Optimal sequence estimators for statistically unknown binary sources and channels

1973 ◽  
Author(s):  
I. Rubin
Keyword(s):  
Optimal Sequence ◽  
Binary Sources

Optimizing Diagnostic Test Sequences: The Probability Modifying Plot

1999 ◽  
Vol 38 (01) ◽  
pp. 50-55 ◽  
Author(s):  
P. F. de Vries Robbé ◽  
A. L. M. Verbeek ◽  
J. L. Severens
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Decision Trees ◽  
Diagnostic Tests ◽  
Test Sequence ◽  
Optimal Sequence ◽  
Specific Test ◽  
Total Cost ◽  
Modelling Techniques

Abstract:The problem of deciding the optimal sequence of diagnostic tests can be structured in decision trees, but unmanageable bushy decision trees result when the sequence of two or more tests is investigated. Most modelling techniques include tests on the basis of gain in certainty. The aim of this study was to explore a model for optimizing the sequence of diagnostic tests based on efficiency criteria. The probability modifying plot shows, when in a specific test sequence further testing is redundant and which costs are involved. In this way different sequences can be compared. The model is illustrated with data on urinary tract infection. The sequence of diagnostic tests was optimized on the basis of efficiency, which was either defined as the test sequence with the least number of tests or the least total cost for testing. Further research on the model is needed to handle current limitations.

scholarly journals Novel Route Planning Method to Improve the Operational Efficiency of Capacitated Operations. Case: Application of Organic Fertilizer

2021 ◽  
Vol 3 (3) ◽  
pp. 458-477
Author(s):  
Mahdi Vahdanjoo ◽  
Claus G. Sorensen
Keyword(s):  
Organic Fertilizer ◽  
Route Planning ◽  
Fertilizer Application ◽  
Operational Efficiency ◽  
Application Rate ◽  
Simultaneous Optimization ◽  
Limiting Factor ◽  
Application Process ◽  
Optimal Sequence ◽  
Proposed Model

A field area coverage-planning algorithm has been developed for the optimization and simulation of capacitated field operations such as the organic fertilizer application process. The proposed model provides an optimal coverage plan, which includes the optimal sequence of the visited tracks with a designated application rate. The objective of this paper is to present a novel approach for route planning involving two simultaneous optimization criteria, non-working distance minimization and the optimization of application rates, for the capacitated field operations such as organic fertilizer application to improve the overall operational efficiency. The study and the developed algorithm have shown that it is possible to generate the optimized coverage plan based on the required defined capacity of the distributer. In this case, the capacity of the distributer is not considered a limiting factor for the farmers. To validate this new method, a shallow injection application process was considered, and the results of applying the optimization algorithm were compared with the conventional methods. The results show that the proposed method increase operational efficiency by 19.7%. Furthermore, the applicability of the proposed model in robotic application were demonstrated by way of two defined scenarios.

scholarly journals Effects of Time-Varying Parent Input on Children’s Language Outcomes Differ for Vocabulary and Syntax

2021 ◽  
pp. 095679762097055
Author(s):  
Catriona Silvey ◽  
Özlem Ece Demir-Lira ◽  
Susan Goldin-Meadow ◽  
Stephen W. Raudenbush
Keyword(s):  
Standardized Tests ◽  
Child Outcomes ◽  
Time Varying ◽  
Syntactic Complexity ◽  
Language Outcomes ◽  
Optimal Sequence ◽  
Linguistic Input ◽  
Language Input ◽  
The Impact ◽  
Over Time

Early linguistic input is a powerful predictor of children’s language outcomes. We investigated two novel questions about this relationship: Does the impact of language input vary over time, and does the impact of time-varying language input on child outcomes differ for vocabulary and for syntax? Using methods from epidemiology to account for baseline and time-varying confounding, we predicted 64 children’s outcomes on standardized tests of vocabulary and syntax in kindergarten from their parents’ vocabulary and syntax input when the children were 14 and 30 months old. For vocabulary, children whose parents provided diverse input earlier as well as later in development were predicted to have the highest outcomes. For syntax, children whose parents’ input substantially increased in syntactic complexity over time were predicted to have the highest outcomes. The optimal sequence of parents’ linguistic input for supporting children’s language acquisition thus varies for vocabulary and for syntax.

scholarly journals Treatment with Antiangiogenic Drugs in Multiple Lines in Patients with Metastatic Colorectal Cancer: Meta-Analysis of Randomized Trials

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
R.-D. Hofheinz ◽  
U. Ronellenfitsch ◽  
S. Kubicka ◽  
A. Falcone ◽  
I. Burkholder ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Kinase Inhibitors ◽  
Meta Analysis ◽  
Progression Free Survival ◽  
Optimal Sequence ◽  
Primary Endpoints ◽  
Disease Stabilization ◽  
Antiangiogenic Drugs ◽  
The Impact

Background. In metastatic colorectal cancer (mCRC), continuing antiangiogenic drugs beyond progression might provide clinical benefit. We synthesized the available evidence in a meta-analysis.Patients and Methods. We conducted a meta-analysis of studies investigating the use of antiangiogenic drugs beyond progression. Eligible studies were randomized phase II/III trials. Primary endpoints were overall survival (OS) and progression-free survival (PFS). Secondary endpoints were the impact of continuing antiangiogenic drugs (i) in subgroups, (ii) in different types of compounds targeting the VEGF-axis (monoclonal antibodies versus tyrosine kinase inhibitors), and (iii) on remission rates and prevention of progression.Results. Eight studies (3,668 patients) were included. Continuing antiangiogenic treatment beyond progression significantly improved PFS (HR 0.64; 95%-CI, 0.55–0.75) and OS (HR 0.83; 95%-CI, 0.76–0.89). PFS was significantly improved in all subgroups with comparable HR. OS was improved in all subgroups stratified by age, gender, and ECOG status. The rate of patients achieving at least stable disease was improved with an OR of 2.25 (95%-CI, 1.41–3.58).Conclusions. This analysis shows a significant PFS and OS benefit as well as a benefit regarding disease stabilization when using antiangiogenic drugs beyond progression in mCRC. Future studies should focus on the optimal sequence of administering antiangiogenic drugs.

scholarly journals The optimal sequence of radiotherapy and chemotherapy in adjuvant treatment of breast cancer

2011 ◽  
Vol 4 (1) ◽  
pp. 35 ◽  
Author(s):  
Hamza Abbas ◽  
Ashraf Elyamany ◽  
Mohamed Salem ◽  
Ahmed Salem ◽  
Salah Binziad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adjuvant Treatment ◽  
Optimal Sequence

A Method to Define the Best Weld Sequence Using a Limited Number of Welding Simulation Analysis

2015 ◽  
Author(s):  
Mahyar Asadi ◽  
Ghazi Alsoruji
Keyword(s):  
Simulation Model ◽  
Surrogate Model ◽  
Simulation Analysis ◽  
Combinatorial Problem ◽  
Fem Analysis ◽  
Simulation Models ◽  
Computational Time ◽  
Optimal Sequence ◽  
Welded Structure ◽  
Welding Sequence

Weld sequence optimization, which is determining the best (and worst) welding sequence for welding work pieces, is a very common problem in welding design. The solution for such a combinatorial problem is limited by available resources. Although there are fast simulation models that support sequencing design, still it takes long because of many possible combinations, e.g. millions in a welded structure involving 10 passes. It is not feasible to choose the optimal sequence by evaluating all possible combinations, therefore this paper employs surrogate modeling that partially explores the design space and constructs an approximation model from some combinations of solutions of the expensive simulation model to mimic the behavior of the simulation model as closely as possible but at a much lower computational time and cost. This surrogate model, then, could be used to approximate the behavior of the other combinations and to find the best (and worst) sequence in terms of distortion. The technique is developed and tested on a simple panel structure with 4 weld passes, but essentially can be generalized to many weld passes. A comparison between the results of the surrogate model and the full transient FEM analysis all possible combinations shows the accuracy of the algorithm/model.

scholarly journals A feasibility study of combined epigenetic and vaccine therapy in advanced colorectal cancer with pharmacodynamic endpoint

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Katherine M. Bever ◽  
Dwayne L. Thomas ◽  
Jiajia Zhang ◽  
Ernie A. Diaz Rivera ◽  
Gary L. Rosner ◽  
...  
Keyword(s):  
Primary Endpoint ◽  
Dna Methyltransferase ◽  
Optimal Sequence ◽  
Gm Csf ◽  
Investigational Therapies ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Grade 3 ◽  
Immunologic Activity ◽  
Stimulating Factor

AbstractEpigenetic therapies may modulate the tumor microenvironment. We evaluated the safety and optimal sequence of combination DNA methyltransferase inhibitor guadecitabine with a granulocyte macrophage-colony-stimulating-factor (GM-CSF) secreting colon cancer (CRC) vaccine (GVAX) using a primary endpoint of change in CD45RO + T cells. 18 patients with advanced CRC enrolled, 11 underwent paired biopsies and were evaluable for the primary endpoint. No significant increase in CD45RO + cells was noted. Grade 3–4 toxicities were expected and manageable. Guadecitabine + GVAX was tolerable but demonstrated no significant immunologic activity in CRC. We report a novel trial design to efficiently evaluate investigational therapies with a primary pharmacodynamic endpoint.Trial registry Clinicaltrials.gov: NCT01966289. Registered 21 October, 2013.

On-board electronic telecommunication equipment with laser illumination in integrated search systems of underwater vehicles

2021 ◽  
Vol 4 ◽  
pp. 20-28
Author(s):  
V. L. Martynov ◽  
◽  
I. L. Skripnik ◽  
Y. G. Ksenofontov ◽  
M. S. Shimanskaya ◽  
...  
Keyword(s):  
Search Algorithm ◽  
World Ocean ◽  
Underwater Vehicles ◽  
Optimal System ◽  
Electronic Systems ◽  
Underwater Robotics ◽  
Optimal Sequence ◽  
Radio Electronic ◽  
The Creation ◽  
Search Systems

The intensive development of autonomous underwater robotic complexes is very important for the development of the World Ocean. One of the main problems of using underwater robotic complexes is an increase searching efficiency of underwater devices based on the integration of the capabilities of onboard radio-electronic systems of obtaining information in various physical fields. Analyzing the physical basis of the search, including the consideration of the environment of its conduct, objects, as well as detection tools, it can be noted that the result of the search operations of the same objects in the same water areas for various underwater robotic complexes depends on what means of detection they are equipped. The presence of a certain set of the technical means will specify the development of the optimal sequence of actions of the search algorithm. The creation of such algorithms in relation to the task of increasing the search potential of underwater robotics will determine the direction of the research that ensures the formation of an optimal system of underwater search. Efficient use of search resources substantiates the conclusion that radio-electronic means of submersibles forming the system of underwater search, include the number of devices functionally interconnected for its effective conduct. The specified combination is aimed at the formation of the so-called integrated search system, which provides an exchange of information between different channels of searching devices about all objects detected. The article provides proposals for the creation of integrated search systems taking into account practical experiments and experience in designing underwater vehicles capable to implement the optimal system of underwater search using laser technologies.

Sign in / Sign up

Export Citation Format

Share Document