scholarly journals A video-based behavioural intervention associated with improved HPV knowledge and intention to vaccinate

2021 ◽  
Author(s):  
Sarah Marshall ◽  
Anne C Moore ◽  
Aoife Fleming ◽  
Laura Sahm
Keyword(s):  
Hpv Vaccine ◽  
Cost Effective ◽  
Knowledge Assessment ◽  
Feasibility Trial ◽  
Behavioural Intervention ◽  
Evidence Based ◽  
Baseline Knowledge ◽  
Effective Cost ◽  
Randomised Controlled ◽  
The Impact

Aims: The aim of this study was to design, develop and evaluate a theory and evidence-based intervention to improve human papillomavirus (HPV) and HPV vaccine knowledge, and intention to vaccinate, among parent-daughter dyads. Methods: A theory and evidence-based online behavioural intervention, "Is the HPV vaccine for me?" was developed to improve HPV and HPV vaccine knowledge, and intention to vaccinate. The impact and feasibility of the intervention was evaluated in a prospective randomised controlled feasibility trial. Results: A total of 49 parent-daughter dyads completed baseline knowledge assessment (n=24 control, n=25 intervention), and 35 dyads completed knowledge assessment at week 2 (n=17 control, n=18 intervention). The intervention was associated with a statistically significant increase in HPV, and HPV vaccine knowledge and intention to vaccinate. All intervention participants found the video interesting, while 96% found it useful. Conclusions: This intervention was found to be affordable, practicable, effective (cost-effective), acceptable, safe, and equitable, in this feasibility study.

scholarly journals Study protocol for a randomised controlled feasibility trial of a virtual intervention (STRIDE) for symptom management, distress and adherence to adjuvant endocrine therapy after breast cancer

BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e041626
Author(s):  
Jamie M Jacobs ◽  
Chelsea S Rapoport ◽  
Arielle Horenstein ◽  
Madison Clay ◽  
Emily A Walsh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endocrine Therapy ◽  
Symptom Management ◽  
Adjuvant Endocrine Therapy ◽  
Feasibility Trial ◽  
Cancer Center ◽  
Control Group ◽  
Evidence Based ◽  
Pill Bottle ◽  
Randomised Controlled

IntroductionPatient adherence to adjuvant endocrine therapy (AET) after a diagnosis of hormone-sensitive breast cancer is poor. Previous interventions have failed to produce changes in adherence, address patient preferences or include theoretically informed and evidence-based components. Therefore, we iteratively developed a patient-centred, evidence-based, small-group, videoconference intervention to improve adherence and symptom management as well as reduce distress for patients taking AET after breast cancer (Symptom-Targeted Randomised Intervention for Distress and Adherence to Adjuvant Endocrine Therapy, STRIDE).Methods and analysisThe current study is a non-blinded, randomised, controlled, feasibility trial of STRIDE compared with a medication monitoring control group. The primary objective is to examine the feasibility and acceptability of STRIDE, while secondary objectives are to assess changes in objective and subjective adherence, symptom distress and satisfaction with AET. Patients will be recruited from the Massachusetts General Hospital Cancer Center in Boston, Massachusetts. The total number of patients accrued will be 75, with ≥60 patients completing the study. All patients will store their AET in an electronic pill bottle for objective adherence monitoring. Patients randomly assigned to the STRIDE intervention will receive 6 weekly 1-hour sessions, in small groups of two, delivered via videoconferencing by a trained mental health professional. Patients assigned to the control group will store their medication in the electronic pill bottle and receive follow-up oncology care as usual. All participants will complete self-report psychosocial measures at baseline, 12 weeks and 24 weeks postbaseline.Ethics and disseminationThe study is funded by the National Cancer Institute of the National Institutes of Health and is approved by the Dana-Farber/Harvard Cancer Center Institutional Review Board (Protocol #18–603, V.1.2, first approval date 1 February 2019). The study will be reported in accordance with the Consolidated Standards of Reporting Trials statement for non-pharmacological trials. Results will be published in peer-reviewed academic journals, presented at scientific meetings and disseminated to patient organisations and media outlets.Trial registration numberNCT03837496; Pre-results.

Feasibility and efficacy of an educational programme to increase awareness of stroke and heart attack in children

2019 ◽  
Vol 78 (7) ◽  
pp. 812-823 ◽  
Author(s):  
Robert Mikulik ◽  
Lucie Vondráčková ◽  
Hana Pokorná ◽  
Veronika Svobodová ◽  
Andreea Madalina Grecu ◽  
...  
Keyword(s):  
Heart Attack ◽  
Controlled Trial ◽  
Target Population ◽  
Educational Programme ◽  
Control Population ◽  
Knowledge Assessment ◽  
Control Group ◽  
Baseline Knowledge ◽  
Time Periods ◽  
Randomised Controlled

Objective:The objective of this study was to evaluate the feasibility and effectiveness of an innovative school stroke and heart attack educational programme for children.Design:Non-randomised controlled trial with intervention and control group conducted in set time periods. Results were compared among time periods in both groups and also between both groups.Setting:The study included children from 47 schools in Czech Republic. Children from 37 schools in one county ( N = 2,436) participated as the target population. The control group involved 900 pupils from 10 schools in another county.Methods:The 45-minute multimedia Web-based video programme was designed to teach the appropriate response to stroke and heart attack symptoms. The target population received education and testing. The control population received only testing and no education.Results:Baseline knowledge assessment was identical across the target and the control populations. After education, knowledge in the target population had improved significantly. After 3 months, knowledge assessment scored 65% in the target population and 66% in the control population (intergroup difference p = .75).Conclusion:The educational programme increased response to stroke and heart attack symptoms compared to the control group, although in the target group comprehension improved only in short term when compared to the baseline. Knowledge for heart attack was better than for stroke.

scholarly journals Preventing depression in the community by voluntary sector providers (PERSUADE): intervention development and protocol for a parallel randomised controlled feasibility trial

BMJ Open ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. e023791 ◽  
Author(s):  
Cassandra Kenning ◽  
Amy Blakemore ◽  
Peter Bower ◽  
Melina Safari ◽  
Pim Cuijpers ◽  
...  
Keyword(s):  
Service Providers ◽  
Intervention Group ◽  
Voluntary Sector ◽  
Feasibility Trial ◽  
Depression Symptom ◽  
Subthreshold Depression ◽  
Framework Analysis ◽  
Depression Prevention ◽  
Randomised Controlled ◽  
The Impact

IntroductionDepression is now the most common illness worldwide affecting more than 300 million people. Studies modelling the impact of depression interventions have shown that the burden of depression cannot be minimised by more than 35% with existing treatments. There is a need to develop better preventative interventions. The overall aim of this programme of work is to develop interventions to reduce depression symptom scores and prevent development of depression in people with subthreshold depression. The objectives are to adapt a low intensity community-based depression prevention intervention, establish the acceptability and uptake of this model and conduct a parallel randomised controlled feasibility trial to inform a full-scale trial.Methods and analysisFocus groups will be run with members of the public, voluntary sector providers and researchers to inform the adaptation of an existing depression prevention course. Sixty-four people with subthreshold depression, as represented by a score of between 5 and 9 on the Patient Health Questionnaire-9 depression measure, will be recruited to take part in the feasibility trial. Participants will be randomised equally to the intervention or usual care control groups. Participants in the intervention group will receive the new revised manual and attend a 1-day workshop delivered by voluntary sector service providers. Outcome measures will be completed 3 months after baseline. Quantitative data on recruitment, randomisation, attendance, retention, questionnaire completion rates will be collected. Primary analyses will be descriptive and a process evaluation will be conducted to assess the processes involved in implementing the intervention. Interviews will be conducted to explore acceptability and framework analysis will be used to analyse the data.Ethics and disseminationThe study has been reviewed and approved by NHS Research and Ethics Committee: NW-Greater Manchester East. The results will be actively disseminated through peer-reviewed journals, conference presentations, social media, the internet and community engagement activities.Trial registration numberISRCTN23278208;Pre-results.

scholarly journals Co-Designing a Behavioural Intervention for Reducing the Impact of Chemotherapy-Induced Peripheral Neuropathy Symptoms: An Evidence- and Theory-Driven Approach

2021 ◽  
Author(s):  
Mary Anne Lagmay Tanay ◽  
Jo Armes ◽  
Catherine Oakley ◽  
Liz Bryson ◽  
Robin Johnston ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Behavioural Change ◽  
Self Regulation ◽  
Complex Interventions ◽  
Action Planning ◽  
Feasibility Trial ◽  
Behavioural Intervention ◽  
Behavioural Interventions ◽  
Regulation Model ◽  
The Impact

Abstract PurposeThe processes and mechanisms of action which explain how behavioural interventions for chemotherapy-induced peripheral neuropathy (CIPN) work or not are unclear. We describe a co-design process for developing an evidence and theory-based behavioural intervention to reduce the impact of CIPN symptoms on patients’ quality of life.Methods Guided by the Medical Research Council Framework for developing and evaluating complex interventions, our process of intervention development was informed by: (a) findings of systematic reviews, (b) inductive analysis of thirty-nine hours of observational fieldwork, twelve patient and eleven clinician interviews, (c) deductive analysis using the Common-Sense Self-Regulation Model and (d) fifteen patients and twenty clinicians being actively involved as co-designers. ResultsCIPN perception and coping behaviours (including, for example, self-monitoring of symptoms and engaging in self-management and safety strategies to reduce impact of CIPN symptoms) were highlighted as processes to target when co-designing an intervention. To address these behaviours, a psychoeducational approach was deemed suitable. Four behavioural change techniques informed the co-design of the intervention: (a) information about health consequences, (b) salience of consequences, (c) instruction on how to perform a behaviour and (d) action planning.ConclusionCurrent behavioural interventions for CIPN have rarely involved stakeholders, e.g. patients and clinicians, in their development process. We developed a logic model for documenting the proposed mechanism of action of our co-designed intervention for reducing impact of CIPN symptoms. This model will be refined and tested in a subsequent process evaluation as part of a feasibility trial of the intervention.

scholarly journals The Debate About the Human Papilloma Virus Vaccine: The Impact of an Evidence-Based Communicative Method on Increasing Free Choice

2020 ◽  
Vol 26 (8-9) ◽  
pp. 989-995
Author(s):  
Mimar Ramis-Salas
Keyword(s):  
Human Papilloma Virus ◽  
Focus Groups ◽  
Hpv Vaccine ◽  
Life Stories ◽  
Daily Life ◽  
Hpv Infection ◽  
Human Papilloma Virus Vaccine ◽  
Evidence Based ◽  
Papilloma Virus ◽  
The Impact

Democratic access to scientific evidence contributes to the freedom of individuals to make informed decisions regarding scientific findings that affect their lives. In the case of the human papilloma virus (HPV), which causes cervical cancer, a debate exists regarding preventing HPV infection that is not supported by evidence-based interventions. For instance, there are positions both in favor of and against an HPV vaccine that are not evidence-based, thus preventing women from deciding freely whether to be vaccinated. Based on a communicative approach, this article describes the use of communicative focus groups and communicative daily life stories in which the researcher shares up-to-date information on HPV prevention, particularly through vaccination and screening, with high-schoolgirls in an urban context in Spain. Through the focus groups and daily life stories, the young women evaluated the impact of evidence-based dialogues, which could increase their opportunities to make free choices regarding the HPV vaccine and other medicines.

Economic evaluation of a crisis resolution service: A randomised controlled trial

2009 ◽  
Vol 18 (1) ◽  
pp. 54-58 ◽  
Author(s):  
Paul McCrone ◽  
Sonia Johnson ◽  
Fiona Nolan ◽  
Stephen Pilling ◽  
Andrew Sandor ◽  
...  
Keyword(s):  
Mental Health ◽  
Service Use ◽  
Primary Outcome ◽  
Controlled Trial ◽  
Cost Effective ◽  
Primary Outcome Measure ◽  
Crisis Resolution ◽  
Randomised Controlled ◽  
The Impact

SummaryAims – The use of specialised services to avoid admission to hospital for people experiencing mental health crises is seen as an integral part of psychiatric services in some countries. The aim of this paper is to assess the impact on costs and costeffectiveness of a crisis resolution team (CRT). Methods – Patients who were experiencing mental health crises sufficient for admission to be considered were randomised to either care provided by a CRT or standard services. The primary outcome measure was inpatient days over a six-month follow-up period. Service use was measured, costs calculated and cost-effectiveness assessed. Results – Patients receiving care from the CRT had non-inpatient costs £768 higher than patients receiving standard care (90% CI, £153 to £1375). With the inclusion of inpatient costs the costs for the CRT group were £2438 lower for the CRT group (90% CI, £937 to £3922). If one less day spent as an inpatient was valued at £100, there would be a 99.5% likelihood of the CRT being costeffective. Conclusion – This CRT was shown to be cost-effective for modest values placed on reductions in inpatient stays.

scholarly journals A randomised controlled trial of energetic activity for depression in young people (READY): a multi-site feasibility trial protocol

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
N. Howlett ◽  
L. Bottoms ◽  
A. Chater ◽  
A. B. Clark ◽  
T. Clarke ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Young People ◽  
Large Scale ◽  
Exercise Intervention ◽  
Controlled Trial ◽  
Retention Rates ◽  
Feasibility Trial ◽  
Exercise Session ◽  
Randomised Controlled ◽  
The Impact

Abstract Background Prevalence of depression is increasing in young people, and there is a need to develop and evaluate behavioural interventions which may provide benefits equal to or greater than talking therapies or pharmacological alternatives. Exercise could be beneficial for young people living with depression, but robust, large-scale trials of effectiveness and the impact of exercise intensity are lacking. This study aims to test whether a randomised controlled trial (RCT) of an intervention targeting young people living with depression is feasible by determining whether it is possible to recruit and retain young people, develop and deliver the intervention as planned, and evaluate training and delivery. Methods The design is a three-arm cluster randomised controlled feasibility trial with embedded process evaluation. Participants will be help-seeking young people, aged 13–17 years experiencing mild to moderate low mood or depression, referred from three counties in England. The intervention will be delivered by registered exercise professionals, supported by mental health support workers, twice a week for 12 weeks. The three arms will be high-intensity exercise, low-intensity exercise, and a social activity control. All arms will receive a ‘healthy living’ behaviour change session prior to each exercise session and the two exercise groups are energy matched. The outcomes are referral, recruitment, and retention rates; attendance at exercise sessions; adherence to and ability to reach intensity during exercise sessions; proportions of missing data; adverse events, all measured at baseline, 3, and 6 months; resource use; and reach and representativeness. Discussion UK National Health Service (NHS) policy is to provide young people with advice about using exercise to help depression but there is no evidence-based exercise intervention to either complement or as an alternative to medication or talking therapies. UK National Institute for Health and Care Excellence (NICE) guidelines suggest that exercise can be an effective treatment, but the evidence base is relatively weak. This feasibility trial will provide evidence about whether it is feasible to recruit and retain young people to a full RCT to assess the effectiveness and cost-effectiveness of an exercise intervention for depression. Trial registration ISRCTN, ISRCTN66452702. Registered 9 April 2020.

scholarly journals Evaluating Palin Stammering Therapy for School Children (Palin STSC 8-14): Protocol for a Feasibility Randomised Control Trial Comparing Palin STSC(8-14) with Usual Treatment

2021 ◽  
Author(s):  
Sharon K Millard ◽  
Suzanne Murphy ◽  
Garry Barton ◽  
Maria Lethersich ◽  
Lorna Rixon ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Peer Relations ◽  
School Children ◽  
Controlled Trial ◽  
Feasibility Trial ◽  
Randomised Control Trial ◽  
Treatment As Usual ◽  
Children And Parents ◽  
Randomised Controlled ◽  
The Impact

Abstract Background: Having a stammer can have a significant effect on a child’s social, emotional and educational development. With approximately 66,000 children in the UK having a stammer, there is a need to establish an adequate evidence base to inform clinical practise. We describe a feasibility trial to explore the effectiveness of a new therapy programme for children aged 8-14: Palin Stammering Therapy for School Children (Palin STSC(8-14)). Preliminary data from the Michael Palin Centre, where the programme was developed, indicate that Palin STSC(8-14) is effective in reducing stammering frequency and impact for children, with beneficial effects for parents too. We will investigate the feasibility of the methods required for a definitive randomised control trial to investigate the application of this therapy by NHS speech and language therapists (SLTs), compared with ‘treatment as usual’ (TAU), beyond the specialist context in which it was developed.Methods: This is a two-arm feasibility cluster-randomised controlled trial of Palin STSC(8-14) with TAU control arm, and randomisation at the level of the SLT. Quantitative and qualitative data will be collected to examine: the recruitment and retention of therapists and families; the acceptability of the research processes and the therapeutic intervention; the appropriateness of the therapy outcome measures. Assessments will be completed by children and parents at baseline and six months later, including measures of: stammering severity; the impact of child’s stammering on both children and parents; child temperament, behaviour, peer relations, anxiety; quality of life; and, economic outcomes. There will also be a qualitative process evaluation, including interviews with parents, children, SLTs and SLT managers to explore the acceptability of both the research and therapy methods. Treatment fidelity will be examined through analysis of therapy session records and recordings. Discussion: The findings of this feasibility trial will inform the decision as to whether to progress to a full-scale randomised controlled trial to explore the effectiveness of Palin STSC(8-14) when compared to Treatment as Usual in NHS SLT services. There is a strong need for an evidence based intervention for school age children who stammer. Trial registration: ISRCTN. ISRCTN17058884. Registered 18th December 2019. https://www.isrctn.com/ISRCTN17058884

scholarly journals A scoping review of Finnish doctoral dissertations in older people nursing science

2017 ◽  
Vol 37 (3) ◽  
pp. 151-163 ◽  
Author(s):  
Minna Stolt ◽  
Sini Eloranta ◽  
Satu Elo ◽  
Arja Isola ◽  
Riitta Suhonen
Keyword(s):  
Older People ◽  
Scoping Review ◽  
Controlled Trial ◽  
Cost Effective ◽  
Evidence Based ◽  
Nursing Science ◽  
Clinical Nursing ◽  
Randomised Controlled ◽  
Doctoral Dissertations ◽  
Current Stage

Scientific research is important in guiding the development of evidence-based, cost-effective and comprehensive healthcare. The purpose of this scoping review was to analyse the current stage of research in the field of older people nursing science based on doctoral dissertations completed in Finnish universities. Altogether 418 doctoral dissertations in nursing science were published (1990–2015), and 44 of these (11%) represented older people nursing. The majority of the dissertations focused on patient and family or nursing activities. Usual topics were care procedures and clinical nursing (36%); self-care ability, independence (23%) and existence, being and feeling as an individual person (18%). Only one randomised controlled trial was conducted. The main informants were older people (78%) who were typically interviewed or surveyed. Research in older people nursing science in Finland is focusing on traditional clinical nursing settings. More innovative research is necessary from the perspective of health promotion and technological solutions.

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