scholarly journals How frequent are acute reactions to COVID-19 vaccination and who is at risk?

2021 ◽  
Author(s):  
Nancy A Dreyer ◽  
Matthew W Reynolds ◽  
Lisa M Albert ◽  
Emma Brinkley ◽  
Tom Kwon ◽  
...  
Keyword(s):  
Side Effects ◽  
Medical Care ◽  
Side Effect ◽  
Median Number ◽  
Long Term Effects ◽  
Short Term ◽  
Web Based ◽  
Post Vaccination ◽  
Life Impact ◽  
The Usa

Introduction: Our objective was to describe and compare self-reported side effects of COVID-19 vaccines in the USA. Methods: A web-based registry enrolled volunteers who received a COVID-19 vaccine between March 19 and July 15, 2021. We collected self-reported short-term side effects, medical consultation, hospitalization, and quality of life impact following completed vaccination regimens (Pfizer, Moderna, J&J). Results: We recruited 6,966 volunteers who completed their full course of vaccination (median age 48 years, IQR 35.0-62.0; 83.6% female): Pfizer 3,486; Moderna 2,857; J&J 623. Few (3.1%) sought medical care for post-vaccination side effects. Hospitalization (n=17; 0.3%) and severe allergic reactions (n=39; 0.6%) also were rare. Those with autoimmune disease or lung disease were approximately twice as likely to seek medical care (adjusted odds ratio (aOR) 2.01 [95% CI: 1.39;2.92] and 1.70 [95% CI: 1.12;2.58] respectively). 92.4% of participants reported >1 side effect (median 3), with injection site reactions (78.9%), fatigue (70.3%), headache (49.0%) reported most frequently. More side effects were reported after the second dose of two-dose vaccines (medians: 1 vs. 2 for Pfizer and 1 vs. 3 for Moderna for first and second doses respectively) versus 3 for J&J's single-dose vaccine. For the employed, the median number of workdays missed was one. Diabetics and those vaccinated against influenza were substantially less likely to report >3 symptoms (aOR 0.68, 95% CI 0.56,0.82 and aOR 0.82, 95% CI 0.73,0.93, respectively.) Discussion: The total side effect burden was, not unexpectedly, greater with two-dose regimens but all three vaccines appear relatively safe. Very few subjects reported side effects serious enough to warrant medical care or reported post-vaccination hospitalization. While these findings do not address possible long-term effects, they do inform on their short-term safety and tolerability and will hopefully provide some reassurance and positively inform the benefit-risk and pharmacoeconomic assessment for all three vaccines. Clinicaltrials.gov NCT04368065

scholarly journals Side Effects of mRNA-Based COVID-19 Vaccine: Nationwide Phase IV Study among Healthcare Workers in Slovakia

2021 ◽  
Vol 14 (9) ◽  
pp. 873
Author(s):  
Abanoub Riad ◽  
Barbora Hocková ◽  
Lucia Kantorová ◽  
Rastislav Slávik ◽  
Lucia Spurná ◽  
...  
Keyword(s):  
Side Effects ◽  
Side Effect ◽  
Healthcare Workers ◽  
Large Scale ◽  
Large Population ◽  
Medical Attention ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Post Vaccination ◽  
Phase Iv

mRNA-based COVID-19 vaccines such as BNT162b2 have recently been a target of anti-vaccination campaigns due to their novelty in the healthcare industry; nevertheless, these vaccines have exhibited excellent results in terms of efficacy and safety. As a consequence, they acquired the first approvals from drug regulators and were deployed at a large scale among priority groups, including healthcare workers. This phase IV study was designed as a nationwide cross-sectional survey to evaluate the post-vaccination side effects among healthcare workers in Slovakia. The study used a validated self-administered questionnaire that inquired about participants’ demographic information, medical anamneses, COVID-19-related anamnesis, and local, systemic, oral, and skin-related side effects following receiving the BNT162b2 vaccine. A total of 522 participants were included in this study, of whom 77% were females, 55.7% were aged between 31 and 54 years, and 41.6% were from Banska Bystrica. Most of the participants (91.6%) reported at least one side effect. Injection site pain (85.2%) was the most common local side effect, while fatigue (54.2%), headache (34.3%), muscle pain (28.4%), and chills (26.4%) were the most common systemic side effects. The reported side effects were of a mild nature (99.6%) that did not require medical attention and a short duration, as most of them (90.4%) were resolved within three days. Females and young adults were more likely to report post-vaccination side effects; such a finding is also consistent with what was previously reported by other phase IV studies worldwide. The role of chronic illnesses and medical treatments in post-vaccination side effect incidence and intensity requires further robust investigation among large population groups.

scholarly journals What side effects are problematic for patients prescribed antipsychotic medication? The Maudsley Side Effects (MSE) measure for antipsychotic medication

2017 ◽  
Vol 47 (13) ◽  
pp. 2369-2378 ◽  
Author(s):  
T. Wykes ◽  
J. Evans ◽  
C. Paton ◽  
T. R. E. Barnes ◽  
D. Taylor ◽  
...  
Keyword(s):  
Side Effects ◽  
Antipsychotic Medication ◽  
Side Effect ◽  
Self Report ◽  
Psychotic Symptoms ◽  
Service Users ◽  
Good Reliability ◽  
Starting Point ◽  
Two Samples ◽  
Life Impact

BackgroundCapturing service users’ perspectives can highlight additional and different concerns to those of clinicians, but there are no up to date, self-report psychometrically sound measures of side effects of antipsychotic medications.AimTo develop a psychometrically sound measure to identify antipsychotic side effects important to service users, the Maudsley Side Effects (MSE) measure.MethodAn initial item bank was subjected to a Delphi exercise (n = 9) with psychiatrists and pharmacists, followed by service user focus groups and expert panels (n = 15) to determine item relevance and language. Feasibility and comprehensive psychometric properties were established in two samples (N43 and N50). We investigated whether we could predict the three most important side effects for individuals from their frequency, severity and life impact.ResultsMSE is a 53-item measure with good reliability and validity. Poorer mental and physical health, but not psychotic symptoms, was related to side-effect burden. Seventy-nine percent of items were chosen as one of the three most important effects. Severity, impact and distress only predicted ‘putting on weight’ which was more distressing, more severe and had more life impact in those for whom it was most important.ConclusionsMSE is a self-report questionnaire that identifies reliably the side-effect burden as experienced by patients. Identifying key side effects important to patients can act as a starting point for joint decision making on the type and the dose of medication.

Symptoms and Side Effects of the ChAdOx1 nCoV-19 vaccine (AZD1222) among healthcare workers

2021 ◽  
Vol 15 (12) ◽  
pp. 3202-3204
Author(s):  
Dawood Javed ◽  
Yazeed Hadi Alharbi ◽  
Abdullah Javed ◽  
Javed Iqbal
Keyword(s):  
Side Effects ◽  
Sampling Strategy ◽  
Effective Vaccine ◽  
Healthy Population ◽  
Snowball Sampling ◽  
Web Based ◽  
Post Vaccination ◽  
Local Methods ◽  
Novel Coronavirus ◽  
A Prospective Study

Aim: Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a novel coronavirus which has infected millions of people across the globe in the form of a deadly pandemic. Safe and efficacious vaccines are needed urgently to prevent disease in the healthy population or at least decrease the intensity of illness post vaccination. Aim: To assess the post vaccination side effects among groups of individuals so that an effective vaccine can be proposed according to the individuals and thus avoiding reactogenicity, both systemic and local. Methods: A prospective study was conducted with the help of a web-based questionnaire (among health care workers) which used snowball sampling strategy and assigned persons aged ≥25-65 years, who received an intramuscular injection of the vaccine manufactured by Oxford-AstraZeneca. Safety and side effects were observed over a period of 15-20 days post vaccination to obtain results. Results: A total of 564 participants took part in the survey who received the vaccine via intramuscular route. Both systemic and local reactogenicity were recorded. Of the respondents, 280 (49.6%) people reported fever, 322 (57.18%) had pain, 89 (15.77%) had swelling and 53 (9.3%) had redness at the injection site. Total of 368 (65.2%) individuals suffered from body aches of whom 324 (57.4%) also reported headaches. Conclusion: Assessing the post vaccination symptoms, side effects and complications of AstraZeneca among different individuals helped in providing crucial and important information regarding the efficacy, safety and nature of the vaccine. Keywords: Covid-19, pandemic, vaccines, reactogenicity

scholarly journals Kikuchi–Fujimoto Disease Post COVID-19 Vaccination: Case Report and Review of Literature

Vaccines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1251
Author(s):  
Hui Min Tan ◽  
Susan Swee-Shan Hue ◽  
Aileen Wee ◽  
Kay Choong See
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Literature Review ◽  
Side Effect ◽  
Clinical Course ◽  
Rapid Development ◽  
Asian Population ◽  
Common Side Effect ◽  
Review Of Literature ◽  
Post Vaccination

With the rapid development of various coronavirus disease 2019 (COVID-19) vaccines in a bid to counter and contain the COVID-19 pandemic, unusual and uncommon side effects of COVID-19 vaccination have been increasingly reported in the literature. Ipsilateral lymphadenopathy is a fairly common side effect of vaccination of any kind, with its etiology most commonly related to reactive lymphadenopathy. However, Kikuchi–Fujimoto Disease (KFD) or necrotizing histiocytic lymphadenitis is rarely observed post-vaccination, with only one other case of KFD post COVID-19 vaccination reported to date. We report two more cases of KFD post COVID-19 vaccination in the Asian population, highlighting the clinical course and salient clinical, radiological and histologic findings. In addition, we provide a literature review of the existing cases of lymphadenopathy post COVID-19 vaccination with cytologic and/or histologic correlation.

scholarly journals Sodium Polystyrene Sulfonate-Induced Gastric Pneumatosis: A Rare Side Effect

2021 ◽  
pp. 878-883
Author(s):  
Neethi Dasu ◽  
Yaser Khalid ◽  
Kirti Dasu ◽  
Lucy Joo ◽  
Brian Blair
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Side Effect ◽  
Case Reports ◽  
Sodium Polystyrene Sulfonate ◽  
Polystyrene Sulfonate ◽  
Unique Case ◽  
Rare Side Effect ◽  
Colonic Necrosis ◽  
The Usa

Kayexalate has been used in the USA since 1975 for the treatment of hyperkalemia. Prior case reports have shown that sorbitol added to kayexalate has been known to cause rare side effects of colonic necrosis. We present a unique case report of gastric pneumatosis as a complication of kayexalate.

scholarly journals Safety Monitoring of COVID Vaccines and Perception of Post-vaccination Side-Effects: Preliminary Findings From The First Month of Routine Monitoring in a Hospital Vaccination Setting of China

2021 ◽  
Author(s):  
Aihua Feng ◽  
Ruoyan Gai Tobe ◽  
Yongqiang Wang ◽  
Ting Yang ◽  
Xiuting Mo ◽  
...  
Keyword(s):  
Immune Deficiency ◽  
Side Effects ◽  
Side Effect ◽  
Safety Monitoring ◽  
Affecting Factors ◽  
Post Vaccination ◽  
Perceived Safety ◽  
Vaccination Uptake ◽  
Routine Monitoring ◽  
History Of

Abstract Objectives: This study aims to explore the occurrence of post-vaccination side-effects from COVID-19 vaccines and its affecting factors in a hospital vaccination setting of China.Results: A total of 811 vaccinees aged 17 to 58 years, who finished the full package of two doses in February 2021, have been recruited at the second vaccination uptake. Among all, there have been 66 participants who reported one or more mild side effects, while none of them developed severe cases. Those with history of immune deficiency were more likely to report side effect(s). Although with several concerns, most participants showed willingness to get vaccinated (98.8%) with relevant high proportions of perceived safety (99.5%) and effectiveness (97.3%).

Hemodialysis in Chronic Kidney Disease - Balancing Fluid and Salt on the Inflammation Tightrope

2012 ◽  
Vol 35 (6) ◽  
pp. 409-412 ◽  
Author(s):  
Patrick M. Honoré ◽  
Rita Jacobs ◽  
Olivier Joannes-Boyau ◽  
Willem Boer ◽  
Eisabeth De Waele ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Side Effects ◽  
Kidney Disease ◽  
Therapeutic Interventions ◽  
Electrolyte Balance ◽  
Angiotensin Ii Receptor ◽  
Long Term Effects ◽  
Short Term ◽  
The Impact

Haemodialysis (HD) is a well-established, longstanding, and life-saving treatment for patients with chronic kidney disease (CKD) or acute kidney injury (AKI). However, side-effects of HD in CKD patients are numerous and remain problematic. Amongst others, CKD patients are susceptible to short-term effects caused by abnormalities in water and electrolyte balance and long-term effects related to sustained inflammation short-term side-effects of HD such as errors in sodium content of dialysate could readily be overcome by correct baseline labelling of dialysates and the ongoing rigorous implementation of safety procedures by staff nurses and physicians. The proper implementation of biofeedback systems, with tight safety alarm limits and conductivity based detection systems including the analysis of ionic mass balance could have prevented the shortfalls described. Long-term untoward effects of HD are mainly due to sustained inflammation and are correlated with higher morbidity and mortality. Unfortunately, the pathophysiologic mechanisms that underpin the inflammatory processes induced by HD remain poorly understood or incompletely unravelled. Within the wide array of inflammatory (interactions, cytokines are undoubtedly key players but interesting biomarkers (e.g. follistatin) and pathways (e.g. erythropoietin hyporesponsiveness) have come into play. Therapeutic interventions in differing fields such as vascular access, avoidance of intra-dialytic hypotension and pharmacologic interventions with statins, angiotensin II receptor antagonists or vitamine D supplementation may be of significance. However, confirmatory trials investigating of all these promising therapies are, as yet, lacking. The impact of the dialysis technique itself should not be underestimated.

Enhancing Case Managers' Skills in the Assessment and Management of Antipsychotic Medication Side-Effects

2000 ◽  
Vol 34 (5) ◽  
pp. 814-821 ◽  
Author(s):  
Paul Morrison ◽  
Tom Meehan ◽  
Deanne Gaskill ◽  
Paul Lunney ◽  
Paul Collings
Keyword(s):  
Side Effects ◽  
Training Program ◽  
Antipsychotic Medication ◽  
Side Effect ◽  
Rating Scale ◽  
Intervention Group ◽  
Case Managers ◽  
Short Term ◽  
Medication Side Effects ◽  
Medication Side

Objective: Our goal was to reduce the prevalence of antipsychotic medication side-effects by providing a short-term training program on the assessment and management of side-effects to case managers. Method: Forty-four patients in receipt of community-based mental health services were allocated to comparison (n = 20) and intervention (n = 24) groups based on the health service district in which they resided. While case managers working with the intervention group attended a short-term training program to improve their assessment and management of neuroleptic side-effects, case managers providing services to the comparison group received no additional training. Side-effects were assessed pre- and postintervention using the Liverpool University Neuroleptic Side-effect Rating Scale (LUNSERS). Results: A reduction in the overall prevalence of side-effects in both groups was observed, however, only those patients in the intervention group reported a statistically significant reduction in mean side-effect scores between the pre- and post-measures (Wilcoxon Matched Pairs Signed-ranks Test, z = −2.8411, two-tailed, p < 0.01). In addition, qualitative data collected during the second survey revealed that patients in the intervention group had acquired some positive management strategies for dealing with unwanted side-effects. The strategies were elicited from eight different patients distributed across six of the 12 case managers who took part in the training program. Conclusions: Training cases managers in the assessment and management of side-effects may help to reduce their impact on the lives of people prescribed neuroleptic medication.

scholarly journals Side Effects of mRNA-Based and Viral Vector-Based COVID-19 Vaccines among German Healthcare Workers

Biology ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 752
Author(s):  
Miloslav Klugar ◽  
Abanoub Riad ◽  
Mohamed Mekhemar ◽  
Jonas Conrad ◽  
Mayte Buchbender ◽  
...  
Keyword(s):  
Side Effects ◽  
Side Effect ◽  
Healthcare Workers ◽  
Viral Vector ◽  
Demographic Data ◽  
Cross Sectional Survey ◽  
Post Vaccination ◽  
Increased Risk ◽  
Systemic Side Effects ◽  
Local Side

Background: the increasing number of COVID-19 vaccines available to the public may trigger hesitancy or selectivity towards vaccination. This study aimed to evaluate the post-vaccination side effects of the different vaccines approved in Germany; Methods: a cross-sectional survey-based study was carried out using an online questionnaire validated and tested for a priori reliability. The questionnaire inquired about demographic data, medical and COVID-19-related anamneses, and local, systemic, oral, and skin-related side effects following COVID-19 vaccination; Results: out of the 599 participating healthcare workers, 72.3% were females, and 79.1% received mRNA-based vaccines, while 20.9% received a viral vector-based vaccine. 88.1% of the participants reported at least one side effect. Injection site pain (75.6%) was the most common local side effect, and headache/fatigue (53.6%), muscle pain (33.2%), malaise (25%), chills (23%), and joint pain (21.2%) were the most common systemic side effects. The vast majority (84.9%) of side effects resolved within 1–3 days post-vaccination; Conclusions: the mRNA-based vaccines were associated with a higher prevalence of local side effects (78.3% vs. 70.4%; Sig. = 0.064), while the viral vector-based vaccine was associated with a higher prevalence of systemic side effects (87.2% vs. 61%; Sig. < 0.001). Females and the younger age group were associated with an increased risk of side effects either after mRNA-based or viral vector-based vaccines. The gender- and age-based differences warrant further rigorous investigation and standardized methodology.

scholarly journals Evaluation of Side Effects Associated with COVID-19 Vaccines in Saudi Arabia

Vaccines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 674
Author(s):  
Abdulaziz Alhazmi ◽  
Edrous Alamer ◽  
Dalia Daws ◽  
Mashael Hakami ◽  
Majid Darraj ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Saudi Arabia ◽  
Side Effects ◽  
Demographic Data ◽  
Short Term ◽  
Online Questionnaire ◽  
Cross Sectional ◽  
Post Vaccination ◽  
Final Sample ◽  
Study Participants

Background: Pfizer-BioNTech and Oxford-AstraZeneca are recently introduced vaccines to combat COVID-19 pandemic. During clinical trials, mild to moderate side effects have been associated with these vaccines. Thus, we aimed to evaluate short-term post-vaccination side effects. Methods: Cross-sectional, retrospective study using an online questionnaire was conducted among COVID-19 vaccines recipients in Saudi Arabia. General and demographic data were collected, and vaccine-associated side effects after receiving at least one dose of each vaccine were evaluated. Results: Our final sample consisted of 515 participants with a median age of 26 years. Most of the study participants were female (57%). Nearly 13% of the study subjects have reported previous infections with SARS-CoV-2. Oxford-AstraZeneca and Pfizer-BioNTech vaccines have been received by 75% and 25% of the study participants, respectively. Side effects associated with COVID-19 vaccines have been reported by 60% of the study subjects, and most of them reported fatigue (90%), pain at the site of the injections (85%). Conclusion: Side effects that are reported post Oxford-AstraZeneca and Pfizer-BioNTech vaccines among our study participants are not different from those that were reported in the clinical trials, indicating safe profiles for both vaccines. Further studies are needed to evaluate the effectiveness of the current vaccines in protection against SARS-CoV-2 reinfections.

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