Machine Learning Multi-Modality Fusion Approaches Outperform Single-Modality & Traditional Approaches

2021 ◽  
Author(s):  
Denis Garagic ◽  
Daniel Pelgrift ◽  
Jacob Peskoe ◽  
Ronald D. Hagan ◽  
Peter Zulch ◽  
...  
Keyword(s):  
Machine Learning ◽  
Traditional Approaches ◽  
Single Modality

Recent Progress in Machine Learning-based Prediction of Peptide Activity for Drug Discovery

2019 ◽  
Vol 19 (1) ◽  
pp. 4-16 ◽  
Author(s):  
Qihui Wu ◽  
Hanzhong Ke ◽  
Dongli Li ◽  
Qi Wang ◽  
Jiansong Fang ◽  
...  
Keyword(s):  
Machine Learning ◽  
Drug Discovery ◽  
Large Scale ◽  
Recent Progress ◽  
High Specificity ◽  
Learning Approaches ◽  
Anticancer Peptides ◽  
The Past ◽  
Traditional Approaches ◽  
Large Scale Screening

Over the past decades, peptide as a therapeutic candidate has received increasing attention in drug discovery, especially for antimicrobial peptides (AMPs), anticancer peptides (ACPs) and antiinflammatory peptides (AIPs). It is considered that the peptides can regulate various complex diseases which are previously untouchable. In recent years, the critical problem of antimicrobial resistance drives the pharmaceutical industry to look for new therapeutic agents. Compared to organic small drugs, peptide- based therapy exhibits high specificity and minimal toxicity. Thus, peptides are widely recruited in the design and discovery of new potent drugs. Currently, large-scale screening of peptide activity with traditional approaches is costly, time-consuming and labor-intensive. Hence, in silico methods, mainly machine learning approaches, for their accuracy and effectiveness, have been introduced to predict the peptide activity. In this review, we document the recent progress in machine learning-based prediction of peptides which will be of great benefit to the discovery of potential active AMPs, ACPs and AIPs.

scholarly journals Advances in the Application of Machine Learning Techniques for Power System Analytics: A Survey

Energies ◽  
2021 ◽  
Vol 14 (16) ◽  
pp. 4776
Author(s):  
Seyed Mahdi Miraftabzadeh ◽  
Michela Longo ◽  
Federica Foiadelli ◽  
Marco Pasetti ◽  
Raul Igual
Keyword(s):  
Machine Learning ◽  
Power Systems ◽  
Smart Grids ◽  
State Of The Art ◽  
Smart Cities ◽  
Power Grids ◽  
Machine Learning Techniques ◽  
Learning Techniques ◽  
New Research ◽  
Traditional Approaches

The recent advances in computing technologies and the increasing availability of large amounts of data in smart grids and smart cities are generating new research opportunities in the application of Machine Learning (ML) for improving the observability and efficiency of modern power grids. However, as the number and diversity of ML techniques increase, questions arise about their performance and applicability, and on the most suitable ML method depending on the specific application. Trying to answer these questions, this manuscript presents a systematic review of the state-of-the-art studies implementing ML techniques in the context of power systems, with a specific focus on the analysis of power flows, power quality, photovoltaic systems, intelligent transportation, and load forecasting. The survey investigates, for each of the selected topics, the most recent and promising ML techniques proposed by the literature, by highlighting their main characteristics and relevant results. The review revealed that, when compared to traditional approaches, ML algorithms can handle massive quantities of data with high dimensionality, by allowing the identification of hidden characteristics of (even) complex systems. In particular, even though very different techniques can be used for each application, hybrid models generally show better performances when compared to single ML-based models.

scholarly journals All-cause Dementia Prediction by Machine Learning: The Health, Aging, and Body Composition Study

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 487-487
Author(s):  
Chenkai Wu ◽  
Xurui Jin
Keyword(s):  
Machine Learning ◽  
Body Composition ◽  
Risk Prediction ◽  
Risk Score ◽  
Body Composition Study ◽  
C Statistic ◽  
Dementia Risk ◽  
Health Aging ◽  
Composition Study ◽  
Traditional Approaches

Abstract There are several shortcomings of the currently available risk prediction models for dementia. We developed a risk prediction model for dementia using machine-learning approach and compared its performance with traditional approaches. Data were from the Health, Aging, and Body Composition Study, comprising 3,075 older adults (at least 70 years). Dementia was defined as (1) use of a prescribed dementia medication, (2) adjudicated dementia diagnosis, or (3) a race-stratified cognitive decline>1.5 SDs from the baseline mean. We selected 275 predictors collected from questionnaires, imaging data, performance testing, and biospecimen. We used random survival forest (RSF) to build the full model and rank the importance of predictors. Subsequently, we built parsimonious models with top-20 predictors using RSF and Cox regression. A dementia risk score was developed using top-ranked variables. We used the C-statistic for performance evaluation. Over a median of 11.4 years of follow-up, 659 dementias (21.4%) occurred. The RSF model (both including all and top-20 variables) showed a higher C-statistic than the regression model. Digit symbol score, physical performance battery, finger tapping score, weight change since age 50, serum adiponectin, and APOE genotype were the top-6 variables. We created a dementia risk score (0-10) using the top-6 variables. A 1-unit increase in the risk score was associated with an 8% higher risk of dementia. The risk score demonstrated good discrimination (C-statistic=0.75). Machine learning methods offered improvement over traditional approaches in predicting dementia. The risk prediction score derived from a parsimonious model had good prediction performance.

scholarly journals International agricultural trade forecasting using machine learning

Data & Policy ◽  
2021 ◽  
Vol 3 ◽  
Author(s):  
Munisamy Gopinath ◽  
Feras A. Batarseh ◽  
Jayson Beckman ◽  
Ajay Kulkarni ◽  
Sei Jeong
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Agricultural Trade ◽  
Supervised Machine Learning ◽  
Trade Patterns ◽  
Subjective Assessments ◽  
History Of ◽  
Network Approaches ◽  
Traditional Approaches

Abstract Focusing on seven major agricultural commodities with a long history of trade, this study employs data-driven analytics to decipher patterns of trade, namely using supervised machine learning (ML), as well as neural networks. The supervised ML and neural network techniques are trained on data until 2010 and 2014, respectively. Results show the high relevance of ML models to forecasting trade patterns in near- and long-term relative to traditional approaches, which are often subjective assessments or time-series projections. While supervised ML techniques quantified key economic factors underlying agricultural trade flows, neural network approaches provide better fits over the long term.

scholarly journals Machine learning classification of new asteroid families members

2020 ◽  
Author(s):  
Valerio Carruba
Keyword(s):  
Machine Learning ◽  
Family Members ◽  
Classification Algorithms ◽  
New Members ◽  
Machine Learning Classification ◽  
New Family ◽  
Robotic Telescope ◽  
Traditional Approaches ◽  
Asteroid Families

<p>Asteroid families are groups of asteroids that are the product of collisions or of the rotational fission of a parent object.  These groups are mainly identified in proper elements or frequencies domains.   Because of robotic telescope surveys, the number of known asteroids has increased from about 10,000 in the early 90's to more than 750,000 nowadays. Traditional approaches for identifying new members of asteroid families, like the hierarchical clustering method (HCM), may   struggle to keep up with the growing rate of new discoveries. Here we used machine learning classification algorithms to identify new family members based on the orbital distribution in proper (a,e,sin(i)) of previously known family constituents. We compared the outcome of nine classification algorithms from stand alone and ensemble approaches.  The Extremely Randomized Trees (ExtraTree) method had the highest precision, enabling to  retrieve up to 97% of family members identified with standard HCM.</p>

Machine Learning and Medication Adherence: Scoping Review (Preprint)

2021 ◽  
Author(s):  
Aaron Bohlmann ◽  
Javed Mostafa
Keyword(s):  
Machine Learning ◽  
Medication Adherence ◽  
Scoping Review ◽  
Developmental Stages ◽  
Medication Compliance ◽  
Medication Administration ◽  
Sensor Data ◽  
Medication Monitoring ◽  
User Acceptability ◽  
Traditional Approaches

BACKGROUND This is the first scoping review broadly focused on machine learning and medication adherence. OBJECTIVE To categorize and summarize literature focused on using machine learning for medication compliance activities. METHODS PubMed, Scopus, ACM Digital library, IEEE, and Web of Science were searched to find works that meet the inclusion criteria. Study information of interest was systematically charted before inclusion in the final draft. Studies were placed into natural categories for additional analysis dependent upon the combination of medication adherence activities carried out. The protocol for this scoping review was created using the PRISMA-ScR guidelines. RESULTS Publications focused on predicting medication adherence have uncovered strong predictors that were significant across multiple studies. Studies that used machine learning to monitor medication compliance are generally still in early developmental stages and used a variety of sensor data to detect medication administration. Systems that combined medication monitoring with intervention were mostly concerned with detecting medication administration and only a few compared their system against more traditional approaches. CONCLUSIONS In general, this topic currently has relatively few publications but has been generating more interest over the last few years. Although important features for predicting adherence have been identified more work needs to be done to understand the complex interplay between these features. Systems used to monitor medication compliance also require further testing in more realistic environments and user acceptability evaluations. When interventions are attempted the effectiveness of the system should be evaluated against current systems used to encourage medication compliance. CLINICALTRIAL NONE

scholarly journals Identification of selection and inhibition components in a Go/NoGo task from EEG spectra using a machine learning model

2019 ◽  
Author(s):  
Bambi L. DeLaRosa ◽  
Jeffrey S. Spence ◽  
Michael A. Motes ◽  
Wing To ◽  
Sven Vanneste ◽  
...  
Keyword(s):  
Machine Learning ◽  
Neural Mechanisms ◽  
Frequency Bands ◽  
Time Frequency ◽  
Eeg Spectra ◽  
Therapeutic Uses ◽  
Machine Learning Model ◽  
Superior Parietal Cortex ◽  
Task Conditions ◽  
Traditional Approaches

AbstractPrior Go/NoGo studies have localized specific regions and EEG spectra for which traditional approaches have distinguished between Go and NoGo conditions. A more detailed characterization of the spatial distribution and timing of the synchronization of frequency bands would contribute substantially to the clarification of neural mechanisms that underlie performance of the Go/NoGo task. The present study used a machine learning approach to learn the features that distinguish between ERSPs involved in selection and inhibition in a Go/NoGo task. A neural network classifier was used to predict task conditions for each subject to characterize ERSPs associated with Go versus NoGo trials. The final model accurately identified individual task conditions at an overall rate of 92%, estimated by 5-fold cross-validation. The detailed accounting of EEG time-frequency patterns localized to brain sources (i.e., thalamus, preSMA, orbitofrontal cortex, and superior parietal cortex) provides elaboration on previous findings from fMRI and EEG studies and more information about EEG power changes in multiple frequency bands (i.e., primarily theta power increase, alpha decreases, and beta increases and decreases) within these regions underlying the selection and inhibition processes engaged in the Go and NoGo trials. This extends previous findings, providing more information about neural mechanisms underlying selection and inhibition processes engaged in the Go and NoGo trials, respectively, and may offer insight into therapeutic uses of neuromodulation in neural dysfunction.

scholarly journals Multi Labeled Imbalanced Data Classification Based on Advanced Min-Max Machine Learning

2019 ◽  
Vol 9 (1) ◽  
pp. 1776-1778
Keyword(s):  
Machine Learning ◽  
Uncertain Data ◽  
Imbalanced Data ◽  
Data Classification ◽  
Data Sets ◽  
Imbalanced Data Classification ◽  
Different Types ◽  
Measured System ◽  
Traditional Approaches

Some true applications, for example, content arrangement and sub-cell confinement of protein successions, include multi-mark grouping with imbalanced information. Different types of traditional approaches are introduced to describe the relation of hubristic and undertaking formations, classification of different attributes with imbalanced for different uncertain data sets. Here this addresses the issues by utilizing the min-max particular system. The min-max measured system can break down a multi-mark issue into a progression of little two-class sub-issues, which would then be able to be consolidated by two straightforward standards. Additionally present a few decay procedures to improve the presentation of min-max particular systems. Trial results on sub-cellular restriction demonstrate that our strategy has preferable speculation execution over customary SVMs in settling the multi-name and imbalanced information issues. In addition, it is additionally a lot quicker than customary SVMs

scholarly journals Comparative Analysis of Automatic Exudate Detection between Machine Learning and Traditional Approaches

2009 ◽  
Vol E92-D (11) ◽  
pp. 2264-2271
Author(s):  
Akara SOPHARAK ◽  
Bunyarit UYYANONVARA ◽  
Sarah BARMAN ◽  
Thomas WILLIAMSON
Keyword(s):  
Machine Learning ◽  
Comparative Analysis ◽  
Traditional Approaches

scholarly journals Detection of Talking in Respiratory Signals: A Feasibility Study Using Machine Learning and Wearable Textile-Based Sensors

Sensors ◽  
2018 ◽  
Vol 18 (8) ◽  
pp. 2474 ◽  
Author(s):  
Andreas Ejupi ◽  
Carlo Menon
Keyword(s):  
Machine Learning ◽  
Social Interaction ◽  
Social Isolation ◽  
Machine Learning Algorithms ◽  
Major Health ◽  
Subject Analysis ◽  
Average Accuracy ◽  
Self Reports ◽  
Speech Breathing ◽  
Traditional Approaches

Social isolation and loneliness are major health concerns in young and older people. Traditional approaches to monitor the level of social interaction rely on self-reports. The goal of this study was to investigate if wearable textile-based sensors can be used to accurately detect if the user is talking as a future indicator of social interaction. In a laboratory study, fifteen healthy young participants were asked to talk while performing daily activities such as sitting, standing and walking. It is known that the breathing pattern differs significantly between normal and speech breathing (i.e., talking). We integrated resistive stretch sensors into wearable elastic bands, with a future integration into clothing in mind, to record the expansion and contraction of the chest and abdomen while breathing. We developed an algorithm incorporating machine learning and evaluated its performance in distinguishing between periods of talking and non-talking. In an intra-subject analysis, our algorithm detected talking with an average accuracy of 85%. The highest accuracy of 88% was achieved during sitting and the lowest accuracy of 80.6% during walking. Complete segments of talking were correctly identified with 96% accuracy. From the evaluated machine learning algorithms, the random forest classifier performed best on our dataset. We demonstrate that wearable textile-based sensors in combination with machine learning can be used to detect when the user is talking. In the future, this approach may be used as an indicator of social interaction to prevent social isolation and loneliness.

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