scholarly journals Hepatic Leukemia Factor supports the propagation of leukemia and hematopoietic stem cell function during stress-induced regeneration

2021 ◽  
Author(s):  
Aurélie Baudet ◽  
Karolina Komorowska ◽  
Simon Hultmark ◽  
Marion Chapellier ◽  
Kenichi Miharada ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Function ◽  
Molecular Networks ◽  
List Type ◽  
Hematopoietic Stem ◽  
Disease Propagation ◽  
Hematopoietic Recovery ◽  
Key Points ◽  
Essential Transcription Factor ◽  
Dependent Mechanism

AbstractThe processes regulating hematopoietic stem cells (HSC) during aging are not fully understood1, but it is clear that the incidence of hematological malignancies increases with age, highlighting the importance of unravelling the cellular and molecular networks involved. Recently, we identified Hepatic Leukemia Factor (HLF) as an essential transcription factor in maintaining the HSC pool during regeneration2 and showed that failure to downregulate HLF leads to disrupted differentiation3.Here, we found that HLF is dispensable for hematopoiesis during systemic aging, but needed during stress-induced hematopoietic recovery of aged HSC after transplantation. Additionally, HLF was dispensable for leukemic initiation but required for disease propagation. Taken together, our findings demonstrate the existence of a HLF-dependent mechanism that uncouples stress-induced regeneration from hematopoietic homeostasis during aging, that can be used by malignant cells to gain stem cell properties to propagate the disease.Key pointsHLF is dispensable for HSC function and hematopoietic homeostasis during physiological aging, but crucial during stress induced regeneration.HLF supports the propagation of leukemia-initiating cells

scholarly journals Deletion of the NF-κB subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function

Blood ◽  
2013 ◽  
Vol 121 (25) ◽  
pp. 5015-5024 ◽  
Author(s):  
Sarah J. Stein ◽  
Albert S. Baldwin
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Lineage Commitment ◽  
Key Factors ◽  
Cell Homeostasis ◽  
Hematopoietic Stem ◽  
Expression Of Genes ◽  
Key Points ◽  
Genes Encoding

Key Points p65 is an important factor in hematopoiesis through the regulation of hematopoietic stem cell function and lineage commitment. p65 controls the expression of genes encoding key factors that promote hematopoietic stem cell homeostasis.

scholarly journals Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2

Blood ◽  
2015 ◽  
Vol 125 (12) ◽  
pp. 1890-1900 ◽  
Author(s):  
Sarah A. Kinkel ◽  
Roman Galeev ◽  
Christoffer Flensburg ◽  
Andrew Keniry ◽  
Kelsey Breslin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Hematopoietic Stem Cells ◽  
Progenitor Cells ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Hematopoietic Stem ◽  
Polycomb Repressive Complex 2 ◽  
Key Points ◽  
Stem And Progenitor Cells

Key Points Depletion of Jarid2 in mouse and human hematopoietic stem cells enhances their activity. Jarid2 acts as part of PRC2 in hematopoietic stem and progenitor cells.

scholarly journals ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells

Blood ◽  
2017 ◽  
Vol 130 (5) ◽  
pp. 619-624 ◽  
Author(s):  
Brian S. Garrison ◽  
Adrian P. Rybak ◽  
Isabel Beerman ◽  
Balthasar Heesters ◽  
Francois E. Mercier ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Human Cells ◽  
Self Renewal ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Murine Hematopoietic Stem Cell

Key Points ZFP521 regulates HSC self-renewal and differentiation. ZFP521 facilitates leukemogenesis in an MLL-AF9–mediated leukemia model.

Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress

Blood ◽  
2014 ◽  
Vol 123 (1) ◽  
pp. 41-50 ◽  
Author(s):  
Ikue Tai-Nagara ◽  
Sahoko Matsuoka ◽  
Hiroyoshi Ariga ◽  
Toshio Suda
Keyword(s):  
Oxidative Stress ◽  
Stem Cell ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Mitochondrial Heat Shock Protein

Key Points Mitochondrial heat shock protein, mortalin, is essential for the maintenance of HSCs via the control of oxidative stress. Mortalin directly interact with DJ-1 to regulate ROS levels in the mitochondria of HSCs.

scholarly journals FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function

Blood ◽  
2013 ◽  
Vol 122 (16) ◽  
pp. 2903-2910 ◽  
Author(s):  
John C. H. Byon ◽  
Jing Chen ◽  
Raymond T. Doty ◽  
Janis L. Abkowitz
Keyword(s):  
Stem Cell ◽  
Steady State ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Stress Conditions ◽  
Hematopoietic Stem ◽  
Platelet Counts ◽  
Key Points ◽  
Erythroid Maturation

Key Points FLVCR deletion causes proerythroblast apoptosis and lethal anemia but leads to increased megakaryocyte ploidy and platelet counts. Loss of FLVCR is dispensable for hematopoietic stem cell function during steady-state and stress conditions.

scholarly journals Osteomacs interact with megakaryocytes and osteoblasts to regulate murine hematopoietic stem cell function

2017 ◽  
Vol 1 (26) ◽  
pp. 2520-2528 ◽  
Author(s):  
Safa F. Mohamad ◽  
Linlin Xu ◽  
Joydeep Ghosh ◽  
Paul J. Childress ◽  
Irushi Abeysekera ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Murine Hematopoietic Stem Cell

Key Points OM, osteoblast, and megakaryocyte interactions regulate HSC function in the niche. OMs differ functionally and phenotypically from BM-derived macrophages.

scholarly journals PLZF mutation alters mouse hematopoietic stem cell function and cell cycle progression

Blood ◽  
2016 ◽  
Vol 127 (15) ◽  
pp. 1881-1885 ◽  
Author(s):  
Christelle Vincent-Fabert ◽  
Nadine Platet ◽  
Amelle Vandevelde ◽  
Mathilde Poplineau ◽  
Myriam Koubi ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Cycle Progression ◽  
Cell Function ◽  
Cycle Progression ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Mouse Hematopoietic Stem Cell

Key Points Inactivation of PLZF promotes phenotype of HSC aging. PLZF controls HSC cell cycle.

scholarly journals MLL fusion protein–driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction

Blood ◽  
2013 ◽  
Vol 122 (11) ◽  
pp. 1914-1922 ◽  
Author(s):  
Andrew G. Muntean ◽  
Wei Chen ◽  
Morgan Jones ◽  
Eric M. Granowicz ◽  
Ivan Maillard ◽  
...  
Keyword(s):  
Stem Cell ◽  
Fusion Protein ◽  
Hematopoietic Stem Cell ◽  
Epigenetic Regulation ◽  
Cell Function ◽  
Leukemic Cells ◽  
Targeted Disruption ◽  
Hematopoietic Stem ◽  
Key Points

Key Points The PAFc subunit, Cdc73, is required for the proliferation and proper epigenetic regulation of proleukemic oncogenes in AML cells. Disrupting the MLL-PAFc interaction selectively inhibits the growth of MLL-associated leukemic cells without altering normal hematopoietic stem cell function.

scholarly journals Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis

Blood ◽  
2015 ◽  
Vol 126 (2) ◽  
pp. 167-175 ◽  
Author(s):  
Stanley C. W. Lee ◽  
Sarah Miller ◽  
Craig Hyland ◽  
Maria Kauppi ◽  
Marion Lebois ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Polycomb Repressive Complex ◽  
Hematopoietic Stem ◽  
Polycomb Repressive Complex 2 ◽  
Lymphoid Development ◽  
Key Points

Key Points Inactivation of Suz12 results in a rapid and marked exhaustion of the HSC pool. Lymphoid development is completely dependent on PRC2, but numerous myeloid lineages develop in the absence of PRC2.

scholarly journals Steady-state and regenerative hematopoiesis occurs normally in mice in the absence of GDF11

Blood ◽  
2019 ◽  
Vol 134 (20) ◽  
pp. 1712-1716 ◽  
Author(s):  
Jill M. Goldstein ◽  
Hilal Sengul ◽  
Kathleen A. Messemer ◽  
Marcos Fernández-Alfara ◽  
Jessica C. Garbern ◽  
...  
Keyword(s):  
Stem Cell ◽  
Steady State ◽  
Blood Cell ◽  
Hematopoietic Stem Cell ◽  
Red Blood Cell ◽  
Cell Function ◽  
Cell Formation ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Genetic Deletion

Key Points Genetic deletion of Gdf11 does not affect red blood cell formation during homeostasis or after transplant. Hematopoietic stem cell function is preserved in mice lacking Gdf11 expression within the blood lineage.

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