scholarly journals Tissue fibroblasts are a critical source of prostacyclin and anti-thrombotic

2022 ◽  
Author(s):  
Jane A Mitchell ◽  
Maria Vinokurova ◽  
Maria E Lopes-Pires ◽  
Fisnik Shala ◽  
Paul C Armstrong ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Vascular Endothelium ◽  
Knockout Mice ◽  
Cardiovascular Health ◽  
Human Tissues ◽  
New Paradigm ◽  
Prostacyclin Synthesis

Prostacyclin is an anti-thrombotic hormone long considered to be derived from the vascular endothelium. However, the role of non-vascular sources for prostacyclin synthesis has not been systematically evaluated due to a lack of tools. Here we used cell-specific knockout mice and human tissues to show that lung, and other tissues, are powerful producers of prostacyclin independent of their vascular components. Instead, in mice and humans, lung prostacyclin synthesis is associated with fibroblasts. The fibroblast-derived prostaglandins enter the circulation and provide systemic anti-thrombotic protection. These observations define a new paradigm in prostacyclin biology in which fibroblast/non-vascular-derived prostacyclin works in parallel with prostaglandins produced by the endothelium to control cardiovascular health. These results may explain how local diseases of the lung and elsewhere result in cardiovascular risk.

scholarly journals Prostacyclin expression by a continuous human cell line derived from vascular endothelium

Blood ◽  
1986 ◽  
Vol 68 (4) ◽  
pp. 825-829 ◽  
Author(s):  
JE Suggs ◽  
MC Madden ◽  
M Friedman ◽  
CJ Edgell
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Platelet Aggregation ◽  
Cell Line ◽  
Human Cell ◽  
Vascular Endothelium ◽  
Human Cell Line ◽  
Cell Product ◽  
Prostacyclin Synthesis

Abstract Prostacyclin is primarily an endothelial cell product. It contributes to the important role of endothelium in maintaining the fluidity of blood by inhibiting platelet aggregation and by promoting vasodilation. Endothelial cells in culture tend to senesce, and the level of prostacyclin expression decreases. A permanent human cell line, EA.hy 926, derived from a fusion of primary endothelial cells with cells of a less differentiated line, has been found to sustain basal and stimulated levels of prostacyclin synthesis.

scholarly journals Prostacyclin expression by a continuous human cell line derived from vascular endothelium

Blood ◽  
1986 ◽  
Vol 68 (4) ◽  
pp. 825-829 ◽  
Author(s):  
JE Suggs ◽  
MC Madden ◽  
M Friedman ◽  
CJ Edgell
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Platelet Aggregation ◽  
Cell Line ◽  
Human Cell ◽  
Vascular Endothelium ◽  
Human Cell Line ◽  
Cell Product ◽  
Prostacyclin Synthesis

Prostacyclin is primarily an endothelial cell product. It contributes to the important role of endothelium in maintaining the fluidity of blood by inhibiting platelet aggregation and by promoting vasodilation. Endothelial cells in culture tend to senesce, and the level of prostacyclin expression decreases. A permanent human cell line, EA.hy 926, derived from a fusion of primary endothelial cells with cells of a less differentiated line, has been found to sustain basal and stimulated levels of prostacyclin synthesis.

scholarly journals Beneficial Role of Vitexin and Isovitexin Flavonoids in the Vascular Endothelium and Cardiovascular System

2020 ◽  
Vol 01 ◽  
Author(s):  
Sharon O. Azubuike-Osu ◽  
Ikenna C. Ohanenye ◽  
Claus Jacob ◽  
Chukwunonso E.C.C. Ejike ◽  
Chibuike C. Udenigwe
Keyword(s):  
Vascular Endothelium ◽  
Cardiovascular Health ◽  
Perfusion Pressure ◽  
Vascular System ◽  
Therapeutic Agents ◽  
Pharmacological Effects ◽  
Medicinal Products

Abstract: Various medicinal plants contain phenolic compounds, which are useful in the treatment of many disease conditions. Particularly, vitexin and its isomer, isovitexin, possess many pharmacological effects including antioxidant, anti-inflammatory, anticancer, antidiabetic, neuroprotective, and antinociceptive activities. Current research has provided evidence for the prospective use of vitexin and isovitexin in the formulation of medicinal products useful in the prevention and treatment of specific ailments. The aim of this review was therefore to examine the influence of vitexin and isovitexin on the vascular system as well as the possible mechanisms through which the flavonoids exert their effects. The review also discussed the importance of vitexin and isovitexin in cardiovascular health through the vascular endothelium. In vivo and in vitro studies suggest that vitexin and isovitexin play a cardioprotective role during ischaemic reperfusion injury and angiogenesis, while isovitexin decreases perfusion pressure and increases the bioavailability of nitric oxide. Taken together, vitexin and isovitexin are promising as therapeutic agents for the formulation of nutraceuticals for the prevention, management and treatment of cardiovascular diseases.

INOVASI PEMBELAJARAN AKIDAH AKHLAK MENGGUNAKAN METODE ROLE PLAY DALAM MENINGKATKAN PRESTASI BELAJAR SISWA

2018 ◽  
Vol 2 (1) ◽  
pp. 52-63
Author(s):  
Ansori Ansori
Keyword(s):  
Data Reduction ◽  
Role Play ◽  
Learning Goals ◽  
New Paradigm ◽  
Learning Materials ◽  
Analysis Technique ◽  
Flexible Schedule ◽  
Using Data ◽  
Real Action

The use of various methods will greatly help students in achieving learning goals. As role play method is one way mastery of learning materials through the development of imagination and appreciation of students on learning materials. Data collection techniques in this study are observation, interviews, and documentation. To analyze the data in this research using data analysis technique of Miles and Huberman model that is data reduction (Data Reduction), data presentation (Data Display) and conclusion (Conclution Drawing / verification) The findings in this research is innovation of role play method can change paradigm to the new paradigm so that the role of the teacher is more as a facilitator, counselor, consultant, and comrade study Flexible schedule, open as needed Learning directed by students themselves Problem-based, project, real world, real action, and reflection Design and investigation. Computers as tools, and dynamic media presentations.

Telmisartan in High Cardiovascular Risk Patients

2012 ◽  
Vol 8 (1) ◽  
pp. 10 ◽  
Author(s):  
Roland Asmar ◽  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Ace Inhibitors ◽  
Angiotensin Receptor Blockers ◽  
High Cardiovascular Risk ◽  
Raas Blockade ◽  
Risk Patients ◽  
Receptor Blockers ◽  
Current Guidelines

The worldwide morbidity and mortality burden of cardiovascular disease (CVD) is overwhelming and caused by increasing life expectancy and an epidemic of risk factors, including hypertension. Therapeutic options targeting different areas of the renin–angiotensin–aldosterone system (RAAS) to disrupt pathophysiological processes along the cardiovascular continuum are available. Angiotensin-converting enzyme (ACE) inhibitors are first-line treatments for CVD and angiotensin receptor blockers (ARBs) are suitable alternatives. Both ACE inhibitors and ARBs prevent CVD by lowering blood pressure (BP). Additionally, several studies have demonstrated that RAAS blockade can reduce cardiovascular risk beyond what might be expected from BP lowering alone. However, the ARBs are not all equally effective. Telmisartan is a long-lasting ARB that effectively controls BP over the full 24-hour period. Recently, the Ongoing telmisartan alone and in combination with ramipril global endpoint trial (ONTARGET) study showed that telmisartan reduces cardiovascular events in high cardiovascular risk patients similarly to the gold standard ACE inhibitor ramipril beyond BP lowering alone, but with a better tolerability. Based on the results of the ONTARGET and Telmisartan randomized assessment study in ACE intolerant subjects with cardiovascular disease (TRANSCEND) studies, telmisartan is indicated for the reduction of cardiovascular morbidity. This article aims to review current guidelines for the management of CVD and consider key data from clinical trials and clinical practice evaluating the role of telmisartan in CVD.

A Review of Dietary Influences on Cardiovascular Health: Part 1: the role of Dietary Nutrients

2014 ◽  
Vol 13 (3) ◽  
pp. 208-230 ◽  
Author(s):  
Clare Stradling ◽  
Mash Hamid ◽  
Katherine Fisher ◽  
Shahrad Taheri ◽  
G. Thomas
Keyword(s):  
Cardiovascular Health ◽  
Dietary Nutrients

CD38 as an immunomodulator in cancer

2020 ◽  
Vol 16 (34) ◽  
pp. 2853-2861
Author(s):  
Yanli Li ◽  
Rui Yang ◽  
Limo Chen ◽  
Sufang Wu
Keyword(s):  
Multiple Myeloma ◽  
Cell Activation ◽  
Human Tissues ◽  
Transmembrane Glycoprotein ◽  
Cell Activation Marker ◽  
Research Findings ◽  
A Cell ◽  
And Function ◽  
Human Molecule

CD38 is a transmembrane glycoprotein that is widely expressed in a variety of human tissues and cells, especially those in the immune system. CD38 protein was previously considered as a cell activation marker, and today monoclonal antibodies targeting CD38 have witnessed great achievements in multiple myeloma and promoted researchers to conduct research on other tumors. In this review, we provide a wide-ranging review of the biology and function of the human molecule outside the field of myeloma. We focus mainly on current research findings to summarize and update the findings gathered from diverse areas of study. Based on these findings, we attempt to extend the role of CD38 in the context of therapy of solid tumors and expand the role of the molecule from a simple marker to an immunomodulator.

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