Exercise and the brain: a mechanical model for pulsation on flow of cerebrospinal fluid
Exchange of molecules between cerebrospinal fluid (CSF) and brain cells contributes to brain function and protection from dementia, but the route by which CSF is brought close enough to the neural tissue to be exchanged by extracellular diffusion is not clear. Exogenous molecules injected into CSF are carried along channels outside arteries and reach the basement lamina that surrounds the dense capillary network. Transport of solutes by diffusion along the basement lamina, a gel of macromolcules about 100 nm thick, would be too slow; bulk flow in a static geometry would require unphysiologically high pressures. However, it is known that the pulsation of blood aids transport of CSF, and we hypothesized that this is because the pulsation intermittently squeezes the pericapillary lamina. In a primitive mimicry, we have tested whether intermittent squeezing increases flow through an agar gel. In all but one of 216 tests, pulsation caused a reversible increase, sometimes by a factor of 100 or more. The enhancement was greatest for frequencies 5-11 Hz and, over the tested range of pressure heads (20 - 50 cmH2O), was greatest for the lowest pressure. The results suggest one reason why exercise slows the aging of the brain.