scholarly journals Transcriptomes of Electrophysiologically Recorded Dbx1-derived Inspiratory Neurons of the preBötzinger Complex in Neonatal Mice

2021 ◽  
Author(s):  
Prajkta Shashikant Kallurkar ◽  
Maria Cristina Picardo ◽  
Yae Sugimura ◽  
Margaret A Saha ◽  
Gregory Douglas Conradi Smith ◽  
...  
Keyword(s):  
Cycle Period ◽  
The Public ◽  
Neuropeptide Receptors ◽  
Opioid Drugs ◽  
Inspiratory Motor ◽  
Output Pattern ◽  
Prebotzinger Complex ◽  
Prebötzinger Complex

Breathing depends on interneurons in the preBötzinger complex (preBötC) derived from Dbx1-expressing precursors. Here we investigate whether rhythm- and pattern-generating functions reside in discrete classes of Dbx1 preBötC neurons. In a slice model of breathing with ~5 s cycle period, putatively rhythmogenic Type-1 Dbx1 preBötC neurons activate 100-300 ms prior to Type-2 neurons, putatively specialized for output pattern, and 300-500 ms prior to the inspiratory motor output. We sequenced Type-1 and Type-2 transcriptomes and identified differential expression of 123 genes including ionotropic receptors (Gria3 and Gabra1) that may explain their preinspiratory activation profiles and Ca2+ signaling (Cracr2a, Sgk1) involved in inspiratory and sigh bursts. Surprisingly, neuropeptide receptors that influence breathing (e.g., μ-opioid and bombesin-like peptide receptors) were only sparsely expressed, which suggests that cognate peptides and opioid drugs exert their profound effects on a small fraction of the preBötC core. These data in the public domain help explain the neural origins of breathing.

scholarly journals URINE GLUCOSE DETECTION AS A DIABETES DISEASE IN WOMEN AND ELDERLY IN KEDUNGPANDAN VILLAGE, JABON, SIDOARJO

2021 ◽  
Vol 1 (1) ◽  
pp. 5-10
Author(s):  
Andreas Putro Ragil Santoso ◽  
Devyana Dyah Wulandari
Keyword(s):  
Early Detection ◽  
Community Service ◽  
Metabolic Disorders ◽  
The Elderly ◽  
Total Sample ◽  
Glucose Detection ◽  
Early Detection Of Disease ◽  
The Public

Diabetes is a disease of metabolic disorders caused by poor production of insulin by the pancreas or due to the use of body insulin which is not maximal, causing interference. The main diabetes that often occurs in the community is type 1 and type 2 diabetes because of the influence of body insulin. Examination for detection is intended so that the public can find out about the presence of glucose in the urine so that the community can immediately recover faster, considering that if there is a glucose level in the urine, there is an increase in the level of glucose in the blood. The method used in this community service is to collect residents at the center, which is then carried out by examining the urine sample using a urine dysptic. Based on the results of examinations carried out on 62 people consisting of mothers and the elderly, it showed that there were 10 positive people or 19% of the total sample. This shows that early detection is important because there are still people who do not know the importance of early detection of disease in themselves, especially in the Kedung Pandan area.

scholarly journals The City-Wide Impacts of the Interactions between Shared Autonomous Vehicle-Based Mobility Services and the Public Transportation System

2021 ◽  
Vol 13 (12) ◽  
pp. 6725
Author(s):  
Sehyun Tak ◽  
Soomin Woo ◽  
Sungjin Park ◽  
Sunghoon Kim
Keyword(s):  
Public Transportation ◽  
Autonomous Vehicles ◽  
Impact Analysis ◽  
Autonomous Vehicle ◽  
The Public ◽  
Private Vehicle ◽  
Simulation Based ◽  
Mode Share

When attempts are made to incorporate shared autonomous vehicles (SAVs) into urban mobility services, public transportation (PT) systems are affected by the changes in mode share. In light of that, a simulation-based method is presented herein for analyzing the manner in which mode choices of local travelers change between PT and SAVs. The data used in this study were the modal split ratios measured based on trip generation in the major cities of South Korea. Subsequently, using the simulated results, a city-wide impact analysis method is proposed that can reflect the differences between the two mode types with different travel behaviors. As the supply–demand ratio of SAVs increased in type 1 cities, which rely heavily on PT, use of SAVs gradually increased, whereas use of PT and private vehicles decreased. Private vehicle numbers significantly reduced only when SAVs and PT systems were complementary. In type 2 cities, which rely relatively less on PT, use of SAVs gradually increased, and use of private vehicles decreased; however, no significant impact on PT was observed. Private vehicle numbers were observed to reduce when SAVs were operated, and the reduction was a minimum of thrice that in type 1 cities when SAVs and PT systems interacted. Our results can therefore aid in the development of strategies for future SAV–PT operations.

scholarly journals Diagnosing Diabetes, Diagnosing Colonialism: An Ethnography of the Classification and Counting of a Senegalese Metabolic Disease

2021 ◽  
Vol 8 (2) ◽  
pp. 1-26
Author(s):  
Emma N Bunkley
Keyword(s):  
Global Health ◽  
Public Hospital ◽  
Noncommunicable Diseases ◽  
Diabetes Diagnosis ◽  
Saint Louis ◽  
The Public ◽  
Production And Consumption ◽  
The Individual

This article explores the top-down production of the statistics frequently circulated in global health. These data must first originate in a place like the public hospital in Saint-Louis, Senegal, in doctor’s offices and laboratories and medical archives. At their root, these data are an accumulation of individual bodies, experiences, and intimate diagnostic moments. This aggregation turns the afflicted into categories and statistical regimes that shape a global health understanding of diabetes specifically, and noncommunicable diseases broadly. This article explores the individual diabetes diagnostic moment itself and the politics of the current nosology of Type 1 and Type 2, a seemingly neutral dichotomy that belies colonial relationships between Senegal, slavery, sugar production and consumption, and the effects these relationships have on contemporary conceptions of diabetes diagnosis in Senegal and global health.

Type-3c Diabetes Mellitus, Diabetes of Exocrine Pancreas - An Update

2019 ◽  
Vol 15 (5) ◽  
pp. 382-394 ◽  
Author(s):  
Subrat Kumar Bhattamisra ◽  
Tiew Chin Siang ◽  
Chieng Yi Rong ◽  
Naveenya Chetty Annan ◽  
Esther Ho Yung Sean ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Enzyme ◽  
Diagnostic Procedures ◽  
Pancreatic Tissue ◽  
Medical Practitioners ◽  
The Public ◽  
History Of ◽  
Insufficient Knowledge

Background: The incidence of diabetes is increasing steeply; the number of diabetics has doubled over the past three decades. Surprisingly, the knowledge of type 3c diabetes mellitus (T3cDM) is still unclear to the researchers, scientist and medical practitioners, leading towards erroneous diagnosis, which is sometimes misdiagnosed as type 1 diabetes mellitus (T1DM), or more frequently type 2 diabetes mellitus (T2DM). This review is aimed to outline recent information on the etiology, pathophysiology, diagnostic procedures, and therapeutic management of T3cDM patients. Methods: The literature related to T3cDM was thoroughly searched from the public domains and reviewed extensively to construct this article. Further, existing literature related to the other forms of diabetes is reviewed for projecting the differences among the different forms of diabetes. Detailed and updated information related to epidemiological evidence, risk factors, symptoms, diagnosis, pathogenesis and management is structured in this review. Results: T3cDM is often misdiagnosed as T2DM due to the insufficient knowledge differentiating between T2DM and T3cDM. The pathogenesis of T3cDM is explained which is often linked to the history of chronic pancreatitis, pancreatic cancer. Inflammation, and fibrosis in pancreatic tissue lead to damage both endocrine and exocrine functions, thus leading to insulin/glucagon insufficiency and pancreatic enzyme deficiency. Conclusion: Future advancements should be accompanied by the establishment of a quick diagnostic tool through the understanding of potential biomarkers of the disease and newer treatments for better control of the diseased condition.

Type 2 Diabetes Overtakes Type 1 in Hispanic Girls

2008 ◽  
Vol 38 (15) ◽  
pp. 18
Author(s):  
SHERRY BOSCHERT
Keyword(s):  
Type 2 Diabetes

Molecular analysis of FVIII gene in severe HA patients of Costa Rica

2010 ◽  
Vol 30 (S 01) ◽  
pp. S150-S152
Author(s):  
G. Jiménez-Cruz ◽  
M. Mendez ◽  
P. Chaverri ◽  
P. Alvarado ◽  
W. Schröder ◽  
...  
Keyword(s):  
Factor Viii ◽  
Coagulation Factor ◽  
Costa Rican ◽  
Factor Viii Gene ◽  
Intron 22 Inversion ◽  
Intron 1 ◽  
Polymerase Chain ◽  
Inversion Analysis

SummaryHaemophilia A (HA) is X-chromosome linked bleeding disorders caused by deficiency of the coagulation factor VIII (FVIII). It is caused by FVIII gene intron 22 inversion (Inv22) in approximately 45% and by intron 1 inversion (Inv1) in 5% of the patients. Both inversions occur as a result of intrachromosomal recombination between homologous regions, in intron 1 or 22 and their extragenic copy located telomeric to the FVIII gene. The aim of this study was to analyze the presence of these mutations in 25 HA Costa Rican families. Patients, methods: We studied 34 HA patients and 110 unrelated obligate members and possible carriers for the presence of Inv22or Inv1. Standard analyses of the factor VIII gene were used incl. Southern blot and long-range polymerase chain reaction for inversion analysis. Results: We found altered Inv22 restriction profiles in 21 patients and 37 carriers. It was found type 1 and type 2 of the inversion of Inv22. During the screening for Inv1 among the HA patient, who were Inv22 negative, we did not found this mutation. Discussion: Our data highlight the importance of the analysis of Inv22 for their association with development of inhibitors in the HA patients and we are continuous searching of Inv1 mutation. This knowledge represents a step for genetic counseling and prevention of the inhibitor development.

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