scholarly journals Replicability of introgression under linked, polygenic selection

2018 ◽  
Author(s):  
Himani Sachdeva ◽  
Nicholas H. Barton
Keyword(s):  
Growth Rate ◽  
Initial Phase ◽  
Homogeneous Population ◽  
Fitness Effects ◽  
Single Locus Variant ◽  
Polygenic Adaptation ◽  
Individual Variant ◽  
Highly Correlated ◽  
Polygenic Selection

AbstractWe study how a block of genome with a large number of weakly selected loci introgresses under directional selection into a genetically homogeneous population. We derive exact expressions for the expected rate of growth of any fragment of the introduced block during the initial phase of introgression, and show that the growth rate of a single-locus variant is largely insensitive to its own additive effect, but depends instead on the combined effect of all loci within a characteristic linkage scale. The expected growth rate of a fragment is highly correlated with its long-term introgression probability in populations of moderate size, and can hence identify variants that are likely to introgress across replicate populations. We clarify how the introgression probability of an individual variant is determined by the interplay between hitchhiking with relatively large fragments during the early phase of introgression, and selection on fine scale variation within these, which at longer times results in differential introgression probabilities for beneficial and deleterious loci within successful fragments. By simulating individuals, we also investigate how introgression probabilities at individual loci depend on the variance of fitness effects, the net fitness of the introduced block, and the size of the recipient population, and how this shapes the net advance under selection. Our work suggests that even highly replicable substitutions may be associated with a range of selective effects, which makes it challenging to fine map the causal loci that underlie polygenic adaptation.

ON THE CONSUMPTION/DISTRIBUTION THEOREM UNDER THE LONG-RUN GROWTH CRITERION SUBJECT TO A DRAWDOWN CONSTRAINT

2010 ◽  
Vol 13 (06) ◽  
pp. 931-957 ◽  
Author(s):  
MICHAEL J. KLASS ◽  
KRZYSZTOF NOWICKI
Keyword(s):  
Growth Rate ◽  
Short Term ◽  
Long Run ◽  
Time Period ◽  
Total Capital ◽  
Growth Criterion ◽  
Drawdown Constraint ◽  
Riskless Asset ◽  
Distribution Theorem

Consider any discrete time sequence of investment fortunes Fn which has a finite long-run growth rate [Formula: see text] when subject to the present value capital drawdown constraint Fne-rn ≥ λ* max 0≤k≤nFke-rk, where 0 ≤ λ* < 1, in the presence of a riskless asset affording a return of er dollars per time period per dollar invested. We show that money can be withdrawn for consumption from the invested capital without either reducing the long-run growth rate of such capital or violating the drawdown constraint for our capital sequence, while simultaneously increasing the amount of capital withdrawn for consumption at the identical long-term rate of V(r, λ*). We extend this result to an exponentially increasing number of consumption categories and discuss how additional yearly contributions can temporarily augment the total capital under management. In addition, we assess the short-term practicality of creating such an endowment/consumption/distribution program.

The Effects of Reduced Salinity on the Shell Growth of Small Mytilus Edulis

1984 ◽  
Vol 64 (1) ◽  
pp. 171-182 ◽  
Author(s):  
Patricia C. Almada-Villela
Keyword(s):  
Growth Rate ◽  
Mytilus Edulis ◽  
High Salinity ◽  
Shell Growth ◽  
Experimental Period ◽  
Gradual Decline ◽  
Poor Growth ◽  
Term Response ◽  
Better Than

The shell growth of small coastal Mytilus edulis L. was measured at three different constant low salinities over short periods of time. Growth was significantly depressed in 6·4 and 16‰ S but not in 22·4‰ S. Fluctuating salinities between 0 and 32‰ S depressed growth whether the fluctuations were of sinusoidal or abrupt form. After 1 week of preconditioning to constant 32‰ S the growth of coastal (Bangor) mussels was better than estuarine (Conwy) mussels. However, after two weeks’ preconditioning to 32‰ S the estuarine mussels displayed the best growth. In the fluctuating regime, both coastal and estuarine mussels exhibited poor growth rates. The long-term response of the shell growth of coastal M. edulis was followed over a period of 44 days. Salinities in the range 1·8–9·6‰ S were lethal to the mussels within 10 days. In 12·8 and 16‰ S growth was initially delayed but recovered eventually. There was a gradual decline in the growth rate of the mussels exposed to the higher salinities (19·2–32‰) and an improvement in the growth of the mussels living in lower salinities (12·8 and 16‰) to levels nearly matching that of the high salinity animals by day 37. This suggests that acclimation of the shell growth of M. edulis to salinities in the 12·8–28·8‰ S range was achieved by the mussels during the experimental period.

Walleye (Stizostedion vitreum vitreum) and Yellow Perch (Perca flavescens) Populations and Fisheries of the Red Lakes, Minnesota, 1930–75

1977 ◽  
Vol 34 (10) ◽  
pp. 1774-1783 ◽  
Author(s):  
Lloyd L. Smith Jr.
Keyword(s):  
Growth Rate ◽  
Yellow Perch ◽  
Climatic Factors ◽  
Perca Flavescens ◽  
Growing Season ◽  
Commercial Fishery ◽  
Class Strength ◽  
Parent Stock ◽  
Catch Statistics

In an investigation of the commercial fishery of Red Lakes, Minnesota, for the 46-yr period 1930–75, catch statistics were analyzed, and the dynamics of the perch and walleye populations were examined. Mean annual yields of walleye for two statistical periods, 1930–53 and 1954–75, were 309,900 and 245,100 kg, respectively for walleyes, and 96,400 and 109,500 kg for perch. Annual abundance (CPE based on average catches per day per 5-net units of gill nets) varied from 3.8 to 64.6 kg for walleye, and from 2.5 to 34.4 kg for perch. Causes of fluctuations in harvestable stock were directly related to strength of year-classes and to growth rate during the season of capture. Year-class strength was not related to the abundance of parent stock or of potential predators. The respective strengths of year-classes of perch and walleye in the same year were positively correlated (r = 0.859, P < 0.01), and are directly related to climatic factors. Growth rate of walleye in different calendar years varied from +30.7 to −42.2% of mean growth, and that of perch from +13.4 to −8.6% (1941–56). Growing season began in mid-June and was almost over by September 1. Walleye yield could be enhanced by starting harvest July 1 instead of early June. Perch yield could be improved by harvesting small perch. Key words: Percidae, Perca, population dynamics, Stizostedion, long-term yield

scholarly journals The evolution of gastropod shell form: a developmental model illustrating the roles of heterochrony and non-heterochronic changes

1992 ◽  
Vol 6 ◽  
pp. 245-245
Author(s):  
Sean H. Rice
Keyword(s):  
Growth Rate ◽  
Specific Pattern ◽  
Apex Angle ◽  
Developmental Model ◽  
Gastropod Shell ◽  
Shell Form ◽  
Marine Snails ◽  
Highly Sensitive ◽  
Highly Correlated ◽  
Shell Production

The shape of an isometric gastropod shell can be described completely by specifying the pattern of shell secretion around the aperture (relative to aperture size) and the growth rate of the aperture itself. These descriptors provide a “natural” morphometric in that they correspond to the specific biological processes involved in constructing the shell.Describing shell form in this way allows us to specify what developmental changes must occur during the transition of one shell form to another. In particular, we can distinguish between transitions that can occur through purely heterochronic processes (changes in growth rate) and those that require a change in the specific pattern in which cells of the mantle lay down shell. We can also investigate just what changes occur during the ontogeny of non-isometric shells.Any change in either the pattern of shell secretion or the growth rate of the animal leads to changes in a number of classical morphometric measures, such as apex angle and whorl expansion rate. Those transformations resulting from changes in growth rate, however, are much more predictable than those resulting from changes in the pattern of shell production. A slight increase in the growth rate of the animal, for instance, produces a correspondingly slight increase in the apex angle and the rate of whorl expansion. By contrast, the consequences of a slight change in the pattern of shell production are highly sensitive to just how that change was achieved.Data from 8 genera of marine snails show that the variance within each genus, relative to the variance among all genera, is smaller for measures of aperture shape (which can only be altered through a change in the pattern of secretion of shell material) than for characters that can change through heterochronic transformations (such as apex angle). Furthermore, the shell forms of a number of non isometric shells can be described by a constant pattern of shell production and a variable growth rate.Heterochronic changes thus appear to be the preferred mechanism for changing phenotype in gastropod shells. Those characters that can only be altered by changing the pattern of shell production around the mantle, such as aperture shape, appear to be more conservative than those that can be changed through purely heterochronic transitions. This is consistent with the idea that mutations which alter many characters in a highly correlated manner have a higher probability of being favored by selection than those with relatively unpredictable consequences.

Growth and seasonal weight changes as they relate to spring and autumn set points in mule deer

1991 ◽  
Vol 69 (3) ◽  
pp. 744-747 ◽  
Author(s):  
Lyle A. Renecker ◽  
W. M. Samuel
Keyword(s):  
Growth Rate ◽  
Weight Loss ◽  
Weight Gain ◽  
Mule Deer ◽  
Odocoileus Hemionus ◽  
Weight Changes ◽  
Annual Cycles ◽  
Body Weights ◽  
Compensatory Gain ◽  
Highly Correlated

Growth rate and potential, 25 hand-reared mule deer (Odocoileus hemionus hemionus) were examined. When possible, body weights of all animals were recorded weekly. Female deer matured faster than males, but males attained a larger body size. Regressions of winter weight loss of both sexes on peak autumn weight were highly correlated. Similarly, spring and summer compensatory gain in females could be predicted from the minimum spring weight. Annual cycles of intake and weight gain may have adaptations that improve reproductive success and winter survival.

The performance of pregnant and lactating Merino ewes and their lambs fed survival rations of wheat grain and sawdust

1978 ◽  
Vol 18 (90) ◽  
pp. 34 ◽  
Author(s):  
RA Hunter
Keyword(s):  
Growth Rate ◽  
Birth Weight ◽  
Survival Rate ◽  
Wheat Grain ◽  
Term Survival ◽  
Feeding Level ◽  
Wool Growth ◽  
Eucalyptus Maculata ◽  
Maintenance Ration

Merino ewes were mated at pasture and then fed in pens either a maintenance or an 80 per cent maintenance ration of wheat grain three times a week. Half the animals at each feeding level were offered Spotted Gum (Eucalyptus maculata) sawdust. Addition of sawdust to the ration did not affect liveweight change and the wool growth rate of ewes or the birth weight and growth rate of lambs. It did, however, affect the long-term survival rate of ewes. Of the ewes that died after three months of survival feeding, four were in groups fed wheat alone and one in a group fed sawdust with the wheat. The survival rate and growth rate of lambs in all treatments were poor.

scholarly journals Antioxidative and antimicrobial potentials of Parmelia saxatilis and Pseudoevernia furfuracea

2016 ◽  
pp. 9-18
Author(s):  
Jasmina Cilerdzic ◽  
Mirjana Stajic ◽  
Jelena Vukojevic
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Side Effects ◽  
Klebsiella Pneumoniae ◽  
Bacterial Species ◽  
Phenol Content ◽  
Negative Side Effects ◽  
Highly Correlated ◽  
Ethanol Extracts

Even though numerous lichen species possess significant medical potentials they are still unexplored, and particularly species and strains originating from Serbia. Therefore, the aim of this study was to evaluate the antioxidative and antimicrobial potential of ethanol extracts of Parmelia saxatilis and Pseudoevernia furfuracea collected in Serbia. The tested extracts were good scavengers of DPPH radicals, with capacities ranging from 14.76% to 79.76% in P. saxatilis and from 21.39% to 90.04% in P. furfuracea. In P. saxatilis level of DPPH? neutralisation was highly correlated with phenol content (r2 = 0.9981) and in P. furfuracea with amount of total flavonoides (r2 = 0.9641). The extract of P. furfuracea inhibited the growth of all tested microorganisms with exception of Aspergillus flavus, while P. saxatilis extract affected only growth of bacterial species. Among tested microorganisms, Staphylococcus aureus and Klebsiella pneumoniae were the most sensitive, while Enterococcus faecalis, Pseudomonas aeruginosa as well as micromycetes were the least sensitive to tested extracts. Because of these potentials and the fact that their long term usage does not have any negative side effects on organism and development of microbial resistance, the extracts could be included in conventional therapy.

scholarly journals Assessing the Fiscal Sustainability of Government Finances in European Countries

2013 ◽  
Vol 52 (1) ◽  
pp. 87-93
Author(s):  
Yuriy Melnykov
Keyword(s):  
Growth Rate ◽  
Time Series ◽  
Interest Rate ◽  
Unit Root ◽  
Statistical Approach ◽  
Fiscal Sustainability ◽  
European Countries ◽  
Gdp Growth ◽  
Gdp Growth Rate

This paper analyses the fiscal sustainability of government finances in the 27 EU countries and Norway using an empirical, statistical approach and ADF tests for a unit root in the time series of the differences between the GDP growth rate and the long-term interest rate, and the primary balance.

scholarly journals Molecular function limits divergent protein evolution on planetary timescales

2017 ◽  
Author(s):  
Mariam M. Konaté ◽  
Germán Plata ◽  
Jimin Park ◽  
Dinara R. Usmanova ◽  
Harris H. Wang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Protein Evolution ◽  
Molecular Function ◽  
Functional Conservation ◽  
Fitness Effects ◽  
Sequence Identity ◽  
The Past ◽  
Independent Evolution

AbstractFunctional conservation is known to constrain protein evolution. Nevertheless, the long-term divergence patterns of proteins maintaining the same molecular function and the possible limits of this divergence have not been explored in detail. We investigate these fundamental questions by characterizing the divergence between ancient protein orthologs with conserved molecular function. Our results demonstrate that the decline of sequence and structural similarities between such orthologs significantly slows down after ~1-2 billion years of independent evolution. As a result, their sequence and structural similarities have not substantially decreased for the past billion years. The effective divergence limit (>25% sequence identity) is not primarily due to protein sites universally conserved in all linages. Instead, less than four amino acid types are accepted, on average, per site in orthologs strictly conserving their molecular function. Our analysis also reveals different divergence patterns for protein sites with experimentally determined small and large fitness effects of mutations.

scholarly journals Snowpack variability and trends at long-term stations in northern Colorado, USA

2015 ◽  
Vol 371 ◽  
pp. 131-136 ◽  
Author(s):  
S. R. Fassnacht ◽  
M. Hultstrand
Keyword(s):  
Snow Depth ◽  
Snow Water Equivalent ◽  
Entire Period ◽  
Northern Colorado ◽  
Snow Water ◽  
Highly Correlated ◽  
The Individual

Abstract. The individual measurements from snowcourse stations were digitized for six stations across northern Colorado that had up to 79 years of record (1936 to 2014). These manual measurements are collected at the first of the month from February through May, with additional measurements in January and June. This dataset was used to evaluate the variability in snow depth and snow water equivalent (SWE) across a snowcourse, as well as trends in snowpack patterns across the entire period of record and over two halves of the record (up to 1975 and from 1976). Snowpack variability is correlated to depth and SWE. The snow depth variability is shown to be highly correlated with average April snow depth and day of year. Depth and SWE were found to be significantly decreasing over the entire period of record at two stations, while at another station the significant trends were an increase over the first half of the record and a decrease over the second half. Variability tended to decrease with time, when significant.

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