scholarly journals Mapping Twenty Years of Antimicrobial Resistance Research Trends

2021 ◽  
Author(s):  
Christian F Luz ◽  
Magnus van Niekerk ◽  
Julia Keizer ◽  
Nienke Beerlage-de Jong ◽  
Annemarie Braakman-Jansen ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Research Output ◽  
The United States ◽  
Multidrug Resistant ◽  
Future Research ◽  
Topic Modelling ◽  
African Region ◽  
Comprehensive Overview ◽  
Mdr Tb ◽  
Global Threat

Background: Antimicrobial resistance (AMR) is a global threat to health and healthcare. In response to the growing AMR burden, research funding also increased. However, a comprehensive overview of the research output, including conceptual, temporal, and geographical trends, is missing. Therefore, this study uses topic modelling, a machine learning approach, to reveal the scientific evolution of AMR research and its trends, and provides an interactive user interface for further analyses. Methods: Structural topic modelling (STM) was applied on a text corpus resulting from a PubMed query comprising AMR articles (1999-2018). A topic network was established and topic trends were analysed by frequency, proportion, and importance over time and space. Findings: In total, 88 topics were identified in 158616 articles from 166 countries. AMR publications increased by 450% between 1999 and 2018, emphasizing the vibrancy of the field. Prominent topics in 2018 were Strategies for emerging resistances and diseases, Nanoparticles, and Stewardship. Emerging topics included Water and environment, and Sequencing. Geographical trends showed prominence of Multidrug-resistant tuberculosis (MDR-TB) in the WHO African Region, corresponding with the MDR-TB burden. China and India were growing contributors in recent years, following the United States of America as overall lead contributor. Interpretation: This study provides a comprehensive overview of the AMR research output thereby revealing the AMR research response to the increased AMR burden. Both the results and the publicly available interactive database serve as a base to inform and optimise future research.

scholarly journals Need for Annual Surveillance of Antimicrobial Resistance in Streptococcus pneumoniae in the United States: 2-Year Longitudinal Analysis

2001 ◽  
Vol 45 (4) ◽  
pp. 1037-1042 ◽  
Author(s):  
Daniel F. Sahm ◽  
James A. Karlowsky ◽  
Laurie J. Kelly ◽  
Ian A. Critchley ◽  
Mark E. Jones ◽  
...  
Keyword(s):  
United States ◽  
Streptococcus Pneumoniae ◽  
Antimicrobial Resistance ◽  
Antimicrobial Agents ◽  
The United States ◽  
Multidrug Resistant ◽  
Fluoroquinolone Resistance ◽  
Resistance Patterns ◽  
Changing Patterns ◽  
Resistance To Penicillin

ABSTRACT Although changing patterns in antimicrobial resistance inStreptococcus pneumoniae have prompted several surveillance initiatives in recent years, the frequency with which these studies are needed has not been addressed. To approach this issue, the extent to which resistance patterns change over a 1-year period was examined. In this study we analyzed S. pneumoniaeantimicrobial susceptibility results produced in our laboratory with isolates obtained over 2 consecutive years (1997–1998 and 1998–1999) from the same 96 institutions distributed throughout the United States. Comparison of results revealed increases in resistant percentages for all antimicrobial agents studied except vancomycin. For four of the agents tested (penicillin, cefuroxime, trimethoprim-sulfamethoxazole, and levofloxacin), the increases were statistically significant (P < 0.05). Resistance to the fluoroquinolone remained low in both years (0.1 and 0.6%, respectively); in contrast, resistance to macrolides was consistently greater than 20%, and resistance to trimethoprim-sulfamethoxazole increased from 13.3 to 27.3%. Multidrug resistance, concurrent resistance to three or more antimicrobials of different chemical classes, also increased significantly between years, from 5.9 to 11%. The most prevalent phenotype was resistance to penicillin, azithromycin (representative macrolide), and trimethoprim-sulfamethoxazole. Multidrug-resistant phenotypes that included fluoroquinolone resistance were uncommon; however, two phenotypes that included fluoroquinolone resistance not found in 1997–1998 were encountered in 1998–1999. This longitudinal surveillance study of resistance inS. pneumoniae revealed that significant changes do occur in just a single year and supports the need for surveillance at least on an annual basis, if not continuously.

scholarly journals Multidrug-resistant tuberculosis in the United States, 2011–2016: patient characteristics and risk factors

2020 ◽  
Vol 24 (1) ◽  
pp. 92-99 ◽  
Author(s):  
M. P. Chen ◽  
R. Miramontes ◽  
J. S. Kammerer
Keyword(s):  
United States ◽  
Risk Factors ◽  
Patient Characteristics ◽  
The United States ◽  
Multidrug Resistant ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Recent Transmission ◽  
National Tuberculosis ◽  
Mdr Tb

OBJECTIVE: To determine risk factors for multidrug-resistant tuberculosis (MDR-TB) and describe MDR-TB according to three characteristics: previous TB disease, recent transmission of MDR-TB, and reactivation of latent MDR-TB infection.SETTING and DESIGN: We used 2011–2016 surveillance data from the US National Tuberculosis Surveillance System and National Tuberculosis Genotyping Service and used logistic regression models to estimate risk factors associated with MDR-TB.RESULTS: A total of 615/45 209 (1.4%) cases were confirmed as MDR-TB; 111/615 (18%) reported previous TB disease; 41/615 (6.7%) were attributed to recent MDR-TB transmission; and 449/615 (73%) to reactivation. Only 12/41 (29%) patients with TB attributed to recent transmission were known to be contacts of someone with MDR-TB. For non-US-born patients, the adjusted odds ratios of having MDR-TB were 32.6 (95%CI 14.6–72.6) among those who were known to be contacts of someone with MDR-TB and 6.5 (95%CI 5.1–8.3) among those who had had previous TB disease.CONCLUSION: The majority of MDR-TB cases in the United States were associated with previous TB disease or reactivation of latent MDR-TB infection; only a small proportion of MDR-TB cases were associated with recent transmission.

scholarly journals Antimicrobial Resistance and Genomic Characterization of Salmonella Dublin Isolates in Cattle from the United States.

2021 ◽  
Author(s):  
Mariela Srednik ◽  
Kristina Lantz ◽  
Jessica A Hicks ◽  
Brenda R Morningstar-Shaw ◽  
Tonya A Mackie ◽  
...  
Keyword(s):  
United States ◽  
Antimicrobial Resistance ◽  
Systemic Disease ◽  
The United States ◽  
Multidrug Resistant ◽  
Severe Illness ◽  
Valuable Insight ◽  
Antimicrobial Drugs ◽  
Salmonella Dublin ◽  
Genomic Characterization

Salmonella enterica subspecies enterica serovar Dublin is a host-adapted serotype in cattle, associated with enteritis and systemic disease. While rare in humans, it can cause severe illness, including bacteremia, with hospitalization and death. In the United States, S. Dublin has become one of the most multidrug-resistant serotypes . The objective of this study was to characterize S. Dublin isolates from sick cattle by analyzing phenotypic and genotypic antimicrobial resistance (AMR) profiles, the presence of plasmids, and phylogenetic relationships. S. Dublin isolates (n=140) were selected from submissions to the NVSL for Salmonella serotyping (2014 – 2017) from 21 states. Isolates were tested for susceptibility against 14 class-representative antimicrobial drugs. Resistance profiles were determined using the ABRicate with Resfinder and NCBI databases, AMRFinder and PointFinder. Plasmids were detected using ABRicate with PlasmidFinder. Phylogeny was determined using vSNP. We found 98% of the isolates were resistant to more than 4 antimicrobials . Only 1 isolate was pan-susceptible and had no predicted AMR genes. All S. Dublin isolates were susceptible to azithromycin and meropenem. They showed 96% resistance to sulfonamides, 97% to tetracyclines, 95% to aminoglycosides and 85% to beta-lactams . The most common AMR genes were: sulf2 and tetA (98.6%), aph(3'')-Ib and aph(6)-Id (96.4%), floR (94.3%), and blaCMY-2 (85.7%). All quinolone resistant isolates presented mutations in gyr A. Ten plasmid types were identified among all isolates with IncA/C2, IncX1, and IncFII(S) being the most frequent. The S. Dublin isolates show low genomic genetic diversity. This study provided antimicrobial susceptibility and genomic insight into S . Dublin clinical isolates from cattle in the U.S. Further sequence analysis integrating food and human origin S . Dublin isolates may provide valuable insight on increased virulence observed in humans.

scholarly journals Trends in Susceptibility of Escherichia coli from Intra-Abdominal Infections to Ertapenem and Comparators in the United States According to Data from the SMART Program, 2009 to 2013

2015 ◽  
Vol 59 (6) ◽  
pp. 3606-3610 ◽  
Author(s):  
Sibylle H. Lob ◽  
Krystyna M. Kazmierczak ◽  
Robert E. Badal ◽  
Meredith A. Hackel ◽  
Samuel K. Bouchillon ◽  
...  
Keyword(s):  
United States ◽  
Escherichia Coli ◽  
Antimicrobial Resistance ◽  
Statistical Significance ◽  
The United States ◽  
Multidrug Resistant ◽  
Content Type ◽  
E Coli ◽  
Smart Data ◽  
Abdominal Infections

ABSTRACTAntimicrobial resistance inEnterobacteriaceae, including resistance to carbapenems, is increasing worldwide. However, using U.S. Study for Monitoring Antimicrobial Resistance Trends (SMART) data for 2009 to 2013, no statistically significant decreasing susceptibility trends were found overall forEscherichia coliisolates from patients with intra-abdominal infections. In the subset of isolates from community-associated infections, susceptibility to levofloxacin decreased significantly and the increasing rate of multidrug-resistantE. coliapproached statistical significance. In 2013, ertapenem, imipenem, and amikacin showed the highest susceptibility rates (≥99%) and fluoroquinolones the lowest (<70%). The 10 non-ertapenem-susceptible isolates (0.3% of allE. coliisolates) encoded one or more carbapenemases, extended-spectrum β-lactamases (ESBLs), AmpC β-lactamases, or non-ESBL β-lactamases.

Multidrug-resistant tuberculosis care in the United States

2020 ◽  
Vol 24 (4) ◽  
pp. 409-413 ◽  
Author(s):  
A. N. Gobaud ◽  
C. A. Haley ◽  
J. W. Wilson ◽  
R. Bhavaraju ◽  
A. Lardizabal ◽  
...  
Keyword(s):  
Medical Training ◽  
The United States ◽  
Multidrug Resistant ◽  
Expert Advice ◽  
Provider Type ◽  
Centers Of Excellence ◽  
Public Health Departments ◽  
Tb Treatment ◽  
Resistant Tuberculosis ◽  
Mdr Tb

BACKGROUND: To examine the utilization of the Tuberculosis (TB) Centers of Excellence (COE) medical consultation service and evaluate how these services were being employed for patients in relation to multidrug-resistant TB (MDR-TB).METHODS: Medical consults are documented in a secure database. The database was queried for MDR-TB consultations over the period 1 January 2013–31 December 2017. All were analyzed to assess provider type, center, setting, year of call, and type of patient (pediatric vs. adult). A subgroup was randomly selected for thematic analysis.RESULTS: The centers received 1560 MDR-TB consultation requests over this period. Providers requesting consults were primarily physicians (55%). The majority of requests were from public health departments (64%) and for adult patients (80%). Four major topic areas emerged: 1) initial management of MDR-TB, 2) MDR-TB longitudinal treatment and complications, 3) management of persons exposed to MDR-TB, and 4) MDR-TB treatment completion.CONCLUSIONS: Analysis of these consultations provides insight into the type of expert advice about MDR-TB that was provided. These findings highlight topics where increased medical training and education may help to improve MDR-TB-related practices.

Flow Research in Music Contexts: A Systematic Literature Review

2019 ◽  
pp. 102986491987756 ◽  
Author(s):  
Leonard Tan ◽  
Hui Xing Sin
Keyword(s):  
Research Output ◽  
The United States ◽  
Self Report ◽  
Future Research ◽  
Steady Increase ◽  
Measurement Instruments ◽  
Publication Type ◽  
Qualitative Approaches ◽  
Meta Analyses ◽  
Flow Experiences

The purpose of this study was to review flow research in music contexts from 1975 until the first quarter of 2019. Specifically, frequencies/percentages were calculated for (a) output in five-year periods; (b) publication type; and (c) methodologies employed, including measurement instruments used. Content analyses were also conducted on topics covered. Using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology, a total of 3,341 records were examined, with 95 studies eventually included in the analysis. Findings indicated a steady increase in research output over the last 25 years. Studies overwhelmingly sampled participants from Western populations, especially the United States. The majority of quantitative studies used self-report questionnaires, of which those developed by Jackson and colleagues were most prevalent. Among the qualitative approaches, interviews and observations were the most common means of data collection. Topics covered in the studies reviewed include the psychophysiological aspects of flow, transmission and group experience of flow, the association of flow with a range of positive outcomes, factors that contribute to flow experiences, and flow experiences of young children. Implications for future research were proffered in light of the findings.

A PubMed-Based Exploration of the Course of Yoga Research from 1948 to 2020

2021 ◽  
Author(s):  
Dipak Chetry ◽  
Shirley Telles ◽  
Acharya Balkrishna
Keyword(s):  
United States ◽  
United Kingdom ◽  
Research Output ◽  
Publishing Research ◽  
The United States ◽  
Time Frame ◽  
Health Conditions ◽  
Future Research ◽  
The United Kingdom ◽  
Meta Analyses

Yoga research citations from 1948 to 2020 in PubMed were filtered and sorted in 10-year intervals to explore the occurrence and time frame of change in (1) the focus of research; (2) the number of randomized controlled trials (RCTs), systematic reviews (SRs), and meta-analyses (MAs); (3) health conditions researched for yoga as therapy; (4) journals with yoga research; and (5) the research on yoga from different countries. Publications on yoga between 1948 and 1970 (1.25%) focused on exceptional abilities of experienced yoga practitioners, apparently related to the spiritual goal of yoga; from 1971 to 2000 (6.87%), the focus was on yoga in health and therapy; and from 2001 to 2020 (91.88%), research publications on yoga increased and continued to focus on health and therapy, with fewer RCTs relative to the SRs and MAs on yoga in PubMed. Publications on yoga reported the following health conditions most often: from 1981 to 1990, (1) asthma, (2) stress, and (3) diabetes; from 1991 to 2000, (1) stress followed by (2) asthma, anxiety, and pain (all three with equal percentages); from 2001 to 2010, (1) depression, (2) stress, and (3) anxiety; and from 2011 to 2020, (1) stress, (2) depression, and (3) pain. The journals publishing research on yoga in PubMed have changed between 1971 and 2020 as follows: highly clinically relevant, broad-interest medical journals (1971 to 1990); journals relevant to mind-body interventions (1991 to 2000); and specialized journals for complementary and alternative medicine, particular branches of medicine, or research study designs (2001 to 2020). The highest yoga research output from 1971 to 1980 came from the United Kingdom (RCTs); from 1981 to 1990 the most research came from the United States (RCTs); from 1991 to 2000 the most research came from India (RCTs) and the United Kingdom (SRs); from 2001 to 2010 the most research came from the United States (RCTs, SRs) and the United Kingdom (MAs); and from 2011 to 2020 the most research came from the United States (RCTs, SRs, MAs). The trends in yoga research from this analysis reflect increased research related to yoga and health while suggesting areas for future research based on the strengths and gaps that have emerged.

scholarly journals Immigrant Arrival and Tuberculosis among Large Immigrant- and Refugee-Receiving Countries, 2005–2009

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Zachary White ◽  
John Painter ◽  
Paul Douglas ◽  
Ibrahim Abubakar ◽  
Howard Njoo ◽  
...  
Keyword(s):  
The United States ◽  
Multidrug Resistant ◽  
The Philippines ◽  
Health Concern ◽  
Foreign Born ◽  
Tuberculosis Control ◽  
Tuberculosis Case ◽  
Resistant Tuberculosis ◽  
Mdr Tb ◽  
Immigrant And Refugee

Objective. Tuberculosis control in foreign-born populations is a major public health concern for Australia, Canada, New Zealand, United Kingdom, and the United States, large immigrant- and refugee-receiving countries that comprise the Immigration and Refugee Health Working Group (IRHWG). Identifying and comparing immigration and distribution of foreign-born tuberculosis cases are important for developing targeted and collaborative interventions.Methods. Data stratified by year and country of birth from 2005 to 2009 were received from these five countries. Immigration totals, tuberculosis case totals, and multidrug-resistant tuberculosis (MDR TB) case totals from source countries were analyzed and compared to reveal similarities and differences for each member of the group.Results. Between 2005 and 2009, there were a combined 31,785,002 arrivals, 77,905 tuberculosis cases, and 888 MDR TB cases notified at the federal level in the IRHWG countries. India, China, Vietnam, and the Philippines accounted for 41.4% of the total foreign-born tuberculosis cases and 42.7% of the foreign-born MDR tuberculosis cases to IRHWG.Interpretation. Collaborative efforts across a small number of countries have the potential to yield sizeable gains in tuberculosis control for these large immigrant- and refugee-receiving countries.

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