scholarly journals Interspecies activation correlations reveal functional correspondences between marmoset and human brain areas

2021 ◽  
Vol 118 (37) ◽  
pp. e2110980118
Author(s):  
Yuki Hori ◽  
Justine C. Cléry ◽  
Janahan Selvanayagam ◽  
David J. Schaeffer ◽  
Kevin D. Johnston ◽  
...  
Keyword(s):  
Human Brain ◽  
Visual Processing ◽  
New World ◽  
Higher Order ◽  
Primate Species ◽  
Human Face ◽  
Primate Model ◽  
Brain Functions ◽  
Similar Organization ◽  
Marmoset Monkeys

The common marmoset has enormous promise as a nonhuman primate model of human brain functions. While resting-state functional MRI (fMRI) has provided evidence for a similar organization of marmoset and human cortices, the technique cannot be used to map the functional correspondences of brain regions between species. This limitation can be overcome by movie-driven fMRI (md-fMRI), which has become a popular tool for noninvasively mapping the neural patterns generated by rich and naturalistic stimulation. Here, we used md-fMRI in marmosets and humans to identify whole-brain functional correspondences between the two primate species. In particular, we describe functional correlates for the well-known human face, body, and scene patches in marmosets. We find that these networks have a similar organization in both species, suggesting a largely conserved organization of higher-order visual areas between New World marmoset monkeys and humans. However, while face patches in humans and marmosets were activated by marmoset faces, only human face patches responded to the faces of other animals. Together, the results demonstrate that higher-order visual processing might be a conserved feature between humans and New World marmoset monkeys but that small, potentially important functional differences exist.

scholarly journals Interspecies activation correlations reveal functional correspondences between marmoset and human brain areas

2021 ◽  
Author(s):  
Yuki Hori ◽  
Justine C. Cléry ◽  
David J. Schaeffer ◽  
Ravi S. Menon ◽  
Stefan Everling
Keyword(s):  
Human Brain ◽  
Common Marmoset ◽  
Brain Regions ◽  
Higher Order ◽  
Primate Species ◽  
Human Face ◽  
Primate Model ◽  
Brain Functions ◽  
Similar Organization

AbstractThe common marmoset has enormous promise as a nonhuman primate model of human brain functions. While resting-state functional magnetic resonance imaging (fMRI) has provided evidence for a similar organization of marmoset and human cortices, the technique cannot be used to map the functional correspondences of brain regions between species. This limitation can be overcome by movie-driven fMRI (md-fMRI), which has become a popular tool for non-invasively mapping the neural patterns generated by rich and naturalistic stimulation. Here, we used md-fMRI in marmosets and humans to identify whole-brain functional correspondences between the two primate species. In particular, we describe functional correlates for the well-known human face, body, and scene patches in marmosets. We find that these networks have a similar organization in both species, suggesting a largely conserved organization of higher-order visual areas between New World marmoset monkeys and humans. However, while face patches in humans and marmosets were activated by marmoset faces, only human face patches responded to the faces of other animals. Together, the results demonstrate that md-fMRI is a powerful tool for interspecies functional mapping and characterization of higher-order visual functions.

scholarly journals Evolutionary modifications in human brain connectivity associated with schizophrenia

Brain ◽  
2019 ◽  
Vol 142 (12) ◽  
pp. 3991-4002 ◽  
Author(s):  
Martijn P van den Heuvel ◽  
Lianne H Scholtens ◽  
Siemon C de Lange ◽  
Rory Pijnenburg ◽  
Wiepke Cahn ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Connectivity ◽  
Brain Evolution ◽  
Higher Order ◽  
Brain Functions ◽  
Human Brain Evolution ◽  
The Brain

See Vértes and Seidlitz (doi:10.1093/brain/awz353) for a scientific commentary on this article. Is schizophrenia a by-product of human brain evolution? By comparing the human and chimpanzee connectomes, van den Heuvel et al. demonstrate that connections unique to the human brain show greater involvement in schizophrenia pathology. Modifications in service of higher-order brain functions may have rendered the brain more vulnerable to dysfunction.

scholarly journals Alzheimer’s Disease Progressively Reduces Visual Functional Network Connectivity

2021 ◽  
pp. 1-14
Author(s):  
Jie Huang ◽  
Paul Beach ◽  
Andrea Bozoki ◽  
David C. Zhu
Keyword(s):  
Visual Cortex ◽  
Lower Order ◽  
Resting State ◽  
Visual Processing ◽  
Network Connectivity ◽  
Higher Order ◽  
Functional Network ◽  
Functional Networks ◽  
The Face ◽  
Processing Network

Background: Postmortem studies of brains with Alzheimer’s disease (AD) not only find amyloid-beta (Aβ) and neurofibrillary tangles (NFT) in the visual cortex, but also reveal temporally sequential changes in AD pathology from higher-order association areas to lower-order areas and then primary visual area (V1) with disease progression. Objective: This study investigated the effect of AD severity on visual functional network. Methods: Eight severe AD (SAD) patients, 11 mild/moderate AD (MAD), and 26 healthy senior (HS) controls undertook a resting-state fMRI (rs-fMRI) and a task fMRI of viewing face photos. A resting-state visual functional connectivity (FC) network and a face-evoked visual-processing network were identified for each group. Results: For the HS, the identified group-mean face-evoked visual-processing network in the ventral pathway started from V1 and ended within the fusiform gyrus. In contrast, the resting-state visual FC network was mainly confined within the visual cortex. AD disrupted these two functional networks in a similar severity dependent manner: the more severe the cognitive impairment, the greater reduction in network connectivity. For the face-evoked visual-processing network, MAD disrupted and reduced activation mainly in the higher-order visual association areas, with SAD further disrupting and reducing activation in the lower-order areas. Conclusion: These findings provide a functional corollary to the canonical view of the temporally sequential advancement of AD pathology through visual cortical areas. The association of the disruption of functional networks, especially the face-evoked visual-processing network, with AD severity suggests a potential predictor or biomarker of AD progression.

Early Modern Spaces in Motion

2020 ◽  
Keyword(s):  
Human Brain ◽  
Early Modern ◽  
Physical Environment ◽  
Social Behaviour ◽  
New World ◽  
Architectural History ◽  
The Sun ◽  
Early Modern Europe ◽  
The Earth ◽  
German Speaking

Stretching back to antiquity, motion had been a key means of designing and describing the physical environment. But during the sixteenth through eighteenth centuries, individuals across Europe increasingly designed, experienced, and described a new world of motion: one characterized by continuous, rather than segmented, movement. New spaces that included vistas along house interiors and uninterrupted library reading rooms offered open expanses for shaping sequences of social behaviour, scientists observed how the Earth rotated around the sun, and philosophers attributed emotions to neural vibrations in the human brain. Early Modern Spaces in Motion examines this increased emphasis on motion with eight essays encompassing a geographical span of Portugal to German-speaking lands and a disciplinary range from architectural history to English. It consequently merges longstanding strands of analysis considering people in motion and buildings in motion to explore the cultural historical attitudes underpinning the varied impacts of motion in early modern Europe.

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