The problems and causes of match-fixing: are legal sports betting regimes to blame?

2018 ◽  
Vol 4 (1) ◽  
pp. 73-87 ◽  
Author(s):  
Minhyeok Tak ◽  
Michael P. Sam ◽  
Steven J. Jackson
Keyword(s):  
Regulatory System ◽  
Legal Framework ◽  
Sports Betting ◽  
Human Beings ◽  
Content Type ◽  
Policy Problem ◽  
A Value ◽  
Incentive Structures ◽  
Wide Range ◽  
National Boundaries

Purpose Sport match-fixing has emerged as a complex global problem. The purpose of this paper is twofold. First, it critically reviews how match-fixing is typified as a policy problem. Second, it advances an analysis of the legal framework and regulatory system for sports betting as a causal source for “routinized” match-fixing. Design/methodology/approach This study extracts and synthesises (cross-national) materials from policies, media releases and scholarly works on the subject of match-fixing and sports betting. The analysis is framed by the contrasts between rational choice and sociological institutionalist approaches. Findings Match-fixing is typically attributed to: criminal organisations and illegal sports betting; vulnerable individuals; and failure of governance on the part of sports organisations. Each cause holds assumptions of utility-maximising actors and it is argued that due consideration be given to the fundamental risks inherent in legal sports betting regimes. Research limitations/implications Match-fixing in sport is a recurrent social problem, transcending national boundaries and involving a wide range of actors and, sporting disciplines and levels of competition. Within such an environment, it may matter little how strong the incentive structures and education programmes are, when betting on human beings is both normatively and cognitively advanced as a value and institutionally permitted as a practice. Originality/value This paper argues that legal betting regimes paradoxically contribute to routinised match-fixing because: for betting customers there is no qualitative, ethical difference between legal and illegal operators; and legalisation serves to normalise and legitimate the view of athletes as objects for betting (like cards or dice).

Minds and brains: angels, humans, and brutes

1982 ◽  
Vol 57 (3) ◽  
pp. 309-315
Author(s):  
Mortimer J. Adler
Keyword(s):  
Nervous System ◽  
Animal Behavior ◽  
Personal Experience ◽  
Human Beings ◽  
Content Type ◽  
The Past ◽  
Wide Range ◽  
Conceptual Thought ◽  
The Brain ◽  
Fine Print

✓ In his 1982 Cushing oration, a distinguished philosopher, author, and discerning critic presents a distillate of his phenomenally wide range of personal experience and his familiarity with the great books and teachers of the present and the past. He explores the differences and relationships between human beings, brute animals, and machines. Knowledge of the brain and nervous system contribute to the explanation of all aspects of animal behavior, intelligence, and mentality, but cannot completely explain human conceptual thought.

scholarly journals Gene Cluster Responsible for Secretion of and Immunity to Multiple Bacteriocins, the NKR-5-3 Enterocins

2014 ◽  
Vol 80 (21) ◽  
pp. 6647-6655 ◽  
Author(s):  
Naoki Ishibashi ◽  
Kohei Himeno ◽  
Yoshimitsu Masuda ◽  
Rodney Honrada Perez ◽  
Shun Iwatani ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Abc Transporter ◽  
Response Regulator ◽  
Regulatory System ◽  
Content Type ◽  
Expression Studies ◽  
A Genome ◽  
Wide Range ◽  
Close Proximity ◽  
Immunity Genes

ABSTRACTEnterococcus faeciumNKR-5-3, isolated from Thai fermented fish, is characterized by the unique ability to produce five bacteriocins, namely, enterocins NKR-5-3A, -B, -C, -D, and -Z (Ent53A, Ent53B, Ent53C, Ent53D, and Ent53Z). Genetic analysis with a genome library revealed that the bacteriocin structural genes (enkA[ent53A],enkC[ent53C],enkD[ent53D], andenkZ[ent53Z]) that encode these peptides (except for Ent53B) are located in close proximity to each other. This NKR-5-3ACDZ (Ent53ACDZ) enterocin gene cluster (approximately 13 kb long) includes certain bacteriocin biosynthetic genes such as an ABC transporter gene (enkT), two immunity genes (enkIazandenkIc), a response regulator (enkR), and a histidine protein kinase (enkK). Heterologous-expression studies ofenkTand ΔenkTmutant strains showed thatenkTis responsible for the secretion of Ent53A, Ent53C, Ent53D, and Ent53Z, suggesting that EnkT is a wide-range ABC transporter that contributes to the effective production of these bacteriocins. In addition, EnkIaz and EnkIc were found to confer self-immunity to the respective bacteriocins. Furthermore, bacteriocin induction assays performed with the ΔenkRKmutant strain showed that EnkR and EnkK are regulatory proteins responsible for bacteriocin production and that, together with Ent53D, they constitute a three-component regulatory system. Thus, the Ent53ACDZ gene cluster is essential for the biosynthesis and regulation of NKR-5-3 enterocins, and this is, to our knowledge, the first report that demonstrates the secretion of multiple bacteriocins by an ABC transporter.

scholarly journals Perhaps the Dodo should have accounted for human beings? Accounts of humanity and (its) extinction

2018 ◽  
Vol 31 (3) ◽  
pp. 826-848 ◽  
Author(s):  
Rob Gray ◽  
Markus J. Milne
Keyword(s):  
Human Beings ◽  
Species Extinction ◽  
Content Type ◽  
Root Cause ◽  
Counter Narrative ◽  
Wide Range ◽  
Underlying Causes ◽  
Specific Species ◽  
Substantial Change

Purpose The purpose of this paper is to offer a counter-narrative to accounts of specific species extinction. The authors place humanity’s ways of organising at the core and recognise that only fundamental re-appraisal of humanity’s taken-for-granted narratives offers hope for biodiversity and sustainability. The authors challenge producers of accounts of all sorts to reconsider the context and level of resolution of their accounts. The authors argue that humankind is the root cause of most (if not all) current species extinctions; that such extinctions represent one reason why humanity might itself be threatened with extinction; and why human extinction might be a good thing. The authors need to imagine other, better, futures. Design/methodology/approach The piece is an essay which assembles a wide range of literature in order to support its contentions. Findings There are many individual accounts of species which explore the (albeit very serious) symptoms of a problem without, the authors maintain, examining the systematic source of the problem. The source problem is western mankind’s organisation and somewhat taciturn conception of humanity. There is a lack of accounts offering new possibilities. Research limitations/implications The piece is an essay and, consequently, limited to the quality of the argument presented. The essay suggests that the principal implications relate to how producers of counter-accounts frame their construction of accounts and how accounts of species extinction need to be more cognisant of underlying causes. Practical implications Without substantial change, planetary ecology, including humanity, is very seriously threatened. Imagining a plausible future is a most practical act of faith. Social implications The essay suggests that as accountants the authors might think to approach the counter-accounts with a lower level of resolution: one that is directed towards a more challenging notion of what it is to be human. Originality/value Whilst building upon the growing sophistication in the understanding of (new) accounts and responding to the emerging literatures on biodiversity, species extinction and utopian vision the authors offer what the authors believe to be a unique suggestion in the accounting literature about the extinction of mankind.

scholarly journals An AlgU-Regulated Antisense Transcript Encoded within thePseudomonas syringaefleQGene Has a Positive Effect on Motility

2018 ◽  
Vol 200 (7) ◽  
Author(s):  
Eric Markel ◽  
Hollie Dalenberg ◽  
Caroline L. Monteil ◽  
Boris A. Vinatzer ◽  
Bryan Swingle
Keyword(s):  
Pseudomonas Syringae ◽  
Antisense Transcript ◽  
Gene Expression Regulation ◽  
Regulatory System ◽  
Comparative Sequence Analysis ◽  
Regulation Mechanism ◽  
Tomato Dc3000 ◽  
Sequence Comparisons ◽  
Content Type ◽  
Wide Range

ABSTRACTProduction of bacterial flagella is controlled by a multitiered regulatory system that coordinates the expression of 40 to 50 subunits and ordered assembly of these elaborate structures. Flagellar expression is environmentally controlled, presumably to optimize the benefits and liabilities of having these organelles on cell growth and survival. We recently reported a global survey of AlgU-dependent regulation and binding inPseudomonas syringaepv. tomato DC3000 that included evidence for strong downregulation of many flagellar and chemotaxis motility genes. Here, we returned to those data to look for other AlgU-dependent influences on the flagellar regulatory network. We identified an AlgU-dependent antisense transcript expressed from within thefleQgene, the master regulator of flagellar biosynthesis inPseudomonas. We tested whether expression of this antisense RNA influenced bacterial behavior and found that it reduces AlgU-dependent downregulation of motility. Importantly, this antisense expression influenced motility only under conditions in which AlgU was expressed. Comparative sequence analysis of the locus containing the antisense transcript's AlgU-dependent promoter in over 300Pseudomonasgenomes revealed sequence conservation in most strains that encode AlgU. This suggests that the antisense transcript plays an important role that is conserved across most of the genusPseudomonas.IMPORTANCEPseudomonas syringaeis a globally distributed host-specific bacterial pathogen that causes disease in a wide-range of plants. An elaborate gene expression regulation network controls flagellum production, which is important for proper flagellum assembly and a key aspect of certain lifestyle transitions.P. syringaepv. tomato DC3000 uses flagellum-powered motility in the early stages of host colonization and adopts a sessile lifestyle after entering plant tissues, but the regulation of this transition is not understood. Our work demonstrates a link between regulation of motility and global transcriptional control that facilitates bacterial growth and disease in plants. Additionally, sequence comparisons suggest that this regulation mechanism is conserved in most members of the genusPseudomonas.

Striving for sustainable value chain establishment: a multiple feasibility analysis approach

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Marie Ingrid Herman ◽  
Minh Thi Thai
Keyword(s):  
Value Chain ◽  
New Caledonia ◽  
Feasibility Analysis ◽  
Environmental Drivers ◽  
Research Approach ◽  
Content Type ◽  
A Value ◽  
Wide Range ◽  
Sustainable Value ◽  
Cut Foliage

PurposeOver the last decade, value chain for development has shown its bias towards global value chain approaches. This article proposes a holistic framework to carry out feasibility analysis for the establishment of a value chain.Design/methodology/approachA qualitative research approach was used to collect and analyse data from a wide range of stakeholders potentially involved in establishment of a global cut-foliage value chain based on wild harvesting of ornamental ferns in New Caledonia.FindingsMultiple feasibility analyses revealed issues that need to be addressed, priorities for different stakeholders and possible ways forward in the establishment of a value chain.Research limitations/implicationsThe framework supports businesses, entrepreneurs, investors, donors and governments in proceeding with value chain establishment with significant consideration of social, economic and environmental drivers for sustainability.Originality/valueRelevant concepts in several fields are integrated into a single framework that can guide feasibility analysis of value chain establishment.

How effective are the current global standards in combating money laundering and terrorist financing?

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Sisira Dharmasri Jayasekara
Keyword(s):  
Money Laundering ◽  
Quantitative Measure ◽  
Legal Framework ◽  
Content Type ◽  
Future Studies ◽  
Terrorist Financing ◽  
Effective Implementation ◽  
Wide Range ◽  
Effectiveness Index ◽  
The Impact

Purpose The purpose of this paper is to study the impact of global anti-money laundering and countering the financing of terrorism (AML/CFT) standards on combating money laundering and terrorist financing (ML/TF) efforts. This study will assess the impact of AML/CFT legal framework as well as the effective implementation of the framework on combating crimes. Design/methodology/approach The author develops an AML/CFT effectiveness index using the results of 11 immediate outcomes in mutual evaluation reports to measure the overall effectiveness of regimes in combating ML/TF. In addition to this index, the AML/CFT compliance index is used to measure the strength of the AML/CFT legal framework of countries. A model was developed and tested to measure the impact of the AML/CFT legal framework and its effective implementation on corruption, bribery, terrorism and crimes. Findings The results suggest that the effective implementation of the AML/CFT legal framework is important to combat ML/TF. The existence of a sound AML/CFT legal framework alone will not be sufficient to combat ML/TF. Therefore, countries are required to implement their legal framework effectively to achieve the AML/CFT goals of the country as well as the global policymaker. The empirical results show a significant relationship between the AML/CFT effectiveness index with the proxies the author used to capture corruption, bribes and crimes. Considering the wide range of implications of the crimes, which are related to ML/TF, this study suggests the global policymakers to further strengthen the monitoring mechanism of AML/CFT deficient countries to protect the global financial systems from criminals. Practical implications There is a dearth of studies on the impact of the effectiveness of the AML/CFT regime on combating ML/TF. Therefore, this study will lay the foundation for future studies on measuring the effectiveness of an AML/CFT regime. More appropriate measures will be developed in the future based on this foundation. Originality/value This paper is an original work done by the author, which discusses the impact of Financial Action Task Force standards on combating ML/TF. The AML/CFT effectiveness index is the original idea of the author, which can be used as a quantitative measure to capture the effectiveness of the AML/CFT regimes in future studies.

scholarly journals Relation between start-ups’ online social media presence and fundraising

2017 ◽  
Vol 8 (2) ◽  
pp. 161-180 ◽  
Author(s):  
Song Yang ◽  
Ron Berger
Keyword(s):  
Social Media ◽  
Fund Raising ◽  
Data Availability ◽  
Human Beings ◽  
Content Type ◽  
Online Social Media ◽  
Start Up ◽  
Wide Range ◽  
Capital Financing ◽  
Start Ups

Purpose The purpose of this study is to examine the emergences of social media such as Facebook, Twitter and Instagram have changed the way human beings communicate and interact. In the past few years, this has become crucial in the context of business, especially in start-up fund raising. Access to venture capital financing is a crucial issue in the entrepreneurial finance literature. To further explore the use of social media for entrepreneurs, the authors have explored how entrepreneurs use social media for fund-raising purposes. The authors have used Application Programming Interfaces (APIs) to collect entrepreneurs’ funding data from Crunchbase and entrepreneurs’ social media data from Facebook and Twitter. The results show that social media is significant for start-ups in their success or failure in fund raising. Investing energy into utilizing online social media and exhausting these platforms consciously contributes to the financial success of start-ups. Therefore, start-ups which are popular among online fans and followers can manage to raise larger amounts of funding in the early stages. Design/methodology/approach This research relies on a wide range of quantitative data, which was obtained from three different online sources which includes Facebook, Twitter and CrunchBase. The use of a variety of internet technologies have been linked to increases in individuals’ social network diversity, which likely increases access to social capital at the individual level (Hampton and Wellman, 2003). The dataset was retrieved by using APIs, which enables the collection of novel metrics, from various sources that provide a well-structured dataset (Priem and Hemminger, 2010). Hypotheses were tested on a longitudinal dataset from 2000 to 2013, comprising general and investment data and social media metrics of start-ups. First, a sample from the database was selected to ensure data availability and reliability. After sampling, all the selected companies’ Twitter and Facebook activities were observed and metrics were analysed. SPSS was used to conduct correlation and regression analyses. Findings This study analysed whether start-ups’ social media convention is able to influence investors’ choices, especially the amount of total funding given. The paper showed that innovative start-up companies were able to benefit from communicating on social media platforms. Start-ups, which were using Facebook and Twitter effectively, focusing on valuable social media metrics, received larger amount of funding in total. Furthermore, it was observed that as their business grew, they intended to put more effort into online social networking. It confirmed the idea that businesses are using social media consciously. Originality/value This is the only paper that the authors could find that examines the relationship between fundraising and activity on social networks.

Impact of Environmental Degradation on Human Health

2016 ◽  
Vol 3 (1) ◽  
pp. 1 ◽  
Author(s):  
_______ Archana ◽  
Charu Datta ◽  
Pratibha Tiwari
Keyword(s):  
Environmental Degradation ◽  
Human Population ◽  
Environmental Problems ◽  
Population Increase ◽  
Human Beings ◽  
The People ◽  
Wide Range ◽  
Different Types ◽  
Economic Institute ◽  
Day By Day

Degradation of environment is one of the most serious challenges before the mankind in today’s world. Mankind has been facing a wide range of problem arising out of the degradation of environment. Not only the areas under human inhabitation, but the areas of the planet without human population have also been suffering from these problems. As the population increase day by day, the amenities are not improved simultaneously. With the advancement of science and technologies the needs of human beings has been changing rapidly. As a result different types of environmental problems have been rising. Environmental degradation is a wide- reaching problem and it is likely to influence the health of human population is great. It may be defined the deterioration of the environment through depletion of resources such as air, water, and soil. The destruction of ecosystem and extinction of wildlife. Environmental degradation has occurred due to the recent activities in the field of socio-economic, institute and technology. Poverty still remains a problem as the root of several environmental problems to create awareness among the people about the ill effect of environmental pollution. In the whole research it is clear that all factors of environmental degradation may be reduced through- Framing the new laws on environmental degradation, Environment friend policy, Controlling all the ways and means of noise, air, soil and water pollution, Through growing more and more trees and by adapting the proper sanitation policy.  

scholarly journals Transfer of Plasmid DNA to Clinical Coagulase-Negative Staphylococcal Pathogens by Using a Unique Bacteriophage

2015 ◽  
Vol 81 (7) ◽  
pp. 2481-2488 ◽  
Author(s):  
Volker Winstel ◽  
Petra Kühner ◽  
Bernhard Krismer ◽  
Andreas Peschel ◽  
Holger Rohde
Keyword(s):  
Plasmid Dna ◽  
Genetic Manipulation ◽  
Current Knowledge ◽  
Virulence Determinants ◽  
Coagulase Negative Staphylococci ◽  
Reliable Technique ◽  
Content Type ◽  
Research Activities ◽  
Wide Range ◽  
Genetic Barriers

ABSTRACTGenetic manipulation of emerging bacterial pathogens, such as coagulase-negative staphylococci (CoNS), is a major hurdle in clinical and basic microbiological research. Strong genetic barriers, such as restriction modification systems or clustered regularly interspaced short palindromic repeats (CRISPR), usually interfere with available techniques for DNA transformation and therefore complicate manipulation of CoNS or render it impossible. Thus, current knowledge of pathogenicity and virulence determinants of CoNS is very limited. Here, a rapid, efficient, and highly reliable technique is presented to transfer plasmid DNA essential for genetic engineering to important CoNS pathogens from a uniqueStaphylococcus aureusstrain via a specificS. aureusbacteriophage, Φ187. Even strains refractory to electroporation can be transduced by this technique once donor and recipient strains share similar Φ187 receptor properties. As a proof of principle, this technique was used to delete the alternative transcription factor sigma B (SigB) via allelic replacement in nasal and clinicalStaphylococcus epidermidisisolates at high efficiencies. The described approach will allow the genetic manipulation of a wide range of CoNS pathogens and might inspire research activities to manipulate other important pathogens in a similar fashion.

scholarly journals Use of Proteins Identified through a Functional Genomic Screen To Develop a Protein Subunit Vaccine That Provides Significant Protection against Virulent Streptococcus suis in Pigs

2017 ◽  
Vol 86 (3) ◽  
Author(s):  
Susan L. Brockmeier ◽  
Crystal L. Loving ◽  
Tracy L. Nicholson ◽  
Jinhong Wang ◽  
Sarah E. Peters ◽  
...  
Keyword(s):  
Immune Response ◽  
Vaccine Trial ◽  
Streptococcus Suis ◽  
Protein Subunit ◽  
Content Type ◽  
Degree Of Protection ◽  
Wide Range ◽  
Associated Proteins ◽  
Clinical Protection ◽  
Cellular Immune

ABSTRACT Streptococcus suis is a bacterium that is commonly carried in the respiratory tract and that is also one of the most important invasive pathogens of swine, commonly causing meningitis, arthritis, and septicemia. Due to the existence of many serotypes and a wide range of immune evasion capabilities, efficacious vaccines are not readily available. The selection of S. suis protein candidates for inclusion in a vaccine was accomplished by identifying fitness genes through a functional genomics screen and selecting conserved predicted surface-associated proteins. Five candidate proteins were selected for evaluation in a vaccine trial and administered both intranasally and intramuscularly with one of two different adjuvant formulations. Clinical protection was evaluated by subsequent intranasal challenge with virulent S. suis . While subunit vaccination with the S. suis proteins induced IgG antibodies to each individual protein and a cellular immune response to the pool of proteins and provided substantial protection from challenge with virulent S. suis , the immune response elicited and the degree of protection were dependent on the parenteral adjuvant given. Subunit vaccination induced IgG reactive against different S. suis serotypes, indicating a potential for cross protection.

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