that these networks have a similar organization in both species, suggesting a largely conserved organization of higher-order visual areas between New World marmoset monkeys and humans. However, while face patches in humans and marmosets were activated by marmoset faces, only human face patches responded to the faces of other animals. Together, the results demonstrate that higher-order visual processing might be a conserved feature between humans and New World marmoset monkeys but that small, potentially important functional differences exist.

scholarly journals Evolutionary modifications in human brain connectivity associated with schizophrenia

Brain ◽  
2019 ◽  
Vol 142 (12) ◽  
pp. 3991-4002 ◽  
Author(s):  
Martijn P van den Heuvel ◽  
Lianne H Scholtens ◽  
Siemon C de Lange ◽  
Rory Pijnenburg ◽  
Wiepke Cahn ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Connectivity ◽  
Brain Evolution ◽  
Higher Order ◽  
Brain Functions ◽  
Human Brain Evolution ◽  
The Brain

See Vértes and Seidlitz (doi:10.1093/brain/awz353) for a scientific commentary on this article. Is schizophrenia a by-product of human brain evolution? By comparing the human and chimpanzee connectomes, van den Heuvel et al. demonstrate that connections unique to the human brain show greater involvement in schizophrenia pathology. Modifications in service of higher-order brain functions may have rendered the brain more vulnerable to dysfunction.

scholarly journals STAB: a spatio-temporal cell atlas of the human brain

2020 ◽  
Vol 49 (D1) ◽  
pp. D1029-D1037
Author(s):  
Liting Song ◽  
Shaojun Pan ◽  
Zichao Zhang ◽  
Longhao Jia ◽  
Wei-Hua Chen ◽  
...  
Keyword(s):  
Human Brain ◽  
Single Cell ◽  
Temporal Dynamics ◽  
Cell Types ◽  
Brain Regions ◽  
Molecular Characteristics ◽  
Great Effort ◽  
Brain Functions ◽  
Spatio Temporal ◽  
The Brain

Abstract The human brain is the most complex organ consisting of billions of neuronal and non-neuronal cells that are organized into distinct anatomical and functional regions. Elucidating the cellular and transcriptome architecture underlying the brain is crucial for understanding brain functions and brain disorders. Thanks to the single-cell RNA sequencing technologies, it is becoming possible to dissect the cellular compositions of the brain. Although great effort has been made to explore the transcriptome architecture of the human brain, a comprehensive database with dynamic cellular compositions and molecular characteristics of the human brain during the lifespan is still not available. Here, we present STAB (a Spatio-Temporal cell Atlas of the human Brain), a database consists of single-cell transcriptomes across multiple brain regions and developmental periods. Right now, STAB contains single-cell gene expression profiling of 42 cell subtypes across 20 brain regions and 11 developmental periods. With STAB, the landscape of cell types and their regional heterogeneity and temporal dynamics across the human brain can be clearly seen, which can help to understand both the development of the normal human brain and the etiology of neuropsychiatric disorders. STAB is available at http://stab.comp-sysbio.org.

scholarly journals Gene expression heterogeneity during brain development and aging: temporal changes and functional consequences

2019 ◽  
Author(s):  
Ulaş Işıldak ◽  
Mehmet Somel ◽  
Janet M. Thornton ◽  
Handan Melike Dönertaş
Keyword(s):  
Gene Expression ◽  
Human Brain ◽  
Meta Analysis ◽  
Brain Regions ◽  
Genetic Alterations ◽  
Individual Heterogeneity ◽  
Brain Functions ◽  
Aging Period ◽  
Gene Expression Heterogeneity ◽  
Development And Aging

AbstractCells in largely non-mitotic tissues such as the brain are prone to stochastic (epi-)genetic alterations that may cause increased variability between cells and individuals over time. Although increased inter-individual heterogeneity in gene expression was previously reported, whether this process starts during development or if it is restricted to the aging period has not yet been studied. The regulatory dynamics and functional significance of putative aging-related heterogeneity are also unknown. Here we address these by a meta-analysis of 19 transcriptome datasets from diverse human brain regions. We observed a significant increase in inter-individual heterogeneity during aging (20+ years) compared to postnatal development (0 to 20 years). Increased heterogeneity during aging was consistent among different brain regions at the gene level and associated with lifespan regulation and neuronal functions. Overall, our results show that increased expression heterogeneity is a characteristic of aging human brain, and may influence aging-related changes in brain functions.

Epilogue

Mind Shift ◽  
2021 ◽  
pp. 411-436
Author(s):  
John Parrington
Keyword(s):  
Human Brain ◽  
Word Meaning ◽  
Brain Regions ◽  
Conscious Awareness ◽  
Human Consciousness ◽  
Grammatical Structure ◽  
Material Force ◽  
Human Culture ◽  
Brain Functions ◽  
The Individual

This chapter returns to the various alternative views about human consciousness first mentioned at the start of this book, and assesses how this book’s account compares to, and hopefully builds on, these other viewpoints. The view of human consciousness developed in this book can explain the uniqueness of our species’ conscious awareness, but in an entirely materialistic fashion. This approach views language—the system of abstract symbols linked in a grammatical structure but also one that connects the individual to the world outside via word meaning—and other forms of human culture like music, art, and literature, as a material force that has reshaped human brain functions at every level. This has led to a qualitative shift in such functions, compared to that of every other species, including our closest animal cousins, the great apes. Unlike a purely ‘bottom up’ approach to human brain function, this view sees language, as well as other mediators of human culture, as imposing both structural and dynamic changes in our brains. Structurally, it sees the different brain regions, as well as their interconnections, as altered in humans. The chapter then reflects on what impact, if any, might this approach to understanding human consciousness have on diagnosis and treatment of mental disorders.

scholarly journals Critique of Pure Marmoset

2019 ◽  
Vol 93 (2-3) ◽  
pp. 92-107 ◽  
Author(s):  
Todd M. Preuss
Keyword(s):  
Rapid Development ◽  
Common Marmoset ◽  
Macaque Monkey ◽  
Careful Consideration ◽  
Human Condition ◽  
Primate Species ◽  
Primate Model ◽  
Short Lifespan ◽  
Trade Offs ◽  
Human Primate

The common marmoset, a New World (platyrrhine) monkey, is currently being fast-tracked as a non-human primate model species, especially for genetic modification but also as a general-purpose model for research on the brain and behavior bearing on the human condition. Compared to the currently dominant primate model, the catarrhine macaque monkey, marmosets are notable for certain evolutionary specializations, including their propensity for twin births, their very small size (a result of phyletic dwarfism), and features related to their small size (rapid development and relatively short lifespan), which result in these animals yielding experimental results more rapidly and at lower cost. Macaques, however, have their own advantages. Importantly, macaques are more closely related to humans (which are also catarrhine primates) than are marmosets, sharing approximately 20 million more years of common descent, and are demonstrably more similar to humans in a variety of genomic, molecular, and neurobiological characteristics. Furthermore, the very specializations of marmosets that make them attractive as experimental subjects, such as their rapid development and short lifespan, are ways in which marmosets differ from humans and in which macaques more closely resemble humans. These facts warrant careful consideration of the trade-offs between convenience and cost, on the one hand, and biological realism, on the other, in choosing between non-human primate models of human biology. Notwithstanding the advantages marmosets offer as models, prudence requires continued commitment to research on macaques and other primate species.

scholarly journals Similarities and differences of face and body perception in the dog (Canis familiaris) and human brain

2021 ◽  
Author(s):  
Magdalena Boch ◽  
Isabella C. Wagner ◽  
Sabrina Karl ◽  
Ludwig Huber ◽  
Claus Lamm
Keyword(s):  
Human Brain ◽  
Canis Familiaris ◽  
Brain Regions ◽  
Primate Species ◽  
Body Perception ◽  
Mammal Species ◽  
Evolutionary Origins ◽  
Similarities And Differences ◽  
Neural Underpinnings ◽  
Perceptual Systems

AbstractAccurately recognizing other individuals is fundamental for successful social interactions. While the neural underpinnings of this skill have been studied extensively in humans, less is known about the evolutionary origins of the brain areas specialized for recognising faces or bodies. Studying dogs (Canis familiaris), a non-primate species with the ability to perceive faces and bodies similarly to humans, promises insights into how visuo-social perception has evolved in mammals. We investigated the neural correlates of face and body perception in dogs (N = 15) and humans (N = 40) using functional MRI. Combining uni- and multivariate analysis approaches, we identified activation levels and patterns that suggested potentially homologous occipito-temporal brain regions in both species responding to faces and bodies compared to inanimate objects. Crucially, only human brain regions showed activation differences between faces and bodies and partly responded more strongly to humans compared to dogs. Moreover, only dogs represented both faces and dog bodies in olfactory regions. Overall, these findings advance our understanding of the similarities and differences in brain function between two phylogenetically distant mammal species. This likely reflects differences in the perceptual systems these species rely on to recognize others, and provides important insights into the foundations of social cognition and behaviour.

scholarly journals Cortico-subcortical functional connectivity profiles of resting-state networks in marmosets and humans

2020 ◽  
Author(s):  
Yuki Hori ◽  
David J. Schaeffer ◽  
Atsushi Yoshida ◽  
Justine C. Cléry ◽  
Lauren K. Hayrynen ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Brain Function ◽  
Common Marmoset ◽  
Primate Species ◽  
Resting State Networks ◽  
Primate Model ◽  
Neuropsychiatric Diseases ◽  
Human Primate ◽  
Nonhuman Primate Species

AbstractUnderstanding the similarity of cortico-subcortical networks topologies between humans and nonhuman primate species is critical to study the origin of network alternations underlying human neurological and neuropsychiatric diseases. The New World common marmoset (Callithrix jacchus) has become popular as a non-human primate model for human brain function. Most marmoset connectomic research, however, has exclusively focused on cortical areas, with connectivity to subcortical networks less extensively explored. In this study, we aimed to first isolate patterns of subcortical connectivity with cortical resting-state networks (RSNs) in awake marmosets using resting-state functional magnetic resonance imaging (RS-fMRI), then to compare these networks to those in humans using connectivity fingerprinting. While we could match several marmoset and human RSNs based on their functional fingerprints, we also found a few striking differences, for example strong functional connectivity of the default mode network with the superior colliculus in marmosets that was much weaker in humans. Together, these findings demonstrate that many of the core cortico-subcortical networks in humans are also present in marmosets, but that small, potentially functionally relevant differences exist.

scholarly journals A High-Resolution In Vivo Atlas of the Human Brain’s Benzodiazepine Binding Site of GABAA Receptors

2020 ◽  
Author(s):  
Martin Nørgaard ◽  
Vincent Beliveau ◽  
Melanie Ganz ◽  
Claus Svarer ◽  
Lars H Pinborg ◽  
...  
Keyword(s):  
High Resolution ◽  
Human Brain ◽  
Mrna Expression ◽  
Brain Regions ◽  
Mrna Levels ◽  
Gamma Aminobutyric Acid ◽  
Healthy Human ◽  
Brain Functions ◽  
The Brain

ABSTRACTGamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the human brain and plays a key role in several brain functions and neuropsychiatric disorders such as anxiety, epilepsy, and depression. The binding of benzodiazepines to the benzodiazepine receptor sites (BZR) located on GABAA receptors (GABAARs) potentiates the inhibitory effect of GABA leading to the anxiolytic, anticonvulsant and sedative effects used for treatment of those disorders. However, the function of GABAARs and the expression of BZR protein is determined by the GABAAR subunit stoichiometry (19 genes coding for individual subunits), and it remains to be established how the pentamer composition varies between brain regions and individuals.Here, we present a quantitative high-resolution in vivo atlas of the human brain BZRs, generated on the basis of [11C]flumazenil Positron Emission Tomography (PET) data. Next, based on autoradiography data, we transform the PET-generated atlas from binding values into BZR protein density. Finally, we examine the brain regional association with mRNA expression for the 19 subunits in the GABAAR, including an estimation of the minimally required expression of mRNA levels for each subunit to translate into BZR protein.This represents the first publicly available quantitative high-resolution in vivo atlas of the spatial distribution of BZR densities in the healthy human brain. The atlas provides a unique neuroscientific tool as well as novel insights into the association between mRNA expression for individual subunits in the GABAAR and the BZR density at each location in the brain.

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