scholarly journals Software Application Profile: SUMnlmr, an R package that facilitates flexible and reproducible non-linear Mendelian randomisation analyses

2021 ◽  
Author(s):  
Amy M Mason ◽  
Stephen Burgess
Keyword(s):  
Linear Model ◽  
Piecewise Linear ◽  
R Package ◽  
Mendelian Randomisation ◽  
Software Application ◽  
Individual Level ◽  
Fractional Polynomial ◽  
Level Data ◽  
Non Linear ◽  
The Individual

Motivation Mendelian randomisation methods that estimate non-linear exposure-outcome relationships typically require individual-level data. This package implements non-linear Mendelian randomisation methods using stratified summarised data, facilitating analyses where individual-level data cannot easily be shared, and additionally increasing reproducibility as summarised data can be reported. Dependence on summarised data means the methods are independent of the form of the individual-level data, increasing flexibility to different outcome types (such as continuous, binary, or time-to-event outcomes). Implementation SUMnlmr is available as an R package (version 3.1.0 or higher). General features The package implements the previously proposed fractional polynomial and piecewise linear methods on stratified summarised data that can either be estimated from individual-level data using the package or supplied by a collaborator. It constructs plots to visualise the estimated exposure-outcome relationship, and provides statistics to assess preference for a non-linear model over a linear model. Availability The package is freely available from GitHub [ https://github.com/amymariemason/SUMnlmr].

Missing Data in Research on Youth and Family Programs

2021 ◽  
pp. 003329412110268
Author(s):  
Jaime Ballard ◽  
Adeya Richmond ◽  
Suzanne van den Hoogenhof ◽  
Lynne Borden ◽  
Daniel Francis Perkins
Keyword(s):  
Missing Data ◽  
Statistical Methods ◽  
Self Report ◽  
Program Participation ◽  
Multilevel Data ◽  
Individual Level ◽  
Level Data ◽  
Before And After ◽  
Post Test ◽  
The Individual

Background Multilevel data can be missing at the individual level or at a nested level, such as family, classroom, or program site. Increased knowledge of higher-level missing data is necessary to develop evaluation design and statistical methods to address it. Methods Participants included 9,514 individuals participating in 47 youth and family programs nationwide who completed multiple self-report measures before and after program participation. Data were marked as missing or not missing at the item, scale, and wave levels for both individuals and program sites. Results Site-level missing data represented a substantial portion of missing data, ranging from 0–46% of missing data at pre-test and 35–71% of missing data at post-test. Youth were the most likely to be missing data, although site-level data did not differ by the age of participants served. In this dataset youth had the most surveys to complete, so their missing data could be due to survey fatigue. Conclusions Much of the missing data for individuals can be explained by the site not administering those questions or scales. These results suggest a need for statistical methods that account for site-level missing data, and for research design methods to reduce the prevalence of site-level missing data or reduce its impact. Researchers can generate buy-in with sites during the community collaboration stage, assessing problematic items for revision or removal and need for ongoing site support, particularly at post-test. We recommend that researchers conducting multilevel data report the amount and mechanism of missing data at each level.

scholarly journals Cigarette smoking and personality: interrogating causality using Mendelian randomisation

2018 ◽  
Vol 49 (13) ◽  
pp. 2197-2205 ◽  
Author(s):  
Hannah M. Sallis ◽  
George Davey Smith ◽  
Marcus R. Munafò
Keyword(s):  
Personality Traits ◽  
Association Studies ◽  
Smoking Initiation ◽  
Mendelian Randomisation ◽  
Genome Wide Association Studies ◽  
Individual Level ◽  
Causal Pathways ◽  
Genome Wide ◽  
Level Data ◽  
Causal Nature

AbstractBackgroundDespite the well-documented association between smoking and personality traits such as neuroticism and extraversion, little is known about the potential causal nature of these findings. If it were possible to unpick the association between personality and smoking, it may be possible to develop tailored smoking interventions that could lead to both improved uptake and efficacy.MethodsRecent genome-wide association studies (GWAS) have identified variants robustly associated with both smoking phenotypes and personality traits. Here we use publicly available GWAS summary statistics in addition to individual-level data from UK Biobank to investigate the link between smoking and personality. We first estimate genetic overlap between traits using LD score regression and then use bidirectional Mendelian randomisation methods to unpick the nature of this relationship.ResultsWe found clear evidence of a modest genetic correlation between smoking behaviours and both neuroticism and extraversion. We found some evidence that personality traits are causally linked to certain smoking phenotypes: among current smokers each additional neuroticism risk allele was associated with smoking an additional 0.07 cigarettes per day (95% CI 0.02–0.12, p = 0.009), and each additional extraversion effect allele was associated with an elevated odds of smoking initiation (OR 1.015, 95% CI 1.01–1.02, p = 9.6 × 10−7).ConclusionWe found some evidence for specific causal pathways from personality to smoking phenotypes, and weaker evidence of an association from smoking initiation to personality. These findings could be used to inform future smoking interventions or to tailor existing schemes.

scholarly journals Meffil: efficient normalisation and analysis of very large DNA methylation samples

2017 ◽  
Author(s):  
Josine Min ◽  
Gibran Hemani ◽  
George Davey Smith ◽  
Caroline Relton ◽  
Matthew Suderman
Keyword(s):  
Dna Methylation ◽  
Association Studies ◽  
R Package ◽  
Individual Level ◽  
Technological Advances ◽  
Level Data ◽  
Fixed And Random Effects ◽  
R Packages ◽  
Meta Analyses ◽  
Dramatic Growth

AbstractBackgroundTechnological advances in high throughput DNA methylation microarrays have allowed dramatic growth of a new branch of epigenetic epidemiology. DNA methylation datasets are growing ever larger in terms of the number of samples profiled, the extent of genome coverage, and the number of studies being meta-analysed. Novel computational solutions are required to efficiently handle these data.MethodsWe have developed meffil, an R package designed to quality control, normalize and perform epigenome-wide association studies (EWAS) efficiently on large samples of Illumina Infinium HumanMethylation450 and MethylationEPIC BeadChip microarrays. We tested meffil by applying it to 6000 450k microarrays generated from blood collected for two different datasets, Accessible Resource for Integrative Epigenomic Studies (ARIES) and The Genetics of Overweight Young Adults (GOYA) study.ResultsA complete reimplementation of functional normalization minimizes computational memory requirements to 5% of that required by other R packages, without increasing running time. Incorporating fixed and random effects alongside functional normalization, and automated estimation of functional normalisation parameters reduces technical variation in DNA methylation levels, thus reducing false positive associations and improving power. We also demonstrate that the ability to normalize datasets distributed across physically different locations without sharing any biologically-based individual-level data may reduce heterogeneity in meta-analyses of epigenome-wide association studies. However, we show that when batch is perfectly confounded with cases and controls functional normalization is unable to prevent spurious associations.Conclusionsmeffil is available online (https://github.com/perishky/meffil/) along with tutorials covering typical use cases.

scholarly journals Cohort Profile: The China Multi-Ethnic Cohort (CMEC) Study

2020 ◽  
Author(s):  
Xing Zhao ◽  
Feng Hong ◽  
Jianzhong Yin ◽  
Wenge Tang ◽  
Gang Zhang ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Disease Incidence ◽  
Data Access ◽  
Population Based ◽  
Baseline Survey ◽  
Individual Level ◽  
Long Term Storage ◽  
Level Data ◽  
The Individual ◽  
Study Participants

AbstractCohort purposeThe China Multi-Ethnic Cohort (CMEC) is a community population-based prospective observational study aiming to address the urgent need for understanding NCD prevalence, risk factors and associated conditions in resource-constrained settings for ethnic minorities in China.Cohort BasicsA total of 99 556 participants aged 30 to 79 years (Tibetan populations include those aged 18 to 30 years) from the Tibetan, Yi, Miao, Bai, Bouyei, and Dong ethnic groups in Southwest China were recruited between May 2018 and September 2019.Follow-up and attritionAll surviving study participants will be invited for re-interviews every 3-5 years with concise questionnaires to review risk exposures and disease incidence. Furthermore, the vital status of study participants will be followed up through linkage with established electronic disease registries annually.Design and MeasuresThe CMEC baseline survey collected data with an electronic questionnaire and face-to-face interviews, medical examinations and clinical laboratory tests. Furthermore, we collected biological specimens, including blood, saliva and stool, for long-term storage. In addition to the individual level data, we also collected regional level data for each investigation site.Collaboration and data accessCollaborations are welcome. Please send specific ideas to corresponding author at: [email protected].

scholarly journals Welsh Government Flying Start Programme Evaluation Using Linked Data

2018 ◽  
Vol 3 (2) ◽  
Author(s):  
Sarah Lowe ◽  
Laura McGinn ◽  
Marcos Quintela ◽  
Luke Player ◽  
Karen Tingay
Keyword(s):  
Evidence Base ◽  
Development Project ◽  
Early Years ◽  
Local Authorities ◽  
Parenting Support ◽  
Individual Level ◽  
Level Data ◽  
Part Time ◽  
The Individual ◽  
Families With Children

BackgroundFlying Start (FS) is the Welsh Government’s (WG) flagship Early Years programme for families with children aged less than 4 years of age. Running since 2006, the four entitlements are: Free part-time childcare for 2-3 year olds Enhanced Health Visiting Parenting support Speech, language, and communication support ObjectivesCurrently, while we know which areas in Wales are receiving FS support, individual-level data on which child received what entitlements is not available. Area-level outcomes can be used as proxy indicators but the individual impact of receiving FS support cannot be examined.The project aims to evaluate FS by linking the FS cohort to a range of outcomes including health, education and social care. MethodsA Dataflow Development Project (DDP) has been launched to install SAIL (Secure Anonymised Information Linkage) appliances into 6 pilot Local Authorities in Wales which will test acquiring and linking the individual level FS data from pilot Local Authorities with other datasets in SAIL. FindingsThe project will report some emerging findings from the analysis of pilot data. ImplicationsThere is a growing interest in using linked administrative data to evaluate government initiatives, and mounting enthusiasm in Local Government. If successful, this model is likely to be adopted by related WG programmes; improving the evidence base, facilitating effective evaluation, and adding to the data available for re-use in Wales.

Agricultural entrepreneurship orientation: is academic training a missing link?

2017 ◽  
Vol 59 (7/8) ◽  
pp. 856-870 ◽  
Author(s):  
Soodeh Mohammadinezhad ◽  
Maryam Sharifzadeh
Keyword(s):  
Content Type ◽  
Individual Level ◽  
Configuration Theory ◽  
University Courses ◽  
Level Data ◽  
Academic Courses ◽  
The Individual ◽  
Agricultural Entrepreneurship ◽  
Hierarchy Process ◽  
Practical Implications

Purpose The purpose of this paper is to investigate the importance of academic courses on agricultural entrepreneurship. Design/methodology/approach Modified global entrepreneurship and development index (GEDI) was used to determine entrepreneurial dimensions among 19 graduated students of agricultural colleges resided in Iran. Fuzzy analytical hierarchy process was applied to understand agricultural graduates’ preferences on effectiveness of university courses (core, free elective and restricted elective). Findings Results suggested the importance of professional restricted elective courses to provide students with necessary skills. These courses were successful in providing a context for entrepreneurial profile. Research limitations/implications Innate talent or acquired skills were always the place of debate on entrepreneurial development. The paper builds on the premise that entrepreneurs are made through education and continuing reconstruction of experience, further research is required as the field develops in experience and complexity. Practical implications The paper provides strategies to effectively modify practical route in higher education to enhance entrepreneurial orientation among students. Originality/value The paper is innovative at a conceptual level in modifying GEDI elements in individual-level variables based on GEDI configuration theory. This approach is particularly useful in addressing the bottleneck problems of entrepreneurship profile and focusses on the information interpreted at weights of the individual-level data.

On the Issues Surrounding Economic Voting

1987 ◽  
Vol 20 (1) ◽  
pp. 3-33 ◽  
Author(s):  
JOHN R. HIBBING
Keyword(s):  
United States ◽  
United Kingdom ◽  
Voting Behavior ◽  
Economic Voting ◽  
The United States ◽  
Individual Level ◽  
The United Kingdom ◽  
Level Data ◽  
Election Results ◽  
The Individual

This is an analysis of the effects of economic factors on voting behavior in the United Kingdom. Aggregate- and individual-level data are used. When the results are compared to findings generated by the United States case, some intriguing differences appear. To mention just two examples, unemployment and inflation seem to be much more important in the United Kingdom than in the United States, and changes in real per capita income are positively related to election results in the United States and negatively related in the United Kingdom. More generally, while the aggregate results are strong and the individual-level results weak in the United States, in the United Kingdom the situation is practically reversed.

Area-level relative deprivation and alcohol use in Denmark: Is there a relationship?

2018 ◽  
Vol 47 (4) ◽  
pp. 428-438 ◽  
Author(s):  
Kim Bloomfield ◽  
Gabriele Berg-Beckhoff ◽  
Abdu Kedir Seid ◽  
Christiane Stock
Keyword(s):  
Alcohol Use ◽  
Relative Deprivation ◽  
Health Behaviours ◽  
Area Deprivation ◽  
Individual Level ◽  
Level Data ◽  
Housing Component ◽  
Disorder Identification ◽  
The Individual ◽  
The Impact

Aims: Greater area-level relative deprivation has been related to poorer health behaviours, but studies specifically on alcohol use and abuse have been equivocal. The main purpose of the present study was to investigate how area-level relative deprivation in Denmark relates to alcohol use and misuse in the country. Methods: As individual-level data, we used the national alcohol and drug survey of 2011 ( n= 5133). Data were procured from Statistics Denmark to construct an index of relative deprivation at the parish level ( n=2119). The deprivation index has two components, which were divided into quintiles. Multilevel linear and logistic regressions analysed the influence of area deprivation on mean alcohol use and hazardous drinking, as measured by the Alcohol Use Disorder Identification Test. Results: Men who lived in parishes designated as ‘very deprived’ on the socioeconomic component were more likely to consume less alcohol; women who lived in parishes designated as ‘deprived’ on the housing component were less likely to drink hazardously. But at the individual level, education was positively related to mean alcohol consumption, and higher individual income was positively related to mean consumption for women. Higher-educated men were more likely to drink hazardously. Conclusions: Area-level measures of relative deprivation were not strongly related to alcohol use, yet in the same models individual-level socioeconomic variables had a more noticeable influence. This suggests that in a stronger welfare state, the impact of area-level relative deprivation may not be as great. Further work is needed to develop more sensitive measures of relative deprivation.

Partisanship, Militarized International Conflict, and Electoral Support for the Incumbent

2017 ◽  
Vol 71 (1) ◽  
pp. 172-183 ◽  
Author(s):  
Shane P. Singh ◽  
Jaroslav Tir
Keyword(s):  
Political Behavior ◽  
Comparative Politics ◽  
International Conflict ◽  
Vote Choice ◽  
Individual Level ◽  
Interstate Disputes ◽  
Electoral Support ◽  
Level Data ◽  
The Individual ◽  
Militarized Interstate Disputes

Comparative politics scholarship often neglects to consider how militarized interstate disputes (MIDs) shape political behavior. In this project, we advance an argument that considers voter responses to international conflict at the individual level. In particular, we consider how the well-known conditioning effects of partisanship manifest in relation to militarized international conflict. Examining individual- and macro-level data across ninety-seven elections in forty-two countries over the 1996–2011 period, we find consistent evidence of militarized conflict impacting vote choice. This relationship is, however, moderated by partisanship, conflict side (initiator or target), and conflict hostility level. Among non-copartisan voters, the incumbent benefits the most electorally from initiating low-hostility MIDs or when the country is a target of a high-hostility MID; the opposite scenarios (initiator of a high-hostility MID or target of a low-hostility MID) lead to punishment among this voter group. Copartisans, meanwhile, tend to either maintain or intensify their support in most scenarios we examine; when a country is targeted in a low-hostility MID, copartisan support erodes mildly.

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