Systematic Review and Meta-analysis on COVID-19 Vaccine Hesitancy

Background: The presented meta-analysis was developed in response to the publication of several studies addressing COVID-19 vaccines hesitancy. We aimed to identify the proportion of vaccine acceptance and rejection, and factors affecting vaccine hesitancy worldwide especially with the fast emergency approval of vaccines. Methods: Online database search was performed, and relevant studies were included with no language restriction. A meta-analysis was conducted using R software to obtain the random effect model of the pooled prevalence of vaccine acceptance and rejection. Egger regression test was performed to assess publication bias. Quality assessment was assessed using Newcastle-Ottawa Scale quality assessment tool. Results: Thirty-nine out of 12246 articles met the predefined inclusion criteria. All studies were cross-sectional designs. The pooled proportion of COVID-19 vaccine hesitancy was 17% (95% CI: 14-20) while the pooled proportion of COVID-19 vaccine acceptance was 75% (95% CI: 71-79). The vaccine hesitancy and the vaccine acceptance showed high heterogeneity (I 2 =100%). Case fatality ratio and the number of reported cases had significant effect on the vaccine acceptance as the pooled proportion of vaccine acceptance increased by 39.95% (95% CI: 20.1-59.8) for each 1% increase in case fatality (P<0.0001) and decreased by 0.1% (95% CI: -0.2-0.01) for each 1000 reported case of COVID-19, P= 0.0183). Conclusion: Transparency in reporting the number of newly diagnosed COVID-19 cases and deaths is mandatory as these factors are the main determinants of COVID-19 vaccine acceptance.

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Postnatal Outcome and Associated Anomalies of Prenatally Diagnosed Right Aortic Arch with Concomitant Right Ductal Arch: A Systematic Review and Meta-Analysis

Diagnostics ◽

10.3390/diagnostics10100831 ◽

2020 ◽

Vol 10 (10) ◽

pp. 831

Author(s):

Paolo Ivo Cavoretto ◽

Alexandros Sotiriadis ◽

Serena Girardelli ◽

Silvia Spinillo ◽

Massimo Candiani ◽

...

Keyword(s):

Systematic Review ◽

Quality Assessment ◽

Aortic Arch ◽

Assessment Tool ◽

Chromosomal Abnormalities ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Case Series ◽

Right Aortic Arch

Right aortic arch presents a reported incidence of 0.1% of the general population; the aim of our study was to evaluate the risk of associated intracardiac (ICA), extracardiac (ECA), or chromosomal abnormalities in fetuses with right aortic arch (RAA) and concomitant right ductal arch (RDA). A systematic review of the literature selected 18 studies including 60 cases of RAA/RDA. A meta-analysis with a random effect model calculated for each outcome the pooled crude proportion of associated abnormal outcomes in cases of RAA/RDA and the pooled proportions and odds ratios in RAA with LDA or RDA. Quality assessment of the included studies was achieved using the NIH quality assessment tool for case series studies. RAA/RDA presents risk of associated conotruncal CHDs of about 30% and risk of 22q11 microdeletion in the region of 1%. Two-thirds of 22q11 microdeletions had concomitant thymic hypoplasia and no other chromosomal defects were described. Risks for ICA, ECA, 22q11 microdeletion, and aberrant left subclavian artery are not substantially different in RAA with right or left arterial duct. RAA increases the risk of associated cardiac defects regardless of laterality of the ductal arch. In isolated RDA/RAA cases, absolute risks of extracardiac associated problems or surgery are rather low, we would therefore recommend reassurance, particularly when the thymus and karyotype are normal.

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Non-prescription dispensing of antibiotic agents among community drug retail outlets in Sub-Saharan African countries: a systematic review and meta-analysis

Antimicrobial Resistance and Infection Control ◽

10.1186/s13756-020-00880-w ◽

2021 ◽

Vol 10 (1) ◽

Author(s):

Sewunet Admasu Belachew ◽

Lisa Hall ◽

Linda A. Selvey

Keyword(s):

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Acute Diarrhoea ◽

Upper Respiratory Tract ◽

Cross Sectional ◽

Retail Outlets ◽

Sub Saharan ◽

Tract Infections ◽

Ssa Countries

Abstract Background The development of antimicrobial resistance, which is partially attributable to the overuse and/or misuse of antibiotics in health care, is one of the greatest global public health challenges. In Sub-Saharan African (SSA) countries, non-prescribed dispensing of antibiotics in community drug retail outlets (CDROs) has been flagged as one of the contributing factors for the widespread misuse of antibiotics in the community. Objective The current review aimed to estimate the proportion of non-prescription antibiotics requests or consultations that resulted in provision of antibiotics without a valid prescription among CDROs in SSA region, and describe the type of antibiotics dispensed. Methods A literature search was conducted using PubMed, CINAHL, Scopus and Google Scholar. We also searched reference lists of relevant articles. Random effect model meta-analysis was employed to determine the pooled proportion of over the counter sale of antibiotics. Subgroup and meta-regression was undertaken to explore the potential cause of heterogeneity in effect size across studies. Results Of 671 total citations retrieved, 23 met the inclusion criteria (seven cross-sectional questionnaire-based surveys and 16 cross-sectional client-based studies). The overall pooled proportion of non-prescription antibiotics requests or consultations that resulted in supply of antibiotics without prescription was 69% (95% CI 58–80). Upper respiratory tract infections and/or acute diarrhoea were the most frequently presented case scenarios, and amoxicillin and co-trimoxazole were the most frequently dispensed antibiotics to treat those symptoms. Conclusions Non-prescribed dispensing of antibiotics was found to be a common practice among CDROs in several SSA countries. Ease of access to and overuse of antibiotics can potentially accelerate the emergence of resistance to antibiotics available in the region. Our review highlights the need for a stringent enforcement of existing policies and/or enacting new regulatory frameworks that would regulate antibiotic supply, and training and educational support for pharmacy personnel (e.g. pharmacists, pharmacy assistants) regarding judicious use of antibiotics and the importance of antimicrobial stewardship.

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Association Between Prediabetes and Retinopathy: A Meta-Analysis

Hormone and Metabolic Research ◽

10.1055/a-1678-7092 ◽

2021 ◽

Vol 53 (12) ◽

pp. 801-809

Author(s):

Ji Jin ◽

Peirong Lu

Keyword(s):

Meta Analysis ◽

Microvascular Complications ◽

Random Effect ◽

Random Effect Model ◽

Community Dwelling ◽

Current Evidence ◽

Cross Sectional ◽

Increased Risk ◽

Study Heterogeneity ◽

Study Characteristics

AbstractDiabetes confers an increased risk of microvascular complications, including retinopathy. However, whether prediabetes is also related to retinopathy has not been comprehensively examined. We performed a meta-analysis to evaluate the relationship between prediabetes and retinopathy. This meta-analysis included relevant observational studies from Medline, Embase, and Web of Science databases. A random-effect model after incorporation of the intra-study heterogeneity was selected to pool the results. Subgroup analyses were applied to evaluate the influences of study characteristics on relationship. Nine cross-sectional studies including 14 751 community dwelling adult participants were included; 3847 (26.1%) of them were prediabetic. Results showed that prediabetes was associated with a higher prevalence of retinopathy compared to normoglycemia [odds ratio (OR): 1.55, 95% confidence interval (CI): 1.10–2.20, p=0.01, I2=34%]. Sensitivity analysis by excluding one study at a time showed consistent result (OR: 1.35 to 1.73, p all<0.05). Subgroup analysis showed study characteristics such as definition of prediabetes, country of study, sample size, mean age of participants, or univariate or multivariate analyses may not significantly affect the association (p for subgroup difference all>0.05). Current evidence suggests that patients with prediabetes may be associated with higher prevalence of retinopathy as compared to those with normoglycemia. Although prospective cohort studies are needed to validate these findings, results of our meta-analysis highlighted the importance of early prevention of retinopathy in patients with prediabetes.

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Effect of Fixed Orthodontic Treatment on Salivary Nickel and Chromium Levels: A Systematic Review and Meta-Analysis of Observational Studies

Dentistry Journal ◽

10.3390/dj7010021 ◽

2019 ◽

Vol 7 (1) ◽

pp. 21 ◽

Cited By ~ 2

Author(s):

Mohammad Imani ◽

Hamid Mozaffari ◽

Mazaher Ramezani ◽

Masoud Sadeghi

Keyword(s):

Orthodontic Treatment ◽

Randomized Clinical Trials ◽

Meta Analysis ◽

Random Effect ◽

Cochrane Library ◽

Orthodontic Appliances ◽

Cross Sectional ◽

Factors Affecting ◽

Number Of Patients ◽

Fixed Orthodontic Appliances

Nickel and chromium ions released from fixed orthodontic appliances may act as allergens. This study aimed to systematically review the effect of fixed orthodontic treatment on salivary levels of these ions by doing a meta-analysis on cross-sectional and cohort studies. The Web of Science, Scopus, Cochrane Library, and PubMed databases were searched for articles on salivary profile of nickel or chromium in patients under fixed orthodontic treatment published from January 1983 to October 2017. A random-effect meta-analysis was done using Review Manager 5.3 to calculate mean difference (MD) and 95% confidence interval (CI), and the quality of questionnaire was evaluated by the Newcastle–Ottawa scale. Fourteen studies were included and analyzed in this meta-analysis. Salivary nickel level was higher in periods of 10 min or less (MD = −11.5 µg/L, 95% CI = −16.92 to −6.07; P < 0.0001) and one day (MD = −1.38 µg/L, 95% CI = −1.97 to −0.80; P < 0.00001) after initiation of treatment compared to baseline (before the insertion of appliance). Salivary chromium level was higher in periods of one day (MD = −6.25 µg/L, 95% CI = −12.00 to −0.49; P = 0.03) and one week (MD = −2.07 µg/L, 95% CI = −3.88 to −0.26; P = 0.03) after the initiation of treatment compared to baseline. Corrosion of fixed orthodontic appliances leads to elevated salivary nickel and chromium concentrations early after initiation of orthodontic treatment. Randomized clinical trials controlling for factors affecting the saliva composition are recommended on a higher number of patients and among different ethnicities.

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Epidemiology of gastric cancer in Africa: a systematic review and meta-analysis protocol

Systematic Reviews ◽

10.1186/s13643-019-1214-2 ◽

2019 ◽

Vol 8 (1) ◽

Cited By ~ 1

Author(s):

Celestin Danwang ◽

Jean Joel Bigna

Keyword(s):

Gastric Cancer ◽

Systematic Review ◽

Data Extraction ◽

Meta Analysis ◽

Random Effect ◽

Case Series ◽

Case Fatality ◽

Cross Sectional ◽

Statistical Heterogeneity ◽

The Usa

Abstract Background Gastric cancer is actually known as the sixth most frequent cancer and the second cancer-related cause of death worldwide. If studies giving an overview of current epidemiology of gastric cancer in Europe, Asia, and the USA are available, in Africa, studies reporting recent data on gastric cancer are sparse. This systematic review and meta-analysis aim therefore to provide relevant data on contemporary epidemiology of gastric cancer in Africa in terms of prevalence, incidence, and case fatality rate. Methods and design We will include cohort, case-control, cross-sectional studies, and case series with more than 30 participants. EMBASE, PubMed, Africa Index Medicus, Africa Journals Online, and Web of Science will be searched for relevant abstracts of studies published and unpublished between January 1, 2000, and April 30, 2019, without language restriction. The review will be reported according to the MOOSE (Meta-analysis Of Observational Studies in Epidemiology) guideline. After screening of abstracts, study selection, data extraction, and risk of bias assessment, we shall assess the studies individually for clinical and statistical heterogeneity. Random-effect meta-analysis will be used to pool studies judged to be clinically homogenous. The Egger test and visual inspection of funnel plots will be used to assess publication bias. Discussion This review will provide relevant data on the current burden of gastric cancer in Africa. Systematic review registration PROSPERO CRD42019130348.

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Effect of HIV Infection on Mortality in Patients with Tuberculosis in Asia: A Meta-Analysis

Childhood Stunting, Wasting, and Obesity, as the Critical Global Health Issues: Forging Cross-Sectoral Solutions ◽

10.26911/the7thicph.01.52 ◽

2020 ◽

Author(s):

Liza Laela Abida ◽

◽

Bhisma Murti ◽

Hanung Prasetya ◽

◽

...

Keyword(s):

Hiv Infection ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Cross Sectional Study ◽

People Living With Hiv ◽

Cross Sectional ◽

Risk Of Mortality ◽

Hiv Mortality ◽

Keywords Hiv

ABSTRACT Background: TB/HIV coinfectioned remains the leading cause of mortality among people living with HIV (PLHIV). The purpose of this study was to explore the effect of HIV infection on mortality in patients with tuberculosis in Asia. Subjects and Method: This was meta-analysis and systematic review. The study was conducted by collecting published studies from Google Scholar, PubMed, Springer Link, Hindawi, Clinical Key, and ProQuest databases, from 2010 to 2020. Keywords used “HIV” AND “mortality” OR “HIV Mortality” OR “Tuberculosis Mortality” AND “cross sectional” AND “adjusted odd ratio”. The inclusion criteria were full text, using English or Indonesian language, using cross-sectional study design, and reporting adjusted odds ratio. The articles were selected by PRISMA flow chart. The quantitative data were analyzed using random effect model run on Review Manager 5.3. Results: 5 studies in Asia (Thailand, China, Malaysia, and Oman) were included for this study. Meta analysis study reported that HIV elevated the risk of mortality in patients with tuberculosis (aOR= 3.45; 95% CI= 1.14 to 10.45; p = 0.030). Conclusion: HIV elevates the risk of mortality in patients with tuberculosis. Keywords: HIV, mortality, Tuberculosis Correspondence: Liza Laela Abida. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: 085640115633. DOI: https://doi.org/10.26911/the7thicph.01.52

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Effect of Secondary Education on Exclusive Breastfeeding: Meta-Analysis

Childhood Stunting, Wasting, and Obesity, as the Critical Global Health Issues: Forging Cross-Sectoral Solutions ◽

10.26911/the7thicph.03.131 ◽

2020 ◽

Author(s):

Ferda Fibi Tyas Nurkholifa ◽

◽

Eti Poncorini Pamungkasari ◽

Hanung Prasetya ◽

◽

...

Keyword(s):

Secondary Education ◽

Exclusive Breastfeeding ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

South Australia ◽

Inclusion Criteria ◽

Or Education ◽

Cross Sectional ◽

Central Java

ABSTRACT Background: Many studies reported the importance of exclusive breastfeeding for infants. However, there are many obstacles faced by lactating mothers to provide exclusive breastfeeding for their children. This study aimed to investigate the effect of secondary education on exclusive breastfeeding using a meta-analysis. Subjects and Method: Meta-analysis and systematic review were conducted by collecting articles from PubMed, Science Direct, and Google Scholar databases. Keywords used exclusive breastfeeding” AND “secondary education” OR “education for breastfeeding” AND “cross sectional” AND “adjusted odd ratio”. The study population was postpartum mothers. Intervention was secondary education with comparison primary education. The study outcome was exclusive breastfeeding. The inclusion criteria were full text, using English or Indonesian language, and reporting adjusted odds ratio. The articles were selected by PRISMA flow chart. The quantitative data were analyzed using random effect model run on Revman 5.3. Results: 7 studies from Peru, China, Nigeria, Korea, Ireland, Sub-Sahara, and South Australia were met the inclusion criteria. There was high heterogeneity between groups (I2= 94%; p<0.001). This study reported that secondary education reduced exclusive breastfeeding, but it was statistically non-significant (aOR= 0.86; 95% CI= 0.60 to 1.24; p= 0.430). Conclusion: Secondary education reduced exclusive breastfeeding, but it was statistically non-significant. Keywords: exclusive breastfeeding, secondary education, postpartum Correspondence: Ferda Fibi Tyas Nurkholifa. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: +6285655778863. DOI: https://doi.org/10.26911/the7thicph.03.131

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Obesity and Gastroesophageal Reflux Disease: A Meta-Analysis Study in Asia and America

Childhood Stunting, Wasting, and Obesity, as the Critical Global Health Issues: Forging Cross-Sectoral Solutions ◽

10.26911/the7thicph.05.50 ◽

2020 ◽

Author(s):

Alfiani Vivi Sutanto ◽

◽

Hanung Prasetya ◽

◽

Keyword(s):

Gastroesophageal Reflux Disease ◽

Gastroesophageal Reflux ◽

Reflux Disease ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

The United States ◽

Cross Sectional Study ◽

Cross Sectional ◽

Central Java

ABSTRACT Background: Gastroesophageal reflux disease (GERD) is a common disorder with a prevalence of 20% in the United States and less than 5% in Asia. Untreated, GERD can result in a symptomatic burden to the patient, poor health-related quality of life, complications, such as esophageal stricture, Barrett’s esophagus, and esophageal adenocarcinoma, and a high direct and indirect cost to the healthcare system. Various pathophysiological mechanisms have been identified to explain the relationship between obesity and GERD, including a high prevalence of hiatal hernia and increased gastroesophageal pressure gradient. This study aimed to examine the association between obesity and GERD in Asia and America. Subjects and Method: This was meta-analysis and systematic review. The study was conducted by collecting articles from PubMed, Google Scholar, BMC Journals, Science Direct, Mendeley, and clinical key databases. Keywords used “Obesity” OR “HMI” AND “Gastroesophageal reflux disease” OR “GERD” AND “Effect obesity for GERD” AND “aOR”. The inclusion criteria were full text, using cross-sectional study design, and reporting adjusted odds ratio. The study population was adults who experienced GERD. Intervention was obesity. The study outcome was gastroesophageal reflux disease (GERD). The articles were selected using PRISMA flow chart. The quantitative data were analyzed using random effect model run on Revman 5.3. Results: 5 studies were analyzed and reviewed for this study. Current study reported that obesity increased the risk of gastroesophageal reflux disease (GERD) (aOR= 2.04; 95% CI=1.42 to 2.92; p= 0.001). Conclusion: Obesity increases the risk of gastroesophageal reflux disease. Keywords: obesity, gastroesophageal reflux disease Correspondence: Alfiani Vivi Sutanto. Masters Program in Public Health. Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: 085799253568. DOI: https://doi.org/10.26911/the7thicph.05.50

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A meta-analysis of copper level and risk of preeclampsia: evidence from 12 publications

Bioscience Reports ◽

10.1042/bsr20160197 ◽

2016 ◽

Vol 36 (4) ◽

Cited By ~ 11

Author(s):

Yuqin Fan ◽

Yan Kang ◽

Min Zhang

Keyword(s):

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Asian Population ◽

Epidemiological Studies ◽

Copper Level ◽

Case Control Studies ◽

Cross Sectional ◽

Healthy Pregnancy ◽

Risk Of Preeclampsia

The association between copper level and risk of preeclampsia (PE) has produced inconsistent results. Thus, a meta-analysis was conducted to summarize the evidence from epidemiological studies for copper level and PE risk. Pertinent studies were identified by a search of PubMed and Web of Knowledge up to April 2016. Standardized mean difference (SMD) was performed to combine the results. Random-effect model (REM) was used. Publication bias was estimated using Egger's regression asymmetry test. Twelve articles (10 case–control studies and 2 cross-sectional studies) involving 442 PE cases and 463 health controls were included in this meta-analysis. Our pooled results suggested that PE patients had a higher copper level compared with healthy pregnancy controls [summary SMD=0.69, 95% CI: 0.54–0.84, I2=96.7%; P<0.001]. The association was also significant in Asian population [SMD=0.73, 95% CI=0.57–0.90, I2=97.3%] and European populations [SMD=0.50, 95% CI=0.14–0.86, I2=58.9%]. After conducting the subgroup analysis and sensitive analysis, the results showed consistent significant association with the one based on all studies. No publication biases were found. Our analysis indicated that plasma or serum copper level in PE patients was significantly higher than that in healthy pregnancy women.

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Association between Toxoplasma gondii infection and headache: a systematic review and meta-analysis

Infectious Disorders - Drug Targets ◽

10.2174/1871526520666200617135851 ◽

2020 ◽

Vol 20 ◽

Author(s):

Tooran Nayeri ◽

Shahabeddin Sarvi ◽

Mahmood Moosazadeh ◽

Zahra Hosseininejad ◽

Afsaneh Amouei ◽

...

Keyword(s):

Toxoplasma Gondii ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Forest Plot ◽

Cross Sectional ◽

Effect Model ◽

Toxoplasma Gondii Infection ◽

And Control ◽

The Impact

Background: The impact of infectious agents, such as Toxoplasma gondii (T. gondii), on human behavior and mental disorders has recently attracted the attention of researchers. T. gondii has emerged as a suitable candidate for such disorders due to its neural nature. Therefore, the current study aimed at investigating the possible relationship between T. gondii infection and headache. Methods: Five databases were thoroughly searched (up to October 4, 2019) for articles on the prevalence of T. gondii in headache sufferer. In this study, the odds ratio (OR) and corresponding 95% confidence interval (CI) were estimated using a random effect model and forest plot to gauge effect size and effect of each study. Results: A total number of four articles, including three case-controls and one cross-sectional studies with 2517 participants entered the meta-analysis out of whom 1205 subjects were afflicted with headache or migraine (17.67% positive for toxoplasmosis) and 1312 participants were not (18.29% for toxoplasmosis). The results of the meta-analysis indicated a common OR of 1.59 (95% CI: 1.03-2.47) by the random effect model. Conclusion: The obtained results of several studies have linked toxoplasmosis and headache. Therefore, more quality studies with larger sample sizes are needed to determine the detailed association between headache and T. gondii infection for the prevention and control of toxoplasmosis among headache sufferers.

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