scholarly journals #COVIDisAirborne: AI-Enabled Multiscale Computational Microscopy of Delta SARS-CoV-2 in a Respiratory Aerosol

2021 ◽  
Author(s):  
Abigail Dommer ◽  
Lorenzo Casalino ◽  
Fiona Kearns ◽  
Mia Rosenfeld ◽  
Nicholas Wauer ◽  
...  
Keyword(s):  
Method Development ◽  
Molecular Level ◽  
Simulation Method ◽  
Experimental Methods ◽  
Respiratory Viruses ◽  
Data Driven ◽  
Airborne Transmission ◽  
Scientific Impact ◽  
Structure And Dynamics ◽  
Composition Structure

We seek to completely revise current models of airborne transmission of respiratory viruses by providing never-before-seen atomic- level views of the SARS-CoV-2 virus within a respiratory aerosol. Our work dramatically extends the capabilities of multiscale computational microscopy to address the significant gaps that exist in current experimental methods, which are limited in their ability to interrogate aerosols at the atomic/molecular level and thus obscure our understanding of airborne transmission. We demonstrate how our integrated data-driven platform provides a new way of exploring the composition, structure, and dynamics of aerosols and aerosolized viruses, while driving simulation method development along several important axes. We present a series of initial scientific discoveries for the SARS-CoV-2 Delta variant, noting that the full scientific impact of this work has yet to be realized.

Composition, structure and dynamics of the earth's lower mantle

Lithos ◽  
2021 ◽  
pp. 106335
Author(s):  
Felix V. Kaminsky ◽  
Dmitry A. Zedgenizov
Keyword(s):  
Lower Mantle ◽  
Structure And Dynamics ◽  
Composition Structure

scholarly journals Protection of Transport Nodes and Resistibility of Pipeline Systems

2019 ◽  
Vol 17 (2) ◽  
pp. 218-229
Author(s):  
I. A. Tararychkin
Keyword(s):  
Emergency Situation ◽  
Simulation Method ◽  
Structural Elements ◽  
Pipeline Transport ◽  
Structural Synthesis ◽  
System Node ◽  
Separate System ◽  
Composition Structure ◽  
Simultaneous Transition ◽  
Selection Of

The analysis has been carried out and the laws of occurrence of emergency threats at pipeline transport facilities associated with the sequential damage of structural elements have been established. When an emergency situation develops, blocking of a separate system node is associated with simultaneous transition to a state of inoperability of all pipelines converging into the zone of that node. Such damage to the point element of the network structure prevents product flows from passing through that point. The ability of a system to withstand a progressive blocking depends on its composition, structure, and is characterized by an indicator of persistence, the value of which is calculated using a simulation method. An example of the use of cluster schemes in solving the problem of structural synthesis and the selection of the best protection option for a pipeline transport system has been considered.

Relationship Between Composition, Structure and Dynamics of Main-Chain Liquid Crystalline Polymers with Biphenyl Mesogens

2016 ◽  
pp. 453-476 ◽  
Author(s):  
Aránzazu Martínez-Gómez ◽  
Mario Encinar ◽  
Juan P. Fernández-Blázquez ◽  
Ramón G. Rubio ◽  
Ernesto Pérez
Keyword(s):  
Liquid Crystalline ◽  
Main Chain ◽  
Liquid Crystalline Polymers ◽  
Crystalline Polymers ◽  
Structure And Dynamics ◽  
Composition Structure

The Scientific Work We Love: A Duplex Theory of Scientific Impact and Its Application to the Top-Cited Articles in the First 30 Years of APS Journals

2018 ◽  
Vol 13 (2) ◽  
pp. 260-267 ◽  
Author(s):  
Robert J. Sternberg
Keyword(s):  
Scientific Work ◽  
High Impact ◽  
Data Driven ◽  
Scientific Impact ◽  
Psychological Science ◽  
Review Articles ◽  
Triangular Elements ◽  
Duplex Theory

This article proposes a duplex theory for understanding the scientific impact of contributions to psychological science. I argue that articles that we “love” can be understood in terms of (a) triangular elements of intimacy, passion, and commitment and (b) types of stories that characterize high-impact articles. Certain kinds of stories (e.g., review articles) are more likely to have lasting impact, on average, than other kinds of stories (e.g., data-driven empirical articles).

scholarly journals An anaesthetic and intensive care perspective on infection control measures for the prevention of airborne transmission of SARS-CoV-2

2020 ◽  
Vol 81 (9) ◽  
pp. 1-9
Author(s):  
Hazel R O'Mahony ◽  
Daniel S Martin
Keyword(s):  
Infection Control ◽  
Personal Protective Equipment ◽  
Scientific Evidence ◽  
Respiratory Viruses ◽  
Control Measures ◽  
Protective Equipment ◽  
Appropriate Use ◽  
Airborne Transmission ◽  
Infection Control Measures ◽  
Current Guidance

Guidance regarding appropriate use of personal protective equipment in hospitals is in constant flux as research into SARS-COV-2 transmission continues to develop our understanding of the virus. The risk associated with procedures classed as ‘aerosol generating’ is under constant debate. Current guidance is largely based on pragmatic and cautious logic, as there is little scientific evidence of aerosolization and transmission of respiratory viruses associated with procedures. The physical properties of aerosol particles which may contain viable virus have implications for the safe use of personal protective equipment and infection control protocols. As elective work in the NHS is reinstated, it is important that the implications of the possibility of airborne transmission of the virus in hospitals are more widely understood. This will facilitate appropriate use of personal protective equipment and help direct further research into the true risks of aerosolization during these procedures to allow safe streamlining of services for staff and patients.

EFFECTS OF SINUSOIDAL ELECTROPHORETIC FIELD ON CHAIN MACROMOLECULES IN A HETEROGENEOUS MEDIUM: STRUCTURE AND DYNAMICS BY A HYBRID COMPUTER SIMULATION

2002 ◽  
Vol 13 (05) ◽  
pp. 625-638
Author(s):  
GRACE M. FOO ◽  
R. B. PANDEY
Keyword(s):  
Molecular Motion ◽  
Heterogeneous Medium ◽  
Simulation Method ◽  
Static Field ◽  
Radius Of Gyration ◽  
Structure And Dynamics ◽  
Global Movement ◽  
Hybrid Computer ◽  
Molecular Clustering ◽  
Sinusoidal Field

Using a hybrid simulation method, structural and dynamic response properties of chain macromolecules are studied in a heterogeneous gel matrix in presence of an electrophoretic field E(t) = Eb + Es sin (2π ft), where Eb is the static field and Es is the amplitude of sinusoidal field of frequency f. We find that the oscillating field enhances the macromolecular mobility at Es > Eb while it becomes ineffective at Es < Eb, consistent with the experimental work of Masubuchi et al. Enhanced segmental and global movement of molecules at Es > Eb leads to interesting effects such as (i) a significant decrease in molecular clustering, (ii) reduced radius of gyration, and (iii) its linear response to Eb. Power law behavior of molecular motion, i.e., the variation rms displacement (R) with the time steps (t), R ∝ tν, is sensitive to temperature, molecular weight, and field.

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